============================================================================= Reading config file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/configfile.txt ============================================================================= ----------------------------------------------------------------------------- Warning: Non-parallel version of QRNA cannot spawn threads. Warning: More threads than cores available. Parameters to be used: Number of minimization steps (NSTEPS): 5000 Golden section step sizes: maximal (MAXSTEP): 0.0001 minimal (MINSTEP): 1e-08 Verbosity (VERBOSE): 1 Write output every: 100 steps (WRITEFREQ) Record trajectory (TRAJECTORY): disabled Pedantic treatment of molecules (PEDANTICMOL): disabled Van der Waals cutoff radius (CUTOFF): 12 Born generalized solvent (USEBORN): disabled Constraints on secondary struct. (SSCONSTR): enabled Auto-detection of secondary struct. (SSDETECT): enabled Secondary structure (SECSTRUCT): none specified Hydrogen bonds (HBONDS): enabled Electrostatics (ELECTR): enabled van der Waals interactions (VANDERWAALS): enabled Anti-blow-up protection (BLOWGUARD): enabled Occupancy as positional restraint (POSRESTRAINTS): disabled Restraints description (RESTRFILE): none Number of parallel threads: 1 ----------------------------------------------------------------------------- Internal Warning: unknown atom type(s) in bond: C2 H5 Internal Warning: unknown atom type(s) in bond: C2 N* Internal Warning: unknown atom type(s) in bond: C2 NB Internal Warning: unknown atom type(s) in bond: C C1 Internal Warning: unknown atom type(s) in bond: CA C1 Internal Warning: unknown atom type(s) in bond: C1 C1 Internal Warning: unknown atom type(s) in bond: C1 CT Internal Warning: unknown atom type(s) in bond: C1 HA Internal Warning: unknown atom type(s) in bond: C1 H4 Internal Warning: unknown atom type(s) in bond: C1 N* Internal Warning: unknown atoms in angle: H5 C2 N* Internal Warning: unknown atoms in angle: H5 C2 NB Internal Warning: unknown atoms in angle: N* C2 NB Internal Warning: unknown atoms in angle: CB N* C2 Internal Warning: unknown atoms in angle: C2 N* CT Internal Warning: unknown atoms in angle: CB NB C2 Internal Warning: unknown atoms in angle: C1 C NA Internal Warning: unknown atoms in angle: C1 C O Internal Warning: unknown atoms in angle: C1 CA N2 Internal Warning: unknown atoms in angle: C1 CA NC Internal Warning: unknown atoms in angle: C C1 C1 Internal Warning: unknown atoms in angle: C C1 CT Internal Warning: unknown atoms in angle: C C1 HA Internal Warning: unknown atoms in angle: C C1 H4 Internal Warning: unknown atoms in angle: CA C1 C1 Internal Warning: unknown atoms in angle: CA C1 HA Internal Warning: unknown atoms in angle: CA C1 H4 Internal Warning: unknown atoms in angle: C1 C1 CT Internal Warning: unknown atoms in angle: C1 C1 HA Internal Warning: unknown atoms in angle: C1 C1 H4 Internal Warning: unknown atoms in angle: C1 C1 N* Internal Warning: unknown atoms in angle: H4 C1 N* Internal Warning: unknown atoms in angle: H1 CT C1 Internal Warning: unknown atoms in angle: HC CT C1 Internal Warning: unknown atoms in angle: C N* C1 Internal Warning: unknown atoms in angle: C1 N* CT Internal Warning: unknown atom(s) in dihedral: X C2 N* X Internal Warning: unknown atom(s) in dihedral: X C2 NB X Internal Warning: unknown atom(s) in dihedral: X C C1 X Internal Warning: unknown atom(s) in dihedral: X CA C1 X Internal Warning: unknown atom(s) in dihedral: X C1 C1 X Internal Warning: unknown atom(s) in dihedral: X C1 CT X Internal Warning: unknown atom(s) in dihedral: X C1 N* X Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in improper: C C1 N* CT Internal Warning: unknown atom(s) in improper: C C1 C1 CT Internal Warning: unknown atom(s) in improper: C1 N2 CA NC Initializing... Generic atom descriptions read: 47 Generic bond descriptions read: 199 Generic angle descriptions read: 567 Generic dihedral descriptions read: 812 Generic improper descriptions read: 116 Generic vdW descriptions read: 47 ----------------------------------------------------------------------------- ============================================================================= Reading PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref.pdb ============================================================================= Atom's 3506 H3' residue renamed to RU3 Atom's 3505 HO'2 residue renamed to RU3 Atom's 3504 H2' residue renamed to RU3 Atom's 3503 H5 residue renamed to RU3 Atom's 3502 H3 residue renamed to RU3 Atom's 3501 H6 residue renamed to RU3 Atom's 3500 H1' residue renamed to RU3 Atom's 3499 H4' residue renamed to RU3 Atom's 3498 H5'2 residue renamed to RU3 Atom's 3497 H5'1 residue renamed to RU3 Atom's 3496 C6 residue renamed to RU3 Atom's 3495 C5 residue renamed to RU3 Atom's 3494 O4 residue renamed to RU3 Atom's 3493 C4 residue renamed to RU3 Atom's 3492 N3 residue renamed to RU3 Atom's 3491 O2 residue renamed to RU3 Atom's 3490 C2 residue renamed to RU3 Atom's 3489 N1 residue renamed to RU3 Atom's 3488 O2' residue renamed to RU3 Atom's 3487 C2' residue renamed to RU3 Atom's 3486 C1' residue renamed to RU3 Atom's 3485 O4' residue renamed to RU3 Atom's 3484 P residue renamed to RU3 Atom's 3483 OP2 residue renamed to RU3 Atom's 3482 OP1 residue renamed to RU3 Atom's 3481 O3' residue renamed to RU3 Atom's 3480 C3' residue renamed to RU3 Atom's 3479 C4' residue renamed to RU3 Atom's 3478 C5' residue renamed to RU3 Atom's 3477 O5' residue renamed to RU3 Missing atom added: ATOM 31 H3T RU3 A 110 47.934 28.042 25.934 1.00 0.00 H Missing atom added: ATOM 7 OP3 G A 1 38.247 41.301 21.865 1.00 0.00 Number of atoms: 3508 Number of residues: 110 Building intraresidual bonds... Building intraresidual angles... Building intraresidual dihedrals... Building intraresidual impropers... Building interresidual bonds... Building interresidual angles... Internal Warning: unknown atoms in angle: H5 C2 N* Internal Warning: unknown atoms in angle: H5 C2 NB Internal Warning: unknown atoms in angle: N* C2 NB Internal Warning: unknown atoms in angle: CB N* C2 Internal Warning: unknown atoms in angle: C2 N* CT Internal Warning: unknown atoms in angle: CB NB C2 Internal Warning: unknown atoms in angle: C1 C NA Internal Warning: unknown atoms in angle: C1 C O Internal Warning: unknown atoms in angle: C1 CA N2 Internal Warning: unknown atoms in angle: C1 CA NC Internal Warning: unknown atoms in angle: C C1 C1 Internal Warning: unknown atoms in angle: C C1 CT Internal Warning: unknown atoms in angle: C C1 HA Internal Warning: unknown atoms in angle: C C1 H4 Internal Warning: unknown atoms in angle: CA C1 C1 Internal Warning: unknown atoms in angle: CA C1 HA Internal Warning: unknown atoms in angle: CA C1 H4 Internal Warning: unknown atoms in angle: C1 C1 CT Internal Warning: unknown atoms in angle: C1 C1 HA Internal Warning: unknown atoms in angle: C1 C1 H4 Internal Warning: unknown atoms in angle: C1 C1 N* Internal Warning: unknown atoms in angle: H4 C1 N* Internal Warning: unknown atoms in angle: H1 CT C1 Internal Warning: unknown atoms in angle: HC CT C1 Internal Warning: unknown atoms in angle: C N* C1 Internal Warning: unknown atoms in angle: C1 N* CT Building interresidual dihedrals... Internal Warning: unknown atom(s) in dihedral: X C2 N* X Internal Warning: unknown atom(s) in dihedral: X C2 NB X Internal Warning: unknown atom(s) in dihedral: X C C1 X Internal Warning: unknown atom(s) in dihedral: X CA C1 X Internal Warning: unknown atom(s) in dihedral: X C1 C1 X Internal Warning: unknown atom(s) in dihedral: X C1 CT X Internal Warning: unknown atom(s) in dihedral: X C1 N* X Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Number of bonds built: 3777 Number of angles built: 6765 Number of dihedrals built: 10303 Number of impropers built: 739 ----------------------------------------------------------------------------- End of molecule (chain) ----------------------------------------------------------------------------- ----------------------------------------------------------------------------- Building interresidual nonbonded pairs & H-bonds (it may take a while)... Number of electrostatic pairs: 6140736 Number of van der Waals pairs: 424298 Number of H-bonds built: 116 Number of spring restraints: 0 Number of positional restraints: 0 Number of base pairs built: 34 Number of molecules (chains) read: 1 ----------------------------------------------------------------------------- Performing minimization step: 1. Total energy = 112409.9735 kcal/mol (112368.6686 without restraints) Performing minimization step: 2. Total energy = 112315.0379 kcal/mol (112273.7444 without restraints) Performing minimization step: 3. Total energy = 112220.1716 kcal/mol (112178.8895 without restraints) Performing minimization step: 4. Total energy = 112125.3747 kcal/mol (112084.1039 without restraints) Performing minimization step: 5. Total energy = 112030.6467 kcal/mol (111989.3871 without restraints) Performing minimization step: 6. Total energy = 111935.9880 kcal/mol (111894.7399 without restraints) Performing minimization step: 7. Total energy = 111841.3989 kcal/mol (111800.1622 without restraints) Performing minimization step: 8. Total energy = 111746.8788 kcal/mol (111705.6536 without restraints) Performing minimization step: 9. Total energy = 111652.4279 kcal/mol (111611.2140 without restraints) Performing minimization step: 10. Total energy = 111558.0466 kcal/mol (111516.8441 without restraints) Performing minimization step: 11. Total energy = 111463.7344 kcal/mol (111422.5432 without restraints) Performing minimization step: 12. Total energy = 111369.4915 kcal/mol (111328.3117 without restraints) Performing minimization step: 13. Total energy = 111275.3177 kcal/mol (111234.1492 without restraints) Performing minimization step: 14. Total energy = 111181.2129 kcal/mol (111140.0558 without restraints) Performing minimization step: 15. Total energy = 111087.1776 kcal/mol (111046.0318 without restraints) Performing minimization step: 16. Total energy = 110993.2114 kcal/mol (110952.0769 without restraints) Performing minimization step: 17. Total energy = 110899.3140 kcal/mol (110858.1908 without restraints) Performing minimization step: 18. Total energy = 110805.4857 kcal/mol (110764.3740 without restraints) Performing minimization step: 19. Total energy = 110711.7260 kcal/mol (110670.6256 without restraints) Performing minimization step: 20. Total energy = 110618.0360 kcal/mol (110576.9471 without restraints) Performing minimization step: 21. Total energy = 110524.4149 kcal/mol (110483.3372 without restraints) Performing minimization step: 22. Total energy = 110430.8629 kcal/mol (110389.7965 without restraints) Performing minimization step: 23. Total energy = 110337.3801 kcal/mol (110296.3250 without restraints) Performing minimization step: 24. Total energy = 110243.9662 kcal/mol (110202.9224 without restraints) Performing minimization step: 25. Total energy = 110150.6213 kcal/mol (110109.5888 without restraints) Performing minimization step: 26. Total energy = 110057.3449 kcal/mol (110016.3237 without restraints) Performing minimization step: 27. Total energy = 109964.1374 kcal/mol (109923.1277 without restraints) Performing minimization step: 28. Total energy = 109870.9988 kcal/mol (109830.0002 without restraints) Performing minimization step: 29. Total energy = 109777.9292 kcal/mol (109736.9419 without restraints) Performing minimization step: 30. Total energy = 109684.9282 kcal/mol (109643.9521 without restraints) Performing minimization step: 31. Total energy = 109591.9961 kcal/mol (109551.0314 without restraints) Performing minimization step: 32. Total energy = 109499.1329 kcal/mol (109458.1796 without restraints) Performing minimization step: 33. Total energy = 109406.3386 kcal/mol (109365.3965 without restraints) Performing minimization step: 34. Total energy = 109313.6129 kcal/mol (109272.6821 without restraints) Performing minimization step: 35. Total energy = 109220.9561 kcal/mol (109180.0365 without restraints) Performing minimization step: 36. Total energy = 109128.3675 kcal/mol (109087.4592 without restraints) Performing minimization step: 37. Total energy = 109035.8482 kcal/mol (108994.9513 without restraints) Performing minimization step: 38. Total energy = 108943.3975 kcal/mol (108902.5118 without restraints) Performing minimization step: 39. Total energy = 108851.0155 kcal/mol (108810.1411 without restraints) Performing minimization step: 40. Total energy = 108758.7016 kcal/mol (108717.8384 without restraints) Performing minimization step: 41. Total energy = 108666.4565 kcal/mol (108625.6044 without restraints) Performing minimization step: 42. Total energy = 108574.2803 kcal/mol (108533.4396 without restraints) Performing minimization step: 43. Total energy = 108482.1726 kcal/mol (108441.3432 without restraints) Performing minimization step: 44. Total energy = 108390.1334 kcal/mol (108349.3152 without restraints) Performing minimization step: 45. Total energy = 108298.1624 kcal/mol (108257.3554 without restraints) Performing minimization step: 46. Total energy = 108206.2605 kcal/mol (108165.4648 without restraints) Performing minimization step: 47. Total energy = 108114.4269 kcal/mol (108073.6425 without restraints) Performing minimization step: 48. Total energy = 108022.6618 kcal/mol (107981.8886 without restraints) Performing minimization step: 49. Total energy = 107930.9653 kcal/mol (107890.2033 without restraints) Performing minimization step: 50. Total energy = 107839.3369 kcal/mol (107798.5860 without restraints) Performing minimization step: 51. Total energy = 107747.7767 kcal/mol (107707.0371 without restraints) Performing minimization step: 52. Total energy = 107656.2851 kcal/mol (107615.5568 without restraints) Performing minimization step: 53. Total energy = 107564.8616 kcal/mol (107524.1444 without restraints) Performing minimization step: 54. Total energy = 107473.5067 kcal/mol (107432.8006 without restraints) Performing minimization step: 55. Total energy = 107382.2198 kcal/mol (107341.5251 without restraints) Performing minimization step: 56. Total energy = 107291.0017 kcal/mol (107250.3182 without restraints) Performing minimization step: 57. Total energy = 107199.8515 kcal/mol (107159.1792 without restraints) Performing minimization step: 58. Total energy = 107108.7696 kcal/mol (107068.1085 without restraints) Performing minimization step: 59. Total energy = 107017.7562 kcal/mol (106977.1063 without restraints) Performing minimization step: 60. Total energy = 106926.8110 kcal/mol (106886.1723 without restraints) Performing minimization step: 61. Total energy = 106835.9341 kcal/mol (106795.3066 without restraints) Performing minimization step: 62. Total energy = 106745.1253 kcal/mol (106704.5090 without restraints) Performing minimization step: 63. Total energy = 106654.3845 kcal/mol (106613.7794 without restraints) Performing minimization step: 64. Total energy = 106563.7121 kcal/mol (106523.1181 without restraints) Performing minimization step: 65. Total energy = 106473.1077 kcal/mol (106432.5250 without restraints) Performing minimization step: 66. Total energy = 106382.5716 kcal/mol (106342.0001 without restraints) Performing minimization step: 67. Total energy = 106292.1028 kcal/mol (106251.5423 without restraints) Performing minimization step: 68. Total energy = 106201.7025 kcal/mol (106161.1531 without restraints) Performing minimization step: 69. Total energy = 106111.3703 kcal/mol (106070.8322 without restraints) Performing minimization step: 70. Total energy = 106021.1063 kcal/mol (105980.5793 without restraints) Performing minimization step: 71. Total energy = 105930.9097 kcal/mol (105890.3938 without restraints) Performing minimization step: 72. Total energy = 105840.7815 kcal/mol (105800.2768 without restraints) Performing minimization step: 73. Total energy = 105750.7212 kcal/mol (105710.2276 without restraints) Performing minimization step: 74. Total energy = 105660.7288 kcal/mol (105620.2462 without restraints) Performing minimization step: 75. Total energy = 105570.8042 kcal/mol (105530.3329 without restraints) Performing minimization step: 76. Total energy = 105480.9477 kcal/mol (105440.4875 without restraints) Performing minimization step: 77. Total energy = 105391.1586 kcal/mol (105350.7096 without restraints) Performing minimization step: 78. Total energy = 105301.4378 kcal/mol (105260.9998 without restraints) Performing minimization step: 79. Total energy = 105211.7847 kcal/mol (105171.3579 without restraints) Performing minimization step: 80. Total energy = 105122.1995 kcal/mol (105081.7838 without restraints) Performing minimization step: 81. Total energy = 105032.6820 kcal/mol (104992.2774 without restraints) Performing minimization step: 82. Total energy = 104943.2320 kcal/mol (104902.8385 without restraints) Performing minimization step: 83. Total energy = 104853.8501 kcal/mol (104813.4676 without restraints) Performing minimization step: 84. Total energy = 104764.5360 kcal/mol (104724.1647 without restraints) Performing minimization step: 85. Total energy = 104675.2893 kcal/mol (104634.9290 without restraints) Performing minimization step: 86. Total energy = 104586.1100 kcal/mol (104545.7608 without restraints) Performing minimization step: 87. Total energy = 104496.9983 kcal/mol (104456.6604 without restraints) Performing minimization step: 88. Total energy = 104407.9546 kcal/mol (104367.6277 without restraints) Performing minimization step: 89. Total energy = 104318.9788 kcal/mol (104278.6630 without restraints) Performing minimization step: 90. Total energy = 104230.0702 kcal/mol (104189.7653 without restraints) Performing minimization step: 91. Total energy = 104141.2289 kcal/mol (104100.9352 without restraints) Performing minimization step: 92. Total energy = 104052.4556 kcal/mol (104012.1729 without restraints) Performing minimization step: 93. Total energy = 103963.7494 kcal/mol (103923.4778 without restraints) Performing minimization step: 94. Total energy = 103875.1112 kcal/mol (103834.8507 without restraints) Performing minimization step: 95. Total energy = 103786.5404 kcal/mol (103746.2910 without restraints) Performing minimization step: 96. Total energy = 103698.0366 kcal/mol (103657.7983 without restraints) Performing minimization step: 97. Total energy = 103609.6005 kcal/mol (103569.3732 without restraints) Performing minimization step: 98. Total energy = 103521.2320 kcal/mol (103481.0158 without restraints) Performing minimization step: 99. Total energy = 103432.9305 kcal/mol (103392.7253 without restraints) Performing minimization step: 100. Total energy = 103344.6965 kcal/mol (103304.5023 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 101. Total energy = 103256.5301 kcal/mol (103216.3470 without restraints) Performing minimization step: 102. Total energy = 103168.4307 kcal/mol (103128.2586 without restraints) Performing minimization step: 103. Total energy = 103080.3986 kcal/mol (103040.2375 without restraints) Performing minimization step: 104. Total energy = 102992.4341 kcal/mol (102952.2840 without restraints) Performing minimization step: 105. Total energy = 102904.5365 kcal/mol (102864.3974 without restraints) Performing minimization step: 106. Total energy = 102816.7061 kcal/mol (102776.5781 without restraints) Performing minimization step: 107. Total energy = 102728.9430 kcal/mol (102688.8260 without restraints) Performing minimization step: 108. Total energy = 102641.2472 kcal/mol (102601.1413 without restraints) Performing minimization step: 109. Total energy = 102553.6186 kcal/mol (102513.5236 without restraints) Performing minimization step: 110. Total energy = 102466.0571 kcal/mol (102425.9731 without restraints) Performing minimization step: 111. Total energy = 102378.5627 kcal/mol (102338.4897 without restraints) Performing minimization step: 112. Total energy = 102291.1351 kcal/mol (102251.0730 without restraints) Performing minimization step: 113. Total energy = 102203.7744 kcal/mol (102163.7234 without restraints) Performing minimization step: 114. Total energy = 102116.4813 kcal/mol (102076.4412 without restraints) Performing minimization step: 115. Total energy = 102029.2551 kcal/mol (101989.2261 without restraints) Performing minimization step: 116. Total energy = 101942.0960 kcal/mol (101902.0780 without restraints) Performing minimization step: 117. Total energy = 101855.0037 kcal/mol (101814.9966 without restraints) Performing minimization step: 118. Total energy = 101767.9784 kcal/mol (101727.9822 without restraints) Performing minimization step: 119. Total energy = 101681.0200 kcal/mol (101641.0349 without restraints) Performing minimization step: 120. Total energy = 101594.1284 kcal/mol (101554.1542 without restraints) Performing minimization step: 121. Total energy = 101507.3033 kcal/mol (101467.3401 without restraints) Performing minimization step: 122. Total energy = 101420.5456 kcal/mol (101380.5934 without restraints) Performing minimization step: 123. Total energy = 101333.8547 kcal/mol (101293.9132 without restraints) Performing minimization step: 124. Total energy = 101247.2302 kcal/mol (101207.2999 without restraints) Performing minimization step: 125. Total energy = 101160.6725 kcal/mol (101120.7530 without restraints) Performing minimization step: 126. Total energy = 101074.1819 kcal/mol (101034.2734 without restraints) Performing minimization step: 127. Total energy = 100987.7576 kcal/mol (100947.8601 without restraints) Performing minimization step: 128. Total energy = 100901.4003 kcal/mol (100861.5137 without restraints) Performing minimization step: 129. Total energy = 100815.1100 kcal/mol (100775.2343 without restraints) Performing minimization step: 130. Total energy = 100728.8864 kcal/mol (100689.0216 without restraints) Performing minimization step: 131. Total energy = 100642.7294 kcal/mol (100602.8755 without restraints) Performing minimization step: 132. Total energy = 100556.6388 kcal/mol (100516.7959 without restraints) Performing minimization step: 133. Total energy = 100470.6151 kcal/mol (100430.7830 without restraints) Performing minimization step: 134. Total energy = 100384.6577 kcal/mol (100344.8365 without restraints) Performing minimization step: 135. Total energy = 100298.7672 kcal/mol (100258.9571 without restraints) Performing minimization step: 136. Total energy = 100212.9432 kcal/mol (100173.1439 without restraints) Performing minimization step: 137. Total energy = 100127.1857 kcal/mol (100087.3973 without restraints) Performing minimization step: 138. Total energy = 100041.4945 kcal/mol (100001.7170 without restraints) Performing minimization step: 139. Total energy = 99955.8699 kcal/mol (99916.1033 without restraints) Performing minimization step: 140. Total energy = 99870.3118 kcal/mol (99830.5561 without restraints) Performing minimization step: 141. Total energy = 99784.8202 kcal/mol (99745.0753 without restraints) Performing minimization step: 142. Total energy = 99699.3947 kcal/mol (99659.6608 without restraints) Performing minimization step: 143. Total energy = 99614.0357 kcal/mol (99574.3126 without restraints) Performing minimization step: 144. Total energy = 99528.7432 kcal/mol (99489.0309 without restraints) Performing minimization step: 145. Total energy = 99443.5168 kcal/mol (99403.8154 without restraints) Performing minimization step: 146. Total energy = 99358.3569 kcal/mol (99318.6664 without restraints) Performing minimization step: 147. Total energy = 99273.2635 kcal/mol (99233.5839 without restraints) Performing minimization step: 148. Total energy = 99188.2362 kcal/mol (99148.5674 without restraints) Performing minimization step: 149. Total energy = 99103.2748 kcal/mol (99063.6168 without restraints) Performing minimization step: 150. Total energy = 99018.3797 kcal/mol (98978.7326 without restraints) Performing minimization step: 151. Total energy = 98933.5509 kcal/mol (98893.9147 without restraints) Performing minimization step: 152. Total energy = 98848.7884 kcal/mol (98809.1630 without restraints) Performing minimization step: 153. Total energy = 98764.0921 kcal/mol (98724.4775 without restraints) Performing minimization step: 154. Total energy = 98679.4617 kcal/mol (98639.8579 without restraints) Performing minimization step: 155. Total energy = 98594.8975 kcal/mol (98555.3046 without restraints) Performing minimization step: 156. Total energy = 98510.3997 kcal/mol (98470.8176 without restraints) Performing minimization step: 157. Total energy = 98425.9679 kcal/mol (98386.3966 without restraints) Performing minimization step: 158. Total energy = 98341.6021 kcal/mol (98302.0417 without restraints) Performing minimization step: 159. Total energy = 98257.3014 kcal/mol (98217.7516 without restraints) Performing minimization step: 160. Total energy = 98173.0674 kcal/mol (98133.5285 without restraints) Performing minimization step: 161. Total energy = 98088.8994 kcal/mol (98049.3714 without restraints) Performing minimization step: 162. Total energy = 98004.7973 kcal/mol (97965.2799 without restraints) Performing minimization step: 163. Total energy = 97920.7611 kcal/mol (97881.2546 without restraints) Performing minimization step: 164. Total energy = 97836.7904 kcal/mol (97797.2945 without restraints) Performing minimization step: 165. Total energy = 97752.8858 kcal/mol (97713.4009 without restraints) Performing minimization step: 166. Total energy = 97669.0471 kcal/mol (97629.5730 without restraints) Performing minimization step: 167. Total energy = 97585.2745 kcal/mol (97545.8112 without restraints) Performing minimization step: 168. Total energy = 97501.5675 kcal/mol (97462.1150 without restraints) Performing minimization step: 169. Total energy = 97417.9266 kcal/mol (97378.4848 without restraints) Performing minimization step: 170. Total energy = 97334.3510 kcal/mol (97294.9199 without restraints) Performing minimization step: 171. Total energy = 97250.8411 kcal/mol (97211.4209 without restraints) Performing minimization step: 172. Total energy = 97167.3974 kcal/mol (97127.9879 without restraints) Performing minimization step: 173. Total energy = 97084.0192 kcal/mol (97044.6205 without restraints) Performing minimization step: 174. Total energy = 97000.7067 kcal/mol (96961.3188 without restraints) Performing minimization step: 175. Total energy = 96917.4598 kcal/mol (96878.0826 without restraints) Performing minimization step: 176. Total energy = 96834.2778 kcal/mol (96794.9112 without restraints) Performing minimization step: 177. Total energy = 96751.1612 kcal/mol (96711.8054 without restraints) Performing minimization step: 178. Total energy = 96668.1109 kcal/mol (96628.7658 without restraints) Performing minimization step: 179. Total energy = 96585.1261 kcal/mol (96545.7918 without restraints) Performing minimization step: 180. Total energy = 96502.2066 kcal/mol (96462.8830 without restraints) Performing minimization step: 181. Total energy = 96419.3527 kcal/mol (96380.0397 without restraints) Performing minimization step: 182. Total energy = 96336.5636 kcal/mol (96297.2615 without restraints) Performing minimization step: 183. Total energy = 96253.8407 kcal/mol (96214.5493 without restraints) Performing minimization step: 184. Total energy = 96171.1832 kcal/mol (96131.9025 without restraints) Performing minimization step: 185. Total energy = 96088.5910 kcal/mol (96049.3209 without restraints) Performing minimization step: 186. Total energy = 96006.0642 kcal/mol (95966.8049 without restraints) Performing minimization step: 187. Total energy = 95923.6028 kcal/mol (95884.3542 without restraints) Performing minimization step: 188. Total energy = 95841.2070 kcal/mol (95801.9692 without restraints) Performing minimization step: 189. Total energy = 95758.8765 kcal/mol (95719.6492 without restraints) Performing minimization step: 190. Total energy = 95676.6108 kcal/mol (95637.3941 without restraints) Performing minimization step: 191. Total energy = 95594.4103 kcal/mol (95555.2043 without restraints) Performing minimization step: 192. Total energy = 95512.2750 kcal/mol (95473.0798 without restraints) Performing minimization step: 193. Total energy = 95430.2051 kcal/mol (95391.0206 without restraints) Performing minimization step: 194. Total energy = 95348.2004 kcal/mol (95309.0266 without restraints) Performing minimization step: 195. Total energy = 95266.2606 kcal/mol (95227.0974 without restraints) Performing minimization step: 196. Total energy = 95184.3861 kcal/mol (95145.2336 without restraints) Performing minimization step: 197. Total energy = 95102.5765 kcal/mol (95063.4346 without restraints) Performing minimization step: 198. Total energy = 95020.8324 kcal/mol (94981.7012 without restraints) Performing minimization step: 199. Total energy = 94939.1533 kcal/mol (94900.0330 without restraints) Performing minimization step: 200. Total energy = 94857.5395 kcal/mol (94818.4296 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 201. Total energy = 94775.9903 kcal/mol (94736.8910 without restraints) Performing minimization step: 202. Total energy = 94694.5058 kcal/mol (94655.4171 without restraints) Performing minimization step: 203. Total energy = 94613.0863 kcal/mol (94574.0082 without restraints) Performing minimization step: 204. Total energy = 94531.7318 kcal/mol (94492.6644 without restraints) Performing minimization step: 205. Total energy = 94450.4423 kcal/mol (94411.3855 without restraints) Performing minimization step: 206. Total energy = 94369.2177 kcal/mol (94330.1715 without restraints) Performing minimization step: 207. Total energy = 94288.0582 kcal/mol (94249.0226 without restraints) Performing minimization step: 208. Total energy = 94206.9629 kcal/mol (94167.9379 without restraints) Performing minimization step: 209. Total energy = 94125.9325 kcal/mol (94086.9181 without restraints) Performing minimization step: 210. Total energy = 94044.9670 kcal/mol (94005.9633 without restraints) Performing minimization step: 211. Total energy = 93964.0662 kcal/mol (93925.0731 without restraints) Performing minimization step: 212. Total energy = 93883.2305 kcal/mol (93844.2479 without restraints) Performing minimization step: 213. Total energy = 93802.4590 kcal/mol (93763.4871 without restraints) Performing minimization step: 214. Total energy = 93721.7524 kcal/mol (93682.7910 without restraints) Performing minimization step: 215. Total energy = 93641.1103 kcal/mol (93602.1596 without restraints) Performing minimization step: 216. Total energy = 93560.5324 kcal/mol (93521.5922 without restraints) Performing minimization step: 217. Total energy = 93480.0197 kcal/mol (93441.0901 without restraints) Performing minimization step: 218. Total energy = 93399.5718 kcal/mol (93360.6527 without restraints) Performing minimization step: 219. Total energy = 93319.1876 kcal/mol (93280.2791 without restraints) Performing minimization step: 220. Total energy = 93238.8682 kcal/mol (93199.9702 without restraints) Performing minimization step: 221. Total energy = 93158.6139 kcal/mol (93119.7265 without restraints) Performing minimization step: 222. Total energy = 93078.4239 kcal/mol (93039.5471 without restraints) Performing minimization step: 223. Total energy = 92998.2982 kcal/mol (92959.4319 without restraints) Performing minimization step: 224. Total energy = 92918.2368 kcal/mol (92879.3811 without restraints) Performing minimization step: 225. Total energy = 92838.2399 kcal/mol (92799.3947 without restraints) Performing minimization step: 226. Total energy = 92758.3076 kcal/mol (92719.4730 without restraints) Performing minimization step: 227. Total energy = 92678.4395 kcal/mol (92639.6154 without restraints) Performing minimization step: 228. Total energy = 92598.6357 kcal/mol (92559.8220 without restraints) Performing minimization step: 229. Total energy = 92518.8961 kcal/mol (92480.0930 without restraints) Performing minimization step: 230. Total energy = 92439.2204 kcal/mol (92400.4277 without restraints) Performing minimization step: 231. Total energy = 92359.6092 kcal/mol (92320.8272 without restraints) Performing minimization step: 232. Total energy = 92280.0623 kcal/mol (92241.2908 without restraints) Performing minimization step: 233. Total energy = 92200.5795 kcal/mol (92161.8184 without restraints) Performing minimization step: 234. Total energy = 92121.1617 kcal/mol (92082.4111 without restraints) Performing minimization step: 235. Total energy = 92041.8071 kcal/mol (92003.0670 without restraints) Performing minimization step: 236. Total energy = 91962.5168 kcal/mol (91923.7872 without restraints) Performing minimization step: 237. Total energy = 91883.2905 kcal/mol (91844.5714 without restraints) Performing minimization step: 238. Total energy = 91804.1278 kcal/mol (91765.4192 without restraints) Performing minimization step: 239. Total energy = 91725.0298 kcal/mol (91686.3316 without restraints) Performing minimization step: 240. Total energy = 91645.9954 kcal/mol (91607.3078 without restraints) Performing minimization step: 241. Total energy = 91567.0253 kcal/mol (91528.3482 without restraints) Performing minimization step: 242. Total energy = 91488.1195 kcal/mol (91449.4528 without restraints) Performing minimization step: 243. Total energy = 91409.2775 kcal/mol (91370.6213 without restraints) Performing minimization step: 244. Total energy = 91330.4992 kcal/mol (91291.8535 without restraints) Performing minimization step: 245. Total energy = 91251.7851 kcal/mol (91213.1497 without restraints) Performing minimization step: 246. Total energy = 91173.1343 kcal/mol (91134.5094 without restraints) Performing minimization step: 247. Total energy = 91094.5476 kcal/mol (91055.9331 without restraints) Performing minimization step: 248. Total energy = 91016.0246 kcal/mol (90977.4206 without restraints) Performing minimization step: 249. Total energy = 90937.5656 kcal/mol (90898.9721 without restraints) Performing minimization step: 250. Total energy = 90859.1700 kcal/mol (90820.5869 without restraints) Performing minimization step: 251. Total energy = 90780.8383 kcal/mol (90742.2656 without restraints) Performing minimization step: 252. Total energy = 90702.5701 kcal/mol (90664.0079 without restraints) Performing minimization step: 253. Total energy = 90624.3658 kcal/mol (90585.8139 without restraints) Performing minimization step: 254. Total energy = 90546.2251 kcal/mol (90507.6836 without restraints) Performing minimization step: 255. Total energy = 90468.1481 kcal/mol (90429.6170 without restraints) Performing minimization step: 256. Total energy = 90390.1348 kcal/mol (90351.6142 without restraints) Performing minimization step: 257. Total energy = 90312.1849 kcal/mol (90273.6747 without restraints) Performing minimization step: 258. Total energy = 90234.2985 kcal/mol (90195.7987 without restraints) Performing minimization step: 259. Total energy = 90156.4757 kcal/mol (90117.9863 without restraints) Performing minimization step: 260. Total energy = 90078.7164 kcal/mol (90040.2374 without restraints) Performing minimization step: 261. Total energy = 90001.0205 kcal/mol (89962.5518 without restraints) Performing minimization step: 262. Total energy = 89923.3879 kcal/mol (89884.9296 without restraints) Performing minimization step: 263. Total energy = 89845.8186 kcal/mol (89807.3707 without restraints) Performing minimization step: 264. Total energy = 89768.3129 kcal/mol (89729.8754 without restraints) Performing minimization step: 265. Total energy = 89690.8706 kcal/mol (89652.4435 without restraints) Performing minimization step: 266. Total energy = 89613.4918 kcal/mol (89575.0750 without restraints) Performing minimization step: 267. Total energy = 89536.1763 kcal/mol (89497.7698 without restraints) Performing minimization step: 268. Total energy = 89458.9241 kcal/mol (89420.5280 without restraints) Performing minimization step: 269. Total energy = 89381.7349 kcal/mol (89343.3491 without restraints) Performing minimization step: 270. Total energy = 89304.6090 kcal/mol (89266.2336 without restraints) Performing minimization step: 271. Total energy = 89227.5463 kcal/mol (89189.1814 without restraints) Performing minimization step: 272. Total energy = 89150.5469 kcal/mol (89112.1922 without restraints) Performing minimization step: 273. Total energy = 89073.6105 kcal/mol (89035.2661 without restraints) Performing minimization step: 274. Total energy = 88996.7371 kcal/mol (88958.4032 without restraints) Performing minimization step: 275. Total energy = 88919.9271 kcal/mol (88881.6033 without restraints) Performing minimization step: 276. Total energy = 88843.1802 kcal/mol (88804.8667 without restraints) Performing minimization step: 277. Total energy = 88766.4965 kcal/mol (88728.1933 without restraints) Performing minimization step: 278. Total energy = 88689.8754 kcal/mol (88651.5826 without restraints) Performing minimization step: 279. Total energy = 88613.3170 kcal/mol (88575.0344 without restraints) Performing minimization step: 280. Total energy = 88536.8218 kcal/mol (88498.5495 without restraints) Performing minimization step: 281. Total energy = 88460.3893 kcal/mol (88422.1274 without restraints) Performing minimization step: 282. Total energy = 88384.0200 kcal/mol (88345.7683 without restraints) Performing minimization step: 283. Total energy = 88307.7135 kcal/mol (88269.4722 without restraints) Performing minimization step: 284. Total energy = 88231.4696 kcal/mol (88193.2385 without restraints) Performing minimization step: 285. Total energy = 88155.2894 kcal/mol (88117.0686 without restraints) Performing minimization step: 286. Total energy = 88079.1716 kcal/mol (88040.9611 without restraints) Performing minimization step: 287. Total energy = 88003.1164 kcal/mol (87964.9162 without restraints) Performing minimization step: 288. Total energy = 87927.1241 kcal/mol (87888.9342 without restraints) Performing minimization step: 289. Total energy = 87851.1945 kcal/mol (87813.0148 without restraints) Performing minimization step: 290. Total energy = 87775.3276 kcal/mol (87737.1582 without restraints) Performing minimization step: 291. Total energy = 87699.5231 kcal/mol (87661.3638 without restraints) Performing minimization step: 292. Total energy = 87623.7810 kcal/mol (87585.6321 without restraints) Performing minimization step: 293. Total energy = 87548.1019 kcal/mol (87509.9632 without restraints) Performing minimization step: 294. Total energy = 87472.4860 kcal/mol (87434.3576 without restraints) Performing minimization step: 295. Total energy = 87396.9322 kcal/mol (87358.8140 without restraints) Performing minimization step: 296. Total energy = 87321.4410 kcal/mol (87283.3330 without restraints) Performing minimization step: 297. Total energy = 87246.0121 kcal/mol (87207.9143 without restraints) Performing minimization step: 298. Total energy = 87170.6455 kcal/mol (87132.5578 without restraints) Performing minimization step: 299. Total energy = 87095.3412 kcal/mol (87057.2638 without restraints) Performing minimization step: 300. Total energy = 87020.0996 kcal/mol (86982.0325 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 301. Total energy = 86944.9203 kcal/mol (86906.8633 without restraints) Performing minimization step: 302. Total energy = 86869.8032 kcal/mol (86831.7565 without restraints) Performing minimization step: 303. Total energy = 86794.7487 kcal/mol (86756.7121 without restraints) Performing minimization step: 304. Total energy = 86719.7565 kcal/mol (86681.7301 without restraints) Performing minimization step: 305. Total energy = 86644.8265 kcal/mol (86606.8103 without restraints) Performing minimization step: 306. Total energy = 86569.9588 kcal/mol (86531.9528 without restraints) Performing minimization step: 307. Total energy = 86495.1530 kcal/mol (86457.1571 without restraints) Performing minimization step: 308. Total energy = 86420.4096 kcal/mol (86382.4240 without restraints) Performing minimization step: 309. Total energy = 86345.7285 kcal/mol (86307.7531 without restraints) Performing minimization step: 310. Total energy = 86271.1095 kcal/mol (86233.1442 without restraints) Performing minimization step: 311. Total energy = 86196.5525 kcal/mol (86158.5973 without restraints) Performing minimization step: 312. Total energy = 86122.0577 kcal/mol (86084.1128 without restraints) Performing minimization step: 313. Total energy = 86047.6251 kcal/mol (86009.6902 without restraints) Performing minimization step: 314. Total energy = 85973.2544 kcal/mol (85935.3297 without restraints) Performing minimization step: 315. Total energy = 85898.9455 kcal/mol (85861.0310 without restraints) Performing minimization step: 316. Total energy = 85824.6989 kcal/mol (85786.7945 without restraints) Performing minimization step: 317. Total energy = 85750.5140 kcal/mol (85712.6198 without restraints) Performing minimization step: 318. Total energy = 85676.3913 kcal/mol (85638.5071 without restraints) Performing minimization step: 319. Total energy = 85602.3302 kcal/mol (85564.4563 without restraints) Performing minimization step: 320. Total energy = 85528.3312 kcal/mol (85490.4672 without restraints) Performing minimization step: 321. Total energy = 85454.3934 kcal/mol (85416.5397 without restraints) Performing minimization step: 322. Total energy = 85380.5183 kcal/mol (85342.6747 without restraints) Performing minimization step: 323. Total energy = 85306.7045 kcal/mol (85268.8710 without restraints) Performing minimization step: 324. Total energy = 85232.9527 kcal/mol (85195.1293 without restraints) Performing minimization step: 325. Total energy = 85159.2624 kcal/mol (85121.4491 without restraints) Performing minimization step: 326. Total energy = 85085.6340 kcal/mol (85047.8308 without restraints) Performing minimization step: 327. Total energy = 85012.0675 kcal/mol (84974.2742 without restraints) Performing minimization step: 328. Total energy = 84938.5625 kcal/mol (84900.7794 without restraints) Performing minimization step: 329. Total energy = 84865.1188 kcal/mol (84827.3458 without restraints) Performing minimization step: 330. Total energy = 84791.7366 kcal/mol (84753.9736 without restraints) Performing minimization step: 331. Total energy = 84718.4161 kcal/mol (84680.6632 without restraints) Performing minimization step: 332. Total energy = 84645.1571 kcal/mol (84607.4145 without restraints) Performing minimization step: 333. Total energy = 84571.9604 kcal/mol (84534.2277 without restraints) Performing minimization step: 334. Total energy = 84498.8244 kcal/mol (84461.1017 without restraints) Performing minimization step: 335. Total energy = 84425.7502 kcal/mol (84388.0375 without restraints) Performing minimization step: 336. Total energy = 84352.7372 kcal/mol (84315.0346 without restraints) Performing minimization step: 337. Total energy = 84279.7859 kcal/mol (84242.0933 without restraints) Performing minimization step: 338. Total energy = 84206.8955 kcal/mol (84169.2130 without restraints) Performing minimization step: 339. Total energy = 84134.0662 kcal/mol (84096.3937 without restraints) Performing minimization step: 340. Total energy = 84061.2986 kcal/mol (84023.6362 without restraints) Performing minimization step: 341. Total energy = 83988.5917 kcal/mol (83950.9390 without restraints) Performing minimization step: 342. Total energy = 83915.9461 kcal/mol (83878.3036 without restraints) Performing minimization step: 343. Total energy = 83843.3622 kcal/mol (83805.7298 without restraints) Performing minimization step: 344. Total energy = 83770.8400 kcal/mol (83733.2177 without restraints) Performing minimization step: 345. Total energy = 83698.3788 kcal/mol (83660.7664 without restraints) Performing minimization step: 346. Total energy = 83625.9785 kcal/mol (83588.3762 without restraints) Performing minimization step: 347. Total energy = 83553.6392 kcal/mol (83516.0468 without restraints) Performing minimization step: 348. Total energy = 83481.3611 kcal/mol (83443.7787 without restraints) Performing minimization step: 349. Total energy = 83409.1439 kcal/mol (83371.5715 without restraints) Performing minimization step: 350. Total energy = 83336.9877 kcal/mol (83299.4252 without restraints) Performing minimization step: 351. Total energy = 83264.8926 kcal/mol (83227.3401 without restraints) Performing minimization step: 352. Total energy = 83192.8583 kcal/mol (83155.3160 without restraints) Performing minimization step: 353. Total energy = 83120.8853 kcal/mol (83083.3528 without restraints) Performing minimization step: 354. Total energy = 83048.9735 kcal/mol (83011.4510 without restraints) Performing minimization step: 355. Total energy = 82977.1218 kcal/mol (82939.6091 without restraints) Performing minimization step: 356. Total energy = 82905.3307 kcal/mol (82867.8281 without restraints) Performing minimization step: 357. Total energy = 82833.6008 kcal/mol (82796.1081 without restraints) Performing minimization step: 358. Total energy = 82761.9318 kcal/mol (82724.4490 without restraints) Performing minimization step: 359. Total energy = 82690.3237 kcal/mol (82652.8509 without restraints) Performing minimization step: 360. Total energy = 82618.7760 kcal/mol (82581.3131 without restraints) Performing minimization step: 361. Total energy = 82547.2885 kcal/mol (82509.8355 without restraints) Performing minimization step: 362. Total energy = 82475.8623 kcal/mol (82438.4194 without restraints) Performing minimization step: 363. Total energy = 82404.4972 kcal/mol (82367.0641 without restraints) Performing minimization step: 364. Total energy = 82333.1922 kcal/mol (82295.7690 without restraints) Performing minimization step: 365. Total energy = 82261.9477 kcal/mol (82224.5343 without restraints) Performing minimization step: 366. Total energy = 82190.7639 kcal/mol (82153.3604 without restraints) Performing minimization step: 367. Total energy = 82119.6407 kcal/mol (82082.2473 without restraints) Performing minimization step: 368. Total energy = 82048.5781 kcal/mol (82011.1946 without restraints) Performing minimization step: 369. Total energy = 81977.5761 kcal/mol (81940.2024 without restraints) Performing minimization step: 370. Total energy = 81906.6345 kcal/mol (81869.2708 without restraints) Performing minimization step: 371. Total energy = 81835.7536 kcal/mol (81798.3997 without restraints) Performing minimization step: 372. Total energy = 81764.9327 kcal/mol (81727.5886 without restraints) Performing minimization step: 373. Total energy = 81694.1720 kcal/mol (81656.8378 without restraints) Performing minimization step: 374. Total energy = 81623.4720 kcal/mol (81586.1477 without restraints) Performing minimization step: 375. Total energy = 81552.8322 kcal/mol (81515.5178 without restraints) Performing minimization step: 376. Total energy = 81482.2527 kcal/mol (81444.9481 without restraints) Performing minimization step: 377. Total energy = 81411.7332 kcal/mol (81374.4385 without restraints) Performing minimization step: 378. Total energy = 81341.2743 kcal/mol (81303.9895 without restraints) Performing minimization step: 379. Total energy = 81270.8752 kcal/mol (81233.6002 without restraints) Performing minimization step: 380. Total energy = 81200.5362 kcal/mol (81163.2711 without restraints) Performing minimization step: 381. Total energy = 81130.2576 kcal/mol (81093.0023 without restraints) Performing minimization step: 382. Total energy = 81060.0391 kcal/mol (81022.7936 without restraints) Performing minimization step: 383. Total energy = 80989.8806 kcal/mol (80952.6448 without restraints) Performing minimization step: 384. Total energy = 80919.7819 kcal/mol (80882.5560 without restraints) Performing minimization step: 385. Total energy = 80849.7437 kcal/mol (80812.5277 without restraints) Performing minimization step: 386. Total energy = 80779.7653 kcal/mol (80742.5591 without restraints) Performing minimization step: 387. Total energy = 80709.8469 kcal/mol (80672.6505 without restraints) Performing minimization step: 388. Total energy = 80639.9883 kcal/mol (80602.8017 without restraints) Performing minimization step: 389. Total energy = 80570.1897 kcal/mol (80533.0128 without restraints) Performing minimization step: 390. Total energy = 80500.4509 kcal/mol (80463.2839 without restraints) Performing minimization step: 391. Total energy = 80430.7717 kcal/mol (80393.6145 without restraints) Performing minimization step: 392. Total energy = 80361.1524 kcal/mol (80324.0049 without restraints) Performing minimization step: 393. Total energy = 80291.5930 kcal/mol (80254.4553 without restraints) Performing minimization step: 394. Total energy = 80222.0933 kcal/mol (80184.9654 without restraints) Performing minimization step: 395. Total energy = 80152.6531 kcal/mol (80115.5348 without restraints) Performing minimization step: 396. Total energy = 80083.2727 kcal/mol (80046.1644 without restraints) Performing minimization step: 397. Total energy = 80013.9520 kcal/mol (79976.8534 without restraints) Performing minimization step: 398. Total energy = 79944.6916 kcal/mol (79907.6029 without restraints) Performing minimization step: 399. Total energy = 79875.4908 kcal/mol (79838.4117 without restraints) Performing minimization step: 400. Total energy = 79806.3486 kcal/mol (79769.2792 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 401. Total energy = 79737.2661 kcal/mol (79700.2064 without restraints) Performing minimization step: 402. Total energy = 79668.2431 kcal/mol (79631.1932 without restraints) Performing minimization step: 403. Total energy = 79599.2798 kcal/mol (79562.2397 without restraints) Performing minimization step: 404. Total energy = 79530.3755 kcal/mol (79493.3452 without restraints) Performing minimization step: 405. Total energy = 79461.5313 kcal/mol (79424.5105 without restraints) Performing minimization step: 406. Total energy = 79392.7465 kcal/mol (79355.7355 without restraints) Performing minimization step: 407. Total energy = 79324.0210 kcal/mol (79287.0197 without restraints) Performing minimization step: 408. Total energy = 79255.3548 kcal/mol (79218.3633 without restraints) Performing minimization step: 409. Total energy = 79186.7475 kcal/mol (79149.7656 without restraints) Performing minimization step: 410. Total energy = 79118.1998 kcal/mol (79081.2277 without restraints) Performing minimization step: 411. Total energy = 79049.7110 kcal/mol (79012.7485 without restraints) Performing minimization step: 412. Total energy = 78981.2813 kcal/mol (78944.3285 without restraints) Performing minimization step: 413. Total energy = 78912.9113 kcal/mol (78875.9681 without restraints) Performing minimization step: 414. Total energy = 78844.6008 kcal/mol (78807.6674 without restraints) Performing minimization step: 415. Total energy = 78776.3490 kcal/mol (78739.4253 without restraints) Performing minimization step: 416. Total energy = 78708.1563 kcal/mol (78671.2420 without restraints) Performing minimization step: 417. Total energy = 78640.0230 kcal/mol (78603.1185 without restraints) Performing minimization step: 418. Total energy = 78571.9478 kcal/mol (78535.0531 without restraints) Performing minimization step: 419. Total energy = 78503.9321 kcal/mol (78467.0470 without restraints) Performing minimization step: 420. Total energy = 78435.9755 kcal/mol (78399.1000 without restraints) Performing minimization step: 421. Total energy = 78368.0778 kcal/mol (78331.2119 without restraints) Performing minimization step: 422. Total energy = 78300.2392 kcal/mol (78263.3830 without restraints) Performing minimization step: 423. Total energy = 78232.4594 kcal/mol (78195.6128 without restraints) Performing minimization step: 424. Total energy = 78164.7384 kcal/mol (78127.9014 without restraints) Performing minimization step: 425. Total energy = 78097.0764 kcal/mol (78060.2491 without restraints) Performing minimization step: 426. Total energy = 78029.4731 kcal/mol (77992.6553 without restraints) Performing minimization step: 427. Total energy = 77961.9282 kcal/mol (77925.1200 without restraints) Performing minimization step: 428. Total energy = 77894.4419 kcal/mol (77857.6433 without restraints) Performing minimization step: 429. Total energy = 77827.0146 kcal/mol (77790.2257 without restraints) Performing minimization step: 430. Total energy = 77759.6459 kcal/mol (77722.8666 without restraints) Performing minimization step: 431. Total energy = 77692.3359 kcal/mol (77655.5661 without restraints) Performing minimization step: 432. Total energy = 77625.0845 kcal/mol (77588.3243 without restraints) Performing minimization step: 433. Total energy = 77557.8922 kcal/mol (77521.1416 without restraints) Performing minimization step: 434. Total energy = 77490.7580 kcal/mol (77454.0170 without restraints) Performing minimization step: 435. Total energy = 77423.6819 kcal/mol (77386.9504 without restraints) Performing minimization step: 436. Total energy = 77356.6645 kcal/mol (77319.9427 without restraints) Performing minimization step: 437. Total energy = 77289.7058 kcal/mol (77252.9935 without restraints) Performing minimization step: 438. Total energy = 77222.8055 kcal/mol (77186.1027 without restraints) Performing minimization step: 439. Total energy = 77155.9638 kcal/mol (77119.2706 without restraints) Performing minimization step: 440. Total energy = 77089.1802 kcal/mol (77052.4966 without restraints) Performing minimization step: 441. Total energy = 77022.4557 kcal/mol (76985.7816 without restraints) Performing minimization step: 442. Total energy = 76955.7888 kcal/mol (76919.1243 without restraints) Performing minimization step: 443. Total energy = 76889.1802 kcal/mol (76852.5252 without restraints) Performing minimization step: 444. Total energy = 76822.6301 kcal/mol (76785.9846 without restraints) Performing minimization step: 445. Total energy = 76756.1385 kcal/mol (76719.5026 without restraints) Performing minimization step: 446. Total energy = 76689.7046 kcal/mol (76653.0782 without restraints) Performing minimization step: 447. Total energy = 76623.3289 kcal/mol (76586.7119 without restraints) Performing minimization step: 448. Total energy = 76557.0107 kcal/mol (76520.4033 without restraints) Performing minimization step: 449. Total energy = 76490.7511 kcal/mol (76454.1532 without restraints) Performing minimization step: 450. Total energy = 76424.5494 kcal/mol (76387.9610 without restraints) Performing minimization step: 451. Total energy = 76358.4060 kcal/mol (76321.8271 without restraints) Performing minimization step: 452. Total energy = 76292.3202 kcal/mol (76255.7506 without restraints) Performing minimization step: 453. Total energy = 76226.2923 kcal/mol (76189.7324 without restraints) Performing minimization step: 454. Total energy = 76160.3228 kcal/mol (76123.7723 without restraints) Performing minimization step: 455. Total energy = 76094.4110 kcal/mol (76057.8700 without restraints) Performing minimization step: 456. Total energy = 76028.5572 kcal/mol (75992.0257 without restraints) Performing minimization step: 457. Total energy = 75962.7615 kcal/mol (75926.2394 without restraints) Performing minimization step: 458. Total energy = 75897.0232 kcal/mol (75860.5106 without restraints) Performing minimization step: 459. Total energy = 75831.3428 kcal/mol (75794.8397 without restraints) Performing minimization step: 460. Total energy = 75765.7201 kcal/mol (75729.2262 without restraints) Performing minimization step: 461. Total energy = 75700.1549 kcal/mol (75663.6706 without restraints) Performing minimization step: 462. Total energy = 75634.6475 kcal/mol (75598.1727 without restraints) Performing minimization step: 463. Total energy = 75569.1980 kcal/mol (75532.7326 without restraints) Performing minimization step: 464. Total energy = 75503.8061 kcal/mol (75467.3501 without restraints) Performing minimization step: 465. Total energy = 75438.4718 kcal/mol (75402.0253 without restraints) Performing minimization step: 466. Total energy = 75373.1951 kcal/mol (75336.7580 without restraints) Performing minimization step: 467. Total energy = 75307.9759 kcal/mol (75271.5482 without restraints) Performing minimization step: 468. Total energy = 75242.8145 kcal/mol (75206.3961 without restraints) Performing minimization step: 469. Total energy = 75177.7107 kcal/mol (75141.3018 without restraints) Performing minimization step: 470. Total energy = 75112.6637 kcal/mol (75076.2642 without restraints) Performing minimization step: 471. Total energy = 75047.6742 kcal/mol (75011.2841 without restraints) Performing minimization step: 472. Total energy = 74982.7420 kcal/mol (74946.3613 without restraints) Performing minimization step: 473. Total energy = 74917.8670 kcal/mol (74881.4955 without restraints) Performing minimization step: 474. Total energy = 74853.0496 kcal/mol (74816.6876 without restraints) Performing minimization step: 475. Total energy = 74788.2896 kcal/mol (74751.9371 without restraints) Performing minimization step: 476. Total energy = 74723.5869 kcal/mol (74687.2437 without restraints) Performing minimization step: 477. Total energy = 74658.9414 kcal/mol (74622.6076 without restraints) Performing minimization step: 478. Total energy = 74594.3533 kcal/mol (74558.0289 without restraints) Performing minimization step: 479. Total energy = 74529.8220 kcal/mol (74493.5067 without restraints) Performing minimization step: 480. Total energy = 74465.3475 kcal/mol (74429.0417 without restraints) Performing minimization step: 481. Total energy = 74400.9308 kcal/mol (74364.6344 without restraints) Performing minimization step: 482. Total energy = 74336.5713 kcal/mol (74300.2841 without restraints) Performing minimization step: 483. Total energy = 74272.2685 kcal/mol (74235.9907 without restraints) Performing minimization step: 484. Total energy = 74208.0226 kcal/mol (74171.7540 without restraints) Performing minimization step: 485. Total energy = 74143.8337 kcal/mol (74107.5746 without restraints) Performing minimization step: 486. Total energy = 74079.7019 kcal/mol (74043.4521 without restraints) Performing minimization step: 487. Total energy = 74015.6272 kcal/mol (73979.3867 without restraints) Performing minimization step: 488. Total energy = 73951.6092 kcal/mol (73915.3780 without restraints) Performing minimization step: 489. Total energy = 73887.6480 kcal/mol (73851.4261 without restraints) Performing minimization step: 490. Total energy = 73823.7434 kcal/mol (73787.5309 without restraints) Performing minimization step: 491. Total energy = 73759.8959 kcal/mol (73723.6926 without restraints) Performing minimization step: 492. Total energy = 73696.1051 kcal/mol (73659.9111 without restraints) Performing minimization step: 493. Total energy = 73632.3707 kcal/mol (73596.1860 without restraints) Performing minimization step: 494. Total energy = 73568.6936 kcal/mol (73532.5181 without restraints) Performing minimization step: 495. Total energy = 73505.0729 kcal/mol (73468.9067 without restraints) Performing minimization step: 496. Total energy = 73441.5088 kcal/mol (73405.3519 without restraints) Performing minimization step: 497. Total energy = 73378.0013 kcal/mol (73341.8537 without restraints) Performing minimization step: 498. Total energy = 73314.5502 kcal/mol (73278.4118 without restraints) Performing minimization step: 499. Total energy = 73251.1558 kcal/mol (73215.0267 without restraints) Performing minimization step: 500. Total energy = 73187.8179 kcal/mol (73151.6980 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 501. Total energy = 73124.5365 kcal/mol (73088.4258 without restraints) Performing minimization step: 502. Total energy = 73061.3115 kcal/mol (73025.2101 without restraints) Performing minimization step: 503. Total energy = 72998.1428 kcal/mol (72962.0506 without restraints) Performing minimization step: 504. Total energy = 72935.0305 kcal/mol (72898.9475 without restraints) Performing minimization step: 505. Total energy = 72871.9745 kcal/mol (72835.9007 without restraints) Performing minimization step: 506. Total energy = 72808.9750 kcal/mol (72772.9105 without restraints) Performing minimization step: 507. Total energy = 72746.0314 kcal/mol (72709.9761 without restraints) Performing minimization step: 508. Total energy = 72683.1445 kcal/mol (72647.0984 without restraints) Performing minimization step: 509. Total energy = 72620.3138 kcal/mol (72584.2769 without restraints) Performing minimization step: 510. Total energy = 72557.5393 kcal/mol (72521.5115 without restraints) Performing minimization step: 511. Total energy = 72494.8209 kcal/mol (72458.8023 without restraints) Performing minimization step: 512. Total energy = 72432.1586 kcal/mol (72396.1493 without restraints) Performing minimization step: 513. Total energy = 72369.5524 kcal/mol (72333.5523 without restraints) Performing minimization step: 514. Total energy = 72307.0023 kcal/mol (72271.0114 without restraints) Performing minimization step: 515. Total energy = 72244.5081 kcal/mol (72208.5263 without restraints) Performing minimization step: 516. Total energy = 72182.0701 kcal/mol (72146.0975 without restraints) Performing minimization step: 517. Total energy = 72119.6879 kcal/mol (72083.7243 without restraints) Performing minimization step: 518. Total energy = 72057.3619 kcal/mol (72021.4075 without restraints) Performing minimization step: 519. Total energy = 71995.0917 kcal/mol (71959.1465 without restraints) Performing minimization step: 520. Total energy = 71932.8770 kcal/mol (71896.9409 without restraints) Performing minimization step: 521. Total energy = 71870.7185 kcal/mol (71834.7916 without restraints) Performing minimization step: 522. Total energy = 71808.6160 kcal/mol (71772.6982 without restraints) Performing minimization step: 523. Total energy = 71746.5689 kcal/mol (71710.6602 without restraints) Performing minimization step: 524. Total energy = 71684.5781 kcal/mol (71648.6784 without restraints) Performing minimization step: 525. Total energy = 71622.6422 kcal/mol (71586.7516 without restraints) Performing minimization step: 526. Total energy = 71560.7623 kcal/mol (71524.8811 without restraints) Performing minimization step: 527. Total energy = 71498.9384 kcal/mol (71463.0663 without restraints) Performing minimization step: 528. Total energy = 71437.1699 kcal/mol (71401.3067 without restraints) Performing minimization step: 529. Total energy = 71375.4567 kcal/mol (71339.6027 without restraints) Performing minimization step: 530. Total energy = 71313.7990 kcal/mol (71277.9540 without restraints) Performing minimization step: 531. Total energy = 71252.1971 kcal/mol (71216.3613 without restraints) Performing minimization step: 532. Total energy = 71190.6508 kcal/mol (71154.8241 without restraints) Performing minimization step: 533. Total energy = 71129.1598 kcal/mol (71093.3422 without restraints) Performing minimization step: 534. Total energy = 71067.7244 kcal/mol (71031.9159 without restraints) Performing minimization step: 535. Total energy = 71006.3441 kcal/mol (70970.5446 without restraints) Performing minimization step: 536. Total energy = 70945.0195 kcal/mol (70909.2290 without restraints) Performing minimization step: 537. Total energy = 70883.7501 kcal/mol (70847.9687 without restraints) Performing minimization step: 538. Total energy = 70822.5361 kcal/mol (70786.7637 without restraints) Performing minimization step: 539. Total energy = 70761.3773 kcal/mol (70725.6140 without restraints) Performing minimization step: 540. Total energy = 70700.2737 kcal/mol (70664.5195 without restraints) Performing minimization step: 541. Total energy = 70639.2254 kcal/mol (70603.4802 without restraints) Performing minimization step: 542. Total energy = 70578.2320 kcal/mol (70542.4958 without restraints) Performing minimization step: 543. Total energy = 70517.2938 kcal/mol (70481.5666 without restraints) Performing minimization step: 544. Total energy = 70456.4106 kcal/mol (70420.6925 without restraints) Performing minimization step: 545. Total energy = 70395.5831 kcal/mol (70359.8739 without restraints) Performing minimization step: 546. Total energy = 70334.8103 kcal/mol (70299.1101 without restraints) Performing minimization step: 547. Total energy = 70274.0924 kcal/mol (70238.4013 without restraints) Performing minimization step: 548. Total energy = 70213.4296 kcal/mol (70177.7475 without restraints) Performing minimization step: 549. Total energy = 70152.8217 kcal/mol (70117.1486 without restraints) Performing minimization step: 550. Total energy = 70092.2688 kcal/mol (70056.6046 without restraints) Performing minimization step: 551. Total energy = 70031.7707 kcal/mol (69996.1155 without restraints) Performing minimization step: 552. Total energy = 69971.3273 kcal/mol (69935.6811 without restraints) Performing minimization step: 553. Total energy = 69910.9388 kcal/mol (69875.3016 without restraints) Performing minimization step: 554. Total energy = 69850.6050 kcal/mol (69814.9768 without restraints) Performing minimization step: 555. Total energy = 69790.3261 kcal/mol (69754.7068 without restraints) Performing minimization step: 556. Total energy = 69730.1020 kcal/mol (69694.4916 without restraints) Performing minimization step: 557. Total energy = 69669.9325 kcal/mol (69634.3311 without restraints) Performing minimization step: 558. Total energy = 69609.8174 kcal/mol (69574.2250 without restraints) Performing minimization step: 559. Total energy = 69549.7572 kcal/mol (69514.1737 without restraints) Performing minimization step: 560. Total energy = 69489.7516 kcal/mol (69454.1770 without restraints) Performing minimization step: 561. Total energy = 69429.8007 kcal/mol (69394.2351 without restraints) Performing minimization step: 562. Total energy = 69369.9042 kcal/mol (69334.3475 without restraints) Performing minimization step: 563. Total energy = 69310.0621 kcal/mol (69274.5144 without restraints) Performing minimization step: 564. Total energy = 69250.2749 kcal/mol (69214.7360 without restraints) Performing minimization step: 565. Total energy = 69190.5414 kcal/mol (69155.0115 without restraints) Performing minimization step: 566. Total energy = 69130.8627 kcal/mol (69095.3417 without restraints) Performing minimization step: 567. Total energy = 69071.2380 kcal/mol (69035.7258 without restraints) Performing minimization step: 568. Total energy = 69011.6679 kcal/mol (68976.1647 without restraints) Performing minimization step: 569. Total energy = 68952.1516 kcal/mol (68916.6573 without restraints) Performing minimization step: 570. Total energy = 68892.6902 kcal/mol (68857.2047 without restraints) Performing minimization step: 571. Total energy = 68833.2830 kcal/mol (68797.8064 without restraints) Performing minimization step: 572. Total energy = 68773.9299 kcal/mol (68738.4621 without restraints) Performing minimization step: 573. Total energy = 68714.6308 kcal/mol (68679.1719 without restraints) Performing minimization step: 574. Total energy = 68655.3860 kcal/mol (68619.9360 without restraints) Performing minimization step: 575. Total energy = 68596.1950 kcal/mol (68560.7538 without restraints) Performing minimization step: 576. Total energy = 68537.0586 kcal/mol (68501.6263 without restraints) Performing minimization step: 577. Total energy = 68477.9763 kcal/mol (68442.5529 without restraints) Performing minimization step: 578. Total energy = 68418.9477 kcal/mol (68383.5330 without restraints) Performing minimization step: 579. Total energy = 68359.9734 kcal/mol (68324.5676 without restraints) Performing minimization step: 580. Total energy = 68301.0526 kcal/mol (68265.6557 without restraints) Performing minimization step: 581. Total energy = 68242.1861 kcal/mol (68206.7980 without restraints) Performing minimization step: 582. Total energy = 68183.3733 kcal/mol (68147.9940 without restraints) Performing minimization step: 583. Total energy = 68124.6144 kcal/mol (68089.2439 without restraints) Performing minimization step: 584. Total energy = 68065.9095 kcal/mol (68030.5480 without restraints) Performing minimization step: 585. Total energy = 68007.2582 kcal/mol (67971.9055 without restraints) Performing minimization step: 586. Total energy = 67948.6608 kcal/mol (67913.3168 without restraints) Performing minimization step: 587. Total energy = 67890.1167 kcal/mol (67854.7814 without restraints) Performing minimization step: 588. Total energy = 67831.6264 kcal/mol (67796.3000 without restraints) Performing minimization step: 589. Total energy = 67773.1898 kcal/mol (67737.8720 without restraints) Performing minimization step: 590. Total energy = 67714.8068 kcal/mol (67679.4978 without restraints) Performing minimization step: 591. Total energy = 67656.4770 kcal/mol (67621.1769 without restraints) Performing minimization step: 592. Total energy = 67598.2012 kcal/mol (67562.9098 without restraints) Performing minimization step: 593. Total energy = 67539.9781 kcal/mol (67504.6955 without restraints) Performing minimization step: 594. Total energy = 67481.8093 kcal/mol (67446.5354 without restraints) Performing minimization step: 595. Total energy = 67423.6937 kcal/mol (67388.4286 without restraints) Performing minimization step: 596. Total energy = 67365.6318 kcal/mol (67330.3754 without restraints) Performing minimization step: 597. Total energy = 67307.6232 kcal/mol (67272.3756 without restraints) Performing minimization step: 598. Total energy = 67249.6675 kcal/mol (67214.4287 without restraints) Performing minimization step: 599. Total energy = 67191.7657 kcal/mol (67156.5355 without restraints) Performing minimization step: 600. Total energy = 67133.9169 kcal/mol (67098.6954 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 601. Total energy = 67076.1216 kcal/mol (67040.9088 without restraints) Performing minimization step: 602. Total energy = 67018.3790 kcal/mol (66983.1750 without restraints) Performing minimization step: 603. Total energy = 66960.6901 kcal/mol (66925.4948 without restraints) Performing minimization step: 604. Total energy = 66903.0543 kcal/mol (66867.8677 without restraints) Performing minimization step: 605. Total energy = 66845.4716 kcal/mol (66810.2936 without restraints) Performing minimization step: 606. Total energy = 66787.9416 kcal/mol (66752.7723 without restraints) Performing minimization step: 607. Total energy = 66730.4648 kcal/mol (66695.3042 without restraints) Performing minimization step: 608. Total energy = 66673.0416 kcal/mol (66637.8897 without restraints) Performing minimization step: 609. Total energy = 66615.6709 kcal/mol (66580.5278 without restraints) Performing minimization step: 610. Total energy = 66558.3535 kcal/mol (66523.2190 without restraints) Performing minimization step: 611. Total energy = 66501.0891 kcal/mol (66465.9633 without restraints) Performing minimization step: 612. Total energy = 66443.8773 kcal/mol (66408.7601 without restraints) Performing minimization step: 613. Total energy = 66386.7182 kcal/mol (66351.6098 without restraints) Performing minimization step: 614. Total energy = 66329.6125 kcal/mol (66294.5128 without restraints) Performing minimization step: 615. Total energy = 66272.5594 kcal/mol (66237.4682 without restraints) Performing minimization step: 616. Total energy = 66215.5587 kcal/mol (66180.4760 without restraints) Performing minimization step: 617. Total energy = 66158.6109 kcal/mol (66123.5370 without restraints) Performing minimization step: 618. Total energy = 66101.7157 kcal/mol (66066.6505 without restraints) Performing minimization step: 619. Total energy = 66044.8733 kcal/mol (66009.8166 without restraints) Performing minimization step: 620. Total energy = 65988.0836 kcal/mol (65953.0355 without restraints) Performing minimization step: 621. Total energy = 65931.3465 kcal/mol (65896.3071 without restraints) Performing minimization step: 622. Total energy = 65874.6620 kcal/mol (65839.6311 without restraints) Performing minimization step: 623. Total energy = 65818.0301 kcal/mol (65783.0079 without restraints) Performing minimization step: 624. Total energy = 65761.4504 kcal/mol (65726.4367 without restraints) Performing minimization step: 625. Total energy = 65704.9236 kcal/mol (65669.9186 without restraints) Performing minimization step: 626. Total energy = 65648.4490 kcal/mol (65613.4526 without restraints) Performing minimization step: 627. Total energy = 65592.0267 kcal/mol (65557.0388 without restraints) Performing minimization step: 628. Total energy = 65535.6569 kcal/mol (65500.6776 without restraints) Performing minimization step: 629. Total energy = 65479.3393 kcal/mol (65444.3686 without restraints) Performing minimization step: 630. Total energy = 65423.0740 kcal/mol (65388.1116 without restraints) Performing minimization step: 631. Total energy = 65366.8609 kcal/mol (65331.9073 without restraints) Performing minimization step: 632. Total energy = 65310.6996 kcal/mol (65275.7546 without restraints) Performing minimization step: 633. Total energy = 65254.5908 kcal/mol (65219.6543 without restraints) Performing minimization step: 634. Total energy = 65198.5347 kcal/mol (65163.6068 without restraints) Performing minimization step: 635. Total energy = 65142.5307 kcal/mol (65107.6113 without restraints) Performing minimization step: 636. Total energy = 65086.5787 kcal/mol (65051.6678 without restraints) Performing minimization step: 637. Total energy = 65030.6787 kcal/mol (64995.7764 without restraints) Performing minimization step: 638. Total energy = 64974.8308 kcal/mol (64939.9370 without restraints) Performing minimization step: 639. Total energy = 64919.0349 kcal/mol (64884.1497 without restraints) Performing minimization step: 640. Total energy = 64863.2907 kcal/mol (64828.4140 without restraints) Performing minimization step: 641. Total energy = 64807.5987 kcal/mol (64772.7305 without restraints) Performing minimization step: 642. Total energy = 64751.9587 kcal/mol (64717.0989 without restraints) Performing minimization step: 643. Total energy = 64696.3700 kcal/mol (64661.5187 without restraints) Performing minimization step: 644. Total energy = 64640.8337 kcal/mol (64605.9910 without restraints) Performing minimization step: 645. Total energy = 64585.3490 kcal/mol (64550.5148 without restraints) Performing minimization step: 646. Total energy = 64529.9161 kcal/mol (64495.0903 without restraints) Performing minimization step: 647. Total energy = 64474.5350 kcal/mol (64439.7177 without restraints) Performing minimization step: 648. Total energy = 64419.2061 kcal/mol (64384.3972 without restraints) Performing minimization step: 649. Total energy = 64363.9282 kcal/mol (64329.1278 without restraints) Performing minimization step: 650. Total energy = 64308.7023 kcal/mol (64273.9103 without restraints) Performing minimization step: 651. Total energy = 64253.5278 kcal/mol (64218.7442 without restraints) Performing minimization step: 652. Total energy = 64198.4051 kcal/mol (64163.6300 without restraints) Performing minimization step: 653. Total energy = 64143.3341 kcal/mol (64108.5674 without restraints) Performing minimization step: 654. Total energy = 64088.3147 kcal/mol (64053.5565 without restraints) Performing minimization step: 655. Total energy = 64033.3466 kcal/mol (63998.5969 without restraints) Performing minimization step: 656. Total energy = 63978.4299 kcal/mol (63943.6886 without restraints) Performing minimization step: 657. Total energy = 63923.5644 kcal/mol (63888.8315 without restraints) Performing minimization step: 658. Total energy = 63868.7502 kcal/mol (63834.0257 without restraints) Performing minimization step: 659. Total energy = 63813.9877 kcal/mol (63779.2716 without restraints) Performing minimization step: 660. Total energy = 63759.2763 kcal/mol (63724.5687 without restraints) Performing minimization step: 661. Total energy = 63704.6165 kcal/mol (63669.9172 without restraints) Performing minimization step: 662. Total energy = 63650.0079 kcal/mol (63615.3170 without restraints) Performing minimization step: 663. Total energy = 63595.4500 kcal/mol (63560.7673 without restraints) Performing minimization step: 664. Total energy = 63540.9430 kcal/mol (63506.2689 without restraints) Performing minimization step: 665. Total energy = 63486.4877 kcal/mol (63451.8220 without restraints) Performing minimization step: 666. Total energy = 63432.0834 kcal/mol (63397.4260 without restraints) Performing minimization step: 667. Total energy = 63377.7301 kcal/mol (63343.0810 without restraints) Performing minimization step: 668. Total energy = 63323.4282 kcal/mol (63288.7876 without restraints) Performing minimization step: 669. Total energy = 63269.1771 kcal/mol (63234.5449 without restraints) Performing minimization step: 670. Total energy = 63214.9773 kcal/mol (63180.3534 without restraints) Performing minimization step: 671. Total energy = 63160.8282 kcal/mol (63126.2127 without restraints) Performing minimization step: 672. Total energy = 63106.7301 kcal/mol (63072.1230 without restraints) Performing minimization step: 673. Total energy = 63052.6828 kcal/mol (63018.0838 without restraints) Performing minimization step: 674. Total energy = 62998.6859 kcal/mol (62964.0953 without restraints) Performing minimization step: 675. Total energy = 62944.7402 kcal/mol (62910.1579 without restraints) Performing minimization step: 676. Total energy = 62890.8451 kcal/mol (62856.2712 without restraints) Performing minimization step: 677. Total energy = 62837.0007 kcal/mol (62802.4350 without restraints) Performing minimization step: 678. Total energy = 62783.2075 kcal/mol (62748.6501 without restraints) Performing minimization step: 679. Total energy = 62729.4646 kcal/mol (62694.9156 without restraints) Performing minimization step: 680. Total energy = 62675.7726 kcal/mol (62641.2318 without restraints) Performing minimization step: 681. Total energy = 62622.1313 kcal/mol (62587.5989 without restraints) Performing minimization step: 682. Total energy = 62568.5405 kcal/mol (62534.0163 without restraints) Performing minimization step: 683. Total energy = 62515.0004 kcal/mol (62480.4846 without restraints) Performing minimization step: 684. Total energy = 62461.5104 kcal/mol (62427.0029 without restraints) Performing minimization step: 685. Total energy = 62408.0705 kcal/mol (62373.5712 without restraints) Performing minimization step: 686. Total energy = 62354.6816 kcal/mol (62320.1905 without restraints) Performing minimization step: 687. Total energy = 62301.3429 kcal/mol (62266.8599 without restraints) Performing minimization step: 688. Total energy = 62248.0550 kcal/mol (62213.5805 without restraints) Performing minimization step: 689. Total energy = 62194.8173 kcal/mol (62160.3509 without restraints) Performing minimization step: 690. Total energy = 62141.6298 kcal/mol (62107.1718 without restraints) Performing minimization step: 691. Total energy = 62088.4928 kcal/mol (62054.0430 without restraints) Performing minimization step: 692. Total energy = 62035.4053 kcal/mol (62000.9635 without restraints) Performing minimization step: 693. Total energy = 61982.3681 kcal/mol (61947.9347 without restraints) Performing minimization step: 694. Total energy = 61929.3814 kcal/mol (61894.9563 without restraints) Performing minimization step: 695. Total energy = 61876.4452 kcal/mol (61842.0283 without restraints) Performing minimization step: 696. Total energy = 61823.5591 kcal/mol (61789.1504 without restraints) Performing minimization step: 697. Total energy = 61770.7228 kcal/mol (61736.3223 without restraints) Performing minimization step: 698. Total energy = 61717.9368 kcal/mol (61683.5445 without restraints) Performing minimization step: 699. Total energy = 61665.2001 kcal/mol (61630.8161 without restraints) Performing minimization step: 700. Total energy = 61612.5144 kcal/mol (61578.1385 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 701. Total energy = 61559.8782 kcal/mol (61525.5105 without restraints) Performing minimization step: 702. Total energy = 61507.2919 kcal/mol (61472.9323 without restraints) Performing minimization step: 703. Total energy = 61454.7554 kcal/mol (61420.4038 without restraints) Performing minimization step: 704. Total energy = 61402.2689 kcal/mol (61367.9258 without restraints) Performing minimization step: 705. Total energy = 61349.8325 kcal/mol (61315.4974 without restraints) Performing minimization step: 706. Total energy = 61297.4456 kcal/mol (61263.1187 without restraints) Performing minimization step: 707. Total energy = 61245.1086 kcal/mol (61210.7898 without restraints) Performing minimization step: 708. Total energy = 61192.8214 kcal/mol (61158.5109 without restraints) Performing minimization step: 709. Total energy = 61140.5841 kcal/mol (61106.2817 without restraints) Performing minimization step: 710. Total energy = 61088.3964 kcal/mol (61054.1021 without restraints) Performing minimization step: 711. Total energy = 61036.2578 kcal/mol (61001.9716 without restraints) Performing minimization step: 712. Total energy = 60984.1691 kcal/mol (60949.8910 without restraints) Performing minimization step: 713. Total energy = 60932.1297 kcal/mol (60897.8598 without restraints) Performing minimization step: 714. Total energy = 60880.1400 kcal/mol (60845.8781 without restraints) Performing minimization step: 715. Total energy = 60828.1995 kcal/mol (60793.9456 without restraints) Performing minimization step: 716. Total energy = 60776.3089 kcal/mol (60742.0633 without restraints) Performing minimization step: 717. Total energy = 60724.4676 kcal/mol (60690.2301 without restraints) Performing minimization step: 718. Total energy = 60672.6758 kcal/mol (60638.4464 without restraints) Performing minimization step: 719. Total energy = 60620.9333 kcal/mol (60586.7120 without restraints) Performing minimization step: 720. Total energy = 60569.2403 kcal/mol (60535.0271 without restraints) Performing minimization step: 721. Total energy = 60517.5965 kcal/mol (60483.3913 without restraints) Performing minimization step: 722. Total energy = 60466.0018 kcal/mol (60431.8046 without restraints) Performing minimization step: 723. Total energy = 60414.4565 kcal/mol (60380.2675 without restraints) Performing minimization step: 724. Total energy = 60362.9603 kcal/mol (60328.7794 without restraints) Performing minimization step: 725. Total energy = 60311.5130 kcal/mol (60277.3401 without restraints) Performing minimization step: 726. Total energy = 60260.1151 kcal/mol (60225.9502 without restraints) Performing minimization step: 727. Total energy = 60208.7666 kcal/mol (60174.6098 without restraints) Performing minimization step: 728. Total energy = 60157.4669 kcal/mol (60123.3181 without restraints) Performing minimization step: 729. Total energy = 60106.2161 kcal/mol (60072.0754 without restraints) Performing minimization step: 730. Total energy = 60055.0146 kcal/mol (60020.8819 without restraints) Performing minimization step: 731. Total energy = 60003.8620 kcal/mol (59969.7373 without restraints) Performing minimization step: 732. Total energy = 59952.7581 kcal/mol (59918.6415 without restraints) Performing minimization step: 733. Total energy = 59901.7034 kcal/mol (59867.5948 without restraints) Performing minimization step: 734. Total energy = 59850.6974 kcal/mol (59816.5967 without restraints) Performing minimization step: 735. Total energy = 59799.7395 kcal/mol (59765.6468 without restraints) Performing minimization step: 736. Total energy = 59748.8311 kcal/mol (59714.7464 without restraints) Performing minimization step: 737. Total energy = 59697.9714 kcal/mol (59663.8947 without restraints) Performing minimization step: 738. Total energy = 59647.1605 kcal/mol (59613.0918 without restraints) Performing minimization step: 739. Total energy = 59596.3982 kcal/mol (59562.3374 without restraints) Performing minimization step: 740. Total energy = 59545.6845 kcal/mol (59511.6318 without restraints) Performing minimization step: 741. Total energy = 59495.0195 kcal/mol (59460.9748 without restraints) Performing minimization step: 742. Total energy = 59444.4029 kcal/mol (59410.3661 without restraints) Performing minimization step: 743. Total energy = 59393.8351 kcal/mol (59359.8063 without restraints) Performing minimization step: 744. Total energy = 59343.3156 kcal/mol (59309.2947 without restraints) Performing minimization step: 745. Total energy = 59292.8448 kcal/mol (59258.8319 without restraints) Performing minimization step: 746. Total energy = 59242.4228 kcal/mol (59208.4178 without restraints) Performing minimization step: 747. Total energy = 59192.0489 kcal/mol (59158.0518 without restraints) Performing minimization step: 748. Total energy = 59141.7234 kcal/mol (59107.7342 without restraints) Performing minimization step: 749. Total energy = 59091.4463 kcal/mol (59057.4650 without restraints) Performing minimization step: 750. Total energy = 59041.2172 kcal/mol (59007.2439 without restraints) Performing minimization step: 751. Total energy = 58991.0365 kcal/mol (58957.0711 without restraints) Performing minimization step: 752. Total energy = 58940.9043 kcal/mol (58906.9469 without restraints) Performing minimization step: 753. Total energy = 58890.8202 kcal/mol (58856.8706 without restraints) Performing minimization step: 754. Total energy = 58840.7842 kcal/mol (58806.8425 without restraints) Performing minimization step: 755. Total energy = 58790.7967 kcal/mol (58756.8629 without restraints) Performing minimization step: 756. Total energy = 58740.8572 kcal/mol (58706.9314 without restraints) Performing minimization step: 757. Total energy = 58690.9659 kcal/mol (58657.0480 without restraints) Performing minimization step: 758. Total energy = 58641.1229 kcal/mol (58607.2128 without restraints) Performing minimization step: 759. Total energy = 58591.3274 kcal/mol (58557.4252 without restraints) Performing minimization step: 760. Total energy = 58541.5801 kcal/mol (58507.6856 without restraints) Performing minimization step: 761. Total energy = 58491.8805 kcal/mol (58457.9939 without restraints) Performing minimization step: 762. Total energy = 58442.2290 kcal/mol (58408.3503 without restraints) Performing minimization step: 763. Total energy = 58392.6253 kcal/mol (58358.7545 without restraints) Performing minimization step: 764. Total energy = 58343.0694 kcal/mol (58309.2064 without restraints) Performing minimization step: 765. Total energy = 58293.5616 kcal/mol (58259.7063 without restraints) Performing minimization step: 766. Total energy = 58244.1015 kcal/mol (58210.2541 without restraints) Performing minimization step: 767. Total energy = 58194.6892 kcal/mol (58160.8497 without restraints) Performing minimization step: 768. Total energy = 58145.3246 kcal/mol (58111.4928 without restraints) Performing minimization step: 769. Total energy = 58096.0080 kcal/mol (58062.1841 without restraints) Performing minimization step: 770. Total energy = 58046.7389 kcal/mol (58012.9228 without restraints) Performing minimization step: 771. Total energy = 57997.5176 kcal/mol (57963.7094 without restraints) Performing minimization step: 772. Total energy = 57948.3439 kcal/mol (57914.5433 without restraints) Performing minimization step: 773. Total energy = 57899.2173 kcal/mol (57865.4247 without restraints) Performing minimization step: 774. Total energy = 57850.1386 kcal/mol (57816.3538 without restraints) Performing minimization step: 775. Total energy = 57801.1072 kcal/mol (57767.3301 without restraints) Performing minimization step: 776. Total energy = 57752.1237 kcal/mol (57718.3544 without restraints) Performing minimization step: 777. Total energy = 57703.1874 kcal/mol (57669.4258 without restraints) Performing minimization step: 778. Total energy = 57654.2985 kcal/mol (57620.5447 without restraints) Performing minimization step: 779. Total energy = 57605.4567 kcal/mol (57571.7108 without restraints) Performing minimization step: 780. Total energy = 57556.6625 kcal/mol (57522.9241 without restraints) Performing minimization step: 781. Total energy = 57507.9153 kcal/mol (57474.1849 without restraints) Performing minimization step: 782. Total energy = 57459.2155 kcal/mol (57425.4928 without restraints) Performing minimization step: 783. Total energy = 57410.5625 kcal/mol (57376.8473 without restraints) Performing minimization step: 784. Total energy = 57361.9567 kcal/mol (57328.2493 without restraints) Performing minimization step: 785. Total energy = 57313.3985 kcal/mol (57279.6990 without restraints) Performing minimization step: 786. Total energy = 57264.8877 kcal/mol (57231.1959 without restraints) Performing minimization step: 787. Total energy = 57216.4240 kcal/mol (57182.7400 without restraints) Performing minimization step: 788. Total energy = 57168.0074 kcal/mol (57134.3310 without restraints) Performing minimization step: 789. Total energy = 57119.6377 kcal/mol (57085.9691 without restraints) Performing minimization step: 790. Total energy = 57071.3152 kcal/mol (57037.6543 without restraints) Performing minimization step: 791. Total energy = 57023.0398 kcal/mol (56989.3866 without restraints) Performing minimization step: 792. Total energy = 56974.8111 kcal/mol (56941.1654 without restraints) Performing minimization step: 793. Total energy = 56926.6292 kcal/mol (56892.9913 without restraints) Performing minimization step: 794. Total energy = 56878.4946 kcal/mol (56844.8644 without restraints) Performing minimization step: 795. Total energy = 56830.4068 kcal/mol (56796.7843 without restraints) Performing minimization step: 796. Total energy = 56782.3657 kcal/mol (56748.7509 without restraints) Performing minimization step: 797. Total energy = 56734.3710 kcal/mol (56700.7639 without restraints) Performing minimization step: 798. Total energy = 56686.4233 kcal/mol (56652.8238 without restraints) Performing minimization step: 799. Total energy = 56638.5222 kcal/mol (56604.9303 without restraints) Performing minimization step: 800. Total energy = 56590.6677 kcal/mol (56557.0836 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 801. Total energy = 56542.8602 kcal/mol (56509.2836 without restraints) Performing minimization step: 802. Total energy = 56495.0992 kcal/mol (56461.5303 without restraints) Performing minimization step: 803. Total energy = 56447.3848 kcal/mol (56413.8236 without restraints) Performing minimization step: 804. Total energy = 56399.7172 kcal/mol (56366.1635 without restraints) Performing minimization step: 805. Total energy = 56352.0959 kcal/mol (56318.5498 without restraints) Performing minimization step: 806. Total energy = 56304.5212 kcal/mol (56270.9828 without restraints) Performing minimization step: 807. Total energy = 56256.9928 kcal/mol (56223.4621 without restraints) Performing minimization step: 808. Total energy = 56209.5109 kcal/mol (56175.9877 without restraints) Performing minimization step: 809. Total energy = 56162.0754 kcal/mol (56128.5599 without restraints) Performing minimization step: 810. Total energy = 56114.6859 kcal/mol (56081.1779 without restraints) Performing minimization step: 811. Total energy = 56067.3428 kcal/mol (56033.8424 without restraints) Performing minimization step: 812. Total energy = 56020.0464 kcal/mol (55986.5536 without restraints) Performing minimization step: 813. Total energy = 55972.7963 kcal/mol (55939.3111 without restraints) Performing minimization step: 814. Total energy = 55925.5923 kcal/mol (55892.1147 without restraints) Performing minimization step: 815. Total energy = 55878.4347 kcal/mol (55844.9646 without restraints) Performing minimization step: 816. Total energy = 55831.3233 kcal/mol (55797.8607 without restraints) Performing minimization step: 817. Total energy = 55784.2578 kcal/mol (55750.8028 without restraints) Performing minimization step: 818. Total energy = 55737.2382 kcal/mol (55703.7908 without restraints) Performing minimization step: 819. Total energy = 55690.2645 kcal/mol (55656.8246 without restraints) Performing minimization step: 820. Total energy = 55643.3370 kcal/mol (55609.9046 without restraints) Performing minimization step: 821. Total energy = 55596.4555 kcal/mol (55563.0307 without restraints) Performing minimization step: 822. Total energy = 55549.6202 kcal/mol (55516.2029 without restraints) Performing minimization step: 823. Total energy = 55502.8306 kcal/mol (55469.4209 without restraints) Performing minimization step: 824. Total energy = 55456.0867 kcal/mol (55422.6845 without restraints) Performing minimization step: 825. Total energy = 55409.3889 kcal/mol (55375.9942 without restraints) Performing minimization step: 826. Total energy = 55362.7370 kcal/mol (55329.3497 without restraints) Performing minimization step: 827. Total energy = 55316.1310 kcal/mol (55282.7513 without restraints) Performing minimization step: 828. Total energy = 55269.5709 kcal/mol (55236.1987 without restraints) Performing minimization step: 829. Total energy = 55223.0562 kcal/mol (55189.6915 without restraints) Performing minimization step: 830. Total energy = 55176.5874 kcal/mol (55143.2304 without restraints) Performing minimization step: 831. Total energy = 55130.1643 kcal/mol (55096.8146 without restraints) Performing minimization step: 832. Total energy = 55083.7867 kcal/mol (55050.4445 without restraints) Performing minimization step: 833. Total energy = 55037.4548 kcal/mol (55004.1200 without restraints) Performing minimization step: 834. Total energy = 54991.1683 kcal/mol (54957.8409 without restraints) Performing minimization step: 835. Total energy = 54944.9272 kcal/mol (54911.6074 without restraints) Performing minimization step: 836. Total energy = 54898.7319 kcal/mol (54865.4197 without restraints) Performing minimization step: 837. Total energy = 54852.5820 kcal/mol (54819.2769 without restraints) Performing minimization step: 838. Total energy = 54806.4774 kcal/mol (54773.1799 without restraints) Performing minimization step: 839. Total energy = 54760.4181 kcal/mol (54727.1283 without restraints) Performing minimization step: 840. Total energy = 54714.4049 kcal/mol (54681.1223 without restraints) Performing minimization step: 841. Total energy = 54668.4364 kcal/mol (54635.1612 without restraints) Performing minimization step: 842. Total energy = 54622.5128 kcal/mol (54589.2451 without restraints) Performing minimization step: 843. Total energy = 54576.6349 kcal/mol (54543.3745 without restraints) Performing minimization step: 844. Total energy = 54530.8021 kcal/mol (54497.5492 without restraints) Performing minimization step: 845. Total energy = 54485.0147 kcal/mol (54451.7691 without restraints) Performing minimization step: 846. Total energy = 54439.2724 kcal/mol (54406.0343 without restraints) Performing minimization step: 847. Total energy = 54393.5755 kcal/mol (54360.3448 without restraints) Performing minimization step: 848. Total energy = 54347.9235 kcal/mol (54314.7001 without restraints) Performing minimization step: 849. Total energy = 54302.3166 kcal/mol (54269.1008 without restraints) Performing minimization step: 850. Total energy = 54256.7554 kcal/mol (54223.5469 without restraints) Performing minimization step: 851. Total energy = 54211.2388 kcal/mol (54178.0378 without restraints) Performing minimization step: 852. Total energy = 54165.7672 kcal/mol (54132.5735 without restraints) Performing minimization step: 853. Total energy = 54120.3405 kcal/mol (54087.1541 without restraints) Performing minimization step: 854. Total energy = 54074.9587 kcal/mol (54041.7797 without restraints) Performing minimization step: 855. Total energy = 54029.6216 kcal/mol (53996.4499 without restraints) Performing minimization step: 856. Total energy = 53984.3295 kcal/mol (53951.1652 without restraints) Performing minimization step: 857. Total energy = 53939.0819 kcal/mol (53905.9249 without restraints) Performing minimization step: 858. Total energy = 53893.8792 kcal/mol (53860.7295 without restraints) Performing minimization step: 859. Total energy = 53848.7215 kcal/mol (53815.5791 without restraints) Performing minimization step: 860. Total energy = 53803.6081 kcal/mol (53770.4730 without restraints) Performing minimization step: 861. Total energy = 53758.5399 kcal/mol (53725.4123 without restraints) Performing minimization step: 862. Total energy = 53713.5162 kcal/mol (53680.3958 without restraints) Performing minimization step: 863. Total energy = 53668.5372 kcal/mol (53635.4241 without restraints) Performing minimization step: 864. Total energy = 53623.6028 kcal/mol (53590.4971 without restraints) Performing minimization step: 865. Total energy = 53578.7130 kcal/mol (53545.6146 without restraints) Performing minimization step: 866. Total energy = 53533.8677 kcal/mol (53500.7766 without restraints) Performing minimization step: 867. Total energy = 53489.0668 kcal/mol (53455.9829 without restraints) Performing minimization step: 868. Total energy = 53444.3105 kcal/mol (53411.2339 without restraints) Performing minimization step: 869. Total energy = 53399.5986 kcal/mol (53366.5294 without restraints) Performing minimization step: 870. Total energy = 53354.9312 kcal/mol (53321.8692 without restraints) Performing minimization step: 871. Total energy = 53310.3075 kcal/mol (53277.2527 without restraints) Performing minimization step: 872. Total energy = 53265.7287 kcal/mol (53232.6813 without restraints) Performing minimization step: 873. Total energy = 53221.1938 kcal/mol (53188.1536 without restraints) Performing minimization step: 874. Total energy = 53176.7037 kcal/mol (53143.6707 without restraints) Performing minimization step: 875. Total energy = 53132.2575 kcal/mol (53099.2318 without restraints) Performing minimization step: 876. Total energy = 53087.8558 kcal/mol (53054.8374 without restraints) Performing minimization step: 877. Total energy = 53043.4986 kcal/mol (53010.4875 without restraints) Performing minimization step: 878. Total energy = 52999.1854 kcal/mol (52966.1816 without restraints) Performing minimization step: 879. Total energy = 52954.9166 kcal/mol (52921.9198 without restraints) Performing minimization step: 880. Total energy = 52910.6915 kcal/mol (52877.7019 without restraints) Performing minimization step: 881. Total energy = 52866.5101 kcal/mol (52833.5278 without restraints) Performing minimization step: 882. Total energy = 52822.3730 kcal/mol (52789.3979 without restraints) Performing minimization step: 883. Total energy = 52778.2796 kcal/mol (52745.3116 without restraints) Performing minimization step: 884. Total energy = 52734.2304 kcal/mol (52701.2697 without restraints) Performing minimization step: 885. Total energy = 52690.2247 kcal/mol (52657.2712 without restraints) Performing minimization step: 886. Total energy = 52646.2634 kcal/mol (52613.3171 without restraints) Performing minimization step: 887. Total energy = 52602.3462 kcal/mol (52569.4071 without restraints) Performing minimization step: 888. Total energy = 52558.4728 kcal/mol (52525.5409 without restraints) Performing minimization step: 889. Total energy = 52514.6432 kcal/mol (52481.7185 without restraints) Performing minimization step: 890. Total energy = 52470.8571 kcal/mol (52437.9395 without restraints) Performing minimization step: 891. Total energy = 52427.1140 kcal/mol (52394.2036 without restraints) Performing minimization step: 892. Total energy = 52383.4154 kcal/mol (52350.5121 without restraints) Performing minimization step: 893. Total energy = 52339.7604 kcal/mol (52306.8642 without restraints) Performing minimization step: 894. Total energy = 52296.1488 kcal/mol (52263.2598 without restraints) Performing minimization step: 895. Total energy = 52252.5814 kcal/mol (52219.6995 without restraints) Performing minimization step: 896. Total energy = 52209.0572 kcal/mol (52176.1825 without restraints) Performing minimization step: 897. Total energy = 52165.5766 kcal/mol (52132.7091 without restraints) Performing minimization step: 898. Total energy = 52122.1395 kcal/mol (52089.2791 without restraints) Performing minimization step: 899. Total energy = 52078.7457 kcal/mol (52045.8925 without restraints) Performing minimization step: 900. Total energy = 52035.3954 kcal/mol (52002.5492 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 901. Total energy = 51992.0886 kcal/mol (51959.2496 without restraints) Performing minimization step: 902. Total energy = 51948.8252 kcal/mol (51915.9933 without restraints) Performing minimization step: 903. Total energy = 51905.6050 kcal/mol (51872.7802 without restraints) Performing minimization step: 904. Total energy = 51862.4280 kcal/mol (51829.6101 without restraints) Performing minimization step: 905. Total energy = 51819.2940 kcal/mol (51786.4833 without restraints) Performing minimization step: 906. Total energy = 51776.2038 kcal/mol (51743.4002 without restraints) Performing minimization step: 907. Total energy = 51733.1569 kcal/mol (51700.3604 without restraints) Performing minimization step: 908. Total energy = 51690.1531 kcal/mol (51657.3637 without restraints) Performing minimization step: 909. Total energy = 51647.1929 kcal/mol (51614.4107 without restraints) Performing minimization step: 910. Total energy = 51604.2751 kcal/mol (51571.4999 without restraints) Performing minimization step: 911. Total energy = 51561.4008 kcal/mol (51528.6328 without restraints) Performing minimization step: 912. Total energy = 51518.5693 kcal/mol (51485.8083 without restraints) Performing minimization step: 913. Total energy = 51475.7811 kcal/mol (51443.0270 without restraints) Performing minimization step: 914. Total energy = 51433.0357 kcal/mol (51400.2886 without restraints) Performing minimization step: 915. Total energy = 51390.3331 kcal/mol (51357.5931 without restraints) Performing minimization step: 916. Total energy = 51347.6735 kcal/mol (51314.9405 without restraints) Performing minimization step: 917. Total energy = 51305.0570 kcal/mol (51272.3310 without restraints) Performing minimization step: 918. Total energy = 51262.4837 kcal/mol (51229.7648 without restraints) Performing minimization step: 919. Total energy = 51219.9527 kcal/mol (51187.2407 without restraints) Performing minimization step: 920. Total energy = 51177.4647 kcal/mol (51144.7598 without restraints) Performing minimization step: 921. Total energy = 51135.0195 kcal/mol (51102.3216 without restraints) Performing minimization step: 922. Total energy = 51092.6170 kcal/mol (51059.9261 without restraints) Performing minimization step: 923. Total energy = 51050.2577 kcal/mol (51017.5738 without restraints) Performing minimization step: 924. Total energy = 51007.9408 kcal/mol (50975.2639 without restraints) Performing minimization step: 925. Total energy = 50965.6666 kcal/mol (50932.9967 without restraints) Performing minimization step: 926. Total energy = 50923.4348 kcal/mol (50890.7719 without restraints) Performing minimization step: 927. Total energy = 50881.2459 kcal/mol (50848.5899 without restraints) Performing minimization step: 928. Total energy = 50839.0992 kcal/mol (50806.4502 without restraints) Performing minimization step: 929. Total energy = 50796.9955 kcal/mol (50764.3535 without restraints) Performing minimization step: 930. Total energy = 50754.9340 kcal/mol (50722.2989 without restraints) Performing minimization step: 931. Total energy = 50712.9147 kcal/mol (50680.2866 without restraints) Performing minimization step: 932. Total energy = 50670.9381 kcal/mol (50638.3170 without restraints) Performing minimization step: 933. Total energy = 50629.0039 kcal/mol (50596.3896 without restraints) Performing minimization step: 934. Total energy = 50587.1119 kcal/mol (50554.5046 without restraints) Performing minimization step: 935. Total energy = 50545.2624 kcal/mol (50512.6620 without restraints) Performing minimization step: 936. Total energy = 50503.4548 kcal/mol (50470.8613 without restraints) Performing minimization step: 937. Total energy = 50461.6895 kcal/mol (50429.1030 without restraints) Performing minimization step: 938. Total energy = 50419.9665 kcal/mol (50387.3869 without restraints) Performing minimization step: 939. Total energy = 50378.2859 kcal/mol (50345.7132 without restraints) Performing minimization step: 940. Total energy = 50336.6474 kcal/mol (50304.0816 without restraints) Performing minimization step: 941. Total energy = 50295.0514 kcal/mol (50262.4927 without restraints) Performing minimization step: 942. Total energy = 50253.4972 kcal/mol (50220.9452 without restraints) Performing minimization step: 943. Total energy = 50211.9850 kcal/mol (50179.4399 without restraints) Performing minimization step: 944. Total energy = 50170.5150 kcal/mol (50137.9768 without restraints) Performing minimization step: 945. Total energy = 50129.0870 kcal/mol (50096.5557 without restraints) Performing minimization step: 946. Total energy = 50087.7013 kcal/mol (50055.1767 without restraints) Performing minimization step: 947. Total energy = 50046.3571 kcal/mol (50013.8395 without restraints) Performing minimization step: 948. Total energy = 50005.0549 kcal/mol (49972.5442 without restraints) Performing minimization step: 949. Total energy = 49963.7947 kcal/mol (49931.2908 without restraints) Performing minimization step: 950. Total energy = 49922.5763 kcal/mol (49890.0793 without restraints) Performing minimization step: 951. Total energy = 49881.3996 kcal/mol (49848.9095 without restraints) Performing minimization step: 952. Total energy = 49840.2652 kcal/mol (49807.7820 without restraints) Performing minimization step: 953. Total energy = 49799.1721 kcal/mol (49766.6956 without restraints) Performing minimization step: 954. Total energy = 49758.1206 kcal/mol (49725.6510 without restraints) Performing minimization step: 955. Total energy = 49717.1111 kcal/mol (49684.6483 without restraints) Performing minimization step: 956. Total energy = 49676.1431 kcal/mol (49643.6872 without restraints) Performing minimization step: 957. Total energy = 49635.2170 kcal/mol (49602.7678 without restraints) Performing minimization step: 958. Total energy = 49594.3323 kcal/mol (49561.8900 without restraints) Performing minimization step: 959. Total energy = 49553.4895 kcal/mol (49521.0539 without restraints) Performing minimization step: 960. Total energy = 49512.6880 kcal/mol (49480.2593 without restraints) Performing minimization step: 961. Total energy = 49471.9279 kcal/mol (49439.5060 without restraints) Performing minimization step: 962. Total energy = 49431.2097 kcal/mol (49398.7945 without restraints) Performing minimization step: 963. Total energy = 49390.5328 kcal/mol (49358.1245 without restraints) Performing minimization step: 964. Total energy = 49349.8974 kcal/mol (49317.4959 without restraints) Performing minimization step: 965. Total energy = 49309.3032 kcal/mol (49276.9085 without restraints) Performing minimization step: 966. Total energy = 49268.7507 kcal/mol (49236.3628 without restraints) Performing minimization step: 967. Total energy = 49228.2394 kcal/mol (49195.8581 without restraints) Performing minimization step: 968. Total energy = 49187.7692 kcal/mol (49155.3947 without restraints) Performing minimization step: 969. Total energy = 49147.3405 kcal/mol (49114.9727 without restraints) Performing minimization step: 970. Total energy = 49106.9528 kcal/mol (49074.5918 without restraints) Performing minimization step: 971. Total energy = 49066.6063 kcal/mol (49034.2521 without restraints) Performing minimization step: 972. Total energy = 49026.3010 kcal/mol (48993.9536 without restraints) Performing minimization step: 973. Total energy = 48986.0372 kcal/mol (48953.6967 without restraints) Performing minimization step: 974. Total energy = 48945.8142 kcal/mol (48913.4802 without restraints) Performing minimization step: 975. Total energy = 48905.6327 kcal/mol (48873.3054 without restraints) Performing minimization step: 976. Total energy = 48865.4918 kcal/mol (48833.1713 without restraints) Performing minimization step: 977. Total energy = 48825.3923 kcal/mol (48793.0784 without restraints) Performing minimization step: 978. Total energy = 48785.3334 kcal/mol (48753.0263 without restraints) Performing minimization step: 979. Total energy = 48745.3155 kcal/mol (48713.0150 without restraints) Performing minimization step: 980. Total energy = 48705.3384 kcal/mol (48673.0447 without restraints) Performing minimization step: 981. Total energy = 48665.4019 kcal/mol (48633.1149 without restraints) Performing minimization step: 982. Total energy = 48625.5064 kcal/mol (48593.2261 without restraints) Performing minimization step: 983. Total energy = 48585.6520 kcal/mol (48553.3784 without restraints) Performing minimization step: 984. Total energy = 48545.8385 kcal/mol (48513.5715 without restraints) Performing minimization step: 985. Total energy = 48506.0655 kcal/mol (48473.8052 without restraints) Performing minimization step: 986. Total energy = 48466.3333 kcal/mol (48434.0796 without restraints) Performing minimization step: 987. Total energy = 48426.6414 kcal/mol (48394.3944 without restraints) Performing minimization step: 988. Total energy = 48386.9906 kcal/mol (48354.7503 without restraints) Performing minimization step: 989. Total energy = 48347.3810 kcal/mol (48315.1474 without restraints) Performing minimization step: 990. Total energy = 48307.8118 kcal/mol (48275.5848 without restraints) Performing minimization step: 991. Total energy = 48268.2830 kcal/mol (48236.0627 without restraints) Performing minimization step: 992. Total energy = 48228.7948 kcal/mol (48196.5811 without restraints) Performing minimization step: 993. Total energy = 48189.3471 kcal/mol (48157.1400 without restraints) Performing minimization step: 994. Total energy = 48149.9396 kcal/mol (48117.7392 without restraints) Performing minimization step: 995. Total energy = 48110.5728 kcal/mol (48078.3790 without restraints) Performing minimization step: 996. Total energy = 48071.2462 kcal/mol (48039.0590 without restraints) Performing minimization step: 997. Total energy = 48031.9598 kcal/mol (47999.7792 without restraints) Performing minimization step: 998. Total energy = 47992.7144 kcal/mol (47960.5404 without restraints) Performing minimization step: 999. Total energy = 47953.5091 kcal/mol (47921.3418 without restraints) Performing minimization step: 1000. Total energy = 47914.3439 kcal/mol (47882.1830 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1001. Total energy = 47875.2192 kcal/mol (47843.0650 without restraints) Performing minimization step: 1002. Total energy = 47836.1346 kcal/mol (47803.9870 without restraints) Performing minimization step: 1003. Total energy = 47797.0905 kcal/mol (47764.9494 without restraints) Performing minimization step: 1004. Total energy = 47758.0866 kcal/mol (47725.9520 without restraints) Performing minimization step: 1005. Total energy = 47719.1226 kcal/mol (47686.9947 without restraints) Performing minimization step: 1006. Total energy = 47680.1990 kcal/mol (47648.0778 without restraints) Performing minimization step: 1007. Total energy = 47641.3155 kcal/mol (47609.2007 without restraints) Performing minimization step: 1008. Total energy = 47602.4719 kcal/mol (47570.3637 without restraints) Performing minimization step: 1009. Total energy = 47563.6683 kcal/mol (47531.5667 without restraints) Performing minimization step: 1010. Total energy = 47524.9050 kcal/mol (47492.8099 without restraints) Performing minimization step: 1011. Total energy = 47486.1814 kcal/mol (47454.0929 without restraints) Performing minimization step: 1012. Total energy = 47447.4985 kcal/mol (47415.4165 without restraints) Performing minimization step: 1013. Total energy = 47408.8544 kcal/mol (47376.7789 without restraints) Performing minimization step: 1014. Total energy = 47370.2508 kcal/mol (47338.1818 without restraints) Performing minimization step: 1015. Total energy = 47331.6863 kcal/mol (47299.6239 without restraints) Performing minimization step: 1016. Total energy = 47293.1622 kcal/mol (47261.1063 without restraints) Performing minimization step: 1017. Total energy = 47254.6780 kcal/mol (47222.6286 without restraints) Performing minimization step: 1018. Total energy = 47216.2333 kcal/mol (47184.1903 without restraints) Performing minimization step: 1019. Total energy = 47177.8281 kcal/mol (47145.7917 without restraints) Performing minimization step: 1020. Total energy = 47139.4627 kcal/mol (47107.4328 without restraints) Performing minimization step: 1021. Total energy = 47101.1371 kcal/mol (47069.1138 without restraints) Performing minimization step: 1022. Total energy = 47062.8513 kcal/mol (47030.8344 without restraints) Performing minimization step: 1023. Total energy = 47024.6050 kcal/mol (46992.5946 without restraints) Performing minimization step: 1024. Total energy = 46986.3980 kcal/mol (46954.3940 without restraints) Performing minimization step: 1025. Total energy = 46948.2310 kcal/mol (46916.2336 without restraints) Performing minimization step: 1026. Total energy = 46910.1035 kcal/mol (46878.1126 without restraints) Performing minimization step: 1027. Total energy = 46872.0152 kcal/mol (46840.0307 without restraints) Performing minimization step: 1028. Total energy = 46833.9667 kcal/mol (46801.9887 without restraints) Performing minimization step: 1029. Total energy = 46795.9575 kcal/mol (46763.9858 without restraints) Performing minimization step: 1030. Total energy = 46757.9874 kcal/mol (46726.0223 without restraints) Performing minimization step: 1031. Total energy = 46720.0571 kcal/mol (46688.0984 without restraints) Performing minimization step: 1032. Total energy = 46682.1657 kcal/mol (46650.2134 without restraints) Performing minimization step: 1033. Total energy = 46644.3141 kcal/mol (46612.3682 without restraints) Performing minimization step: 1034. Total energy = 46606.5012 kcal/mol (46574.5615 without restraints) Performing minimization step: 1035. Total energy = 46568.7279 kcal/mol (46536.7950 without restraints) Performing minimization step: 1036. Total energy = 46530.9939 kcal/mol (46499.0673 without restraints) Performing minimization step: 1037. Total energy = 46493.2991 kcal/mol (46461.3788 without restraints) Performing minimization step: 1038. Total energy = 46455.6431 kcal/mol (46423.7293 without restraints) Performing minimization step: 1039. Total energy = 46418.0267 kcal/mol (46386.1192 without restraints) Performing minimization step: 1040. Total energy = 46380.4492 kcal/mol (46348.5482 without restraints) Performing minimization step: 1041. Total energy = 46342.9106 kcal/mol (46311.0160 without restraints) Performing minimization step: 1042. Total energy = 46305.4108 kcal/mol (46273.5225 without restraints) Performing minimization step: 1043. Total energy = 46267.9504 kcal/mol (46236.0685 without restraints) Performing minimization step: 1044. Total energy = 46230.5288 kcal/mol (46198.6533 without restraints) Performing minimization step: 1045. Total energy = 46193.1461 kcal/mol (46161.2770 without restraints) Performing minimization step: 1046. Total energy = 46155.8023 kcal/mol (46123.9396 without restraints) Performing minimization step: 1047. Total energy = 46118.4974 kcal/mol (46086.6410 without restraints) Performing minimization step: 1048. Total energy = 46081.2313 kcal/mol (46049.3813 without restraints) Performing minimization step: 1049. Total energy = 46044.0042 kcal/mol (46012.1607 without restraints) Performing minimization step: 1050. Total energy = 46006.8158 kcal/mol (45974.9786 without restraints) Performing minimization step: 1051. Total energy = 45969.6665 kcal/mol (45937.8354 without restraints) Performing minimization step: 1052. Total energy = 45932.5556 kcal/mol (45900.7310 without restraints) Performing minimization step: 1053. Total energy = 45895.4834 kcal/mol (45863.6651 without restraints) Performing minimization step: 1054. Total energy = 45858.4505 kcal/mol (45826.6385 without restraints) Performing minimization step: 1055. Total energy = 45821.4555 kcal/mol (45789.6498 without restraints) Performing minimization step: 1056. Total energy = 45784.4987 kcal/mol (45752.6993 without restraints) Performing minimization step: 1057. Total energy = 45747.5810 kcal/mol (45715.7880 without restraints) Performing minimization step: 1058. Total energy = 45710.7017 kcal/mol (45678.9150 without restraints) Performing minimization step: 1059. Total energy = 45673.8612 kcal/mol (45642.0808 without restraints) Performing minimization step: 1060. Total energy = 45637.0592 kcal/mol (45605.2850 without restraints) Performing minimization step: 1061. Total energy = 45600.2955 kcal/mol (45568.5277 without restraints) Performing minimization step: 1062. Total energy = 45563.5701 kcal/mol (45531.8086 without restraints) Performing minimization step: 1063. Total energy = 45526.8831 kcal/mol (45495.1278 without restraints) Performing minimization step: 1064. Total energy = 45490.2345 kcal/mol (45458.4854 without restraints) Performing minimization step: 1065. Total energy = 45453.6244 kcal/mol (45421.8817 without restraints) Performing minimization step: 1066. Total energy = 45417.0524 kcal/mol (45385.3159 without restraints) Performing minimization step: 1067. Total energy = 45380.5188 kcal/mol (45348.7886 without restraints) Performing minimization step: 1068. Total energy = 45344.0234 kcal/mol (45312.2994 without restraints) Performing minimization step: 1069. Total energy = 45307.5661 kcal/mol (45275.8484 without restraints) Performing minimization step: 1070. Total energy = 45271.1472 kcal/mol (45239.4357 without restraints) Performing minimization step: 1071. Total energy = 45234.7664 kcal/mol (45203.0611 without restraints) Performing minimization step: 1072. Total energy = 45198.4235 kcal/mol (45166.7245 without restraints) Performing minimization step: 1073. Total energy = 45162.1188 kcal/mol (45130.4260 without restraints) Performing minimization step: 1074. Total energy = 45125.8520 kcal/mol (45094.1655 without restraints) Performing minimization step: 1075. Total energy = 45089.6232 kcal/mol (45057.9428 without restraints) Performing minimization step: 1076. Total energy = 45053.4325 kcal/mol (45021.7585 without restraints) Performing minimization step: 1077. Total energy = 45017.2799 kcal/mol (44985.6120 without restraints) Performing minimization step: 1078. Total energy = 44981.1653 kcal/mol (44949.5036 without restraints) Performing minimization step: 1079. Total energy = 44945.0884 kcal/mol (44913.4330 without restraints) Performing minimization step: 1080. Total energy = 44909.0495 kcal/mol (44877.4002 without restraints) Performing minimization step: 1081. Total energy = 44873.0484 kcal/mol (44841.4052 without restraints) Performing minimization step: 1082. Total energy = 44837.0847 kcal/mol (44805.4478 without restraints) Performing minimization step: 1083. Total energy = 44801.1594 kcal/mol (44769.5286 without restraints) Performing minimization step: 1084. Total energy = 44765.2714 kcal/mol (44733.6468 without restraints) Performing minimization step: 1085. Total energy = 44729.4213 kcal/mol (44697.8027 without restraints) Performing minimization step: 1086. Total energy = 44693.6088 kcal/mol (44661.9966 without restraints) Performing minimization step: 1087. Total energy = 44657.8339 kcal/mol (44626.2278 without restraints) Performing minimization step: 1088. Total energy = 44622.0967 kcal/mol (44590.4968 without restraints) Performing minimization step: 1089. Total energy = 44586.3974 kcal/mol (44554.8036 without restraints) Performing minimization step: 1090. Total energy = 44550.7355 kcal/mol (44519.1479 without restraints) Performing minimization step: 1091. Total energy = 44515.1110 kcal/mol (44483.5295 without restraints) Performing minimization step: 1092. Total energy = 44479.5245 kcal/mol (44447.9491 without restraints) Performing minimization step: 1093. Total energy = 44443.9751 kcal/mol (44412.4059 without restraints) Performing minimization step: 1094. Total energy = 44408.4633 kcal/mol (44376.9002 without restraints) Performing minimization step: 1095. Total energy = 44372.9889 kcal/mol (44341.4320 without restraints) Performing minimization step: 1096. Total energy = 44337.5520 kcal/mol (44306.0011 without restraints) Performing minimization step: 1097. Total energy = 44302.1523 kcal/mol (44270.6076 without restraints) Performing minimization step: 1098. Total energy = 44266.7896 kcal/mol (44235.2509 without restraints) Performing minimization step: 1099. Total energy = 44231.4645 kcal/mol (44199.9318 without restraints) Performing minimization step: 1100. Total energy = 44196.1769 kcal/mol (44164.6504 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1101. Total energy = 44160.9264 kcal/mol (44129.4059 without restraints) Performing minimization step: 1102. Total energy = 44125.7130 kcal/mol (44094.1988 without restraints) Performing minimization step: 1103. Total energy = 44090.5370 kcal/mol (44059.0289 without restraints) Performing minimization step: 1104. Total energy = 44055.3982 kcal/mol (44023.8961 without restraints) Performing minimization step: 1105. Total energy = 44020.2972 kcal/mol (43988.8011 without restraints) Performing minimization step: 1106. Total energy = 43985.2323 kcal/mol (43953.7423 without restraints) Performing minimization step: 1107. Total energy = 43950.2049 kcal/mol (43918.7210 without restraints) Performing minimization step: 1108. Total energy = 43915.2144 kcal/mol (43883.7365 without restraints) Performing minimization step: 1109. Total energy = 43880.2614 kcal/mol (43848.7898 without restraints) Performing minimization step: 1110. Total energy = 43845.3451 kcal/mol (43813.8795 without restraints) Performing minimization step: 1111. Total energy = 43810.4652 kcal/mol (43779.0055 without restraints) Performing minimization step: 1112. Total energy = 43775.6227 kcal/mol (43744.1690 without restraints) Performing minimization step: 1113. Total energy = 43740.8171 kcal/mol (43709.3696 without restraints) Performing minimization step: 1114. Total energy = 43706.0483 kcal/mol (43674.6067 without restraints) Performing minimization step: 1115. Total energy = 43671.3163 kcal/mol (43639.8807 without restraints) Performing minimization step: 1116. Total energy = 43636.6210 kcal/mol (43605.1915 without restraints) Performing minimization step: 1117. Total energy = 43601.9626 kcal/mol (43570.5391 without restraints) Performing minimization step: 1118. Total energy = 43567.3407 kcal/mol (43535.9231 without restraints) Performing minimization step: 1119. Total energy = 43532.7559 kcal/mol (43501.3444 without restraints) Performing minimization step: 1120. Total energy = 43498.2077 kcal/mol (43466.8021 without restraints) Performing minimization step: 1121. Total energy = 43463.6961 kcal/mol (43432.2967 without restraints) Performing minimization step: 1122. Total energy = 43429.2211 kcal/mol (43397.8274 without restraints) Performing minimization step: 1123. Total energy = 43394.7826 kcal/mol (43363.3950 without restraints) Performing minimization step: 1124. Total energy = 43360.3809 kcal/mol (43328.9993 without restraints) Performing minimization step: 1125. Total energy = 43326.0155 kcal/mol (43294.6397 without restraints) Performing minimization step: 1126. Total energy = 43291.6864 kcal/mol (43260.3169 without restraints) Performing minimization step: 1127. Total energy = 43257.3947 kcal/mol (43226.0310 without restraints) Performing minimization step: 1128. Total energy = 43223.1389 kcal/mol (43191.7813 without restraints) Performing minimization step: 1129. Total energy = 43188.9195 kcal/mol (43157.5677 without restraints) Performing minimization step: 1130. Total energy = 43154.7364 kcal/mol (43123.3905 without restraints) Performing minimization step: 1131. Total energy = 43120.5896 kcal/mol (43089.2497 without restraints) Performing minimization step: 1132. Total energy = 43086.4785 kcal/mol (43055.1446 without restraints) Performing minimization step: 1133. Total energy = 43052.4046 kcal/mol (43021.0766 without restraints) Performing minimization step: 1134. Total energy = 43018.3668 kcal/mol (42987.0447 without restraints) Performing minimization step: 1135. Total energy = 42984.3652 kcal/mol (42953.0490 without restraints) Performing minimization step: 1136. Total energy = 42950.3994 kcal/mol (42919.0892 without restraints) Performing minimization step: 1137. Total energy = 42916.4702 kcal/mol (42885.1659 without restraints) Performing minimization step: 1138. Total energy = 42882.5774 kcal/mol (42851.2790 without restraints) Performing minimization step: 1139. Total energy = 42848.7205 kcal/mol (42817.4280 without restraints) Performing minimization step: 1140. Total energy = 42814.8999 kcal/mol (42783.6133 without restraints) Performing minimization step: 1141. Total energy = 42781.1153 kcal/mol (42749.8346 without restraints) Performing minimization step: 1142. Total energy = 42747.3662 kcal/mol (42716.0914 without restraints) Performing minimization step: 1143. Total energy = 42713.6540 kcal/mol (42682.3851 without restraints) Performing minimization step: 1144. Total energy = 42679.9773 kcal/mol (42648.7142 without restraints) Performing minimization step: 1145. Total energy = 42646.3365 kcal/mol (42615.0795 without restraints) Performing minimization step: 1146. Total energy = 42612.7317 kcal/mol (42581.4803 without restraints) Performing minimization step: 1147. Total energy = 42579.1625 kcal/mol (42547.9169 without restraints) Performing minimization step: 1148. Total energy = 42545.6290 kcal/mol (42514.3894 without restraints) Performing minimization step: 1149. Total energy = 42512.1322 kcal/mol (42480.8986 without restraints) Performing minimization step: 1150. Total energy = 42478.6708 kcal/mol (42447.4429 without restraints) Performing minimization step: 1151. Total energy = 42445.2448 kcal/mol (42414.0227 without restraints) Performing minimization step: 1152. Total energy = 42411.8548 kcal/mol (42380.6386 without restraints) Performing minimization step: 1153. Total energy = 42378.5004 kcal/mol (42347.2900 without restraints) Performing minimization step: 1154. Total energy = 42345.1816 kcal/mol (42313.9771 without restraints) Performing minimization step: 1155. Total energy = 42311.8986 kcal/mol (42280.6999 without restraints) Performing minimization step: 1156. Total energy = 42278.6510 kcal/mol (42247.4582 without restraints) Performing minimization step: 1157. Total energy = 42245.4392 kcal/mol (42214.2520 without restraints) Performing minimization step: 1158. Total energy = 42212.2627 kcal/mol (42181.0814 without restraints) Performing minimization step: 1159. Total energy = 42179.1220 kcal/mol (42147.9465 without restraints) Performing minimization step: 1160. Total energy = 42146.0168 kcal/mol (42114.8472 without restraints) Performing minimization step: 1161. Total energy = 42112.9471 kcal/mol (42081.7833 without restraints) Performing minimization step: 1162. Total energy = 42079.9128 kcal/mol (42048.7548 without restraints) Performing minimization step: 1163. Total energy = 42046.9141 kcal/mol (42015.7619 without restraints) Performing minimization step: 1164. Total energy = 42013.9507 kcal/mol (41982.8043 without restraints) Performing minimization step: 1165. Total energy = 41981.0229 kcal/mol (41949.8822 without restraints) Performing minimization step: 1166. Total energy = 41948.1301 kcal/mol (41916.9952 without restraints) Performing minimization step: 1167. Total energy = 41915.2726 kcal/mol (41884.1434 without restraints) Performing minimization step: 1168. Total energy = 41882.4506 kcal/mol (41851.3273 without restraints) Performing minimization step: 1169. Total energy = 41849.6634 kcal/mol (41818.5458 without restraints) Performing minimization step: 1170. Total energy = 41816.9115 kcal/mol (41785.7997 without restraints) Performing minimization step: 1171. Total energy = 41784.1948 kcal/mol (41753.0888 without restraints) Performing minimization step: 1172. Total energy = 41751.5132 kcal/mol (41720.4127 without restraints) Performing minimization step: 1173. Total energy = 41718.8668 kcal/mol (41687.7721 without restraints) Performing minimization step: 1174. Total energy = 41686.2555 kcal/mol (41655.1666 without restraints) Performing minimization step: 1175. Total energy = 41653.6795 kcal/mol (41622.5964 without restraints) Performing minimization step: 1176. Total energy = 41621.1387 kcal/mol (41590.0614 without restraints) Performing minimization step: 1177. Total energy = 41588.6328 kcal/mol (41557.5612 without restraints) Performing minimization step: 1178. Total energy = 41556.1617 kcal/mol (41525.0957 without restraints) Performing minimization step: 1179. Total energy = 41523.7251 kcal/mol (41492.6648 without restraints) Performing minimization step: 1180. Total energy = 41491.3239 kcal/mol (41460.2693 without restraints) Performing minimization step: 1181. Total energy = 41458.9579 kcal/mol (41427.9090 without restraints) Performing minimization step: 1182. Total energy = 41426.6265 kcal/mol (41395.5833 without restraints) Performing minimization step: 1183. Total energy = 41394.3295 kcal/mol (41363.2920 without restraints) Performing minimization step: 1184. Total energy = 41362.0678 kcal/mol (41331.0359 without restraints) Performing minimization step: 1185. Total energy = 41329.8407 kcal/mol (41298.8146 without restraints) Performing minimization step: 1186. Total energy = 41297.6482 kcal/mol (41266.6278 without restraints) Performing minimization step: 1187. Total energy = 41265.4905 kcal/mol (41234.4757 without restraints) Performing minimization step: 1188. Total energy = 41233.3676 kcal/mol (41202.3585 without restraints) Performing minimization step: 1189. Total energy = 41201.2793 kcal/mol (41170.2759 without restraints) Performing minimization step: 1190. Total energy = 41169.2255 kcal/mol (41138.2277 without restraints) Performing minimization step: 1191. Total energy = 41137.2064 kcal/mol (41106.2143 without restraints) Performing minimization step: 1192. Total energy = 41105.2220 kcal/mol (41074.2355 without restraints) Performing minimization step: 1193. Total energy = 41073.2719 kcal/mol (41042.2910 without restraints) Performing minimization step: 1194. Total energy = 41041.3561 kcal/mol (41010.3809 without restraints) Performing minimization step: 1195. Total energy = 41009.4752 kcal/mol (40978.5058 without restraints) Performing minimization step: 1196. Total energy = 40977.6288 kcal/mol (40946.6649 without restraints) Performing minimization step: 1197. Total energy = 40945.8162 kcal/mol (40914.8578 without restraints) Performing minimization step: 1198. Total energy = 40914.0382 kcal/mol (40883.0855 without restraints) Performing minimization step: 1199. Total energy = 40882.2947 kcal/mol (40851.3476 without restraints) Performing minimization step: 1200. Total energy = 40850.5855 kcal/mol (40819.6441 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1201. Total energy = 40818.9106 kcal/mol (40787.9748 without restraints) Performing minimization step: 1202. Total energy = 40787.2697 kcal/mol (40756.3395 without restraints) Performing minimization step: 1203. Total energy = 40755.6633 kcal/mol (40724.7387 without restraints) Performing minimization step: 1204. Total energy = 40724.0913 kcal/mol (40693.1722 without restraints) Performing minimization step: 1205. Total energy = 40692.5535 kcal/mol (40661.6400 without restraints) Performing minimization step: 1206. Total energy = 40661.0497 kcal/mol (40630.1419 without restraints) Performing minimization step: 1207. Total energy = 40629.5800 kcal/mol (40598.6777 without restraints) Performing minimization step: 1208. Total energy = 40598.1446 kcal/mol (40567.2479 without restraints) Performing minimization step: 1209. Total energy = 40566.7434 kcal/mol (40535.8523 without restraints) Performing minimization step: 1210. Total energy = 40535.3764 kcal/mol (40504.4909 without restraints) Performing minimization step: 1211. Total energy = 40504.0436 kcal/mol (40473.1636 without restraints) Performing minimization step: 1212. Total energy = 40472.7443 kcal/mol (40441.8698 without restraints) Performing minimization step: 1213. Total energy = 40441.4786 kcal/mol (40410.6097 without restraints) Performing minimization step: 1214. Total energy = 40410.2468 kcal/mol (40379.3834 without restraints) Performing minimization step: 1215. Total energy = 40379.0490 kcal/mol (40348.1911 without restraints) Performing minimization step: 1216. Total energy = 40347.8848 kcal/mol (40317.0325 without restraints) Performing minimization step: 1217. Total energy = 40316.7547 kcal/mol (40285.9079 without restraints) Performing minimization step: 1218. Total energy = 40285.6584 kcal/mol (40254.8171 without restraints) Performing minimization step: 1219. Total energy = 40254.5958 kcal/mol (40223.7600 without restraints) Performing minimization step: 1220. Total energy = 40223.5670 kcal/mol (40192.7367 without restraints) Performing minimization step: 1221. Total energy = 40192.5718 kcal/mol (40161.7471 without restraints) Performing minimization step: 1222. Total energy = 40161.6104 kcal/mol (40130.7912 without restraints) Performing minimization step: 1223. Total energy = 40130.6828 kcal/mol (40099.8691 without restraints) Performing minimization step: 1224. Total energy = 40099.7889 kcal/mol (40068.9806 without restraints) Performing minimization step: 1225. Total energy = 40068.9282 kcal/mol (40038.1253 without restraints) Performing minimization step: 1226. Total energy = 40038.1010 kcal/mol (40007.3038 without restraints) Performing minimization step: 1227. Total energy = 40007.3074 kcal/mol (39976.5156 without restraints) Performing minimization step: 1228. Total energy = 39976.5472 kcal/mol (39945.7609 without restraints) Performing minimization step: 1229. Total energy = 39945.8209 kcal/mol (39915.0401 without restraints) Performing minimization step: 1230. Total energy = 39915.1276 kcal/mol (39884.3523 without restraints) Performing minimization step: 1231. Total energy = 39884.4680 kcal/mol (39853.6982 without restraints) Performing minimization step: 1232. Total energy = 39853.8417 kcal/mol (39823.0774 without restraints) Performing minimization step: 1233. Total energy = 39823.2488 kcal/mol (39792.4898 without restraints) Performing minimization step: 1234. Total energy = 39792.6890 kcal/mol (39761.9355 without restraints) Performing minimization step: 1235. Total energy = 39762.1628 kcal/mol (39731.4147 without restraints) Performing minimization step: 1236. Total energy = 39731.6699 kcal/mol (39700.9273 without restraints) Performing minimization step: 1237. Total energy = 39701.2104 kcal/mol (39670.4731 without restraints) Performing minimization step: 1238. Total energy = 39670.7838 kcal/mol (39640.0520 without restraints) Performing minimization step: 1239. Total energy = 39640.3907 kcal/mol (39609.6644 without restraints) Performing minimization step: 1240. Total energy = 39610.0305 kcal/mol (39579.3096 without restraints) Performing minimization step: 1241. Total energy = 39579.7035 kcal/mol (39548.9880 without restraints) Performing minimization step: 1242. Total energy = 39549.4096 kcal/mol (39518.6995 without restraints) Performing minimization step: 1243. Total energy = 39519.1487 kcal/mol (39488.4440 without restraints) Performing minimization step: 1244. Total energy = 39488.9214 kcal/mol (39458.2221 without restraints) Performing minimization step: 1245. Total energy = 39458.7264 kcal/mol (39428.0325 without restraints) Performing minimization step: 1246. Total energy = 39428.5645 kcal/mol (39397.8761 without restraints) Performing minimization step: 1247. Total energy = 39398.4358 kcal/mol (39367.7527 without restraints) Performing minimization step: 1248. Total energy = 39368.3398 kcal/mol (39337.6621 without restraints) Performing minimization step: 1249. Total energy = 39338.2768 kcal/mol (39307.6044 without restraints) Performing minimization step: 1250. Total energy = 39308.2460 kcal/mol (39277.5791 without restraints) Performing minimization step: 1251. Total energy = 39278.2486 kcal/mol (39247.5870 without restraints) Performing minimization step: 1252. Total energy = 39248.2841 kcal/mol (39217.6279 without restraints) Performing minimization step: 1253. Total energy = 39218.3526 kcal/mol (39187.7017 without restraints) Performing minimization step: 1254. Total energy = 39188.4535 kcal/mol (39157.8080 without restraints) Performing minimization step: 1255. Total energy = 39158.5873 kcal/mol (39127.9473 without restraints) Performing minimization step: 1256. Total energy = 39128.7538 kcal/mol (39098.1190 without restraints) Performing minimization step: 1257. Total energy = 39098.9529 kcal/mol (39068.3234 without restraints) Performing minimization step: 1258. Total energy = 39069.1846 kcal/mol (39038.5604 without restraints) Performing minimization step: 1259. Total energy = 39039.4494 kcal/mol (39008.8306 without restraints) Performing minimization step: 1260. Total energy = 39009.7463 kcal/mol (38979.1328 without restraints) Performing minimization step: 1261. Total energy = 38980.0754 kcal/mol (38949.4673 without restraints) Performing minimization step: 1262. Total energy = 38950.4373 kcal/mol (38919.8344 without restraints) Performing minimization step: 1263. Total energy = 38920.8314 kcal/mol (38890.2339 without restraints) Performing minimization step: 1264. Total energy = 38891.2582 kcal/mol (38860.6659 without restraints) Performing minimization step: 1265. Total energy = 38861.7174 kcal/mol (38831.1305 without restraints) Performing minimization step: 1266. Total energy = 38832.2087 kcal/mol (38801.6270 without restraints) Performing minimization step: 1267. Total energy = 38802.7326 kcal/mol (38772.1563 without restraints) Performing minimization step: 1268. Total energy = 38773.2888 kcal/mol (38742.7177 without restraints) Performing minimization step: 1269. Total energy = 38743.8771 kcal/mol (38713.3114 without restraints) Performing minimization step: 1270. Total energy = 38714.4984 kcal/mol (38683.9380 without restraints) Performing minimization step: 1271. Total energy = 38685.1519 kcal/mol (38654.5967 without restraints) Performing minimization step: 1272. Total energy = 38655.8372 kcal/mol (38625.2873 without restraints) Performing minimization step: 1273. Total energy = 38626.5552 kcal/mol (38596.0105 without restraints) Performing minimization step: 1274. Total energy = 38597.3049 kcal/mol (38566.7656 without restraints) Performing minimization step: 1275. Total energy = 38568.0866 kcal/mol (38537.5524 without restraints) Performing minimization step: 1276. Total energy = 38538.9006 kcal/mol (38508.3717 without restraints) Performing minimization step: 1277. Total energy = 38509.7467 kcal/mol (38479.2232 without restraints) Performing minimization step: 1278. Total energy = 38480.6243 kcal/mol (38450.1059 without restraints) Performing minimization step: 1279. Total energy = 38451.5346 kcal/mol (38421.0215 without restraints) Performing minimization step: 1280. Total energy = 38422.4768 kcal/mol (38391.9689 without restraints) Performing minimization step: 1281. Total energy = 38393.4509 kcal/mol (38362.9482 without restraints) Performing minimization step: 1282. Total energy = 38364.4568 kcal/mol (38333.9594 without restraints) Performing minimization step: 1283. Total energy = 38335.4947 kcal/mol (38305.0025 without restraints) Performing minimization step: 1284. Total energy = 38306.5647 kcal/mol (38276.0777 without restraints) Performing minimization step: 1285. Total energy = 38277.6665 kcal/mol (38247.1847 without restraints) Performing minimization step: 1286. Total energy = 38248.7999 kcal/mol (38218.3233 without restraints) Performing minimization step: 1287. Total energy = 38219.9652 kcal/mol (38189.4938 without restraints) Performing minimization step: 1288. Total energy = 38191.1621 kcal/mol (38160.6959 without restraints) Performing minimization step: 1289. Total energy = 38162.3907 kcal/mol (38131.9297 without restraints) Performing minimization step: 1290. Total energy = 38133.6511 kcal/mol (38103.1953 without restraints) Performing minimization step: 1291. Total energy = 38104.9431 kcal/mol (38074.4925 without restraints) Performing minimization step: 1292. Total energy = 38076.2665 kcal/mol (38045.8209 without restraints) Performing minimization step: 1293. Total energy = 38047.6221 kcal/mol (38017.1820 without restraints) Performing minimization step: 1294. Total energy = 38019.0094 kcal/mol (37988.5743 without restraints) Performing minimization step: 1295. Total energy = 37990.4278 kcal/mol (37959.9978 without restraints) Performing minimization step: 1296. Total energy = 37961.8777 kcal/mol (37931.4529 without restraints) Performing minimization step: 1297. Total energy = 37933.3590 kcal/mol (37902.9394 without restraints) Performing minimization step: 1298. Total energy = 37904.8719 kcal/mol (37874.4574 without restraints) Performing minimization step: 1299. Total energy = 37876.4165 kcal/mol (37846.0072 without restraints) Performing minimization step: 1300. Total energy = 37847.9922 kcal/mol (37817.5880 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1301. Total energy = 37819.5992 kcal/mol (37789.2002 without restraints) Performing minimization step: 1302. Total energy = 37791.2377 kcal/mol (37760.8438 without restraints) Performing minimization step: 1303. Total energy = 37762.9072 kcal/mol (37732.5184 without restraints) Performing minimization step: 1304. Total energy = 37734.6076 kcal/mol (37704.2238 without restraints) Performing minimization step: 1305. Total energy = 37706.3398 kcal/mol (37675.9612 without restraints) Performing minimization step: 1306. Total energy = 37678.1032 kcal/mol (37647.7297 without restraints) Performing minimization step: 1307. Total energy = 37649.8980 kcal/mol (37619.5297 without restraints) Performing minimization step: 1308. Total energy = 37621.7239 kcal/mol (37591.3606 without restraints) Performing minimization step: 1309. Total energy = 37593.5809 kcal/mol (37563.2227 without restraints) Performing minimization step: 1310. Total energy = 37565.4690 kcal/mol (37535.1159 without restraints) Performing minimization step: 1311. Total energy = 37537.3881 kcal/mol (37507.0401 without restraints) Performing minimization step: 1312. Total energy = 37509.3383 kcal/mol (37478.9954 without restraints) Performing minimization step: 1313. Total energy = 37481.3195 kcal/mol (37450.9817 without restraints) Performing minimization step: 1314. Total energy = 37453.3320 kcal/mol (37422.9993 without restraints) Performing minimization step: 1315. Total energy = 37425.3754 kcal/mol (37395.0478 without restraints) Performing minimization step: 1316. Total energy = 37397.4498 kcal/mol (37367.1272 without restraints) Performing minimization step: 1317. Total energy = 37369.5550 kcal/mol (37339.2373 without restraints) Performing minimization step: 1318. Total energy = 37341.6910 kcal/mol (37311.3786 without restraints) Performing minimization step: 1319. Total energy = 37313.8578 kcal/mol (37283.5504 without restraints) Performing minimization step: 1320. Total energy = 37286.0554 kcal/mol (37255.7530 without restraints) Performing minimization step: 1321. Total energy = 37258.2835 kcal/mol (37227.9862 without restraints) Performing minimization step: 1322. Total energy = 37230.5426 kcal/mol (37200.2503 without restraints) Performing minimization step: 1323. Total energy = 37202.8327 kcal/mol (37172.5454 without restraints) Performing minimization step: 1324. Total energy = 37175.1532 kcal/mol (37144.8710 without restraints) Performing minimization step: 1325. Total energy = 37147.5044 kcal/mol (37117.2273 without restraints) Performing minimization step: 1326. Total energy = 37119.8863 kcal/mol (37089.6141 without restraints) Performing minimization step: 1327. Total energy = 37092.2989 kcal/mol (37062.0318 without restraints) Performing minimization step: 1328. Total energy = 37064.7422 kcal/mol (37034.4801 without restraints) Performing minimization step: 1329. Total energy = 37037.2158 kcal/mol (37006.9587 without restraints) Performing minimization step: 1330. Total energy = 37009.7200 kcal/mol (36979.4679 without restraints) Performing minimization step: 1331. Total energy = 36982.2548 kcal/mol (36952.0077 without restraints) Performing minimization step: 1332. Total energy = 36954.8202 kcal/mol (36924.5781 without restraints) Performing minimization step: 1333. Total energy = 36927.4156 kcal/mol (36897.1784 without restraints) Performing minimization step: 1334. Total energy = 36900.0414 kcal/mol (36869.8093 without restraints) Performing minimization step: 1335. Total energy = 36872.6979 kcal/mol (36842.4708 without restraints) Performing minimization step: 1336. Total energy = 36845.3847 kcal/mol (36815.1625 without restraints) Performing minimization step: 1337. Total energy = 36818.1017 kcal/mol (36787.8845 without restraints) Performing minimization step: 1338. Total energy = 36790.8493 kcal/mol (36760.6370 without restraints) Performing minimization step: 1339. Total energy = 36763.6266 kcal/mol (36733.4193 without restraints) Performing minimization step: 1340. Total energy = 36736.4346 kcal/mol (36706.2323 without restraints) Performing minimization step: 1341. Total energy = 36709.2728 kcal/mol (36679.0754 without restraints) Performing minimization step: 1342. Total energy = 36682.1410 kcal/mol (36651.9487 without restraints) Performing minimization step: 1343. Total energy = 36655.0394 kcal/mol (36624.8519 without restraints) Performing minimization step: 1344. Total energy = 36627.9677 kcal/mol (36597.7850 without restraints) Performing minimization step: 1345. Total energy = 36600.9265 kcal/mol (36570.7489 without restraints) Performing minimization step: 1346. Total energy = 36573.9150 kcal/mol (36543.7423 without restraints) Performing minimization step: 1347. Total energy = 36546.9338 kcal/mol (36516.7660 without restraints) Performing minimization step: 1348. Total energy = 36519.9824 kcal/mol (36489.8195 without restraints) Performing minimization step: 1349. Total energy = 36493.0606 kcal/mol (36462.9026 without restraints) Performing minimization step: 1350. Total energy = 36466.1691 kcal/mol (36436.0160 without restraints) Performing minimization step: 1351. Total energy = 36439.3074 kcal/mol (36409.1593 without restraints) Performing minimization step: 1352. Total energy = 36412.4759 kcal/mol (36382.3327 without restraints) Performing minimization step: 1353. Total energy = 36385.6740 kcal/mol (36355.5356 without restraints) Performing minimization step: 1354. Total energy = 36358.9021 kcal/mol (36328.7688 without restraints) Performing minimization step: 1355. Total energy = 36332.1597 kcal/mol (36302.0311 without restraints) Performing minimization step: 1356. Total energy = 36305.4473 kcal/mol (36275.3236 without restraints) Performing minimization step: 1357. Total energy = 36278.7645 kcal/mol (36248.6457 without restraints) Performing minimization step: 1358. Total energy = 36252.1115 kcal/mol (36221.9976 without restraints) Performing minimization step: 1359. Total energy = 36225.4882 kcal/mol (36195.3791 without restraints) Performing minimization step: 1360. Total energy = 36198.8942 kcal/mol (36168.7900 without restraints) Performing minimization step: 1361. Total energy = 36172.3301 kcal/mol (36142.2308 without restraints) Performing minimization step: 1362. Total energy = 36145.7955 kcal/mol (36115.7011 without restraints) Performing minimization step: 1363. Total energy = 36119.2906 kcal/mol (36089.2010 without restraints) Performing minimization step: 1364. Total energy = 36092.8150 kcal/mol (36062.7302 without restraints) Performing minimization step: 1365. Total energy = 36066.3690 kcal/mol (36036.2891 without restraints) Performing minimization step: 1366. Total energy = 36039.9528 kcal/mol (36009.8779 without restraints) Performing minimization step: 1367. Total energy = 36013.5661 kcal/mol (35983.4961 without restraints) Performing minimization step: 1368. Total energy = 35987.2087 kcal/mol (35957.1433 without restraints) Performing minimization step: 1369. Total energy = 35960.8806 kcal/mol (35930.8201 without restraints) Performing minimization step: 1370. Total energy = 35934.5818 kcal/mol (35904.5261 without restraints) Performing minimization step: 1371. Total energy = 35908.3122 kcal/mol (35878.2611 without restraints) Performing minimization step: 1372. Total energy = 35882.0718 kcal/mol (35852.0257 without restraints) Performing minimization step: 1373. Total energy = 35855.8611 kcal/mol (35825.8197 without restraints) Performing minimization step: 1374. Total energy = 35829.6793 kcal/mol (35799.6428 without restraints) Performing minimization step: 1375. Total energy = 35803.5267 kcal/mol (35773.4950 without restraints) Performing minimization step: 1376. Total energy = 35777.4034 kcal/mol (35747.3764 without restraints) Performing minimization step: 1377. Total energy = 35751.3087 kcal/mol (35721.2866 without restraints) Performing minimization step: 1378. Total energy = 35725.2436 kcal/mol (35695.2263 without restraints) Performing minimization step: 1379. Total energy = 35699.2076 kcal/mol (35669.1950 without restraints) Performing minimization step: 1380. Total energy = 35673.2004 kcal/mol (35643.1926 without restraints) Performing minimization step: 1381. Total energy = 35647.2226 kcal/mol (35617.2197 without restraints) Performing minimization step: 1382. Total energy = 35621.2740 kcal/mol (35591.2758 without restraints) Performing minimization step: 1383. Total energy = 35595.3541 kcal/mol (35565.3606 without restraints) Performing minimization step: 1384. Total energy = 35569.4633 kcal/mol (35539.4746 without restraints) Performing minimization step: 1385. Total energy = 35543.6013 kcal/mol (35513.6174 without restraints) Performing minimization step: 1386. Total energy = 35517.7675 kcal/mol (35487.7883 without restraints) Performing minimization step: 1387. Total energy = 35491.9632 kcal/mol (35461.9887 without restraints) Performing minimization step: 1388. Total energy = 35466.1875 kcal/mol (35436.2178 without restraints) Performing minimization step: 1389. Total energy = 35440.4408 kcal/mol (35410.4758 without restraints) Performing minimization step: 1390. Total energy = 35414.7228 kcal/mol (35384.7626 without restraints) Performing minimization step: 1391. Total energy = 35389.0336 kcal/mol (35359.0780 without restraints) Performing minimization step: 1392. Total energy = 35363.3727 kcal/mol (35333.4217 without restraints) Performing minimization step: 1393. Total energy = 35337.7413 kcal/mol (35307.7953 without restraints) Performing minimization step: 1394. Total energy = 35312.1382 kcal/mol (35282.1968 without restraints) Performing minimization step: 1395. Total energy = 35286.5635 kcal/mol (35256.6269 without restraints) Performing minimization step: 1396. Total energy = 35261.0177 kcal/mol (35231.0857 without restraints) Performing minimization step: 1397. Total energy = 35235.5001 kcal/mol (35205.5728 without restraints) Performing minimization step: 1398. Total energy = 35210.0109 kcal/mol (35180.0883 without restraints) Performing minimization step: 1399. Total energy = 35184.5504 kcal/mol (35154.6323 without restraints) Performing minimization step: 1400. Total energy = 35159.1183 kcal/mol (35129.2052 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1401. Total energy = 35133.7150 kcal/mol (35103.8065 without restraints) Performing minimization step: 1402. Total energy = 35108.3398 kcal/mol (35078.4359 without restraints) Performing minimization step: 1403. Total energy = 35082.9929 kcal/mol (35053.0937 without restraints) Performing minimization step: 1404. Total energy = 35057.6744 kcal/mol (35027.7799 without restraints) Performing minimization step: 1405. Total energy = 35032.3845 kcal/mol (35002.4946 without restraints) Performing minimization step: 1406. Total energy = 35007.1230 kcal/mol (34977.2378 without restraints) Performing minimization step: 1407. Total energy = 34981.8896 kcal/mol (34952.0091 without restraints) Performing minimization step: 1408. Total energy = 34956.6846 kcal/mol (34926.8088 without restraints) Performing minimization step: 1409. Total energy = 34931.5078 kcal/mol (34901.6365 without restraints) Performing minimization step: 1410. Total energy = 34906.3591 kcal/mol (34876.4925 without restraints) Performing minimization step: 1411. Total energy = 34881.2387 kcal/mol (34851.3767 without restraints) Performing minimization step: 1412. Total energy = 34856.1458 kcal/mol (34826.2884 without restraints) Performing minimization step: 1413. Total energy = 34831.0814 kcal/mol (34801.2286 without restraints) Performing minimization step: 1414. Total energy = 34806.0451 kcal/mol (34776.1970 without restraints) Performing minimization step: 1415. Total energy = 34781.0369 kcal/mol (34751.1933 without restraints) Performing minimization step: 1416. Total energy = 34756.0567 kcal/mol (34726.2179 without restraints) Performing minimization step: 1417. Total energy = 34731.1045 kcal/mol (34701.2702 without restraints) Performing minimization step: 1418. Total energy = 34706.1801 kcal/mol (34676.3505 without restraints) Performing minimization step: 1419. Total energy = 34681.2837 kcal/mol (34651.4587 without restraints) Performing minimization step: 1420. Total energy = 34656.4151 kcal/mol (34626.5947 without restraints) Performing minimization step: 1421. Total energy = 34631.5744 kcal/mol (34601.7585 without restraints) Performing minimization step: 1422. Total energy = 34606.7617 kcal/mol (34576.9505 without restraints) Performing minimization step: 1423. Total energy = 34581.9767 kcal/mol (34552.1701 without restraints) Performing minimization step: 1424. Total energy = 34557.2196 kcal/mol (34527.4175 without restraints) Performing minimization step: 1425. Total energy = 34532.4900 kcal/mol (34502.6925 without restraints) Performing minimization step: 1426. Total energy = 34507.7884 kcal/mol (34477.9955 without restraints) Performing minimization step: 1427. Total energy = 34483.1145 kcal/mol (34453.3262 without restraints) Performing minimization step: 1428. Total energy = 34458.4685 kcal/mol (34428.6848 without restraints) Performing minimization step: 1429. Total energy = 34433.8497 kcal/mol (34404.0705 without restraints) Performing minimization step: 1430. Total energy = 34409.2585 kcal/mol (34379.4838 without restraints) Performing minimization step: 1431. Total energy = 34384.6948 kcal/mol (34354.9246 without restraints) Performing minimization step: 1432. Total energy = 34360.1588 kcal/mol (34330.3932 without restraints) Performing minimization step: 1433. Total energy = 34335.6501 kcal/mol (34305.8891 without restraints) Performing minimization step: 1434. Total energy = 34311.1690 kcal/mol (34281.4125 without restraints) Performing minimization step: 1435. Total energy = 34286.7153 kcal/mol (34256.9634 without restraints) Performing minimization step: 1436. Total energy = 34262.2891 kcal/mol (34232.5416 without restraints) Performing minimization step: 1437. Total energy = 34237.8901 kcal/mol (34208.1472 without restraints) Performing minimization step: 1438. Total energy = 34213.5186 kcal/mol (34183.7801 without restraints) Performing minimization step: 1439. Total energy = 34189.1746 kcal/mol (34159.4408 without restraints) Performing minimization step: 1440. Total energy = 34164.8578 kcal/mol (34135.1283 without restraints) Performing minimization step: 1441. Total energy = 34140.5682 kcal/mol (34110.8433 without restraints) Performing minimization step: 1442. Total energy = 34116.3060 kcal/mol (34086.5856 without restraints) Performing minimization step: 1443. Total energy = 34092.0710 kcal/mol (34062.3551 without restraints) Performing minimization step: 1444. Total energy = 34067.8629 kcal/mol (34038.1513 without restraints) Performing minimization step: 1445. Total energy = 34043.6817 kcal/mol (34013.9748 without restraints) Performing minimization step: 1446. Total energy = 34019.5280 kcal/mol (33989.8256 without restraints) Performing minimization step: 1447. Total energy = 33995.4015 kcal/mol (33965.7035 without restraints) Performing minimization step: 1448. Total energy = 33971.3022 kcal/mol (33941.6088 without restraints) Performing minimization step: 1449. Total energy = 33947.2298 kcal/mol (33917.5408 without restraints) Performing minimization step: 1450. Total energy = 33923.1843 kcal/mol (33893.4997 without restraints) Performing minimization step: 1451. Total energy = 33899.1658 kcal/mol (33869.4857 without restraints) Performing minimization step: 1452. Total energy = 33875.1742 kcal/mol (33845.4986 without restraints) Performing minimization step: 1453. Total energy = 33851.2097 kcal/mol (33821.5386 without restraints) Performing minimization step: 1454. Total energy = 33827.2718 kcal/mol (33797.6050 without restraints) Performing minimization step: 1455. Total energy = 33803.3609 kcal/mol (33773.6986 without restraints) Performing minimization step: 1456. Total energy = 33779.4768 kcal/mol (33749.8190 without restraints) Performing minimization step: 1457. Total energy = 33755.6193 kcal/mol (33725.9659 without restraints) Performing minimization step: 1458. Total energy = 33731.7892 kcal/mol (33702.1403 without restraints) Performing minimization step: 1459. Total energy = 33707.9858 kcal/mol (33678.3412 without restraints) Performing minimization step: 1460. Total energy = 33684.2090 kcal/mol (33654.5689 without restraints) Performing minimization step: 1461. Total energy = 33660.4587 kcal/mol (33630.8230 without restraints) Performing minimization step: 1462. Total energy = 33636.7351 kcal/mol (33607.1039 without restraints) Performing minimization step: 1463. Total energy = 33613.0383 kcal/mol (33583.4113 without restraints) Performing minimization step: 1464. Total energy = 33589.3680 kcal/mol (33559.7455 without restraints) Performing minimization step: 1465. Total energy = 33565.7243 kcal/mol (33536.1062 without restraints) Performing minimization step: 1466. Total energy = 33542.1072 kcal/mol (33512.4935 without restraints) Performing minimization step: 1467. Total energy = 33518.5163 kcal/mol (33488.9070 without restraints) Performing minimization step: 1468. Total energy = 33494.9521 kcal/mol (33465.3473 without restraints) Performing minimization step: 1469. Total energy = 33471.4143 kcal/mol (33441.8138 without restraints) Performing minimization step: 1470. Total energy = 33447.9029 kcal/mol (33418.3067 without restraints) Performing minimization step: 1471. Total energy = 33424.4179 kcal/mol (33394.8261 without restraints) Performing minimization step: 1472. Total energy = 33400.9588 kcal/mol (33371.3714 without restraints) Performing minimization step: 1473. Total energy = 33377.5264 kcal/mol (33347.9434 without restraints) Performing minimization step: 1474. Total energy = 33354.1207 kcal/mol (33324.5420 without restraints) Performing minimization step: 1475. Total energy = 33330.7407 kcal/mol (33301.1664 without restraints) Performing minimization step: 1476. Total energy = 33307.3874 kcal/mol (33277.8174 without restraints) Performing minimization step: 1477. Total energy = 33284.0599 kcal/mol (33254.4943 without restraints) Performing minimization step: 1478. Total energy = 33260.7588 kcal/mol (33231.1975 without restraints) Performing minimization step: 1479. Total energy = 33237.4840 kcal/mol (33207.9270 without restraints) Performing minimization step: 1480. Total energy = 33214.2354 kcal/mol (33184.6828 without restraints) Performing minimization step: 1481. Total energy = 33191.0130 kcal/mol (33161.4648 without restraints) Performing minimization step: 1482. Total energy = 33167.8165 kcal/mol (33138.2724 without restraints) Performing minimization step: 1483. Total energy = 33144.6459 kcal/mol (33115.1063 without restraints) Performing minimization step: 1484. Total energy = 33121.5014 kcal/mol (33091.9661 without restraints) Performing minimization step: 1485. Total energy = 33098.3828 kcal/mol (33068.8518 without restraints) Performing minimization step: 1486. Total energy = 33075.2902 kcal/mol (33045.7635 without restraints) Performing minimization step: 1487. Total energy = 33052.2235 kcal/mol (33022.7011 without restraints) Performing minimization step: 1488. Total energy = 33029.1826 kcal/mol (32999.6645 without restraints) Performing minimization step: 1489. Total energy = 33006.1677 kcal/mol (32976.6539 without restraints) Performing minimization step: 1490. Total energy = 32983.1784 kcal/mol (32953.6691 without restraints) Performing minimization step: 1491. Total energy = 32960.2153 kcal/mol (32930.7101 without restraints) Performing minimization step: 1492. Total energy = 32937.2775 kcal/mol (32907.7766 without restraints) Performing minimization step: 1493. Total energy = 32914.3657 kcal/mol (32884.8691 without restraints) Performing minimization step: 1494. Total energy = 32891.4797 kcal/mol (32861.9874 without restraints) Performing minimization step: 1495. Total energy = 32868.6194 kcal/mol (32839.1313 without restraints) Performing minimization step: 1496. Total energy = 32845.7850 kcal/mol (32816.3012 without restraints) Performing minimization step: 1497. Total energy = 32822.9762 kcal/mol (32793.4966 without restraints) Performing minimization step: 1498. Total energy = 32800.1928 kcal/mol (32770.7175 without restraints) Performing minimization step: 1499. Total energy = 32777.4348 kcal/mol (32747.9637 without restraints) Performing minimization step: 1500. Total energy = 32754.7027 kcal/mol (32725.2359 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1501. Total energy = 32731.9958 kcal/mol (32702.5332 without restraints) Performing minimization step: 1502. Total energy = 32709.3147 kcal/mol (32679.8564 without restraints) Performing minimization step: 1503. Total energy = 32686.6589 kcal/mol (32657.2048 without restraints) Performing minimization step: 1504. Total energy = 32664.0286 kcal/mol (32634.5788 without restraints) Performing minimization step: 1505. Total energy = 32641.4239 kcal/mol (32611.9783 without restraints) Performing minimization step: 1506. Total energy = 32618.8441 kcal/mol (32589.4027 without restraints) Performing minimization step: 1507. Total energy = 32596.2899 kcal/mol (32566.8527 without restraints) Performing minimization step: 1508. Total energy = 32573.7609 kcal/mol (32544.3280 without restraints) Performing minimization step: 1509. Total energy = 32551.2571 kcal/mol (32521.8284 without restraints) Performing minimization step: 1510. Total energy = 32528.7787 kcal/mol (32499.3542 without restraints) Performing minimization step: 1511. Total energy = 32506.3255 kcal/mol (32476.9052 without restraints) Performing minimization step: 1512. Total energy = 32483.8969 kcal/mol (32454.4807 without restraints) Performing minimization step: 1513. Total energy = 32461.4941 kcal/mol (32432.0821 without restraints) Performing minimization step: 1514. Total energy = 32439.1164 kcal/mol (32409.7087 without restraints) Performing minimization step: 1515. Total energy = 32416.7639 kcal/mol (32387.3604 without restraints) Performing minimization step: 1516. Total energy = 32394.4364 kcal/mol (32365.0371 without restraints) Performing minimization step: 1517. Total energy = 32372.1341 kcal/mol (32342.7389 without restraints) Performing minimization step: 1518. Total energy = 32349.8567 kcal/mol (32320.4658 without restraints) Performing minimization step: 1519. Total energy = 32327.6045 kcal/mol (32298.2176 without restraints) Performing minimization step: 1520. Total energy = 32305.3767 kcal/mol (32275.9939 without restraints) Performing minimization step: 1521. Total energy = 32283.1740 kcal/mol (32253.7954 without restraints) Performing minimization step: 1522. Total energy = 32260.9964 kcal/mol (32231.6220 without restraints) Performing minimization step: 1523. Total energy = 32238.8437 kcal/mol (32209.4736 without restraints) Performing minimization step: 1524. Total energy = 32216.7160 kcal/mol (32187.3499 without restraints) Performing minimization step: 1525. Total energy = 32194.6130 kcal/mol (32165.2511 without restraints) Performing minimization step: 1526. Total energy = 32172.5349 kcal/mol (32143.1772 without restraints) Performing minimization step: 1527. Total energy = 32150.4815 kcal/mol (32121.1279 without restraints) Performing minimization step: 1528. Total energy = 32128.4524 kcal/mol (32099.1029 without restraints) Performing minimization step: 1529. Total energy = 32106.4486 kcal/mol (32077.1034 without restraints) Performing minimization step: 1530. Total energy = 32084.4694 kcal/mol (32055.1282 without restraints) Performing minimization step: 1531. Total energy = 32062.5148 kcal/mol (32033.1777 without restraints) Performing minimization step: 1532. Total energy = 32040.5850 kcal/mol (32011.2520 without restraints) Performing minimization step: 1533. Total energy = 32018.6798 kcal/mol (31989.3509 without restraints) Performing minimization step: 1534. Total energy = 31996.7991 kcal/mol (31967.4744 without restraints) Performing minimization step: 1535. Total energy = 31974.9430 kcal/mol (31945.6223 without restraints) Performing minimization step: 1536. Total energy = 31953.1111 kcal/mol (31923.7946 without restraints) Performing minimization step: 1537. Total energy = 31931.3040 kcal/mol (31901.9916 without restraints) Performing minimization step: 1538. Total energy = 31909.5212 kcal/mol (31880.2127 without restraints) Performing minimization step: 1539. Total energy = 31887.7626 kcal/mol (31858.4584 without restraints) Performing minimization step: 1540. Total energy = 31866.0286 kcal/mol (31836.7284 without restraints) Performing minimization step: 1541. Total energy = 31844.3187 kcal/mol (31815.0225 without restraints) Performing minimization step: 1542. Total energy = 31822.6332 kcal/mol (31793.3412 without restraints) Performing minimization step: 1543. Total energy = 31800.9722 kcal/mol (31771.6844 without restraints) Performing minimization step: 1544. Total energy = 31779.3354 kcal/mol (31750.0515 without restraints) Performing minimization step: 1545. Total energy = 31757.7227 kcal/mol (31728.4428 without restraints) Performing minimization step: 1546. Total energy = 31736.1341 kcal/mol (31706.8583 without restraints) Performing minimization step: 1547. Total energy = 31714.5699 kcal/mol (31685.2982 without restraints) Performing minimization step: 1548. Total energy = 31693.0297 kcal/mol (31663.7620 without restraints) Performing minimization step: 1549. Total energy = 31671.5138 kcal/mol (31642.2502 without restraints) Performing minimization step: 1550. Total energy = 31650.0219 kcal/mol (31620.7622 without restraints) Performing minimization step: 1551. Total energy = 31628.5543 kcal/mol (31599.2988 without restraints) Performing minimization step: 1552. Total energy = 31607.1106 kcal/mol (31577.8591 without restraints) Performing minimization step: 1553. Total energy = 31585.6910 kcal/mol (31556.4435 without restraints) Performing minimization step: 1554. Total energy = 31564.2953 kcal/mol (31535.0519 without restraints) Performing minimization step: 1555. Total energy = 31542.9236 kcal/mol (31513.6842 without restraints) Performing minimization step: 1556. Total energy = 31521.5759 kcal/mol (31492.3406 without restraints) Performing minimization step: 1557. Total energy = 31500.2521 kcal/mol (31471.0207 without restraints) Performing minimization step: 1558. Total energy = 31478.9521 kcal/mol (31449.7247 without restraints) Performing minimization step: 1559. Total energy = 31457.6759 kcal/mol (31428.4526 without restraints) Performing minimization step: 1560. Total energy = 31436.4236 kcal/mol (31407.2043 without restraints) Performing minimization step: 1561. Total energy = 31415.1953 kcal/mol (31385.9799 without restraints) Performing minimization step: 1562. Total energy = 31393.9904 kcal/mol (31364.7791 without restraints) Performing minimization step: 1563. Total energy = 31372.8095 kcal/mol (31343.6022 without restraints) Performing minimization step: 1564. Total energy = 31351.6519 kcal/mol (31322.4485 without restraints) Performing minimization step: 1565. Total energy = 31330.5183 kcal/mol (31301.3188 without restraints) Performing minimization step: 1566. Total energy = 31309.4082 kcal/mol (31280.2127 without restraints) Performing minimization step: 1567. Total energy = 31288.3217 kcal/mol (31259.1302 without restraints) Performing minimization step: 1568. Total energy = 31267.2589 kcal/mol (31238.0714 without restraints) Performing minimization step: 1569. Total energy = 31246.2193 kcal/mol (31217.0358 without restraints) Performing minimization step: 1570. Total energy = 31225.2035 kcal/mol (31196.0239 without restraints) Performing minimization step: 1571. Total energy = 31204.2114 kcal/mol (31175.0358 without restraints) Performing minimization step: 1572. Total energy = 31183.2426 kcal/mol (31154.0709 without restraints) Performing minimization step: 1573. Total energy = 31162.2972 kcal/mol (31133.1295 without restraints) Performing minimization step: 1574. Total energy = 31141.3751 kcal/mol (31112.2113 without restraints) Performing minimization step: 1575. Total energy = 31120.4764 kcal/mol (31091.3166 without restraints) Performing minimization step: 1576. Total energy = 31099.6012 kcal/mol (31070.4454 without restraints) Performing minimization step: 1577. Total energy = 31078.7498 kcal/mol (31049.5979 without restraints) Performing minimization step: 1578. Total energy = 31057.9212 kcal/mol (31028.7732 without restraints) Performing minimization step: 1579. Total energy = 31037.1159 kcal/mol (31007.9718 without restraints) Performing minimization step: 1580. Total energy = 31016.3338 kcal/mol (30987.1937 without restraints) Performing minimization step: 1581. Total energy = 30995.5749 kcal/mol (30966.4387 without restraints) Performing minimization step: 1582. Total energy = 30974.8393 kcal/mol (30945.7071 without restraints) Performing minimization step: 1583. Total energy = 30954.1269 kcal/mol (30924.9985 without restraints) Performing minimization step: 1584. Total energy = 30933.4373 kcal/mol (30904.3127 without restraints) Performing minimization step: 1585. Total energy = 30912.7707 kcal/mol (30883.6501 without restraints) Performing minimization step: 1586. Total energy = 30892.1275 kcal/mol (30863.0108 without restraints) Performing minimization step: 1587. Total energy = 30871.5069 kcal/mol (30842.3941 without restraints) Performing minimization step: 1588. Total energy = 30850.9099 kcal/mol (30821.8012 without restraints) Performing minimization step: 1589. Total energy = 30830.3359 kcal/mol (30801.2309 without restraints) Performing minimization step: 1590. Total energy = 30809.7846 kcal/mol (30780.6835 without restraints) Performing minimization step: 1591. Total energy = 30789.2568 kcal/mol (30760.1596 without restraints) Performing minimization step: 1592. Total energy = 30768.7518 kcal/mol (30739.6584 without restraints) Performing minimization step: 1593. Total energy = 30748.2693 kcal/mol (30719.1799 without restraints) Performing minimization step: 1594. Total energy = 30727.8098 kcal/mol (30698.7241 without restraints) Performing minimization step: 1595. Total energy = 30707.3727 kcal/mol (30678.2909 without restraints) Performing minimization step: 1596. Total energy = 30686.9586 kcal/mol (30657.8807 without restraints) Performing minimization step: 1597. Total energy = 30666.5674 kcal/mol (30637.4934 without restraints) Performing minimization step: 1598. Total energy = 30646.1991 kcal/mol (30617.1289 without restraints) Performing minimization step: 1599. Total energy = 30625.8533 kcal/mol (30596.7869 without restraints) Performing minimization step: 1600. Total energy = 30605.5298 kcal/mol (30576.4673 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1601. Total energy = 30585.2293 kcal/mol (30556.1706 without restraints) Performing minimization step: 1602. Total energy = 30564.9518 kcal/mol (30535.8969 without restraints) Performing minimization step: 1603. Total energy = 30544.6967 kcal/mol (30515.6457 without restraints) Performing minimization step: 1604. Total energy = 30524.4638 kcal/mol (30495.4165 without restraints) Performing minimization step: 1605. Total energy = 30504.2532 kcal/mol (30475.2098 without restraints) Performing minimization step: 1606. Total energy = 30484.0656 kcal/mol (30455.0260 without restraints) Performing minimization step: 1607. Total energy = 30463.9005 kcal/mol (30434.8648 without restraints) Performing minimization step: 1608. Total energy = 30443.7575 kcal/mol (30414.7255 without restraints) Performing minimization step: 1609. Total energy = 30423.6370 kcal/mol (30394.6090 without restraints) Performing minimization step: 1610. Total energy = 30403.5393 kcal/mol (30374.5149 without restraints) Performing minimization step: 1611. Total energy = 30383.4636 kcal/mol (30354.4431 without restraints) Performing minimization step: 1612. Total energy = 30363.4103 kcal/mol (30334.3936 without restraints) Performing minimization step: 1613. Total energy = 30343.3795 kcal/mol (30314.3668 without restraints) Performing minimization step: 1614. Total energy = 30323.3712 kcal/mol (30294.3620 without restraints) Performing minimization step: 1615. Total energy = 30303.3848 kcal/mol (30274.3794 without restraints) Performing minimization step: 1616. Total energy = 30283.4206 kcal/mol (30254.4190 without restraints) Performing minimization step: 1617. Total energy = 30263.4789 kcal/mol (30234.4812 without restraints) Performing minimization step: 1618. Total energy = 30243.5589 kcal/mol (30214.5649 without restraints) Performing minimization step: 1619. Total energy = 30223.6613 kcal/mol (30194.6712 without restraints) Performing minimization step: 1620. Total energy = 30203.7859 kcal/mol (30174.7995 without restraints) Performing minimization step: 1621. Total energy = 30183.9325 kcal/mol (30154.9498 without restraints) Performing minimization step: 1622. Total energy = 30164.1013 kcal/mol (30135.1223 without restraints) Performing minimization step: 1623. Total energy = 30144.2919 kcal/mol (30115.3167 without restraints) Performing minimization step: 1624. Total energy = 30124.5044 kcal/mol (30095.5330 without restraints) Performing minimization step: 1625. Total energy = 30104.7392 kcal/mol (30075.7715 without restraints) Performing minimization step: 1626. Total energy = 30084.9957 kcal/mol (30056.0317 without restraints) Performing minimization step: 1627. Total energy = 30065.2741 kcal/mol (30036.3139 without restraints) Performing minimization step: 1628. Total energy = 30045.5744 kcal/mol (30016.6179 without restraints) Performing minimization step: 1629. Total energy = 30025.8966 kcal/mol (29996.9438 without restraints) Performing minimization step: 1630. Total energy = 30006.2404 kcal/mol (29977.2914 without restraints) Performing minimization step: 1631. Total energy = 29986.6061 kcal/mol (29957.6608 without restraints) Performing minimization step: 1632. Total energy = 29966.9936 kcal/mol (29938.0521 without restraints) Performing minimization step: 1633. Total energy = 29947.4032 kcal/mol (29918.4653 without restraints) Performing minimization step: 1634. Total energy = 29927.8343 kcal/mol (29898.9003 without restraints) Performing minimization step: 1635. Total energy = 29908.2871 kcal/mol (29879.3567 without restraints) Performing minimization step: 1636. Total energy = 29888.7616 kcal/mol (29859.8349 without restraints) Performing minimization step: 1637. Total energy = 29869.2577 kcal/mol (29840.3347 without restraints) Performing minimization step: 1638. Total energy = 29849.7756 kcal/mol (29820.8563 without restraints) Performing minimization step: 1639. Total energy = 29830.3149 kcal/mol (29801.3993 without restraints) Performing minimization step: 1640. Total energy = 29810.8759 kcal/mol (29781.9640 without restraints) Performing minimization step: 1641. Total energy = 29791.4579 kcal/mol (29762.5497 without restraints) Performing minimization step: 1642. Total energy = 29772.0618 kcal/mol (29743.1572 without restraints) Performing minimization step: 1643. Total energy = 29752.6871 kcal/mol (29723.7862 without restraints) Performing minimization step: 1644. Total energy = 29733.3339 kcal/mol (29704.4367 without restraints) Performing minimization step: 1645. Total energy = 29714.0023 kcal/mol (29685.1087 without restraints) Performing minimization step: 1646. Total energy = 29694.6916 kcal/mol (29665.8017 without restraints) Performing minimization step: 1647. Total energy = 29675.4027 kcal/mol (29646.5165 without restraints) Performing minimization step: 1648. Total energy = 29656.1353 kcal/mol (29627.2529 without restraints) Performing minimization step: 1649. Total energy = 29636.8889 kcal/mol (29608.0101 without restraints) Performing minimization step: 1650. Total energy = 29617.6638 kcal/mol (29588.7886 without restraints) Performing minimization step: 1651. Total energy = 29598.4599 kcal/mol (29569.5884 without restraints) Performing minimization step: 1652. Total energy = 29579.2772 kcal/mol (29550.4093 without restraints) Performing minimization step: 1653. Total energy = 29560.1157 kcal/mol (29531.2515 without restraints) Performing minimization step: 1654. Total energy = 29540.9754 kcal/mol (29512.1148 without restraints) Performing minimization step: 1655. Total energy = 29521.8565 kcal/mol (29492.9996 without restraints) Performing minimization step: 1656. Total energy = 29502.7587 kcal/mol (29473.9054 without restraints) Performing minimization step: 1657. Total energy = 29483.6818 kcal/mol (29454.8321 without restraints) Performing minimization step: 1658. Total energy = 29464.6260 kcal/mol (29435.7799 without restraints) Performing minimization step: 1659. Total energy = 29445.5911 kcal/mol (29416.7486 without restraints) Performing minimization step: 1660. Total energy = 29426.5772 kcal/mol (29397.7383 without restraints) Performing minimization step: 1661. Total energy = 29407.5843 kcal/mol (29378.7491 without restraints) Performing minimization step: 1662. Total energy = 29388.6123 kcal/mol (29359.7805 without restraints) Performing minimization step: 1663. Total energy = 29369.6611 kcal/mol (29340.8331 without restraints) Performing minimization step: 1664. Total energy = 29350.7310 kcal/mol (29321.9066 without restraints) Performing minimization step: 1665. Total energy = 29331.8218 kcal/mol (29303.0010 without restraints) Performing minimization step: 1666. Total energy = 29312.9334 kcal/mol (29284.1162 without restraints) Performing minimization step: 1667. Total energy = 29294.0659 kcal/mol (29265.2522 without restraints) Performing minimization step: 1668. Total energy = 29275.2189 kcal/mol (29246.4088 without restraints) Performing minimization step: 1669. Total energy = 29256.3935 kcal/mol (29227.5870 without restraints) Performing minimization step: 1670. Total energy = 29237.5882 kcal/mol (29208.7853 without restraints) Performing minimization step: 1671. Total energy = 29218.8039 kcal/mol (29190.0046 without restraints) Performing minimization step: 1672. Total energy = 29200.0399 kcal/mol (29171.2442 without restraints) Performing minimization step: 1673. Total energy = 29181.2966 kcal/mol (29152.5045 without restraints) Performing minimization step: 1674. Total energy = 29162.5740 kcal/mol (29133.7854 without restraints) Performing minimization step: 1675. Total energy = 29143.8722 kcal/mol (29115.0872 without restraints) Performing minimization step: 1676. Total energy = 29125.1909 kcal/mol (29096.4095 without restraints) Performing minimization step: 1677. Total energy = 29106.5300 kcal/mol (29077.7521 without restraints) Performing minimization step: 1678. Total energy = 29087.8893 kcal/mol (29059.1149 without restraints) Performing minimization step: 1679. Total energy = 29069.2695 kcal/mol (29040.4988 without restraints) Performing minimization step: 1680. Total energy = 29050.6702 kcal/mol (29021.9029 without restraints) Performing minimization step: 1681. Total energy = 29032.0911 kcal/mol (29003.3274 without restraints) Performing minimization step: 1682. Total energy = 29013.5325 kcal/mol (28984.7723 without restraints) Performing minimization step: 1683. Total energy = 28994.9944 kcal/mol (28966.2378 without restraints) Performing minimization step: 1684. Total energy = 28976.4766 kcal/mol (28947.7235 without restraints) Performing minimization step: 1685. Total energy = 28957.9793 kcal/mol (28929.2297 without restraints) Performing minimization step: 1686. Total energy = 28939.5020 kcal/mol (28910.7559 without restraints) Performing minimization step: 1687. Total energy = 28921.0452 kcal/mol (28892.3027 without restraints) Performing minimization step: 1688. Total energy = 28902.6084 kcal/mol (28873.8694 without restraints) Performing minimization step: 1689. Total energy = 28884.1924 kcal/mol (28855.4569 without restraints) Performing minimization step: 1690. Total energy = 28865.7963 kcal/mol (28837.0643 without restraints) Performing minimization step: 1691. Total energy = 28847.4201 kcal/mol (28818.6916 without restraints) Performing minimization step: 1692. Total energy = 28829.0642 kcal/mol (28800.3393 without restraints) Performing minimization step: 1693. Total energy = 28810.7284 kcal/mol (28782.0069 without restraints) Performing minimization step: 1694. Total energy = 28792.4128 kcal/mol (28763.6948 without restraints) Performing minimization step: 1695. Total energy = 28774.1172 kcal/mol (28745.4028 without restraints) Performing minimization step: 1696. Total energy = 28755.8415 kcal/mol (28727.1306 without restraints) Performing minimization step: 1697. Total energy = 28737.5859 kcal/mol (28708.8784 without restraints) Performing minimization step: 1698. Total energy = 28719.3499 kcal/mol (28690.6459 without restraints) Performing minimization step: 1699. Total energy = 28701.1343 kcal/mol (28672.4338 without restraints) Performing minimization step: 1700. Total energy = 28682.9388 kcal/mol (28654.2419 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1701. Total energy = 28664.7632 kcal/mol (28636.0697 without restraints) Performing minimization step: 1702. Total energy = 28646.6067 kcal/mol (28617.9166 without restraints) Performing minimization step: 1703. Total energy = 28628.4707 kcal/mol (28599.7841 without restraints) Performing minimization step: 1704. Total energy = 28610.3541 kcal/mol (28581.6710 without restraints) Performing minimization step: 1705. Total energy = 28592.2576 kcal/mol (28563.5779 without restraints) Performing minimization step: 1706. Total energy = 28574.1808 kcal/mol (28545.5046 without restraints) Performing minimization step: 1707. Total energy = 28556.1242 kcal/mol (28527.4512 without restraints) Performing minimization step: 1708. Total energy = 28538.0868 kcal/mol (28509.4175 without restraints) Performing minimization step: 1709. Total energy = 28520.0692 kcal/mol (28491.4033 without restraints) Performing minimization step: 1710. Total energy = 28502.0712 kcal/mol (28473.4088 without restraints) Performing minimization step: 1711. Total energy = 28484.0933 kcal/mol (28455.4343 without restraints) Performing minimization step: 1712. Total energy = 28466.1349 kcal/mol (28437.4796 without restraints) Performing minimization step: 1713. Total energy = 28448.1960 kcal/mol (28419.5439 without restraints) Performing minimization step: 1714. Total energy = 28430.2766 kcal/mol (28401.6279 without restraints) Performing minimization step: 1715. Total energy = 28412.3765 kcal/mol (28383.7312 without restraints) Performing minimization step: 1716. Total energy = 28394.4959 kcal/mol (28365.8541 without restraints) Performing minimization step: 1717. Total energy = 28376.6349 kcal/mol (28347.9965 without restraints) Performing minimization step: 1718. Total energy = 28358.7931 kcal/mol (28330.1581 without restraints) Performing minimization step: 1719. Total energy = 28340.9710 kcal/mol (28312.3395 without restraints) Performing minimization step: 1720. Total energy = 28323.1688 kcal/mol (28294.5408 without restraints) Performing minimization step: 1721. Total energy = 28305.3855 kcal/mol (28276.7607 without restraints) Performing minimization step: 1722. Total energy = 28287.6212 kcal/mol (28258.9998 without restraints) Performing minimization step: 1723. Total energy = 28269.8765 kcal/mol (28241.2586 without restraints) Performing minimization step: 1724. Total energy = 28252.1510 kcal/mol (28223.5365 without restraints) Performing minimization step: 1725. Total energy = 28234.4450 kcal/mol (28205.8339 without restraints) Performing minimization step: 1726. Total energy = 28216.7581 kcal/mol (28188.1504 without restraints) Performing minimization step: 1727. Total energy = 28199.0906 kcal/mol (28170.4862 without restraints) Performing minimization step: 1728. Total energy = 28181.4420 kcal/mol (28152.8410 without restraints) Performing minimization step: 1729. Total energy = 28163.8126 kcal/mol (28135.2150 without restraints) Performing minimization step: 1730. Total energy = 28146.2022 kcal/mol (28117.6079 without restraints) Performing minimization step: 1731. Total energy = 28128.6111 kcal/mol (28100.0202 without restraints) Performing minimization step: 1732. Total energy = 28111.0391 kcal/mol (28082.4515 without restraints) Performing minimization step: 1733. Total energy = 28093.4861 kcal/mol (28064.9019 without restraints) Performing minimization step: 1734. Total energy = 28075.9521 kcal/mol (28047.3713 without restraints) Performing minimization step: 1735. Total energy = 28058.4372 kcal/mol (28029.8597 without restraints) Performing minimization step: 1736. Total energy = 28040.9410 kcal/mol (28012.3670 without restraints) Performing minimization step: 1737. Total energy = 28023.4642 kcal/mol (27994.8935 without restraints) Performing minimization step: 1738. Total energy = 28006.0065 kcal/mol (27977.4392 without restraints) Performing minimization step: 1739. Total energy = 27988.5674 kcal/mol (27960.0034 without restraints) Performing minimization step: 1740. Total energy = 27971.1474 kcal/mol (27942.5867 without restraints) Performing minimization step: 1741. Total energy = 27953.7460 kcal/mol (27925.1887 without restraints) Performing minimization step: 1742. Total energy = 27936.3636 kcal/mol (27907.8098 without restraints) Performing minimization step: 1743. Total energy = 27918.9998 kcal/mol (27890.4491 without restraints) Performing minimization step: 1744. Total energy = 27901.6546 kcal/mol (27873.1073 without restraints) Performing minimization step: 1745. Total energy = 27884.3290 kcal/mol (27855.7850 without restraints) Performing minimization step: 1746. Total energy = 27867.0213 kcal/mol (27838.4806 without restraints) Performing minimization step: 1747. Total energy = 27849.7323 kcal/mol (27821.1949 without restraints) Performing minimization step: 1748. Total energy = 27832.4621 kcal/mol (27803.9281 without restraints) Performing minimization step: 1749. Total energy = 27815.2109 kcal/mol (27786.6802 without restraints) Performing minimization step: 1750. Total energy = 27797.9780 kcal/mol (27769.4506 without restraints) Performing minimization step: 1751. Total energy = 27780.7636 kcal/mol (27752.2396 without restraints) Performing minimization step: 1752. Total energy = 27763.5684 kcal/mol (27735.0476 without restraints) Performing minimization step: 1753. Total energy = 27746.3914 kcal/mol (27717.8739 without restraints) Performing minimization step: 1754. Total energy = 27729.2325 kcal/mol (27700.7183 without restraints) Performing minimization step: 1755. Total energy = 27712.0921 kcal/mol (27683.5813 without restraints) Performing minimization step: 1756. Total energy = 27694.9705 kcal/mol (27666.4629 without restraints) Performing minimization step: 1757. Total energy = 27677.8673 kcal/mol (27649.3630 without restraints) Performing minimization step: 1758. Total energy = 27660.7827 kcal/mol (27632.2817 without restraints) Performing minimization step: 1759. Total energy = 27643.7166 kcal/mol (27615.2189 without restraints) Performing minimization step: 1760. Total energy = 27626.6690 kcal/mol (27598.1747 without restraints) Performing minimization step: 1761. Total energy = 27609.6395 kcal/mol (27581.1484 without restraints) Performing minimization step: 1762. Total energy = 27592.6283 kcal/mol (27564.1406 without restraints) Performing minimization step: 1763. Total energy = 27575.6355 kcal/mol (27547.1510 without restraints) Performing minimization step: 1764. Total energy = 27558.6608 kcal/mol (27530.1795 without restraints) Performing minimization step: 1765. Total energy = 27541.7044 kcal/mol (27513.2264 without restraints) Performing minimization step: 1766. Total energy = 27524.7663 kcal/mol (27496.2914 without restraints) Performing minimization step: 1767. Total energy = 27507.8462 kcal/mol (27479.3746 without restraints) Performing minimization step: 1768. Total energy = 27490.9444 kcal/mol (27462.4761 without restraints) Performing minimization step: 1769. Total energy = 27474.0606 kcal/mol (27445.5956 without restraints) Performing minimization step: 1770. Total energy = 27457.1949 kcal/mol (27428.7331 without restraints) Performing minimization step: 1771. Total energy = 27440.3472 kcal/mol (27411.8886 without restraints) Performing minimization step: 1772. Total energy = 27423.5178 kcal/mol (27395.0626 without restraints) Performing minimization step: 1773. Total energy = 27406.7064 kcal/mol (27378.2543 without restraints) Performing minimization step: 1774. Total energy = 27389.9134 kcal/mol (27361.4646 without restraints) Performing minimization step: 1775. Total energy = 27373.1380 kcal/mol (27344.6924 without restraints) Performing minimization step: 1776. Total energy = 27356.3803 kcal/mol (27327.9379 without restraints) Performing minimization step: 1777. Total energy = 27339.6408 kcal/mol (27311.2017 without restraints) Performing minimization step: 1778. Total energy = 27322.9192 kcal/mol (27294.4835 without restraints) Performing minimization step: 1779. Total energy = 27306.2156 kcal/mol (27277.7829 without restraints) Performing minimization step: 1780. Total energy = 27289.5300 kcal/mol (27261.1005 without restraints) Performing minimization step: 1781. Total energy = 27272.8622 kcal/mol (27244.4359 without restraints) Performing minimization step: 1782. Total energy = 27256.2119 kcal/mol (27227.7890 without restraints) Performing minimization step: 1783. Total energy = 27239.5798 kcal/mol (27211.1601 without restraints) Performing minimization step: 1784. Total energy = 27222.9658 kcal/mol (27194.5492 without restraints) Performing minimization step: 1785. Total energy = 27206.3691 kcal/mol (27177.9557 without restraints) Performing minimization step: 1786. Total energy = 27189.7900 kcal/mol (27161.3798 without restraints) Performing minimization step: 1787. Total energy = 27173.2286 kcal/mol (27144.8216 without restraints) Performing minimization step: 1788. Total energy = 27156.6847 kcal/mol (27128.2809 without restraints) Performing minimization step: 1789. Total energy = 27140.1586 kcal/mol (27111.7580 without restraints) Performing minimization step: 1790. Total energy = 27123.6500 kcal/mol (27095.2525 without restraints) Performing minimization step: 1791. Total energy = 27107.1593 kcal/mol (27078.7649 without restraints) Performing minimization step: 1792. Total energy = 27090.6860 kcal/mol (27062.2950 without restraints) Performing minimization step: 1793. Total energy = 27074.2304 kcal/mol (27045.8426 without restraints) Performing minimization step: 1794. Total energy = 27057.7922 kcal/mol (27029.4075 without restraints) Performing minimization step: 1795. Total energy = 27041.3715 kcal/mol (27012.9901 without restraints) Performing minimization step: 1796. Total energy = 27024.9684 kcal/mol (26996.5901 without restraints) Performing minimization step: 1797. Total energy = 27008.5829 kcal/mol (26980.2078 without restraints) Performing minimization step: 1798. Total energy = 26992.2146 kcal/mol (26963.8426 without restraints) Performing minimization step: 1799. Total energy = 26975.8640 kcal/mol (26947.4952 without restraints) Performing minimization step: 1800. Total energy = 26959.5307 kcal/mol (26931.1650 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1801. Total energy = 26943.2149 kcal/mol (26914.8526 without restraints) Performing minimization step: 1802. Total energy = 26926.9163 kcal/mol (26898.5571 without restraints) Performing minimization step: 1803. Total energy = 26910.6343 kcal/mol (26882.2780 without restraints) Performing minimization step: 1804. Total energy = 26894.3700 kcal/mol (26866.0170 without restraints) Performing minimization step: 1805. Total energy = 26878.1230 kcal/mol (26849.7731 without restraints) Performing minimization step: 1806. Total energy = 26861.8930 kcal/mol (26833.5461 without restraints) Performing minimization step: 1807. Total energy = 26845.6805 kcal/mol (26817.3369 without restraints) Performing minimization step: 1808. Total energy = 26829.4853 kcal/mol (26801.1449 without restraints) Performing minimization step: 1809. Total energy = 26813.3071 kcal/mol (26784.9698 without restraints) Performing minimization step: 1810. Total energy = 26797.1462 kcal/mol (26768.8120 without restraints) Performing minimization step: 1811. Total energy = 26781.0025 kcal/mol (26752.6714 without restraints) Performing minimization step: 1812. Total energy = 26764.8751 kcal/mol (26736.5470 without restraints) Performing minimization step: 1813. Total energy = 26748.7649 kcal/mol (26720.4400 without restraints) Performing minimization step: 1814. Total energy = 26732.6721 kcal/mol (26704.3504 without restraints) Performing minimization step: 1815. Total energy = 26716.5963 kcal/mol (26688.2777 without restraints) Performing minimization step: 1816. Total energy = 26700.5376 kcal/mol (26672.2221 without restraints) Performing minimization step: 1817. Total energy = 26684.4960 kcal/mol (26656.1836 without restraints) Performing minimization step: 1818. Total energy = 26668.4714 kcal/mol (26640.1621 without restraints) Performing minimization step: 1819. Total energy = 26652.4634 kcal/mol (26624.1573 without restraints) Performing minimization step: 1820. Total energy = 26636.4724 kcal/mol (26608.1694 without restraints) Performing minimization step: 1821. Total energy = 26620.4983 kcal/mol (26592.1983 without restraints) Performing minimization step: 1822. Total energy = 26604.5408 kcal/mol (26576.2438 without restraints) Performing minimization step: 1823. Total energy = 26588.6001 kcal/mol (26560.3064 without restraints) Performing minimization step: 1824. Total energy = 26572.6765 kcal/mol (26544.3858 without restraints) Performing minimization step: 1825. Total energy = 26556.7695 kcal/mol (26528.4819 without restraints) Performing minimization step: 1826. Total energy = 26540.8796 kcal/mol (26512.5952 without restraints) Performing minimization step: 1827. Total energy = 26525.0062 kcal/mol (26496.7248 without restraints) Performing minimization step: 1828. Total energy = 26509.1495 kcal/mol (26480.8712 without restraints) Performing minimization step: 1829. Total energy = 26493.3094 kcal/mol (26465.0342 without restraints) Performing minimization step: 1830. Total energy = 26477.4862 kcal/mol (26449.2141 without restraints) Performing minimization step: 1831. Total energy = 26461.6796 kcal/mol (26433.4105 without restraints) Performing minimization step: 1832. Total energy = 26445.8895 kcal/mol (26417.6235 without restraints) Performing minimization step: 1833. Total energy = 26430.1161 kcal/mol (26401.8532 without restraints) Performing minimization step: 1834. Total energy = 26414.3592 kcal/mol (26386.0994 without restraints) Performing minimization step: 1835. Total energy = 26398.6188 kcal/mol (26370.3620 without restraints) Performing minimization step: 1836. Total energy = 26382.8947 kcal/mol (26354.6410 without restraints) Performing minimization step: 1837. Total energy = 26367.1874 kcal/mol (26338.9367 without restraints) Performing minimization step: 1838. Total energy = 26351.4965 kcal/mol (26323.2488 without restraints) Performing minimization step: 1839. Total energy = 26335.8222 kcal/mol (26307.5776 without restraints) Performing minimization step: 1840. Total energy = 26320.1644 kcal/mol (26291.9228 without restraints) Performing minimization step: 1841. Total energy = 26304.5222 kcal/mol (26276.2836 without restraints) Performing minimization step: 1842. Total energy = 26288.8970 kcal/mol (26260.6616 without restraints) Performing minimization step: 1843. Total energy = 26273.2882 kcal/mol (26245.0558 without restraints) Performing minimization step: 1844. Total energy = 26257.6955 kcal/mol (26229.4660 without restraints) Performing minimization step: 1845. Total energy = 26242.1191 kcal/mol (26213.8928 without restraints) Performing minimization step: 1846. Total energy = 26226.5595 kcal/mol (26198.3363 without restraints) Performing minimization step: 1847. Total energy = 26211.0157 kcal/mol (26182.7955 without restraints) Performing minimization step: 1848. Total energy = 26195.4883 kcal/mol (26167.2711 without restraints) Performing minimization step: 1849. Total energy = 26179.9770 kcal/mol (26151.7628 without restraints) Performing minimization step: 1850. Total energy = 26164.4817 kcal/mol (26136.2706 without restraints) Performing minimization step: 1851. Total energy = 26149.0029 kcal/mol (26120.7947 without restraints) Performing minimization step: 1852. Total energy = 26133.5402 kcal/mol (26105.3350 without restraints) Performing minimization step: 1853. Total energy = 26118.0936 kcal/mol (26089.8915 without restraints) Performing minimization step: 1854. Total energy = 26102.6633 kcal/mol (26074.4641 without restraints) Performing minimization step: 1855. Total energy = 26087.2488 kcal/mol (26059.0527 without restraints) Performing minimization step: 1856. Total energy = 26071.8507 kcal/mol (26043.6576 without restraints) Performing minimization step: 1857. Total energy = 26056.4685 kcal/mol (26028.2784 without restraints) Performing minimization step: 1858. Total energy = 26041.1021 kcal/mol (26012.9150 without restraints) Performing minimization step: 1859. Total energy = 26025.7513 kcal/mol (25997.5672 without restraints) Performing minimization step: 1860. Total energy = 26010.4170 kcal/mol (25982.2359 without restraints) Performing minimization step: 1861. Total energy = 25995.0990 kcal/mol (25966.9209 without restraints) Performing minimization step: 1862. Total energy = 25979.7966 kcal/mol (25951.6215 without restraints) Performing minimization step: 1863. Total energy = 25964.5105 kcal/mol (25936.3385 without restraints) Performing minimization step: 1864. Total energy = 25949.2399 kcal/mol (25921.0708 without restraints) Performing minimization step: 1865. Total energy = 25933.9852 kcal/mol (25905.8191 without restraints) Performing minimization step: 1866. Total energy = 25918.7458 kcal/mol (25890.5826 without restraints) Performing minimization step: 1867. Total energy = 25903.5232 kcal/mol (25875.3630 without restraints) Performing minimization step: 1868. Total energy = 25888.3159 kcal/mol (25860.1586 without restraints) Performing minimization step: 1869. Total energy = 25873.1243 kcal/mol (25844.9701 without restraints) Performing minimization step: 1870. Total energy = 25857.9484 kcal/mol (25829.7971 without restraints) Performing minimization step: 1871. Total energy = 25842.7882 kcal/mol (25814.6399 without restraints) Performing minimization step: 1872. Total energy = 25827.6436 kcal/mol (25799.4981 without restraints) Performing minimization step: 1873. Total energy = 25812.5145 kcal/mol (25784.3722 without restraints) Performing minimization step: 1874. Total energy = 25797.4012 kcal/mol (25769.2617 without restraints) Performing minimization step: 1875. Total energy = 25782.3037 kcal/mol (25754.1673 without restraints) Performing minimization step: 1876. Total energy = 25767.2218 kcal/mol (25739.0882 without restraints) Performing minimization step: 1877. Total energy = 25752.1553 kcal/mol (25724.0248 without restraints) Performing minimization step: 1878. Total energy = 25737.1047 kcal/mol (25708.9771 without restraints) Performing minimization step: 1879. Total energy = 25722.0695 kcal/mol (25693.9449 without restraints) Performing minimization step: 1880. Total energy = 25707.0497 kcal/mol (25678.9281 without restraints) Performing minimization step: 1881. Total energy = 25692.0454 kcal/mol (25663.9267 without restraints) Performing minimization step: 1882. Total energy = 25677.0564 kcal/mol (25648.9406 without restraints) Performing minimization step: 1883. Total energy = 25662.0830 kcal/mol (25633.9701 without restraints) Performing minimization step: 1884. Total energy = 25647.1252 kcal/mol (25619.0153 without restraints) Performing minimization step: 1885. Total energy = 25632.1825 kcal/mol (25604.0756 without restraints) Performing minimization step: 1886. Total energy = 25617.2553 kcal/mol (25589.1513 without restraints) Performing minimization step: 1887. Total energy = 25602.3435 kcal/mol (25574.2424 without restraints) Performing minimization step: 1888. Total energy = 25587.4472 kcal/mol (25559.3490 without restraints) Performing minimization step: 1889. Total energy = 25572.5659 kcal/mol (25544.4707 without restraints) Performing minimization step: 1890. Total energy = 25557.7001 kcal/mol (25529.6077 without restraints) Performing minimization step: 1891. Total energy = 25542.8494 kcal/mol (25514.7600 without restraints) Performing minimization step: 1892. Total energy = 25528.0140 kcal/mol (25499.9275 without restraints) Performing minimization step: 1893. Total energy = 25513.1938 kcal/mol (25485.1102 without restraints) Performing minimization step: 1894. Total energy = 25498.3894 kcal/mol (25470.3088 without restraints) Performing minimization step: 1895. Total energy = 25483.5996 kcal/mol (25455.5218 without restraints) Performing minimization step: 1896. Total energy = 25468.8249 kcal/mol (25440.7501 without restraints) Performing minimization step: 1897. Total energy = 25454.0656 kcal/mol (25425.9937 without restraints) Performing minimization step: 1898. Total energy = 25439.3213 kcal/mol (25411.2522 without restraints) Performing minimization step: 1899. Total energy = 25424.5917 kcal/mol (25396.5255 without restraints) Performing minimization step: 1900. Total energy = 25409.8776 kcal/mol (25381.8145 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 1901. Total energy = 25395.1786 kcal/mol (25367.1183 without restraints) Performing minimization step: 1902. Total energy = 25380.4943 kcal/mol (25352.4368 without restraints) Performing minimization step: 1903. Total energy = 25365.8249 kcal/mol (25337.7704 without restraints) Performing minimization step: 1904. Total energy = 25351.1706 kcal/mol (25323.1189 without restraints) Performing minimization step: 1905. Total energy = 25336.5316 kcal/mol (25308.4828 without restraints) Performing minimization step: 1906. Total energy = 25321.9073 kcal/mol (25293.8614 without restraints) Performing minimization step: 1907. Total energy = 25307.2978 kcal/mol (25279.2549 without restraints) Performing minimization step: 1908. Total energy = 25292.7037 kcal/mol (25264.6635 without restraints) Performing minimization step: 1909. Total energy = 25278.1239 kcal/mol (25250.0866 without restraints) Performing minimization step: 1910. Total energy = 25263.5591 kcal/mol (25235.5247 without restraints) Performing minimization step: 1911. Total energy = 25249.0094 kcal/mol (25220.9779 without restraints) Performing minimization step: 1912. Total energy = 25234.4746 kcal/mol (25206.4459 without restraints) Performing minimization step: 1913. Total energy = 25219.9543 kcal/mol (25191.9285 without restraints) Performing minimization step: 1914. Total energy = 25205.4486 kcal/mol (25177.4257 without restraints) Performing minimization step: 1915. Total energy = 25190.9580 kcal/mol (25162.9379 without restraints) Performing minimization step: 1916. Total energy = 25176.4819 kcal/mol (25148.4647 without restraints) Performing minimization step: 1917. Total energy = 25162.0206 kcal/mol (25134.0062 without restraints) Performing minimization step: 1918. Total energy = 25147.5741 kcal/mol (25119.5626 without restraints) Performing minimization step: 1919. Total energy = 25133.1421 kcal/mol (25105.1334 without restraints) Performing minimization step: 1920. Total energy = 25118.7245 kcal/mol (25090.7188 without restraints) Performing minimization step: 1921. Total energy = 25104.3218 kcal/mol (25076.3190 without restraints) Performing minimization step: 1922. Total energy = 25089.9339 kcal/mol (25061.9338 without restraints) Performing minimization step: 1923. Total energy = 25075.5604 kcal/mol (25047.5631 without restraints) Performing minimization step: 1924. Total energy = 25061.2013 kcal/mol (25033.2070 without restraints) Performing minimization step: 1925. Total energy = 25046.8568 kcal/mol (25018.8653 without restraints) Performing minimization step: 1926. Total energy = 25032.5268 kcal/mol (25004.5381 without restraints) Performing minimization step: 1927. Total energy = 25018.2108 kcal/mol (24990.2250 without restraints) Performing minimization step: 1928. Total energy = 25003.9107 kcal/mol (24975.9279 without restraints) Performing minimization step: 1929. Total energy = 24989.6244 kcal/mol (24961.6442 without restraints) Performing minimization step: 1930. Total energy = 24975.3527 kcal/mol (24947.3753 without restraints) Performing minimization step: 1931. Total energy = 24961.0946 kcal/mol (24933.1199 without restraints) Performing minimization step: 1932. Total energy = 24946.8510 kcal/mol (24918.8793 without restraints) Performing minimization step: 1933. Total energy = 24932.6219 kcal/mol (24904.6530 without restraints) Performing minimization step: 1934. Total energy = 24918.4075 kcal/mol (24890.4414 without restraints) Performing minimization step: 1935. Total energy = 24904.2070 kcal/mol (24876.2437 without restraints) Performing minimization step: 1936. Total energy = 24890.0203 kcal/mol (24862.0599 without restraints) Performing minimization step: 1937. Total energy = 24875.8485 kcal/mol (24847.8909 without restraints) Performing minimization step: 1938. Total energy = 24861.6909 kcal/mol (24833.7361 without restraints) Performing minimization step: 1939. Total energy = 24847.5473 kcal/mol (24819.5953 without restraints) Performing minimization step: 1940. Total energy = 24833.4188 kcal/mol (24805.4696 without restraints) Performing minimization step: 1941. Total energy = 24819.3038 kcal/mol (24791.3574 without restraints) Performing minimization step: 1942. Total energy = 24805.2031 kcal/mol (24777.2596 without restraints) Performing minimization step: 1943. Total energy = 24791.1165 kcal/mol (24763.1757 without restraints) Performing minimization step: 1944. Total energy = 24777.0440 kcal/mol (24749.1060 without restraints) Performing minimization step: 1945. Total energy = 24762.9855 kcal/mol (24735.0503 without restraints) Performing minimization step: 1946. Total energy = 24748.9411 kcal/mol (24721.0088 without restraints) Performing minimization step: 1947. Total energy = 24734.9111 kcal/mol (24706.9815 without restraints) Performing minimization step: 1948. Total energy = 24720.8947 kcal/mol (24692.9679 without restraints) Performing minimization step: 1949. Total energy = 24706.8927 kcal/mol (24678.9686 without restraints) Performing minimization step: 1950. Total energy = 24692.9044 kcal/mol (24664.9832 without restraints) Performing minimization step: 1951. Total energy = 24678.9302 kcal/mol (24651.0117 without restraints) Performing minimization step: 1952. Total energy = 24664.9702 kcal/mol (24637.0545 without restraints) Performing minimization step: 1953. Total energy = 24651.0244 kcal/mol (24623.1115 without restraints) Performing minimization step: 1954. Total energy = 24637.0922 kcal/mol (24609.1820 without restraints) Performing minimization step: 1955. Total energy = 24623.1737 kcal/mol (24595.2663 without restraints) Performing minimization step: 1956. Total energy = 24609.2690 kcal/mol (24581.3645 without restraints) Performing minimization step: 1957. Total energy = 24595.3783 kcal/mol (24567.4765 without restraints) Performing minimization step: 1958. Total energy = 24581.5007 kcal/mol (24553.6015 without restraints) Performing minimization step: 1959. Total energy = 24567.6373 kcal/mol (24539.7411 without restraints) Performing minimization step: 1960. Total energy = 24553.7879 kcal/mol (24525.8945 without restraints) Performing minimization step: 1961. Total energy = 24539.9524 kcal/mol (24512.0617 without restraints) Performing minimization step: 1962. Total energy = 24526.1308 kcal/mol (24498.2429 without restraints) Performing minimization step: 1963. Total energy = 24512.3225 kcal/mol (24484.4374 without restraints) Performing minimization step: 1964. Total energy = 24498.5279 kcal/mol (24470.6454 without restraints) Performing minimization step: 1965. Total energy = 24484.7471 kcal/mol (24456.8675 without restraints) Performing minimization step: 1966. Total energy = 24470.9798 kcal/mol (24443.1029 without restraints) Performing minimization step: 1967. Total energy = 24457.2267 kcal/mol (24429.3525 without restraints) Performing minimization step: 1968. Total energy = 24443.4869 kcal/mol (24415.6155 without restraints) Performing minimization step: 1969. Total energy = 24429.7608 kcal/mol (24401.8921 without restraints) Performing minimization step: 1970. Total energy = 24416.0484 kcal/mol (24388.1824 without restraints) Performing minimization step: 1971. Total energy = 24402.3493 kcal/mol (24374.4861 without restraints) Performing minimization step: 1972. Total energy = 24388.6642 kcal/mol (24360.8037 without restraints) Performing minimization step: 1973. Total energy = 24374.9921 kcal/mol (24347.1344 without restraints) Performing minimization step: 1974. Total energy = 24361.3337 kcal/mol (24333.4787 without restraints) Performing minimization step: 1975. Total energy = 24347.6889 kcal/mol (24319.8367 without restraints) Performing minimization step: 1976. Total energy = 24334.0577 kcal/mol (24306.2082 without restraints) Performing minimization step: 1977. Total energy = 24320.4399 kcal/mol (24292.5931 without restraints) Performing minimization step: 1978. Total energy = 24306.8353 kcal/mol (24278.9912 without restraints) Performing minimization step: 1979. Total energy = 24293.2446 kcal/mol (24265.4034 without restraints) Performing minimization step: 1980. Total energy = 24279.6676 kcal/mol (24251.8290 without restraints) Performing minimization step: 1981. Total energy = 24266.1034 kcal/mol (24238.2677 without restraints) Performing minimization step: 1982. Total energy = 24252.5523 kcal/mol (24224.7191 without restraints) Performing minimization step: 1983. Total energy = 24239.0146 kcal/mol (24211.1843 without restraints) Performing minimization step: 1984. Total energy = 24225.4904 kcal/mol (24197.6626 without restraints) Performing minimization step: 1985. Total energy = 24211.9793 kcal/mol (24184.1543 without restraints) Performing minimization step: 1986. Total energy = 24198.4814 kcal/mol (24170.6591 without restraints) Performing minimization step: 1987. Total energy = 24184.9965 kcal/mol (24157.1770 without restraints) Performing minimization step: 1988. Total energy = 24171.5256 kcal/mol (24143.7087 without restraints) Performing minimization step: 1989. Total energy = 24158.0673 kcal/mol (24130.2531 without restraints) Performing minimization step: 1990. Total energy = 24144.6228 kcal/mol (24116.8113 without restraints) Performing minimization step: 1991. Total energy = 24131.1906 kcal/mol (24103.3818 without restraints) Performing minimization step: 1992. Total energy = 24117.7719 kcal/mol (24089.9659 without restraints) Performing minimization step: 1993. Total energy = 24104.3666 kcal/mol (24076.5632 without restraints) Performing minimization step: 1994. Total energy = 24090.9741 kcal/mol (24063.1734 without restraints) Performing minimization step: 1995. Total energy = 24077.5947 kcal/mol (24049.7967 without restraints) Performing minimization step: 1996. Total energy = 24064.2283 kcal/mol (24036.4331 without restraints) Performing minimization step: 1997. Total energy = 24050.8750 kcal/mol (24023.0824 without restraints) Performing minimization step: 1998. Total energy = 24037.5348 kcal/mol (24009.7448 without restraints) Performing minimization step: 1999. Total energy = 24024.2077 kcal/mol (23996.4205 without restraints) Performing minimization step: 2000. Total energy = 24010.8938 kcal/mol (23983.1093 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2001. Total energy = 23997.5925 kcal/mol (23969.8107 without restraints) Performing minimization step: 2002. Total energy = 23984.3040 kcal/mol (23956.5248 without restraints) Performing minimization step: 2003. Total energy = 23971.0287 kcal/mol (23943.2522 without restraints) Performing minimization step: 2004. Total energy = 23957.7661 kcal/mol (23929.9923 without restraints) Performing minimization step: 2005. Total energy = 23944.5166 kcal/mol (23916.7453 without restraints) Performing minimization step: 2006. Total energy = 23931.2798 kcal/mol (23903.5114 without restraints) Performing minimization step: 2007. Total energy = 23918.0558 kcal/mol (23890.2900 without restraints) Performing minimization step: 2008. Total energy = 23904.8450 kcal/mol (23877.0820 without restraints) Performing minimization step: 2009. Total energy = 23891.6468 kcal/mol (23863.8864 without restraints) Performing minimization step: 2010. Total energy = 23878.4618 kcal/mol (23850.7040 without restraints) Performing minimization step: 2011. Total energy = 23865.2891 kcal/mol (23837.5340 without restraints) Performing minimization step: 2012. Total energy = 23852.1293 kcal/mol (23824.3768 without restraints) Performing minimization step: 2013. Total energy = 23838.9822 kcal/mol (23811.2327 without restraints) Performing minimization step: 2014. Total energy = 23825.8481 kcal/mol (23798.1009 without restraints) Performing minimization step: 2015. Total energy = 23812.7263 kcal/mol (23784.9818 without restraints) Performing minimization step: 2016. Total energy = 23799.6173 kcal/mol (23771.8755 without restraints) Performing minimization step: 2017. Total energy = 23786.5207 kcal/mol (23758.7815 without restraints) Performing minimization step: 2018. Total energy = 23773.4367 kcal/mol (23745.7004 without restraints) Performing minimization step: 2019. Total energy = 23760.3656 kcal/mol (23732.6318 without restraints) Performing minimization step: 2020. Total energy = 23747.3072 kcal/mol (23719.5759 without restraints) Performing minimization step: 2021. Total energy = 23734.2609 kcal/mol (23706.5322 without restraints) Performing minimization step: 2022. Total energy = 23721.2272 kcal/mol (23693.5012 without restraints) Performing minimization step: 2023. Total energy = 23708.2060 kcal/mol (23680.4828 without restraints) Performing minimization step: 2024. Total energy = 23695.1973 kcal/mol (23667.4765 without restraints) Performing minimization step: 2025. Total energy = 23682.2012 kcal/mol (23654.4833 without restraints) Performing minimization step: 2026. Total energy = 23669.2179 kcal/mol (23641.5025 without restraints) Performing minimization step: 2027. Total energy = 23656.2467 kcal/mol (23628.5339 without restraints) Performing minimization step: 2028. Total energy = 23643.2882 kcal/mol (23615.5780 without restraints) Performing minimization step: 2029. Total energy = 23630.3421 kcal/mol (23602.6346 without restraints) Performing minimization step: 2030. Total energy = 23617.4086 kcal/mol (23589.7038 without restraints) Performing minimization step: 2031. Total energy = 23604.4867 kcal/mol (23576.7845 without restraints) Performing minimization step: 2032. Total energy = 23591.5779 kcal/mol (23563.8783 without restraints) Performing minimization step: 2033. Total energy = 23578.6813 kcal/mol (23550.9843 without restraints) Performing minimization step: 2034. Total energy = 23565.7968 kcal/mol (23538.1024 without restraints) Performing minimization step: 2035. Total energy = 23552.9245 kcal/mol (23525.2328 without restraints) Performing minimization step: 2036. Total energy = 23540.0646 kcal/mol (23512.3755 without restraints) Performing minimization step: 2037. Total energy = 23527.2170 kcal/mol (23499.5307 without restraints) Performing minimization step: 2038. Total energy = 23514.3818 kcal/mol (23486.6979 without restraints) Performing minimization step: 2039. Total energy = 23501.5589 kcal/mol (23473.8776 without restraints) Performing minimization step: 2040. Total energy = 23488.7478 kcal/mol (23461.0691 without restraints) Performing minimization step: 2041. Total energy = 23475.9487 kcal/mol (23448.2726 without restraints) Performing minimization step: 2042. Total energy = 23463.1622 kcal/mol (23435.4888 without restraints) Performing minimization step: 2043. Total energy = 23450.3877 kcal/mol (23422.7169 without restraints) Performing minimization step: 2044. Total energy = 23437.6254 kcal/mol (23409.9571 without restraints) Performing minimization step: 2045. Total energy = 23424.8751 kcal/mol (23397.2095 without restraints) Performing minimization step: 2046. Total energy = 23412.1369 kcal/mol (23384.4739 without restraints) Performing minimization step: 2047. Total energy = 23399.4108 kcal/mol (23371.7503 without restraints) Performing minimization step: 2048. Total energy = 23386.6963 kcal/mol (23359.0385 without restraints) Performing minimization step: 2049. Total energy = 23373.9946 kcal/mol (23346.3394 without restraints) Performing minimization step: 2050. Total energy = 23361.3046 kcal/mol (23333.6520 without restraints) Performing minimization step: 2051. Total energy = 23348.6266 kcal/mol (23320.9766 without restraints) Performing minimization step: 2052. Total energy = 23335.9605 kcal/mol (23308.3130 without restraints) Performing minimization step: 2053. Total energy = 23323.3067 kcal/mol (23295.6618 without restraints) Performing minimization step: 2054. Total energy = 23310.6645 kcal/mol (23283.0222 without restraints) Performing minimization step: 2055. Total energy = 23298.0343 kcal/mol (23270.3945 without restraints) Performing minimization step: 2056. Total energy = 23285.4157 kcal/mol (23257.7786 without restraints) Performing minimization step: 2057. Total energy = 23272.8093 kcal/mol (23245.1747 without restraints) Performing minimization step: 2058. Total energy = 23260.2147 kcal/mol (23232.5827 without restraints) Performing minimization step: 2059. Total energy = 23247.6324 kcal/mol (23220.0030 without restraints) Performing minimization step: 2060. Total energy = 23235.0614 kcal/mol (23207.4346 without restraints) Performing minimization step: 2061. Total energy = 23222.5021 kcal/mol (23194.8777 without restraints) Performing minimization step: 2062. Total energy = 23209.9545 kcal/mol (23182.3328 without restraints) Performing minimization step: 2063. Total energy = 23197.4190 kcal/mol (23169.7998 without restraints) Performing minimization step: 2064. Total energy = 23184.8953 kcal/mol (23157.2788 without restraints) Performing minimization step: 2065. Total energy = 23172.3834 kcal/mol (23144.7694 without restraints) Performing minimization step: 2066. Total energy = 23159.8830 kcal/mol (23132.2716 without restraints) Performing minimization step: 2067. Total energy = 23147.3943 kcal/mol (23119.7855 without restraints) Performing minimization step: 2068. Total energy = 23134.9175 kcal/mol (23107.3113 without restraints) Performing minimization step: 2069. Total energy = 23122.4526 kcal/mol (23094.8489 without restraints) Performing minimization step: 2070. Total energy = 23109.9991 kcal/mol (23082.3980 without restraints) Performing minimization step: 2071. Total energy = 23097.5571 kcal/mol (23069.9585 without restraints) Performing minimization step: 2072. Total energy = 23085.1264 kcal/mol (23057.5303 without restraints) Performing minimization step: 2073. Total energy = 23072.7076 kcal/mol (23045.1140 without restraints) Performing minimization step: 2074. Total energy = 23060.3002 kcal/mol (23032.7092 without restraints) Performing minimization step: 2075. Total energy = 23047.9039 kcal/mol (23020.3155 without restraints) Performing minimization step: 2076. Total energy = 23035.5197 kcal/mol (23007.9339 without restraints) Performing minimization step: 2077. Total energy = 23023.1467 kcal/mol (22995.5634 without restraints) Performing minimization step: 2078. Total energy = 23010.7855 kcal/mol (22983.2047 without restraints) Performing minimization step: 2079. Total energy = 22998.4357 kcal/mol (22970.8574 without restraints) Performing minimization step: 2080. Total energy = 22986.0973 kcal/mol (22958.5216 without restraints) Performing minimization step: 2081. Total energy = 22973.7709 kcal/mol (22946.1979 without restraints) Performing minimization step: 2082. Total energy = 22961.4555 kcal/mol (22933.8850 without restraints) Performing minimization step: 2083. Total energy = 22949.1510 kcal/mol (22921.5829 without restraints) Performing minimization step: 2084. Total energy = 22936.8584 kcal/mol (22909.2929 without restraints) Performing minimization step: 2085. Total energy = 22924.5775 kcal/mol (22897.0148 without restraints) Performing minimization step: 2086. Total energy = 22912.3078 kcal/mol (22884.7475 without restraints) Performing minimization step: 2087. Total energy = 22900.0494 kcal/mol (22872.4915 without restraints) Performing minimization step: 2088. Total energy = 22887.8019 kcal/mol (22860.2465 without restraints) Performing minimization step: 2089. Total energy = 22875.5657 kcal/mol (22848.0128 without restraints) Performing minimization step: 2090. Total energy = 22863.3410 kcal/mol (22835.7907 without restraints) Performing minimization step: 2091. Total energy = 22851.1276 kcal/mol (22823.5798 without restraints) Performing minimization step: 2092. Total energy = 22838.9252 kcal/mol (22811.3799 without restraints) Performing minimization step: 2093. Total energy = 22826.7340 kcal/mol (22799.1913 without restraints) Performing minimization step: 2094. Total energy = 22814.5543 kcal/mol (22787.0140 without restraints) Performing minimization step: 2095. Total energy = 22802.3855 kcal/mol (22774.8477 without restraints) Performing minimization step: 2096. Total energy = 22790.2277 kcal/mol (22762.6926 without restraints) Performing minimization step: 2097. Total energy = 22778.0813 kcal/mol (22750.5485 without restraints) Performing minimization step: 2098. Total energy = 22765.9463 kcal/mol (22738.4161 without restraints) Performing minimization step: 2099. Total energy = 22753.8220 kcal/mol (22726.2944 without restraints) Performing minimization step: 2100. Total energy = 22741.7086 kcal/mol (22714.1835 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2101. Total energy = 22729.6064 kcal/mol (22702.0837 without restraints) Performing minimization step: 2102. Total energy = 22717.5152 kcal/mol (22689.9951 without restraints) Performing minimization step: 2103. Total energy = 22705.4352 kcal/mol (22677.9175 without restraints) Performing minimization step: 2104. Total energy = 22693.3659 kcal/mol (22665.8508 without restraints) Performing minimization step: 2105. Total energy = 22681.3081 kcal/mol (22653.7954 without restraints) Performing minimization step: 2106. Total energy = 22669.2609 kcal/mol (22641.7507 without restraints) Performing minimization step: 2107. Total energy = 22657.2253 kcal/mol (22629.7176 without restraints) Performing minimization step: 2108. Total energy = 22645.2002 kcal/mol (22617.6950 without restraints) Performing minimization step: 2109. Total energy = 22633.1860 kcal/mol (22605.6835 without restraints) Performing minimization step: 2110. Total energy = 22621.1827 kcal/mol (22593.6826 without restraints) Performing minimization step: 2111. Total energy = 22609.1902 kcal/mol (22581.6925 without restraints) Performing minimization step: 2112. Total energy = 22597.2085 kcal/mol (22569.7134 without restraints) Performing minimization step: 2113. Total energy = 22585.2376 kcal/mol (22557.7449 without restraints) Performing minimization step: 2114. Total energy = 22573.2778 kcal/mol (22545.7876 without restraints) Performing minimization step: 2115. Total energy = 22561.3289 kcal/mol (22533.8412 without restraints) Performing minimization step: 2116. Total energy = 22549.3906 kcal/mol (22521.9054 without restraints) Performing minimization step: 2117. Total energy = 22537.4630 kcal/mol (22509.9803 without restraints) Performing minimization step: 2118. Total energy = 22525.5463 kcal/mol (22498.0661 without restraints) Performing minimization step: 2119. Total energy = 22513.6402 kcal/mol (22486.1625 without restraints) Performing minimization step: 2120. Total energy = 22501.7444 kcal/mol (22474.2691 without restraints) Performing minimization step: 2121. Total energy = 22489.8598 kcal/mol (22462.3870 without restraints) Performing minimization step: 2122. Total energy = 22477.9858 kcal/mol (22450.5154 without restraints) Performing minimization step: 2123. Total energy = 22466.1224 kcal/mol (22438.6545 without restraints) Performing minimization step: 2124. Total energy = 22454.2697 kcal/mol (22426.8043 without restraints) Performing minimization step: 2125. Total energy = 22442.4278 kcal/mol (22414.9650 without restraints) Performing minimization step: 2126. Total energy = 22430.5966 kcal/mol (22403.1362 without restraints) Performing minimization step: 2127. Total energy = 22418.7759 kcal/mol (22391.3179 without restraints) Performing minimization step: 2128. Total energy = 22406.9658 kcal/mol (22379.5103 without restraints) Performing minimization step: 2129. Total energy = 22395.1662 kcal/mol (22367.7131 without restraints) Performing minimization step: 2130. Total energy = 22383.3770 kcal/mol (22355.9262 without restraints) Performing minimization step: 2131. Total energy = 22371.5983 kcal/mol (22344.1502 without restraints) Performing minimization step: 2132. Total energy = 22359.8304 kcal/mol (22332.3847 without restraints) Performing minimization step: 2133. Total energy = 22348.0731 kcal/mol (22320.6298 without restraints) Performing minimization step: 2134. Total energy = 22336.3260 kcal/mol (22308.8853 without restraints) Performing minimization step: 2135. Total energy = 22324.5894 kcal/mol (22297.1510 without restraints) Performing minimization step: 2136. Total energy = 22312.8631 kcal/mol (22285.4272 without restraints) Performing minimization step: 2137. Total energy = 22301.1473 kcal/mol (22273.7138 without restraints) Performing minimization step: 2138. Total energy = 22289.4421 kcal/mol (22262.0111 without restraints) Performing minimization step: 2139. Total energy = 22277.7472 kcal/mol (22250.3187 without restraints) Performing minimization step: 2140. Total energy = 22266.0625 kcal/mol (22238.6365 without restraints) Performing minimization step: 2141. Total energy = 22254.3884 kcal/mol (22226.9648 without restraints) Performing minimization step: 2142. Total energy = 22242.7245 kcal/mol (22215.3034 without restraints) Performing minimization step: 2143. Total energy = 22231.0707 kcal/mol (22203.6520 without restraints) Performing minimization step: 2144. Total energy = 22219.4274 kcal/mol (22192.0110 without restraints) Performing minimization step: 2145. Total energy = 22207.7942 kcal/mol (22180.3803 without restraints) Performing minimization step: 2146. Total energy = 22196.1712 kcal/mol (22168.7599 without restraints) Performing minimization step: 2147. Total energy = 22184.5589 kcal/mol (22157.1499 without restraints) Performing minimization step: 2148. Total energy = 22172.9567 kcal/mol (22145.5501 without restraints) Performing minimization step: 2149. Total energy = 22161.3644 kcal/mol (22133.9603 without restraints) Performing minimization step: 2150. Total energy = 22149.7823 kcal/mol (22122.3807 without restraints) Performing minimization step: 2151. Total energy = 22138.2107 kcal/mol (22110.8114 without restraints) Performing minimization step: 2152. Total energy = 22126.6490 kcal/mol (22099.2521 without restraints) Performing minimization step: 2153. Total energy = 22115.0973 kcal/mol (22087.7029 without restraints) Performing minimization step: 2154. Total energy = 22103.5558 kcal/mol (22076.1639 without restraints) Performing minimization step: 2155. Total energy = 22092.0245 kcal/mol (22064.6349 without restraints) Performing minimization step: 2156. Total energy = 22080.5032 kcal/mol (22053.1161 without restraints) Performing minimization step: 2157. Total energy = 22068.9920 kcal/mol (22041.6073 without restraints) Performing minimization step: 2158. Total energy = 22057.4909 kcal/mol (22030.1086 without restraints) Performing minimization step: 2159. Total energy = 22045.9997 kcal/mol (22018.6198 without restraints) Performing minimization step: 2160. Total energy = 22034.5186 kcal/mol (22007.1411 without restraints) Performing minimization step: 2161. Total energy = 22023.0474 kcal/mol (21995.6724 without restraints) Performing minimization step: 2162. Total energy = 22011.5865 kcal/mol (21984.2138 without restraints) Performing minimization step: 2163. Total energy = 22000.1351 kcal/mol (21972.7648 without restraints) Performing minimization step: 2164. Total energy = 21988.6936 kcal/mol (21961.3256 without restraints) Performing minimization step: 2165. Total energy = 21977.2621 kcal/mol (21949.8967 without restraints) Performing minimization step: 2166. Total energy = 21965.8407 kcal/mol (21938.4777 without restraints) Performing minimization step: 2167. Total energy = 21954.4292 kcal/mol (21927.0686 without restraints) Performing minimization step: 2168. Total energy = 21943.0277 kcal/mol (21915.6696 without restraints) Performing minimization step: 2169. Total energy = 21931.6359 kcal/mol (21904.2802 without restraints) Performing minimization step: 2170. Total energy = 21920.2544 kcal/mol (21892.9011 without restraints) Performing minimization step: 2171. Total energy = 21908.8823 kcal/mol (21881.5314 without restraints) Performing minimization step: 2172. Total energy = 21897.5199 kcal/mol (21870.1714 without restraints) Performing minimization step: 2173. Total energy = 21886.1674 kcal/mol (21858.8212 without restraints) Performing minimization step: 2174. Total energy = 21874.8249 kcal/mol (21847.4812 without restraints) Performing minimization step: 2175. Total energy = 21863.4919 kcal/mol (21836.1506 without restraints) Performing minimization step: 2176. Total energy = 21852.1688 kcal/mol (21824.8298 without restraints) Performing minimization step: 2177. Total energy = 21840.8552 kcal/mol (21813.5186 without restraints) Performing minimization step: 2178. Total energy = 21829.5513 kcal/mol (21802.2171 without restraints) Performing minimization step: 2179. Total energy = 21818.2570 kcal/mol (21790.9253 without restraints) Performing minimization step: 2180. Total energy = 21806.9726 kcal/mol (21779.6432 without restraints) Performing minimization step: 2181. Total energy = 21795.6977 kcal/mol (21768.3707 without restraints) Performing minimization step: 2182. Total energy = 21784.4327 kcal/mol (21757.1081 without restraints) Performing minimization step: 2183. Total energy = 21773.1773 kcal/mol (21745.8550 without restraints) Performing minimization step: 2184. Total energy = 21761.9313 kcal/mol (21734.6114 without restraints) Performing minimization step: 2185. Total energy = 21750.6952 kcal/mol (21723.3777 without restraints) Performing minimization step: 2186. Total energy = 21739.4683 kcal/mol (21712.1532 without restraints) Performing minimization step: 2187. Total energy = 21728.2512 kcal/mol (21700.9384 without restraints) Performing minimization step: 2188. Total energy = 21717.0432 kcal/mol (21689.7328 without restraints) Performing minimization step: 2189. Total energy = 21705.8450 kcal/mol (21678.5370 without restraints) Performing minimization step: 2190. Total energy = 21694.6562 kcal/mol (21667.3506 without restraints) Performing minimization step: 2191. Total energy = 21683.4769 kcal/mol (21656.1737 without restraints) Performing minimization step: 2192. Total energy = 21672.3070 kcal/mol (21645.0061 without restraints) Performing minimization step: 2193. Total energy = 21661.1468 kcal/mol (21633.8483 without restraints) Performing minimization step: 2194. Total energy = 21649.9958 kcal/mol (21622.6996 without restraints) Performing minimization step: 2195. Total energy = 21638.8542 kcal/mol (21611.5604 without restraints) Performing minimization step: 2196. Total energy = 21627.7222 kcal/mol (21600.4308 without restraints) Performing minimization step: 2197. Total energy = 21616.5997 kcal/mol (21589.3108 without restraints) Performing minimization step: 2198. Total energy = 21605.4864 kcal/mol (21578.1997 without restraints) Performing minimization step: 2199. Total energy = 21594.3824 kcal/mol (21567.0981 without restraints) Performing minimization step: 2200. Total energy = 21583.2876 kcal/mol (21556.0056 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2201. Total energy = 21572.2023 kcal/mol (21544.9227 without restraints) Performing minimization step: 2202. Total energy = 21561.1263 kcal/mol (21533.8490 without restraints) Performing minimization step: 2203. Total energy = 21550.0593 kcal/mol (21522.7845 without restraints) Performing minimization step: 2204. Total energy = 21539.0016 kcal/mol (21511.7291 without restraints) Performing minimization step: 2205. Total energy = 21527.9534 kcal/mol (21500.6832 without restraints) Performing minimization step: 2206. Total energy = 21516.9141 kcal/mol (21489.6463 without restraints) Performing minimization step: 2207. Total energy = 21505.8844 kcal/mol (21478.6189 without restraints) Performing minimization step: 2208. Total energy = 21494.8635 kcal/mol (21467.6004 without restraints) Performing minimization step: 2209. Total energy = 21483.8519 kcal/mol (21456.5911 without restraints) Performing minimization step: 2210. Total energy = 21472.8493 kcal/mol (21445.5909 without restraints) Performing minimization step: 2211. Total energy = 21461.8561 kcal/mol (21434.6001 without restraints) Performing minimization step: 2212. Total energy = 21450.8720 kcal/mol (21423.6183 without restraints) Performing minimization step: 2213. Total energy = 21439.8971 kcal/mol (21412.6457 without restraints) Performing minimization step: 2214. Total energy = 21428.9310 kcal/mol (21401.6820 without restraints) Performing minimization step: 2215. Total energy = 21417.9743 kcal/mol (21390.7275 without restraints) Performing minimization step: 2216. Total energy = 21407.0264 kcal/mol (21379.7820 without restraints) Performing minimization step: 2217. Total energy = 21396.0876 kcal/mol (21368.8456 without restraints) Performing minimization step: 2218. Total energy = 21385.1578 kcal/mol (21357.9181 without restraints) Performing minimization step: 2219. Total energy = 21374.2370 kcal/mol (21346.9996 without restraints) Performing minimization step: 2220. Total energy = 21363.3251 kcal/mol (21336.0901 without restraints) Performing minimization step: 2221. Total energy = 21352.4221 kcal/mol (21325.1894 without restraints) Performing minimization step: 2222. Total energy = 21341.5281 kcal/mol (21314.2978 without restraints) Performing minimization step: 2223. Total energy = 21330.6433 kcal/mol (21303.4153 without restraints) Performing minimization step: 2224. Total energy = 21319.7678 kcal/mol (21292.5422 without restraints) Performing minimization step: 2225. Total energy = 21308.9010 kcal/mol (21281.6776 without restraints) Performing minimization step: 2226. Total energy = 21298.0427 kcal/mol (21270.8217 without restraints) Performing minimization step: 2227. Total energy = 21287.1933 kcal/mol (21259.9745 without restraints) Performing minimization step: 2228. Total energy = 21276.3528 kcal/mol (21249.1365 without restraints) Performing minimization step: 2229. Total energy = 21265.5213 kcal/mol (21238.3071 without restraints) Performing minimization step: 2230. Total energy = 21254.6983 kcal/mol (21227.4864 without restraints) Performing minimization step: 2231. Total energy = 21243.8841 kcal/mol (21216.6746 without restraints) Performing minimization step: 2232. Total energy = 21233.0790 kcal/mol (21205.8718 without restraints) Performing minimization step: 2233. Total energy = 21222.2825 kcal/mol (21195.0776 without restraints) Performing minimization step: 2234. Total energy = 21211.4950 kcal/mol (21184.2925 without restraints) Performing minimization step: 2235. Total energy = 21200.7164 kcal/mol (21173.5162 without restraints) Performing minimization step: 2236. Total energy = 21189.9462 kcal/mol (21162.7484 without restraints) Performing minimization step: 2237. Total energy = 21179.1849 kcal/mol (21151.9893 without restraints) Performing minimization step: 2238. Total energy = 21168.4322 kcal/mol (21141.2389 without restraints) Performing minimization step: 2239. Total energy = 21157.6878 kcal/mol (21130.4968 without restraints) Performing minimization step: 2240. Total energy = 21146.9523 kcal/mol (21119.7636 without restraints) Performing minimization step: 2241. Total energy = 21136.2253 kcal/mol (21109.0390 without restraints) Performing minimization step: 2242. Total energy = 21125.5071 kcal/mol (21098.3230 without restraints) Performing minimization step: 2243. Total energy = 21114.7976 kcal/mol (21087.6158 without restraints) Performing minimization step: 2244. Total energy = 21104.0968 kcal/mol (21076.9173 without restraints) Performing minimization step: 2245. Total energy = 21093.4041 kcal/mol (21066.2269 without restraints) Performing minimization step: 2246. Total energy = 21082.7200 kcal/mol (21055.5451 without restraints) Performing minimization step: 2247. Total energy = 21072.0446 kcal/mol (21044.8720 without restraints) Performing minimization step: 2248. Total energy = 21061.3778 kcal/mol (21034.2075 without restraints) Performing minimization step: 2249. Total energy = 21050.7196 kcal/mol (21023.5516 without restraints) Performing minimization step: 2250. Total energy = 21040.0696 kcal/mol (21012.9039 without restraints) Performing minimization step: 2251. Total energy = 21029.4284 kcal/mol (21002.2650 without restraints) Performing minimization step: 2252. Total energy = 21018.7952 kcal/mol (20991.6340 without restraints) Performing minimization step: 2253. Total energy = 21008.1707 kcal/mol (20981.0120 without restraints) Performing minimization step: 2254. Total energy = 20997.5549 kcal/mol (20970.3983 without restraints) Performing minimization step: 2255. Total energy = 20986.9474 kcal/mol (20959.7931 without restraints) Performing minimization step: 2256. Total energy = 20976.3481 kcal/mol (20949.1961 without restraints) Performing minimization step: 2257. Total energy = 20965.7575 kcal/mol (20938.6078 without restraints) Performing minimization step: 2258. Total energy = 20955.1747 kcal/mol (20928.0273 without restraints) Performing minimization step: 2259. Total energy = 20944.6003 kcal/mol (20917.4551 without restraints) Performing minimization step: 2260. Total energy = 20934.0346 kcal/mol (20906.8917 without restraints) Performing minimization step: 2261. Total energy = 20923.4772 kcal/mol (20896.3366 without restraints) Performing minimization step: 2262. Total energy = 20912.9281 kcal/mol (20885.7898 without restraints) Performing minimization step: 2263. Total energy = 20902.3870 kcal/mol (20875.2510 without restraints) Performing minimization step: 2264. Total energy = 20891.8541 kcal/mol (20864.7203 without restraints) Performing minimization step: 2265. Total energy = 20881.3294 kcal/mol (20854.1978 without restraints) Performing minimization step: 2266. Total energy = 20870.8132 kcal/mol (20843.6840 without restraints) Performing minimization step: 2267. Total energy = 20860.3051 kcal/mol (20833.1781 without restraints) Performing minimization step: 2268. Total energy = 20849.8054 kcal/mol (20822.6807 without restraints) Performing minimization step: 2269. Total energy = 20839.3139 kcal/mol (20812.1915 without restraints) Performing minimization step: 2270. Total energy = 20828.8301 kcal/mol (20801.7100 without restraints) Performing minimization step: 2271. Total energy = 20818.3548 kcal/mol (20791.2369 without restraints) Performing minimization step: 2272. Total energy = 20807.8876 kcal/mol (20780.7719 without restraints) Performing minimization step: 2273. Total energy = 20797.4282 kcal/mol (20770.3148 without restraints) Performing minimization step: 2274. Total energy = 20786.9771 kcal/mol (20759.8660 without restraints) Performing minimization step: 2275. Total energy = 20776.5344 kcal/mol (20749.4257 without restraints) Performing minimization step: 2276. Total energy = 20766.0997 kcal/mol (20738.9931 without restraints) Performing minimization step: 2277. Total energy = 20755.6729 kcal/mol (20728.5685 without restraints) Performing minimization step: 2278. Total energy = 20745.2540 kcal/mol (20718.1519 without restraints) Performing minimization step: 2279. Total energy = 20734.8437 kcal/mol (20707.7439 without restraints) Performing minimization step: 2280. Total energy = 20724.4410 kcal/mol (20697.3434 without restraints) Performing minimization step: 2281. Total energy = 20714.0463 kcal/mol (20686.9509 without restraints) Performing minimization step: 2282. Total energy = 20703.6598 kcal/mol (20676.5669 without restraints) Performing minimization step: 2283. Total energy = 20693.2816 kcal/mol (20666.1908 without restraints) Performing minimization step: 2284. Total energy = 20682.9108 kcal/mol (20655.8222 without restraints) Performing minimization step: 2285. Total energy = 20672.5478 kcal/mol (20645.4615 without restraints) Performing minimization step: 2286. Total energy = 20662.1931 kcal/mol (20635.1091 without restraints) Performing minimization step: 2287. Total energy = 20651.8461 kcal/mol (20624.7642 without restraints) Performing minimization step: 2288. Total energy = 20641.5068 kcal/mol (20614.4272 without restraints) Performing minimization step: 2289. Total energy = 20631.1757 kcal/mol (20604.0983 without restraints) Performing minimization step: 2290. Total energy = 20620.8522 kcal/mol (20593.7770 without restraints) Performing minimization step: 2291. Total energy = 20610.5364 kcal/mol (20583.4635 without restraints) Performing minimization step: 2292. Total energy = 20600.2287 kcal/mol (20573.1580 without restraints) Performing minimization step: 2293. Total energy = 20589.9286 kcal/mol (20562.8601 without restraints) Performing minimization step: 2294. Total energy = 20579.6362 kcal/mol (20552.5700 without restraints) Performing minimization step: 2295. Total energy = 20569.3519 kcal/mol (20542.2879 without restraints) Performing minimization step: 2296. Total energy = 20559.0751 kcal/mol (20532.0134 without restraints) Performing minimization step: 2297. Total energy = 20548.8061 kcal/mol (20521.7465 without restraints) Performing minimization step: 2298. Total energy = 20538.5451 kcal/mol (20511.4879 without restraints) Performing minimization step: 2299. Total energy = 20528.2917 kcal/mol (20501.2367 without restraints) Performing minimization step: 2300. Total energy = 20518.0458 kcal/mol (20490.9930 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2301. Total energy = 20507.8074 kcal/mol (20480.7568 without restraints) Performing minimization step: 2302. Total energy = 20497.5770 kcal/mol (20470.5286 without restraints) Performing minimization step: 2303. Total energy = 20487.3539 kcal/mol (20460.3077 without restraints) Performing minimization step: 2304. Total energy = 20477.1386 kcal/mol (20450.0947 without restraints) Performing minimization step: 2305. Total energy = 20466.9308 kcal/mol (20439.8891 without restraints) Performing minimization step: 2306. Total energy = 20456.7305 kcal/mol (20429.6910 without restraints) Performing minimization step: 2307. Total energy = 20446.5386 kcal/mol (20419.5013 without restraints) Performing minimization step: 2308. Total energy = 20436.3538 kcal/mol (20409.3187 without restraints) Performing minimization step: 2309. Total energy = 20426.1764 kcal/mol (20399.1435 without restraints) Performing minimization step: 2310. Total energy = 20416.0068 kcal/mol (20388.9763 without restraints) Performing minimization step: 2311. Total energy = 20405.8449 kcal/mol (20378.8165 without restraints) Performing minimization step: 2312. Total energy = 20395.6901 kcal/mol (20368.6638 without restraints) Performing minimization step: 2313. Total energy = 20385.5429 kcal/mol (20358.5188 without restraints) Performing minimization step: 2314. Total energy = 20375.4032 kcal/mol (20348.3814 without restraints) Performing minimization step: 2315. Total energy = 20365.2710 kcal/mol (20338.2514 without restraints) Performing minimization step: 2316. Total energy = 20355.1460 kcal/mol (20328.1286 without restraints) Performing minimization step: 2317. Total energy = 20345.0289 kcal/mol (20318.0137 without restraints) Performing minimization step: 2318. Total energy = 20334.9188 kcal/mol (20307.9058 without restraints) Performing minimization step: 2319. Total energy = 20324.8161 kcal/mol (20297.8053 without restraints) Performing minimization step: 2320. Total energy = 20314.7211 kcal/mol (20287.7126 without restraints) Performing minimization step: 2321. Total energy = 20304.6337 kcal/mol (20277.6273 without restraints) Performing minimization step: 2322. Total energy = 20294.5530 kcal/mol (20267.5489 without restraints) Performing minimization step: 2323. Total energy = 20284.4797 kcal/mol (20257.4777 without restraints) Performing minimization step: 2324. Total energy = 20274.4136 kcal/mol (20247.4138 without restraints) Performing minimization step: 2325. Total energy = 20264.3549 kcal/mol (20237.3573 without restraints) Performing minimization step: 2326. Total energy = 20254.3035 kcal/mol (20227.3081 without restraints) Performing minimization step: 2327. Total energy = 20244.2596 kcal/mol (20217.2664 without restraints) Performing minimization step: 2328. Total energy = 20234.2228 kcal/mol (20207.2318 without restraints) Performing minimization step: 2329. Total energy = 20224.1933 kcal/mol (20197.2046 without restraints) Performing minimization step: 2330. Total energy = 20214.1710 kcal/mol (20187.1844 without restraints) Performing minimization step: 2331. Total energy = 20204.1559 kcal/mol (20177.1714 without restraints) Performing minimization step: 2332. Total energy = 20194.1479 kcal/mol (20167.1656 without restraints) Performing minimization step: 2333. Total energy = 20184.1469 kcal/mol (20157.1668 without restraints) Performing minimization step: 2334. Total energy = 20174.1533 kcal/mol (20147.1754 without restraints) Performing minimization step: 2335. Total energy = 20164.1664 kcal/mol (20137.1907 without restraints) Performing minimization step: 2336. Total energy = 20154.1871 kcal/mol (20127.2136 without restraints) Performing minimization step: 2337. Total energy = 20144.2150 kcal/mol (20117.2436 without restraints) Performing minimization step: 2338. Total energy = 20134.2499 kcal/mol (20107.2807 without restraints) Performing minimization step: 2339. Total energy = 20124.2919 kcal/mol (20097.3250 without restraints) Performing minimization step: 2340. Total energy = 20114.3413 kcal/mol (20087.3764 without restraints) Performing minimization step: 2341. Total energy = 20104.3977 kcal/mol (20077.4350 without restraints) Performing minimization step: 2342. Total energy = 20094.4612 kcal/mol (20067.5008 without restraints) Performing minimization step: 2343. Total energy = 20084.5315 kcal/mol (20057.5732 without restraints) Performing minimization step: 2344. Total energy = 20074.6082 kcal/mol (20047.6521 without restraints) Performing minimization step: 2345. Total energy = 20064.6924 kcal/mol (20037.7384 without restraints) Performing minimization step: 2346. Total energy = 20054.7836 kcal/mol (20027.8318 without restraints) Performing minimization step: 2347. Total energy = 20044.8818 kcal/mol (20017.9322 without restraints) Performing minimization step: 2348. Total energy = 20034.9870 kcal/mol (20008.0395 without restraints) Performing minimization step: 2349. Total energy = 20025.0992 kcal/mol (19998.1539 without restraints) Performing minimization step: 2350. Total energy = 20015.2184 kcal/mol (19988.2752 without restraints) Performing minimization step: 2351. Total energy = 20005.3443 kcal/mol (19978.4033 without restraints) Performing minimization step: 2352. Total energy = 19995.4773 kcal/mol (19968.5385 without restraints) Performing minimization step: 2353. Total energy = 19985.6171 kcal/mol (19958.6804 without restraints) Performing minimization step: 2354. Total energy = 19975.7639 kcal/mol (19948.8293 without restraints) Performing minimization step: 2355. Total energy = 19965.9175 kcal/mol (19938.9851 without restraints) Performing minimization step: 2356. Total energy = 19956.0777 kcal/mol (19929.1475 without restraints) Performing minimization step: 2357. Total energy = 19946.2450 kcal/mol (19919.3169 without restraints) Performing minimization step: 2358. Total energy = 19936.4189 kcal/mol (19909.4929 without restraints) Performing minimization step: 2359. Total energy = 19926.5995 kcal/mol (19899.6758 without restraints) Performing minimization step: 2360. Total energy = 19916.7872 kcal/mol (19889.8656 without restraints) Performing minimization step: 2361. Total energy = 19906.9811 kcal/mol (19880.0616 without restraints) Performing minimization step: 2362. Total energy = 19897.1820 kcal/mol (19870.2647 without restraints) Performing minimization step: 2363. Total energy = 19887.3897 kcal/mol (19860.4746 without restraints) Performing minimization step: 2364. Total energy = 19877.6044 kcal/mol (19850.6913 without restraints) Performing minimization step: 2365. Total energy = 19867.8255 kcal/mol (19840.9146 without restraints) Performing minimization step: 2366. Total energy = 19858.0533 kcal/mol (19831.1446 without restraints) Performing minimization step: 2367. Total energy = 19848.2880 kcal/mol (19821.3814 without restraints) Performing minimization step: 2368. Total energy = 19838.5291 kcal/mol (19811.6247 without restraints) Performing minimization step: 2369. Total energy = 19828.7771 kcal/mol (19801.8748 without restraints) Performing minimization step: 2370. Total energy = 19819.0316 kcal/mol (19792.1314 without restraints) Performing minimization step: 2371. Total energy = 19809.2932 kcal/mol (19782.3953 without restraints) Performing minimization step: 2372. Total energy = 19799.5610 kcal/mol (19772.6650 without restraints) Performing minimization step: 2373. Total energy = 19789.8348 kcal/mol (19762.9411 without restraints) Performing minimization step: 2374. Total energy = 19780.1156 kcal/mol (19753.2239 without restraints) Performing minimization step: 2375. Total energy = 19770.4031 kcal/mol (19743.5136 without restraints) Performing minimization step: 2376. Total energy = 19760.6969 kcal/mol (19733.8095 without restraints) Performing minimization step: 2377. Total energy = 19750.9973 kcal/mol (19724.1121 without restraints) Performing minimization step: 2378. Total energy = 19741.3043 kcal/mol (19714.4212 without restraints) Performing minimization step: 2379. Total energy = 19731.6179 kcal/mol (19704.7369 without restraints) Performing minimization step: 2380. Total energy = 19721.9378 kcal/mol (19695.0589 without restraints) Performing minimization step: 2381. Total energy = 19712.2645 kcal/mol (19685.3877 without restraints) Performing minimization step: 2382. Total energy = 19702.5977 kcal/mol (19675.7231 without restraints) Performing minimization step: 2383. Total energy = 19692.9373 kcal/mol (19666.0649 without restraints) Performing minimization step: 2384. Total energy = 19683.2834 kcal/mol (19656.4130 without restraints) Performing minimization step: 2385. Total energy = 19673.6357 kcal/mol (19646.7675 without restraints) Performing minimization step: 2386. Total energy = 19663.9946 kcal/mol (19637.1285 without restraints) Performing minimization step: 2387. Total energy = 19654.3596 kcal/mol (19627.4955 without restraints) Performing minimization step: 2388. Total energy = 19644.7309 kcal/mol (19617.8691 without restraints) Performing minimization step: 2389. Total energy = 19635.1088 kcal/mol (19608.2490 without restraints) Performing minimization step: 2390. Total energy = 19625.4928 kcal/mol (19598.6351 without restraints) Performing minimization step: 2391. Total energy = 19615.8832 kcal/mol (19589.0276 without restraints) Performing minimization step: 2392. Total energy = 19606.2799 kcal/mol (19579.4264 without restraints) Performing minimization step: 2393. Total energy = 19596.6829 kcal/mol (19569.8315 without restraints) Performing minimization step: 2394. Total energy = 19587.0921 kcal/mol (19560.2429 without restraints) Performing minimization step: 2395. Total energy = 19577.5076 kcal/mol (19550.6605 without restraints) Performing minimization step: 2396. Total energy = 19567.9296 kcal/mol (19541.0847 without restraints) Performing minimization step: 2397. Total energy = 19558.3577 kcal/mol (19531.5148 without restraints) Performing minimization step: 2398. Total energy = 19548.7924 kcal/mol (19521.9516 without restraints) Performing minimization step: 2399. Total energy = 19539.2338 kcal/mol (19512.3951 without restraints) Performing minimization step: 2400. Total energy = 19529.6803 kcal/mol (19502.8436 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2401. Total energy = 19520.1334 kcal/mol (19493.2990 without restraints) Performing minimization step: 2402. Total energy = 19510.5926 kcal/mol (19483.7602 without restraints) Performing minimization step: 2403. Total energy = 19501.0575 kcal/mol (19474.2271 without restraints) Performing minimization step: 2404. Total energy = 19491.5288 kcal/mol (19464.7005 without restraints) Performing minimization step: 2405. Total energy = 19482.0062 kcal/mol (19455.1801 without restraints) Performing minimization step: 2406. Total energy = 19472.4899 kcal/mol (19445.6659 without restraints) Performing minimization step: 2407. Total energy = 19462.9796 kcal/mol (19436.1576 without restraints) Performing minimization step: 2408. Total energy = 19453.4754 kcal/mol (19426.6556 without restraints) Performing minimization step: 2409. Total energy = 19443.9774 kcal/mol (19417.1597 without restraints) Performing minimization step: 2410. Total energy = 19434.4854 kcal/mol (19407.6697 without restraints) Performing minimization step: 2411. Total energy = 19424.9994 kcal/mol (19398.1858 without restraints) Performing minimization step: 2412. Total energy = 19415.5194 kcal/mol (19388.7079 without restraints) Performing minimization step: 2413. Total energy = 19406.0458 kcal/mol (19379.2364 without restraints) Performing minimization step: 2414. Total energy = 19396.5781 kcal/mol (19369.7708 without restraints) Performing minimization step: 2415. Total energy = 19387.1163 kcal/mol (19360.3111 without restraints) Performing minimization step: 2416. Total energy = 19377.6604 kcal/mol (19350.8573 without restraints) Performing minimization step: 2417. Total energy = 19368.2105 kcal/mol (19341.4094 without restraints) Performing minimization step: 2418. Total energy = 19358.7663 kcal/mol (19331.9673 without restraints) Performing minimization step: 2419. Total energy = 19349.3284 kcal/mol (19322.5316 without restraints) Performing minimization step: 2420. Total energy = 19339.8964 kcal/mol (19313.1015 without restraints) Performing minimization step: 2421. Total energy = 19330.4703 kcal/mol (19303.6776 without restraints) Performing minimization step: 2422. Total energy = 19321.0499 kcal/mol (19294.2592 without restraints) Performing minimization step: 2423. Total energy = 19311.6359 kcal/mol (19284.8473 without restraints) Performing minimization step: 2424. Total energy = 19302.2271 kcal/mol (19275.4406 without restraints) Performing minimization step: 2425. Total energy = 19292.8244 kcal/mol (19266.0399 without restraints) Performing minimization step: 2426. Total energy = 19283.4277 kcal/mol (19256.6453 without restraints) Performing minimization step: 2427. Total energy = 19274.0367 kcal/mol (19247.2565 without restraints) Performing minimization step: 2428. Total energy = 19264.6515 kcal/mol (19237.8733 without restraints) Performing minimization step: 2429. Total energy = 19255.2723 kcal/mol (19228.4961 without restraints) Performing minimization step: 2430. Total energy = 19245.8986 kcal/mol (19219.1245 without restraints) Performing minimization step: 2431. Total energy = 19236.5310 kcal/mol (19209.7590 without restraints) Performing minimization step: 2432. Total energy = 19227.1692 kcal/mol (19200.3992 without restraints) Performing minimization step: 2433. Total energy = 19217.8126 kcal/mol (19191.0447 without restraints) Performing minimization step: 2434. Total energy = 19208.4623 kcal/mol (19181.6965 without restraints) Performing minimization step: 2435. Total energy = 19199.1176 kcal/mol (19172.3538 without restraints) Performing minimization step: 2436. Total energy = 19189.7784 kcal/mol (19163.0167 without restraints) Performing minimization step: 2437. Total energy = 19180.4450 kcal/mol (19153.6853 without restraints) Performing minimization step: 2438. Total energy = 19171.1172 kcal/mol (19144.3596 without restraints) Performing minimization step: 2439. Total energy = 19161.7952 kcal/mol (19135.0397 without restraints) Performing minimization step: 2440. Total energy = 19152.4793 kcal/mol (19125.7258 without restraints) Performing minimization step: 2441. Total energy = 19143.1685 kcal/mol (19116.4171 without restraints) Performing minimization step: 2442. Total energy = 19133.8634 kcal/mol (19107.1140 without restraints) Performing minimization step: 2443. Total energy = 19124.5640 kcal/mol (19097.8167 without restraints) Performing minimization step: 2444. Total energy = 19115.2702 kcal/mol (19088.5249 without restraints) Performing minimization step: 2445. Total energy = 19105.9814 kcal/mol (19079.2381 without restraints) Performing minimization step: 2446. Total energy = 19096.6982 kcal/mol (19069.9570 without restraints) Performing minimization step: 2447. Total energy = 19087.4208 kcal/mol (19060.6817 without restraints) Performing minimization step: 2448. Total energy = 19078.1492 kcal/mol (19051.4121 without restraints) Performing minimization step: 2449. Total energy = 19068.8832 kcal/mol (19042.1481 without restraints) Performing minimization step: 2450. Total energy = 19059.6231 kcal/mol (19032.8901 without restraints) Performing minimization step: 2451. Total energy = 19050.3678 kcal/mol (19023.6368 without restraints) Performing minimization step: 2452. Total energy = 19041.1182 kcal/mol (19014.3893 without restraints) Performing minimization step: 2453. Total energy = 19031.8742 kcal/mol (19005.1473 without restraints) Performing minimization step: 2454. Total energy = 19022.6356 kcal/mol (18995.9108 without restraints) Performing minimization step: 2455. Total energy = 19013.4024 kcal/mol (18986.6797 without restraints) Performing minimization step: 2456. Total energy = 19004.1747 kcal/mol (18977.4539 without restraints) Performing minimization step: 2457. Total energy = 18994.9525 kcal/mol (18968.2337 without restraints) Performing minimization step: 2458. Total energy = 18985.7356 kcal/mol (18959.0189 without restraints) Performing minimization step: 2459. Total energy = 18976.5242 kcal/mol (18949.8096 without restraints) Performing minimization step: 2460. Total energy = 18967.3186 kcal/mol (18940.6059 without restraints) Performing minimization step: 2461. Total energy = 18958.1182 kcal/mol (18931.4076 without restraints) Performing minimization step: 2462. Total energy = 18948.9230 kcal/mol (18922.2143 without restraints) Performing minimization step: 2463. Total energy = 18939.7333 kcal/mol (18913.0269 without restraints) Performing minimization step: 2464. Total energy = 18930.5485 kcal/mol (18903.8440 without restraints) Performing minimization step: 2465. Total energy = 18921.3689 kcal/mol (18894.6664 without restraints) Performing minimization step: 2466. Total energy = 18912.1950 kcal/mol (18885.4946 without restraints) Performing minimization step: 2467. Total energy = 18903.0267 kcal/mol (18876.3283 without restraints) Performing minimization step: 2468. Total energy = 18893.8632 kcal/mol (18867.1668 without restraints) Performing minimization step: 2469. Total energy = 18884.7052 kcal/mol (18858.0107 without restraints) Performing minimization step: 2470. Total energy = 18875.5527 kcal/mol (18848.8603 without restraints) Performing minimization step: 2471. Total energy = 18866.4050 kcal/mol (18839.7146 without restraints) Performing minimization step: 2472. Total energy = 18857.2631 kcal/mol (18830.5747 without restraints) Performing minimization step: 2473. Total energy = 18848.1257 kcal/mol (18821.4394 without restraints) Performing minimization step: 2474. Total energy = 18838.9942 kcal/mol (18812.3098 without restraints) Performing minimization step: 2475. Total energy = 18829.8677 kcal/mol (18803.1853 without restraints) Performing minimization step: 2476. Total energy = 18820.7463 kcal/mol (18794.0660 without restraints) Performing minimization step: 2477. Total energy = 18811.6300 kcal/mol (18784.9516 without restraints) Performing minimization step: 2478. Total energy = 18802.5186 kcal/mol (18775.8423 without restraints) Performing minimization step: 2479. Total energy = 18793.4130 kcal/mol (18766.7387 without restraints) Performing minimization step: 2480. Total energy = 18784.3123 kcal/mol (18757.6400 without restraints) Performing minimization step: 2481. Total energy = 18775.2166 kcal/mol (18748.5465 without restraints) Performing minimization step: 2482. Total energy = 18766.1262 kcal/mol (18739.4580 without restraints) Performing minimization step: 2483. Total energy = 18757.0409 kcal/mol (18730.3747 without restraints) Performing minimization step: 2484. Total energy = 18747.9609 kcal/mol (18721.2968 without restraints) Performing minimization step: 2485. Total energy = 18738.8860 kcal/mol (18712.2238 without restraints) Performing minimization step: 2486. Total energy = 18729.8160 kcal/mol (18703.1559 without restraints) Performing minimization step: 2487. Total energy = 18720.7512 kcal/mol (18694.0931 without restraints) Performing minimization step: 2488. Total energy = 18711.6912 kcal/mol (18685.0348 without restraints) Performing minimization step: 2489. Total energy = 18702.6363 kcal/mol (18675.9821 without restraints) Performing minimization step: 2490. Total energy = 18693.5869 kcal/mol (18666.9347 without restraints) Performing minimization step: 2491. Total energy = 18684.5421 kcal/mol (18657.8918 without restraints) Performing minimization step: 2492. Total energy = 18675.5026 kcal/mol (18648.8543 without restraints) Performing minimization step: 2493. Total energy = 18666.4677 kcal/mol (18639.8214 without restraints) Performing minimization step: 2494. Total energy = 18657.4378 kcal/mol (18630.7935 without restraints) Performing minimization step: 2495. Total energy = 18648.4128 kcal/mol (18621.7706 without restraints) Performing minimization step: 2496. Total energy = 18639.3930 kcal/mol (18612.7530 without restraints) Performing minimization step: 2497. Total energy = 18630.3782 kcal/mol (18603.7399 without restraints) Performing minimization step: 2498. Total energy = 18621.3682 kcal/mol (18594.7320 without restraints) Performing minimization step: 2499. Total energy = 18612.3633 kcal/mol (18585.7291 without restraints) Performing minimization step: 2500. Total energy = 18603.3637 kcal/mol (18576.7314 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2501. Total energy = 18594.3682 kcal/mol (18567.7378 without restraints) Performing minimization step: 2502. Total energy = 18585.3776 kcal/mol (18558.7493 without restraints) Performing minimization step: 2503. Total energy = 18576.3919 kcal/mol (18549.7656 without restraints) Performing minimization step: 2504. Total energy = 18567.4114 kcal/mol (18540.7871 without restraints) Performing minimization step: 2505. Total energy = 18558.4357 kcal/mol (18531.8133 without restraints) Performing minimization step: 2506. Total energy = 18549.4647 kcal/mol (18522.8443 without restraints) Performing minimization step: 2507. Total energy = 18540.4988 kcal/mol (18513.8804 without restraints) Performing minimization step: 2508. Total energy = 18531.5379 kcal/mol (18504.9215 without restraints) Performing minimization step: 2509. Total energy = 18522.5812 kcal/mol (18495.9668 without restraints) Performing minimization step: 2510. Total energy = 18513.6294 kcal/mol (18487.0169 without restraints) Performing minimization step: 2511. Total energy = 18504.6822 kcal/mol (18478.0716 without restraints) Performing minimization step: 2512. Total energy = 18495.7400 kcal/mol (18469.1315 without restraints) Performing minimization step: 2513. Total energy = 18486.8025 kcal/mol (18460.1959 without restraints) Performing minimization step: 2514. Total energy = 18477.8694 kcal/mol (18451.2649 without restraints) Performing minimization step: 2515. Total energy = 18468.9414 kcal/mol (18442.3388 without restraints) Performing minimization step: 2516. Total energy = 18460.0182 kcal/mol (18433.4176 without restraints) Performing minimization step: 2517. Total energy = 18451.0996 kcal/mol (18424.5010 without restraints) Performing minimization step: 2518. Total energy = 18442.1857 kcal/mol (18415.5890 without restraints) Performing minimization step: 2519. Total energy = 18433.2765 kcal/mol (18406.6818 without restraints) Performing minimization step: 2520. Total energy = 18424.3723 kcal/mol (18397.7796 without restraints) Performing minimization step: 2521. Total energy = 18415.4724 kcal/mol (18388.8816 without restraints) Performing minimization step: 2522. Total energy = 18406.5770 kcal/mol (18379.9882 without restraints) Performing minimization step: 2523. Total energy = 18397.6862 kcal/mol (18371.0993 without restraints) Performing minimization step: 2524. Total energy = 18388.8003 kcal/mol (18362.2156 without restraints) Performing minimization step: 2525. Total energy = 18379.9190 kcal/mol (18353.3360 without restraints) Performing minimization step: 2526. Total energy = 18371.0424 kcal/mol (18344.4614 without restraints) Performing minimization step: 2527. Total energy = 18362.1704 kcal/mol (18335.5914 without restraints) Performing minimization step: 2528. Total energy = 18353.3030 kcal/mol (18326.7260 without restraints) Performing minimization step: 2529. Total energy = 18344.4402 kcal/mol (18317.8651 without restraints) Performing minimization step: 2530. Total energy = 18335.5818 kcal/mol (18309.0086 without restraints) Performing minimization step: 2531. Total energy = 18326.7278 kcal/mol (18300.1566 without restraints) Performing minimization step: 2532. Total energy = 18317.8781 kcal/mol (18291.3089 without restraints) Performing minimization step: 2533. Total energy = 18309.0333 kcal/mol (18282.4660 without restraints) Performing minimization step: 2534. Total energy = 18300.1930 kcal/mol (18273.6276 without restraints) Performing minimization step: 2535. Total energy = 18291.3571 kcal/mol (18264.7937 without restraints) Performing minimization step: 2536. Total energy = 18282.5256 kcal/mol (18255.9642 without restraints) Performing minimization step: 2537. Total energy = 18273.6988 kcal/mol (18247.1393 without restraints) Performing minimization step: 2538. Total energy = 18264.8767 kcal/mol (18238.3192 without restraints) Performing minimization step: 2539. Total energy = 18256.0586 kcal/mol (18229.5029 without restraints) Performing minimization step: 2540. Total energy = 18247.2451 kcal/mol (18220.6915 without restraints) Performing minimization step: 2541. Total energy = 18238.4361 kcal/mol (18211.8845 without restraints) Performing minimization step: 2542. Total energy = 18229.6318 kcal/mol (18203.0821 without restraints) Performing minimization step: 2543. Total energy = 18220.8319 kcal/mol (18194.2841 without restraints) Performing minimization step: 2544. Total energy = 18212.0360 kcal/mol (18185.4901 without restraints) Performing minimization step: 2545. Total energy = 18203.2446 kcal/mol (18176.7007 without restraints) Performing minimization step: 2546. Total energy = 18194.4579 kcal/mol (18167.9157 without restraints) Performing minimization step: 2547. Total energy = 18185.6752 kcal/mol (18159.1352 without restraints) Performing minimization step: 2548. Total energy = 18176.8970 kcal/mol (18150.3589 without restraints) Performing minimization step: 2549. Total energy = 18168.1237 kcal/mol (18141.5877 without restraints) Performing minimization step: 2550. Total energy = 18159.3544 kcal/mol (18132.8202 without restraints) Performing minimization step: 2551. Total energy = 18150.5892 kcal/mol (18124.0569 without restraints) Performing minimization step: 2552. Total energy = 18141.8286 kcal/mol (18115.2982 without restraints) Performing minimization step: 2553. Total energy = 18133.0721 kcal/mol (18106.5437 without restraints) Performing minimization step: 2554. Total energy = 18124.3200 kcal/mol (18097.7935 without restraints) Performing minimization step: 2555. Total energy = 18115.5722 kcal/mol (18089.0477 without restraints) Performing minimization step: 2556. Total energy = 18106.8287 kcal/mol (18080.3061 without restraints) Performing minimization step: 2557. Total energy = 18098.0892 kcal/mol (18071.5685 without restraints) Performing minimization step: 2558. Total energy = 18089.3546 kcal/mol (18062.8358 without restraints) Performing minimization step: 2559. Total energy = 18080.6235 kcal/mol (18054.1066 without restraints) Performing minimization step: 2560. Total energy = 18071.8971 kcal/mol (18045.3822 without restraints) Performing minimization step: 2561. Total energy = 18063.1747 kcal/mol (18036.6617 without restraints) Performing minimization step: 2562. Total energy = 18054.4567 kcal/mol (18027.9457 without restraints) Performing minimization step: 2563. Total energy = 18045.7427 kcal/mol (18019.2336 without restraints) Performing minimization step: 2564. Total energy = 18037.0331 kcal/mol (18010.5259 without restraints) Performing minimization step: 2565. Total energy = 18028.3275 kcal/mol (18001.8220 without restraints) Performing minimization step: 2566. Total energy = 18019.6263 kcal/mol (17993.1230 without restraints) Performing minimization step: 2567. Total energy = 18010.9295 kcal/mol (17984.4280 without restraints) Performing minimization step: 2568. Total energy = 18002.2364 kcal/mol (17975.7369 without restraints) Performing minimization step: 2569. Total energy = 17993.5480 kcal/mol (17967.0503 without restraints) Performing minimization step: 2570. Total energy = 17984.8633 kcal/mol (17958.3675 without restraints) Performing minimization step: 2571. Total energy = 17976.1827 kcal/mol (17949.6888 without restraints) Performing minimization step: 2572. Total energy = 17967.5062 kcal/mol (17941.0143 without restraints) Performing minimization step: 2573. Total energy = 17958.8336 kcal/mol (17932.3436 without restraints) Performing minimization step: 2574. Total energy = 17950.1651 kcal/mol (17923.6770 without restraints) Performing minimization step: 2575. Total energy = 17941.5009 kcal/mol (17915.0147 without restraints) Performing minimization step: 2576. Total energy = 17932.8408 kcal/mol (17906.3565 without restraints) Performing minimization step: 2577. Total energy = 17924.1846 kcal/mol (17897.7022 without restraints) Performing minimization step: 2578. Total energy = 17915.5330 kcal/mol (17889.0525 without restraints) Performing minimization step: 2579. Total energy = 17906.8853 kcal/mol (17880.4067 without restraints) Performing minimization step: 2580. Total energy = 17898.2419 kcal/mol (17871.7653 without restraints) Performing minimization step: 2581. Total energy = 17889.6023 kcal/mol (17863.1276 without restraints) Performing minimization step: 2582. Total energy = 17880.9665 kcal/mol (17854.4937 without restraints) Performing minimization step: 2583. Total energy = 17872.3349 kcal/mol (17845.8640 without restraints) Performing minimization step: 2584. Total energy = 17863.7074 kcal/mol (17837.2384 without restraints) Performing minimization step: 2585. Total energy = 17855.0837 kcal/mol (17828.6166 without restraints) Performing minimization step: 2586. Total energy = 17846.4639 kcal/mol (17819.9987 without restraints) Performing minimization step: 2587. Total energy = 17837.8483 kcal/mol (17811.3850 without restraints) Performing minimization step: 2588. Total energy = 17829.2365 kcal/mol (17802.7751 without restraints) Performing minimization step: 2589. Total energy = 17820.6286 kcal/mol (17794.1691 without restraints) Performing minimization step: 2590. Total energy = 17812.0247 kcal/mol (17785.5671 without restraints) Performing minimization step: 2591. Total energy = 17803.4247 kcal/mol (17776.9690 without restraints) Performing minimization step: 2592. Total energy = 17794.8285 kcal/mol (17768.3745 without restraints) Performing minimization step: 2593. Total energy = 17786.2361 kcal/mol (17759.7842 without restraints) Performing minimization step: 2594. Total energy = 17777.6482 kcal/mol (17751.1984 without restraints) Performing minimization step: 2595. Total energy = 17769.0642 kcal/mol (17742.6162 without restraints) Performing minimization step: 2596. Total energy = 17760.4839 kcal/mol (17734.0378 without restraints) Performing minimization step: 2597. Total energy = 17751.9072 kcal/mol (17725.4630 without restraints) Performing minimization step: 2598. Total energy = 17743.3345 kcal/mol (17716.8921 without restraints) Performing minimization step: 2599. Total energy = 17734.7657 kcal/mol (17708.3251 without restraints) Performing minimization step: 2600. Total energy = 17726.2008 kcal/mol (17699.7622 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2601. Total energy = 17717.6397 kcal/mol (17691.2029 without restraints) Performing minimization step: 2602. Total energy = 17709.0823 kcal/mol (17682.6473 without restraints) Performing minimization step: 2603. Total energy = 17700.5287 kcal/mol (17674.0957 without restraints) Performing minimization step: 2604. Total energy = 17691.9790 kcal/mol (17665.5479 without restraints) Performing minimization step: 2605. Total energy = 17683.4330 kcal/mol (17657.0037 without restraints) Performing minimization step: 2606. Total energy = 17674.8912 kcal/mol (17648.4638 without restraints) Performing minimization step: 2607. Total energy = 17666.3529 kcal/mol (17639.9274 without restraints) Performing minimization step: 2608. Total energy = 17657.8186 kcal/mol (17631.3950 without restraints) Performing minimization step: 2609. Total energy = 17649.2883 kcal/mol (17622.8666 without restraints) Performing minimization step: 2610. Total energy = 17640.7613 kcal/mol (17614.3415 without restraints) Performing minimization step: 2611. Total energy = 17632.2381 kcal/mol (17605.8201 without restraints) Performing minimization step: 2612. Total energy = 17623.7186 kcal/mol (17597.3025 without restraints) Performing minimization step: 2613. Total energy = 17615.2029 kcal/mol (17588.7887 without restraints) Performing minimization step: 2614. Total energy = 17606.6914 kcal/mol (17580.2790 without restraints) Performing minimization step: 2615. Total energy = 17598.1830 kcal/mol (17571.7726 without restraints) Performing minimization step: 2616. Total energy = 17589.6784 kcal/mol (17563.2698 without restraints) Performing minimization step: 2617. Total energy = 17581.1776 kcal/mol (17554.7709 without restraints) Performing minimization step: 2618. Total energy = 17572.6806 kcal/mol (17546.2757 without restraints) Performing minimization step: 2619. Total energy = 17564.1871 kcal/mol (17537.7841 without restraints) Performing minimization step: 2620. Total energy = 17555.6974 kcal/mol (17529.2963 without restraints) Performing minimization step: 2621. Total energy = 17547.2112 kcal/mol (17520.8120 without restraints) Performing minimization step: 2622. Total energy = 17538.7285 kcal/mol (17512.3310 without restraints) Performing minimization step: 2623. Total energy = 17530.2497 kcal/mol (17503.8542 without restraints) Performing minimization step: 2624. Total energy = 17521.7744 kcal/mol (17495.3808 without restraints) Performing minimization step: 2625. Total energy = 17513.3028 kcal/mol (17486.9111 without restraints) Performing minimization step: 2626. Total energy = 17504.8351 kcal/mol (17478.4452 without restraints) Performing minimization step: 2627. Total energy = 17496.3708 kcal/mol (17469.9828 without restraints) Performing minimization step: 2628. Total energy = 17487.9101 kcal/mol (17461.5239 without restraints) Performing minimization step: 2629. Total energy = 17479.4529 kcal/mol (17453.0686 without restraints) Performing minimization step: 2630. Total energy = 17470.9994 kcal/mol (17444.6170 without restraints) Performing minimization step: 2631. Total energy = 17462.5495 kcal/mol (17436.1689 without restraints) Performing minimization step: 2632. Total energy = 17454.1035 kcal/mol (17427.7248 without restraints) Performing minimization step: 2633. Total energy = 17445.6607 kcal/mol (17419.2838 without restraints) Performing minimization step: 2634. Total energy = 17437.2213 kcal/mol (17410.8463 without restraints) Performing minimization step: 2635. Total energy = 17428.7856 kcal/mol (17402.4124 without restraints) Performing minimization step: 2636. Total energy = 17420.3532 kcal/mol (17393.9819 without restraints) Performing minimization step: 2637. Total energy = 17411.9243 kcal/mol (17385.5549 without restraints) Performing minimization step: 2638. Total energy = 17403.4992 kcal/mol (17377.1316 without restraints) Performing minimization step: 2639. Total energy = 17395.0775 kcal/mol (17368.7118 without restraints) Performing minimization step: 2640. Total energy = 17386.6596 kcal/mol (17360.2957 without restraints) Performing minimization step: 2641. Total energy = 17378.2452 kcal/mol (17351.8832 without restraints) Performing minimization step: 2642. Total energy = 17369.8341 kcal/mol (17343.4739 without restraints) Performing minimization step: 2643. Total energy = 17361.4263 kcal/mol (17335.0681 without restraints) Performing minimization step: 2644. Total energy = 17353.0223 kcal/mol (17326.6658 without restraints) Performing minimization step: 2645. Total energy = 17344.6216 kcal/mol (17318.2669 without restraints) Performing minimization step: 2646. Total energy = 17336.2246 kcal/mol (17309.8718 without restraints) Performing minimization step: 2647. Total energy = 17327.8310 kcal/mol (17301.4800 without restraints) Performing minimization step: 2648. Total energy = 17319.4406 kcal/mol (17293.0915 without restraints) Performing minimization step: 2649. Total energy = 17311.0541 kcal/mol (17284.7069 without restraints) Performing minimization step: 2650. Total energy = 17302.6705 kcal/mol (17276.3250 without restraints) Performing minimization step: 2651. Total energy = 17294.2904 kcal/mol (17267.9470 without restraints) Performing minimization step: 2652. Total energy = 17285.9135 kcal/mol (17259.5718 without restraints) Performing minimization step: 2653. Total energy = 17277.5405 kcal/mol (17251.2007 without restraints) Performing minimization step: 2654. Total energy = 17269.1707 kcal/mol (17242.8326 without restraints) Performing minimization step: 2655. Total energy = 17260.8040 kcal/mol (17234.4678 without restraints) Performing minimization step: 2656. Total energy = 17252.4411 kcal/mol (17226.1070 without restraints) Performing minimization step: 2657. Total energy = 17244.0816 kcal/mol (17217.7490 without restraints) Performing minimization step: 2658. Total energy = 17235.7252 kcal/mol (17209.3945 without restraints) Performing minimization step: 2659. Total energy = 17227.3722 kcal/mol (17201.0434 without restraints) Performing minimization step: 2660. Total energy = 17219.0229 kcal/mol (17192.6959 without restraints) Performing minimization step: 2661. Total energy = 17210.6763 kcal/mol (17184.3511 without restraints) Performing minimization step: 2662. Total energy = 17202.3333 kcal/mol (17176.0097 without restraints) Performing minimization step: 2663. Total energy = 17193.9936 kcal/mol (17167.6721 without restraints) Performing minimization step: 2664. Total energy = 17185.6572 kcal/mol (17159.3376 without restraints) Performing minimization step: 2665. Total energy = 17177.3244 kcal/mol (17151.0066 without restraints) Performing minimization step: 2666. Total energy = 17168.9945 kcal/mol (17142.6785 without restraints) Performing minimization step: 2667. Total energy = 17160.6681 kcal/mol (17134.3539 without restraints) Performing minimization step: 2668. Total energy = 17152.3452 kcal/mol (17126.0329 without restraints) Performing minimization step: 2669. Total energy = 17144.0258 kcal/mol (17117.7153 without restraints) Performing minimization step: 2670. Total energy = 17135.7094 kcal/mol (17109.4008 without restraints) Performing minimization step: 2671. Total energy = 17127.3961 kcal/mol (17101.0893 without restraints) Performing minimization step: 2672. Total energy = 17119.0859 kcal/mol (17092.7809 without restraints) Performing minimization step: 2673. Total energy = 17110.7791 kcal/mol (17084.4759 without restraints) Performing minimization step: 2674. Total energy = 17102.4756 kcal/mol (17076.1742 without restraints) Performing minimization step: 2675. Total energy = 17094.1755 kcal/mol (17067.8759 without restraints) Performing minimization step: 2676. Total energy = 17085.8784 kcal/mol (17059.5807 without restraints) Performing minimization step: 2677. Total energy = 17077.5846 kcal/mol (17051.2887 without restraints) Performing minimization step: 2678. Total energy = 17069.2940 kcal/mol (17042.9999 without restraints) Performing minimization step: 2679. Total energy = 17061.0068 kcal/mol (17034.7145 without restraints) Performing minimization step: 2680. Total energy = 17052.7226 kcal/mol (17026.4321 without restraints) Performing minimization step: 2681. Total energy = 17044.4415 kcal/mol (17018.1527 without restraints) Performing minimization step: 2682. Total energy = 17036.1636 kcal/mol (17009.8768 without restraints) Performing minimization step: 2683. Total energy = 17027.8887 kcal/mol (17001.6036 without restraints) Performing minimization step: 2684. Total energy = 17019.6167 kcal/mol (16993.3336 without restraints) Performing minimization step: 2685. Total energy = 17011.3485 kcal/mol (16985.0672 without restraints) Performing minimization step: 2686. Total energy = 17003.0833 kcal/mol (16976.8038 without restraints) Performing minimization step: 2687. Total energy = 16994.8217 kcal/mol (16968.5440 without restraints) Performing minimization step: 2688. Total energy = 16986.5630 kcal/mol (16960.2871 without restraints) Performing minimization step: 2689. Total energy = 16978.3073 kcal/mol (16952.0332 without restraints) Performing minimization step: 2690. Total energy = 16970.0552 kcal/mol (16943.7829 without restraints) Performing minimization step: 2691. Total energy = 16961.8057 kcal/mol (16935.5353 without restraints) Performing minimization step: 2692. Total energy = 16953.5600 kcal/mol (16927.2915 without restraints) Performing minimization step: 2693. Total energy = 16945.3170 kcal/mol (16919.0502 without restraints) Performing minimization step: 2694. Total energy = 16937.0770 kcal/mol (16910.8120 without restraints) Performing minimization step: 2695. Total energy = 16928.8405 kcal/mol (16902.5773 without restraints) Performing minimization step: 2696. Total energy = 16920.6067 kcal/mol (16894.3453 without restraints) Performing minimization step: 2697. Total energy = 16912.3762 kcal/mol (16886.1167 without restraints) Performing minimization step: 2698. Total energy = 16904.1487 kcal/mol (16877.8910 without restraints) Performing minimization step: 2699. Total energy = 16895.9242 kcal/mol (16869.6682 without restraints) Performing minimization step: 2700. Total energy = 16887.7027 kcal/mol (16861.4485 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2701. Total energy = 16879.4843 kcal/mol (16853.2319 without restraints) Performing minimization step: 2702. Total energy = 16871.2689 kcal/mol (16845.0184 without restraints) Performing minimization step: 2703. Total energy = 16863.0565 kcal/mol (16836.8076 without restraints) Performing minimization step: 2704. Total energy = 16854.8472 kcal/mol (16828.6004 without restraints) Performing minimization step: 2705. Total energy = 16846.6411 kcal/mol (16820.3960 without restraints) Performing minimization step: 2706. Total energy = 16838.4378 kcal/mol (16812.1944 without restraints) Performing minimization step: 2707. Total energy = 16830.2378 kcal/mol (16803.9962 without restraints) Performing minimization step: 2708. Total energy = 16822.0406 kcal/mol (16795.8008 without restraints) Performing minimization step: 2709. Total energy = 16813.8466 kcal/mol (16787.6087 without restraints) Performing minimization step: 2710. Total energy = 16805.6555 kcal/mol (16779.4193 without restraints) Performing minimization step: 2711. Total energy = 16797.4672 kcal/mol (16771.2328 without restraints) Performing minimization step: 2712. Total energy = 16789.2819 kcal/mol (16763.0494 without restraints) Performing minimization step: 2713. Total energy = 16781.0997 kcal/mol (16754.8690 without restraints) Performing minimization step: 2714. Total energy = 16772.9206 kcal/mol (16746.6918 without restraints) Performing minimization step: 2715. Total energy = 16764.7444 kcal/mol (16738.5172 without restraints) Performing minimization step: 2716. Total energy = 16756.5715 kcal/mol (16730.3463 without restraints) Performing minimization step: 2717. Total energy = 16748.4014 kcal/mol (16722.1779 without restraints) Performing minimization step: 2718. Total energy = 16740.2341 kcal/mol (16714.0123 without restraints) Performing minimization step: 2719. Total energy = 16732.0697 kcal/mol (16705.8498 without restraints) Performing minimization step: 2720. Total energy = 16723.9083 kcal/mol (16697.6902 without restraints) Performing minimization step: 2721. Total energy = 16715.7497 kcal/mol (16689.5332 without restraints) Performing minimization step: 2722. Total energy = 16707.5940 kcal/mol (16681.3795 without restraints) Performing minimization step: 2723. Total energy = 16699.4415 kcal/mol (16673.2288 without restraints) Performing minimization step: 2724. Total energy = 16691.2922 kcal/mol (16665.0812 without restraints) Performing minimization step: 2725. Total energy = 16683.1454 kcal/mol (16656.9362 without restraints) Performing minimization step: 2726. Total energy = 16675.0018 kcal/mol (16648.7945 without restraints) Performing minimization step: 2727. Total energy = 16666.8609 kcal/mol (16640.6552 without restraints) Performing minimization step: 2728. Total energy = 16658.7227 kcal/mol (16632.5189 without restraints) Performing minimization step: 2729. Total energy = 16650.5875 kcal/mol (16624.3854 without restraints) Performing minimization step: 2730. Total energy = 16642.4554 kcal/mol (16616.2551 without restraints) Performing minimization step: 2731. Total energy = 16634.3260 kcal/mol (16608.1275 without restraints) Performing minimization step: 2732. Total energy = 16626.1995 kcal/mol (16600.0028 without restraints) Performing minimization step: 2733. Total energy = 16618.0759 kcal/mol (16591.8810 without restraints) Performing minimization step: 2734. Total energy = 16609.9554 kcal/mol (16583.7622 without restraints) Performing minimization step: 2735. Total energy = 16601.8372 kcal/mol (16575.6458 without restraints) Performing minimization step: 2736. Total energy = 16593.7221 kcal/mol (16567.5325 without restraints) Performing minimization step: 2737. Total energy = 16585.6099 kcal/mol (16559.4221 without restraints) Performing minimization step: 2738. Total energy = 16577.5007 kcal/mol (16551.3147 without restraints) Performing minimization step: 2739. Total energy = 16569.3940 kcal/mol (16543.2097 without restraints) Performing minimization step: 2740. Total energy = 16561.2902 kcal/mol (16535.1078 without restraints) Performing minimization step: 2741. Total energy = 16553.1893 kcal/mol (16527.0086 without restraints) Performing minimization step: 2742. Total energy = 16545.0915 kcal/mol (16518.9126 without restraints) Performing minimization step: 2743. Total energy = 16536.9963 kcal/mol (16510.8192 without restraints) Performing minimization step: 2744. Total energy = 16528.9039 kcal/mol (16502.7286 without restraints) Performing minimization step: 2745. Total energy = 16520.8145 kcal/mol (16494.6409 without restraints) Performing minimization step: 2746. Total energy = 16512.7281 kcal/mol (16486.5562 without restraints) Performing minimization step: 2747. Total energy = 16504.6439 kcal/mol (16478.4739 without restraints) Performing minimization step: 2748. Total energy = 16496.5631 kcal/mol (16470.3950 without restraints) Performing minimization step: 2749. Total energy = 16488.4849 kcal/mol (16462.3185 without restraints) Performing minimization step: 2750. Total energy = 16480.4093 kcal/mol (16454.2446 without restraints) Performing minimization step: 2751. Total energy = 16472.3366 kcal/mol (16446.1735 without restraints) Performing minimization step: 2752. Total energy = 16464.2664 kcal/mol (16438.1054 without restraints) Performing minimization step: 2753. Total energy = 16456.1992 kcal/mol (16430.0398 without restraints) Performing minimization step: 2754. Total energy = 16448.1345 kcal/mol (16421.9769 without restraints) Performing minimization step: 2755. Total energy = 16440.0724 kcal/mol (16413.9164 without restraints) Performing minimization step: 2756. Total energy = 16432.0130 kcal/mol (16405.8589 without restraints) Performing minimization step: 2757. Total energy = 16423.9566 kcal/mol (16397.8043 without restraints) Performing minimization step: 2758. Total energy = 16415.9029 kcal/mol (16389.7523 without restraints) Performing minimization step: 2759. Total energy = 16407.8518 kcal/mol (16381.7029 without restraints) Performing minimization step: 2760. Total energy = 16399.8034 kcal/mol (16373.6563 without restraints) Performing minimization step: 2761. Total energy = 16391.7578 kcal/mol (16365.6125 without restraints) Performing minimization step: 2762. Total energy = 16383.7152 kcal/mol (16357.5717 without restraints) Performing minimization step: 2763. Total energy = 16375.6752 kcal/mol (16349.5335 without restraints) Performing minimization step: 2764. Total energy = 16367.6377 kcal/mol (16341.4978 without restraints) Performing minimization step: 2765. Total energy = 16359.6030 kcal/mol (16333.4649 without restraints) Performing minimization step: 2766. Total energy = 16351.5712 kcal/mol (16325.4349 without restraints) Performing minimization step: 2767. Total energy = 16343.5421 kcal/mol (16317.4075 without restraints) Performing minimization step: 2768. Total energy = 16335.5156 kcal/mol (16309.3827 without restraints) Performing minimization step: 2769. Total energy = 16327.4918 kcal/mol (16301.3606 without restraints) Performing minimization step: 2770. Total energy = 16319.4705 kcal/mol (16293.3411 without restraints) Performing minimization step: 2771. Total energy = 16311.4520 kcal/mol (16285.3244 without restraints) Performing minimization step: 2772. Total energy = 16303.4361 kcal/mol (16277.3103 without restraints) Performing minimization step: 2773. Total energy = 16295.4230 kcal/mol (16269.2989 without restraints) Performing minimization step: 2774. Total energy = 16287.4125 kcal/mol (16261.2902 without restraints) Performing minimization step: 2775. Total energy = 16279.4047 kcal/mol (16253.2841 without restraints) Performing minimization step: 2776. Total energy = 16271.3996 kcal/mol (16245.2808 without restraints) Performing minimization step: 2777. Total energy = 16263.3970 kcal/mol (16237.2800 without restraints) Performing minimization step: 2778. Total energy = 16255.3974 kcal/mol (16229.2822 without restraints) Performing minimization step: 2779. Total energy = 16247.4002 kcal/mol (16221.2867 without restraints) Performing minimization step: 2780. Total energy = 16239.4056 kcal/mol (16213.2938 without restraints) Performing minimization step: 2781. Total energy = 16231.4134 kcal/mol (16205.3034 without restraints) Performing minimization step: 2782. Total energy = 16223.4242 kcal/mol (16197.3159 without restraints) Performing minimization step: 2783. Total energy = 16215.4370 kcal/mol (16189.3304 without restraints) Performing minimization step: 2784. Total energy = 16207.4530 kcal/mol (16181.3482 without restraints) Performing minimization step: 2785. Total energy = 16199.4715 kcal/mol (16173.3685 without restraints) Performing minimization step: 2786. Total energy = 16191.4927 kcal/mol (16165.3914 without restraints) Performing minimization step: 2787. Total energy = 16183.5164 kcal/mol (16157.4169 without restraints) Performing minimization step: 2788. Total energy = 16175.5426 kcal/mol (16149.4448 without restraints) Performing minimization step: 2789. Total energy = 16167.5712 kcal/mol (16141.4752 without restraints) Performing minimization step: 2790. Total energy = 16159.6027 kcal/mol (16133.5085 without restraints) Performing minimization step: 2791. Total energy = 16151.6366 kcal/mol (16125.5442 without restraints) Performing minimization step: 2792. Total energy = 16143.6733 kcal/mol (16117.5826 without restraints) Performing minimization step: 2793. Total energy = 16135.7127 kcal/mol (16109.6237 without restraints) Performing minimization step: 2794. Total energy = 16127.7546 kcal/mol (16101.6673 without restraints) Performing minimization step: 2795. Total energy = 16119.7987 kcal/mol (16093.7132 without restraints) Performing minimization step: 2796. Total energy = 16111.8455 kcal/mol (16085.7619 without restraints) Performing minimization step: 2797. Total energy = 16103.8951 kcal/mol (16077.8131 without restraints) Performing minimization step: 2798. Total energy = 16095.9473 kcal/mol (16069.8671 without restraints) Performing minimization step: 2799. Total energy = 16088.0020 kcal/mol (16061.9235 without restraints) Performing minimization step: 2800. Total energy = 16080.0594 kcal/mol (16053.9827 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2801. Total energy = 16072.1192 kcal/mol (16046.0442 without restraints) Performing minimization step: 2802. Total energy = 16064.1815 kcal/mol (16038.1082 without restraints) Performing minimization step: 2803. Total energy = 16056.2463 kcal/mol (16030.1748 without restraints) Performing minimization step: 2804. Total energy = 16048.3139 kcal/mol (16022.2439 without restraints) Performing minimization step: 2805. Total energy = 16040.3836 kcal/mol (16014.3156 without restraints) Performing minimization step: 2806. Total energy = 16032.4565 kcal/mol (16006.3902 without restraints) Performing minimization step: 2807. Total energy = 16024.5314 kcal/mol (15998.4669 without restraints) Performing minimization step: 2808. Total energy = 16016.6088 kcal/mol (15990.5459 without restraints) Performing minimization step: 2809. Total energy = 16008.6886 kcal/mol (15982.6276 without restraints) Performing minimization step: 2810. Total energy = 16000.7711 kcal/mol (15974.7118 without restraints) Performing minimization step: 2811. Total energy = 15992.8561 kcal/mol (15966.7985 without restraints) Performing minimization step: 2812. Total energy = 15984.9438 kcal/mol (15958.8880 without restraints) Performing minimization step: 2813. Total energy = 15977.0338 kcal/mol (15950.9797 without restraints) Performing minimization step: 2814. Total energy = 15969.1263 kcal/mol (15943.0739 without restraints) Performing minimization step: 2815. Total energy = 15961.2211 kcal/mol (15935.1704 without restraints) Performing minimization step: 2816. Total energy = 15953.3184 kcal/mol (15927.2697 without restraints) Performing minimization step: 2817. Total energy = 15945.4188 kcal/mol (15919.3718 without restraints) Performing minimization step: 2818. Total energy = 15937.5215 kcal/mol (15911.4761 without restraints) Performing minimization step: 2819. Total energy = 15929.6264 kcal/mol (15903.5827 without restraints) Performing minimization step: 2820. Total energy = 15921.7339 kcal/mol (15895.6921 without restraints) Performing minimization step: 2821. Total energy = 15913.8441 kcal/mol (15887.8039 without restraints) Performing minimization step: 2822. Total energy = 15905.9567 kcal/mol (15879.9184 without restraints) Performing minimization step: 2823. Total energy = 15898.0718 kcal/mol (15872.0351 without restraints) Performing minimization step: 2824. Total energy = 15890.1891 kcal/mol (15864.1541 without restraints) Performing minimization step: 2825. Total energy = 15882.3088 kcal/mol (15856.2756 without restraints) Performing minimization step: 2826. Total energy = 15874.4310 kcal/mol (15848.3995 without restraints) Performing minimization step: 2827. Total energy = 15866.5556 kcal/mol (15840.5258 without restraints) Performing minimization step: 2828. Total energy = 15858.6829 kcal/mol (15832.6549 without restraints) Performing minimization step: 2829. Total energy = 15850.8127 kcal/mol (15824.7863 without restraints) Performing minimization step: 2830. Total energy = 15842.9445 kcal/mol (15816.9200 without restraints) Performing minimization step: 2831. Total energy = 15835.0790 kcal/mol (15809.0561 without restraints) Performing minimization step: 2832. Total energy = 15827.2158 kcal/mol (15801.1947 without restraints) Performing minimization step: 2833. Total energy = 15819.3548 kcal/mol (15793.3355 without restraints) Performing minimization step: 2834. Total energy = 15811.4968 kcal/mol (15785.4791 without restraints) Performing minimization step: 2835. Total energy = 15803.6409 kcal/mol (15777.6249 without restraints) Performing minimization step: 2836. Total energy = 15795.7874 kcal/mol (15769.7732 without restraints) Performing minimization step: 2837. Total energy = 15787.9366 kcal/mol (15761.9241 without restraints) Performing minimization step: 2838. Total energy = 15780.0885 kcal/mol (15754.0778 without restraints) Performing minimization step: 2839. Total energy = 15772.2423 kcal/mol (15746.2333 without restraints) Performing minimization step: 2840. Total energy = 15764.3987 kcal/mol (15738.3914 without restraints) Performing minimization step: 2841. Total energy = 15756.5575 kcal/mol (15730.5520 without restraints) Performing minimization step: 2842. Total energy = 15748.7184 kcal/mol (15722.7146 without restraints) Performing minimization step: 2843. Total energy = 15740.8817 kcal/mol (15714.8795 without restraints) Performing minimization step: 2844. Total energy = 15733.0473 kcal/mol (15707.0469 without restraints) Performing minimization step: 2845. Total energy = 15725.2153 kcal/mol (15699.2166 without restraints) Performing minimization step: 2846. Total energy = 15717.3859 kcal/mol (15691.3889 without restraints) Performing minimization step: 2847. Total energy = 15709.5588 kcal/mol (15683.5636 without restraints) Performing minimization step: 2848. Total energy = 15701.7341 kcal/mol (15675.7406 without restraints) Performing minimization step: 2849. Total energy = 15693.9119 kcal/mol (15667.9201 without restraints) Performing minimization step: 2850. Total energy = 15686.0920 kcal/mol (15660.1020 without restraints) Performing minimization step: 2851. Total energy = 15678.2746 kcal/mol (15652.2862 without restraints) Performing minimization step: 2852. Total energy = 15670.4595 kcal/mol (15644.4730 without restraints) Performing minimization step: 2853. Total energy = 15662.6468 kcal/mol (15636.6619 without restraints) Performing minimization step: 2854. Total energy = 15654.8364 kcal/mol (15628.8532 without restraints) Performing minimization step: 2855. Total energy = 15647.0284 kcal/mol (15621.0469 without restraints) Performing minimization step: 2856. Total energy = 15639.2227 kcal/mol (15613.2430 without restraints) Performing minimization step: 2857. Total energy = 15631.4189 kcal/mol (15605.4408 without restraints) Performing minimization step: 2858. Total energy = 15623.6182 kcal/mol (15597.6419 without restraints) Performing minimization step: 2859. Total energy = 15615.8201 kcal/mol (15589.8455 without restraints) Performing minimization step: 2860. Total energy = 15608.0246 kcal/mol (15582.0517 without restraints) Performing minimization step: 2861. Total energy = 15600.2308 kcal/mol (15574.2597 without restraints) Performing minimization step: 2862. Total energy = 15592.4393 kcal/mol (15566.4698 without restraints) Performing minimization step: 2863. Total energy = 15584.6501 kcal/mol (15558.6824 without restraints) Performing minimization step: 2864. Total energy = 15576.8633 kcal/mol (15550.8973 without restraints) Performing minimization step: 2865. Total energy = 15569.0789 kcal/mol (15543.1148 without restraints) Performing minimization step: 2866. Total energy = 15561.2968 kcal/mol (15535.3343 without restraints) Performing minimization step: 2867. Total energy = 15553.5173 kcal/mol (15527.5564 without restraints) Performing minimization step: 2868. Total energy = 15545.7395 kcal/mol (15519.7803 without restraints) Performing minimization step: 2869. Total energy = 15537.9640 kcal/mol (15512.0066 without restraints) Performing minimization step: 2870. Total energy = 15530.1913 kcal/mol (15504.2356 without restraints) Performing minimization step: 2871. Total energy = 15522.4207 kcal/mol (15496.4667 without restraints) Performing minimization step: 2872. Total energy = 15514.6520 kcal/mol (15488.6997 without restraints) Performing minimization step: 2873. Total energy = 15506.8860 kcal/mol (15480.9354 without restraints) Performing minimization step: 2874. Total energy = 15499.1223 kcal/mol (15473.1734 without restraints) Performing minimization step: 2875. Total energy = 15491.3615 kcal/mol (15465.4144 without restraints) Performing minimization step: 2876. Total energy = 15483.6024 kcal/mol (15457.6570 without restraints) Performing minimization step: 2877. Total energy = 15475.8457 kcal/mol (15449.9020 without restraints) Performing minimization step: 2878. Total energy = 15468.0917 kcal/mol (15442.1497 without restraints) Performing minimization step: 2879. Total energy = 15460.3395 kcal/mol (15434.3993 without restraints) Performing minimization step: 2880. Total energy = 15452.5896 kcal/mol (15426.6511 without restraints) Performing minimization step: 2881. Total energy = 15444.8420 kcal/mol (15418.9050 without restraints) Performing minimization step: 2882. Total energy = 15437.0966 kcal/mol (15411.1615 without restraints) Performing minimization step: 2883. Total energy = 15429.3536 kcal/mol (15403.4202 without restraints) Performing minimization step: 2884. Total energy = 15421.6129 kcal/mol (15395.6812 without restraints) Performing minimization step: 2885. Total energy = 15413.8745 kcal/mol (15387.9445 without restraints) Performing minimization step: 2886. Total energy = 15406.1384 kcal/mol (15380.2101 without restraints) Performing minimization step: 2887. Total energy = 15398.4045 kcal/mol (15372.4780 without restraints) Performing minimization step: 2888. Total energy = 15390.6728 kcal/mol (15364.7479 without restraints) Performing minimization step: 2889. Total energy = 15382.9433 kcal/mol (15357.0202 without restraints) Performing minimization step: 2890. Total energy = 15375.2166 kcal/mol (15349.2951 without restraints) Performing minimization step: 2891. Total energy = 15367.4917 kcal/mol (15341.5719 without restraints) Performing minimization step: 2892. Total energy = 15359.7690 kcal/mol (15333.8509 without restraints) Performing minimization step: 2893. Total energy = 15352.0487 kcal/mol (15326.1324 without restraints) Performing minimization step: 2894. Total energy = 15344.3311 kcal/mol (15318.4164 without restraints) Performing minimization step: 2895. Total energy = 15336.6151 kcal/mol (15310.7022 without restraints) Performing minimization step: 2896. Total energy = 15328.9018 kcal/mol (15302.9906 without restraints) Performing minimization step: 2897. Total energy = 15321.1907 kcal/mol (15295.2813 without restraints) Performing minimization step: 2898. Total energy = 15313.4819 kcal/mol (15287.5741 without restraints) Performing minimization step: 2899. Total energy = 15305.7753 kcal/mol (15279.8692 without restraints) Performing minimization step: 2900. Total energy = 15298.0710 kcal/mol (15272.1667 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 2901. Total energy = 15290.3684 kcal/mol (15264.4657 without restraints) Performing minimization step: 2902. Total energy = 15282.6686 kcal/mol (15256.7676 without restraints) Performing minimization step: 2903. Total energy = 15274.9708 kcal/mol (15249.0715 without restraints) Performing minimization step: 2904. Total energy = 15267.2756 kcal/mol (15241.3780 without restraints) Performing minimization step: 2905. Total energy = 15259.5825 kcal/mol (15233.6867 without restraints) Performing minimization step: 2906. Total energy = 15251.8918 kcal/mol (15225.9976 without restraints) Performing minimization step: 2907. Total energy = 15244.2032 kcal/mol (15218.3107 without restraints) Performing minimization step: 2908. Total energy = 15236.5168 kcal/mol (15210.6260 without restraints) Performing minimization step: 2909. Total energy = 15228.8327 kcal/mol (15202.9436 without restraints) Performing minimization step: 2910. Total energy = 15221.1510 kcal/mol (15195.2637 without restraints) Performing minimization step: 2911. Total energy = 15213.4714 kcal/mol (15187.5858 without restraints) Performing minimization step: 2912. Total energy = 15205.7940 kcal/mol (15179.9100 without restraints) Performing minimization step: 2913. Total energy = 15198.1188 kcal/mol (15172.2365 without restraints) Performing minimization step: 2914. Total energy = 15190.4461 kcal/mol (15164.5655 without restraints) Performing minimization step: 2915. Total energy = 15182.7753 kcal/mol (15156.8964 without restraints) Performing minimization step: 2916. Total energy = 15175.1068 kcal/mol (15149.2296 without restraints) Performing minimization step: 2917. Total energy = 15167.4405 kcal/mol (15141.5650 without restraints) Performing minimization step: 2918. Total energy = 15159.7765 kcal/mol (15133.9029 without restraints) Performing minimization step: 2919. Total energy = 15152.1148 kcal/mol (15126.2427 without restraints) Performing minimization step: 2920. Total energy = 15144.4552 kcal/mol (15118.5848 without restraints) Performing minimization step: 2921. Total energy = 15136.7977 kcal/mol (15110.9289 without restraints) Performing minimization step: 2922. Total energy = 15129.1425 kcal/mol (15103.2757 without restraints) Performing minimization step: 2923. Total energy = 15121.4899 kcal/mol (15095.6247 without restraints) Performing minimization step: 2924. Total energy = 15113.8390 kcal/mol (15087.9754 without restraints) Performing minimization step: 2925. Total energy = 15106.1907 kcal/mol (15080.3290 without restraints) Performing minimization step: 2926. Total energy = 15098.5447 kcal/mol (15072.6846 without restraints) Performing minimization step: 2927. Total energy = 15090.9006 kcal/mol (15065.0421 without restraints) Performing minimization step: 2928. Total energy = 15083.2587 kcal/mol (15057.4019 without restraints) Performing minimization step: 2929. Total energy = 15075.6190 kcal/mol (15049.7639 without restraints) Performing minimization step: 2930. Total energy = 15067.9814 kcal/mol (15042.1280 without restraints) Performing minimization step: 2931. Total energy = 15060.3460 kcal/mol (15034.4944 without restraints) Performing minimization step: 2932. Total energy = 15052.7133 kcal/mol (15026.8633 without restraints) Performing minimization step: 2933. Total energy = 15045.0823 kcal/mol (15019.2340 without restraints) Performing minimization step: 2934. Total energy = 15037.4536 kcal/mol (15011.6070 without restraints) Performing minimization step: 2935. Total energy = 15029.8270 kcal/mol (15003.9821 without restraints) Performing minimization step: 2936. Total energy = 15022.2027 kcal/mol (14996.3595 without restraints) Performing minimization step: 2937. Total energy = 15014.5805 kcal/mol (14988.7388 without restraints) Performing minimization step: 2938. Total energy = 15006.9601 kcal/mol (14981.1203 without restraints) Performing minimization step: 2939. Total energy = 14999.3424 kcal/mol (14973.5043 without restraints) Performing minimization step: 2940. Total energy = 14991.7275 kcal/mol (14965.8911 without restraints) Performing minimization step: 2941. Total energy = 14984.1139 kcal/mol (14958.2792 without restraints) Performing minimization step: 2942. Total energy = 14976.5030 kcal/mol (14950.6699 without restraints) Performing minimization step: 2943. Total energy = 14968.8943 kcal/mol (14943.0630 without restraints) Performing minimization step: 2944. Total energy = 14961.2874 kcal/mol (14935.4577 without restraints) Performing minimization step: 2945. Total energy = 14953.6825 kcal/mol (14927.8547 without restraints) Performing minimization step: 2946. Total energy = 14946.0806 kcal/mol (14920.2543 without restraints) Performing minimization step: 2947. Total energy = 14938.4803 kcal/mol (14912.6558 without restraints) Performing minimization step: 2948. Total energy = 14930.8822 kcal/mol (14905.0593 without restraints) Performing minimization step: 2949. Total energy = 14923.2863 kcal/mol (14897.4651 without restraints) Performing minimization step: 2950. Total energy = 14915.6928 kcal/mol (14889.8733 without restraints) Performing minimization step: 2951. Total energy = 14908.1014 kcal/mol (14882.2836 without restraints) Performing minimization step: 2952. Total energy = 14900.5120 kcal/mol (14874.6959 without restraints) Performing minimization step: 2953. Total energy = 14892.9248 kcal/mol (14867.1104 without restraints) Performing minimization step: 2954. Total energy = 14885.3398 kcal/mol (14859.5270 without restraints) Performing minimization step: 2955. Total energy = 14877.7569 kcal/mol (14851.9458 without restraints) Performing minimization step: 2956. Total energy = 14870.1762 kcal/mol (14844.3669 without restraints) Performing minimization step: 2957. Total energy = 14862.5977 kcal/mol (14836.7901 without restraints) Performing minimization step: 2958. Total energy = 14855.0214 kcal/mol (14829.2154 without restraints) Performing minimization step: 2959. Total energy = 14847.4472 kcal/mol (14821.6429 without restraints) Performing minimization step: 2960. Total energy = 14839.8747 kcal/mol (14814.0721 without restraints) Performing minimization step: 2961. Total energy = 14832.3048 kcal/mol (14806.5039 without restraints) Performing minimization step: 2962. Total energy = 14824.7369 kcal/mol (14798.9377 without restraints) Performing minimization step: 2963. Total energy = 14817.1713 kcal/mol (14791.3738 without restraints) Performing minimization step: 2964. Total energy = 14809.6079 kcal/mol (14783.8121 without restraints) Performing minimization step: 2965. Total energy = 14802.0469 kcal/mol (14776.2528 without restraints) Performing minimization step: 2966. Total energy = 14794.4878 kcal/mol (14768.6954 without restraints) Performing minimization step: 2967. Total energy = 14786.9308 kcal/mol (14761.1401 without restraints) Performing minimization step: 2968. Total energy = 14779.3763 kcal/mol (14753.5872 without restraints) Performing minimization step: 2969. Total energy = 14771.8238 kcal/mol (14746.0365 without restraints) Performing minimization step: 2970. Total energy = 14764.2732 kcal/mol (14738.4875 without restraints) Performing minimization step: 2971. Total energy = 14756.7251 kcal/mol (14730.9411 without restraints) Performing minimization step: 2972. Total energy = 14749.1788 kcal/mol (14723.3966 without restraints) Performing minimization step: 2973. Total energy = 14741.6349 kcal/mol (14715.8543 without restraints) Performing minimization step: 2974. Total energy = 14734.0931 kcal/mol (14708.3142 without restraints) Performing minimization step: 2975. Total energy = 14726.5536 kcal/mol (14700.7764 without restraints) Performing minimization step: 2976. Total energy = 14719.0163 kcal/mol (14693.2407 without restraints) Performing minimization step: 2977. Total energy = 14711.4807 kcal/mol (14685.7068 without restraints) Performing minimization step: 2978. Total energy = 14703.9478 kcal/mol (14678.1756 without restraints) Performing minimization step: 2979. Total energy = 14696.4167 kcal/mol (14670.6462 without restraints) Performing minimization step: 2980. Total energy = 14688.8878 kcal/mol (14663.1190 without restraints) Performing minimization step: 2981. Total energy = 14681.3613 kcal/mol (14655.5942 without restraints) Performing minimization step: 2982. Total energy = 14673.8366 kcal/mol (14648.0712 without restraints) Performing minimization step: 2983. Total energy = 14666.3141 kcal/mol (14640.5504 without restraints) Performing minimization step: 2984. Total energy = 14658.7937 kcal/mol (14633.0316 without restraints) Performing minimization step: 2985. Total energy = 14651.2754 kcal/mol (14625.5151 without restraints) Performing minimization step: 2986. Total energy = 14643.7594 kcal/mol (14618.0007 without restraints) Performing minimization step: 2987. Total energy = 14636.2453 kcal/mol (14610.4883 without restraints) Performing minimization step: 2988. Total energy = 14628.7335 kcal/mol (14602.9782 without restraints) Performing minimization step: 2989. Total energy = 14621.2239 kcal/mol (14595.4702 without restraints) Performing minimization step: 2990. Total energy = 14613.7164 kcal/mol (14587.9644 without restraints) Performing minimization step: 2991. Total energy = 14606.2110 kcal/mol (14580.4607 without restraints) Performing minimization step: 2992. Total energy = 14598.7079 kcal/mol (14572.9593 without restraints) Performing minimization step: 2993. Total energy = 14591.2069 kcal/mol (14565.4600 without restraints) Performing minimization step: 2994. Total energy = 14583.7081 kcal/mol (14557.9630 without restraints) Performing minimization step: 2995. Total energy = 14576.2114 kcal/mol (14550.4678 without restraints) Performing minimization step: 2996. Total energy = 14568.7168 kcal/mol (14542.9749 without restraints) Performing minimization step: 2997. Total energy = 14561.2241 kcal/mol (14535.4839 without restraints) Performing minimization step: 2998. Total energy = 14553.7337 kcal/mol (14527.9952 without restraints) Performing minimization step: 2999. Total energy = 14546.2454 kcal/mol (14520.5086 without restraints) Performing minimization step: 3000. Total energy = 14538.7593 kcal/mol (14513.0241 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3001. Total energy = 14531.2752 kcal/mol (14505.5418 without restraints) Performing minimization step: 3002. Total energy = 14523.7934 kcal/mol (14498.0616 without restraints) Performing minimization step: 3003. Total energy = 14516.3138 kcal/mol (14490.5837 without restraints) Performing minimization step: 3004. Total energy = 14508.8364 kcal/mol (14483.1079 without restraints) Performing minimization step: 3005. Total energy = 14501.3608 kcal/mol (14475.6341 without restraints) Performing minimization step: 3006. Total energy = 14493.8877 kcal/mol (14468.1626 without restraints) Performing minimization step: 3007. Total energy = 14486.4165 kcal/mol (14460.6931 without restraints) Performing minimization step: 3008. Total energy = 14478.9476 kcal/mol (14453.2260 without restraints) Performing minimization step: 3009. Total energy = 14471.4807 kcal/mol (14445.7607 without restraints) Performing minimization step: 3010. Total energy = 14464.0158 kcal/mol (14438.2975 without restraints) Performing minimization step: 3011. Total energy = 14456.5529 kcal/mol (14430.8362 without restraints) Performing minimization step: 3012. Total energy = 14449.0927 kcal/mol (14423.3777 without restraints) Performing minimization step: 3013. Total energy = 14441.6343 kcal/mol (14415.9210 without restraints) Performing minimization step: 3014. Total energy = 14434.1780 kcal/mol (14408.4664 without restraints) Performing minimization step: 3015. Total energy = 14426.7238 kcal/mol (14401.0139 without restraints) Performing minimization step: 3016. Total energy = 14419.2720 kcal/mol (14393.5637 without restraints) Performing minimization step: 3017. Total energy = 14411.8222 kcal/mol (14386.1156 without restraints) Performing minimization step: 3018. Total energy = 14404.3744 kcal/mol (14378.6695 without restraints) Performing minimization step: 3019. Total energy = 14396.9287 kcal/mol (14371.2255 without restraints) Performing minimization step: 3020. Total energy = 14389.4851 kcal/mol (14363.7836 without restraints) Performing minimization step: 3021. Total energy = 14382.0439 kcal/mol (14356.3441 without restraints) Performing minimization step: 3022. Total energy = 14374.6046 kcal/mol (14348.9065 without restraints) Performing minimization step: 3023. Total energy = 14367.1675 kcal/mol (14341.4710 without restraints) Performing minimization step: 3024. Total energy = 14359.7324 kcal/mol (14334.0376 without restraints) Performing minimization step: 3025. Total energy = 14352.2996 kcal/mol (14326.6065 without restraints) Performing minimization step: 3026. Total energy = 14344.8688 kcal/mol (14319.1774 without restraints) Performing minimization step: 3027. Total energy = 14337.4402 kcal/mol (14311.7504 without restraints) Performing minimization step: 3028. Total energy = 14330.0136 kcal/mol (14304.3256 without restraints) Performing minimization step: 3029. Total energy = 14322.5892 kcal/mol (14296.9028 without restraints) Performing minimization step: 3030. Total energy = 14315.1669 kcal/mol (14289.4822 without restraints) Performing minimization step: 3031. Total energy = 14307.7467 kcal/mol (14282.0637 without restraints) Performing minimization step: 3032. Total energy = 14300.3286 kcal/mol (14274.6473 without restraints) Performing minimization step: 3033. Total energy = 14292.9127 kcal/mol (14267.2331 without restraints) Performing minimization step: 3034. Total energy = 14285.4990 kcal/mol (14259.8210 without restraints) Performing minimization step: 3035. Total energy = 14278.0873 kcal/mol (14252.4110 without restraints) Performing minimization step: 3036. Total energy = 14270.6784 kcal/mol (14245.0038 without restraints) Performing minimization step: 3037. Total energy = 14263.2711 kcal/mol (14237.5982 without restraints) Performing minimization step: 3038. Total energy = 14255.8659 kcal/mol (14230.1946 without restraints) Performing minimization step: 3039. Total energy = 14248.4627 kcal/mol (14222.7931 without restraints) Performing minimization step: 3040. Total energy = 14241.0618 kcal/mol (14215.3939 without restraints) Performing minimization step: 3041. Total energy = 14233.6629 kcal/mol (14207.9966 without restraints) Performing minimization step: 3042. Total energy = 14226.2655 kcal/mol (14200.6008 without restraints) Performing minimization step: 3043. Total energy = 14218.8708 kcal/mol (14193.2079 without restraints) Performing minimization step: 3044. Total energy = 14211.4782 kcal/mol (14185.8170 without restraints) Performing minimization step: 3045. Total energy = 14204.0880 kcal/mol (14178.4285 without restraints) Performing minimization step: 3046. Total energy = 14196.6999 kcal/mol (14171.0420 without restraints) Performing minimization step: 3047. Total energy = 14189.3131 kcal/mol (14163.6568 without restraints) Performing minimization step: 3048. Total energy = 14181.9289 kcal/mol (14156.2744 without restraints) Performing minimization step: 3049. Total energy = 14174.5470 kcal/mol (14148.8942 without restraints) Performing minimization step: 3050. Total energy = 14167.1674 kcal/mol (14141.5163 without restraints) Performing minimization step: 3051. Total energy = 14159.7895 kcal/mol (14134.1400 without restraints) Performing minimization step: 3052. Total energy = 14152.4140 kcal/mol (14126.7662 without restraints) Performing minimization step: 3053. Total energy = 14145.0406 kcal/mol (14119.3945 without restraints) Performing minimization step: 3054. Total energy = 14137.6690 kcal/mol (14112.0246 without restraints) Performing minimization step: 3055. Total energy = 14130.2998 kcal/mol (14104.6571 without restraints) Performing minimization step: 3056. Total energy = 14122.9328 kcal/mol (14097.2917 without restraints) Performing minimization step: 3057. Total energy = 14115.5681 kcal/mol (14089.9287 without restraints) Performing minimization step: 3058. Total energy = 14108.2055 kcal/mol (14082.5678 without restraints) Performing minimization step: 3059. Total energy = 14100.8450 kcal/mol (14075.2090 without restraints) Performing minimization step: 3060. Total energy = 14093.4862 kcal/mol (14067.8517 without restraints) Performing minimization step: 3061. Total energy = 14086.1297 kcal/mol (14060.4970 without restraints) Performing minimization step: 3062. Total energy = 14078.7753 kcal/mol (14053.1443 without restraints) Performing minimization step: 3063. Total energy = 14071.4239 kcal/mol (14045.7945 without restraints) Performing minimization step: 3064. Total energy = 14064.0738 kcal/mol (14038.4461 without restraints) Performing minimization step: 3065. Total energy = 14056.7259 kcal/mol (14031.1000 without restraints) Performing minimization step: 3066. Total energy = 14049.3804 kcal/mol (14023.7561 without restraints) Performing minimization step: 3067. Total energy = 14042.0365 kcal/mol (14016.4138 without restraints) Performing minimization step: 3068. Total energy = 14034.6949 kcal/mol (14009.0740 without restraints) Performing minimization step: 3069. Total energy = 14027.3555 kcal/mol (14001.7362 without restraints) Performing minimization step: 3070. Total energy = 14020.0182 kcal/mol (13994.4006 without restraints) Performing minimization step: 3071. Total energy = 14012.6831 kcal/mol (13987.0671 without restraints) Performing minimization step: 3072. Total energy = 14005.3500 kcal/mol (13979.7358 without restraints) Performing minimization step: 3073. Total energy = 13998.0192 kcal/mol (13972.4066 without restraints) Performing minimization step: 3074. Total energy = 13990.6905 kcal/mol (13965.0796 without restraints) Performing minimization step: 3075. Total energy = 13983.3641 kcal/mol (13957.7549 without restraints) Performing minimization step: 3076. Total energy = 13976.0392 kcal/mol (13950.4318 without restraints) Performing minimization step: 3077. Total energy = 13968.7169 kcal/mol (13943.1111 without restraints) Performing minimization step: 3078. Total energy = 13961.3968 kcal/mol (13935.7926 without restraints) Performing minimization step: 3079. Total energy = 13954.0789 kcal/mol (13928.4764 without restraints) Performing minimization step: 3080. Total energy = 13946.7632 kcal/mol (13921.1623 without restraints) Performing minimization step: 3081. Total energy = 13939.4493 kcal/mol (13913.8502 without restraints) Performing minimization step: 3082. Total energy = 13932.1376 kcal/mol (13906.5401 without restraints) Performing minimization step: 3083. Total energy = 13924.8280 kcal/mol (13899.2322 without restraints) Performing minimization step: 3084. Total energy = 13917.5205 kcal/mol (13891.9264 without restraints) Performing minimization step: 3085. Total energy = 13910.2152 kcal/mol (13884.6228 without restraints) Performing minimization step: 3086. Total energy = 13902.9120 kcal/mol (13877.3212 without restraints) Performing minimization step: 3087. Total energy = 13895.6109 kcal/mol (13870.0218 without restraints) Performing minimization step: 3088. Total energy = 13888.3121 kcal/mol (13862.7248 without restraints) Performing minimization step: 3089. Total energy = 13881.0154 kcal/mol (13855.4297 without restraints) Performing minimization step: 3090. Total energy = 13873.7210 kcal/mol (13848.1369 without restraints) Performing minimization step: 3091. Total energy = 13866.4285 kcal/mol (13840.8461 without restraints) Performing minimization step: 3092. Total energy = 13859.1381 kcal/mol (13833.5574 without restraints) Performing minimization step: 3093. Total energy = 13851.8499 kcal/mol (13826.2709 without restraints) Performing minimization step: 3094. Total energy = 13844.5636 kcal/mol (13818.9863 without restraints) Performing minimization step: 3095. Total energy = 13837.2799 kcal/mol (13811.7043 without restraints) Performing minimization step: 3096. Total energy = 13829.9985 kcal/mol (13804.4245 without restraints) Performing minimization step: 3097. Total energy = 13822.7189 kcal/mol (13797.1465 without restraints) Performing minimization step: 3098. Total energy = 13815.4413 kcal/mol (13789.8706 without restraints) Performing minimization step: 3099. Total energy = 13808.1659 kcal/mol (13782.5970 without restraints) Performing minimization step: 3100. Total energy = 13800.8927 kcal/mol (13775.3254 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3101. Total energy = 13793.6216 kcal/mol (13768.0560 without restraints) Performing minimization step: 3102. Total energy = 13786.3526 kcal/mol (13760.7887 without restraints) Performing minimization step: 3103. Total energy = 13779.0858 kcal/mol (13753.5235 without restraints) Performing minimization step: 3104. Total energy = 13771.8213 kcal/mol (13746.2607 without restraints) Performing minimization step: 3105. Total energy = 13764.5588 kcal/mol (13738.9998 without restraints) Performing minimization step: 3106. Total energy = 13757.2983 kcal/mol (13731.7411 without restraints) Performing minimization step: 3107. Total energy = 13750.0398 kcal/mol (13724.4842 without restraints) Performing minimization step: 3108. Total energy = 13742.7837 kcal/mol (13717.2298 without restraints) Performing minimization step: 3109. Total energy = 13735.5297 kcal/mol (13709.9775 without restraints) Performing minimization step: 3110. Total energy = 13728.2778 kcal/mol (13702.7272 without restraints) Performing minimization step: 3111. Total energy = 13721.0281 kcal/mol (13695.4792 without restraints) Performing minimization step: 3112. Total energy = 13713.7804 kcal/mol (13688.2333 without restraints) Performing minimization step: 3113. Total energy = 13706.5353 kcal/mol (13680.9898 without restraints) Performing minimization step: 3114. Total energy = 13699.2921 kcal/mol (13673.7483 without restraints) Performing minimization step: 3115. Total energy = 13692.0510 kcal/mol (13666.5089 without restraints) Performing minimization step: 3116. Total energy = 13684.8120 kcal/mol (13659.2716 without restraints) Performing minimization step: 3117. Total energy = 13677.5756 kcal/mol (13652.0368 without restraints) Performing minimization step: 3118. Total energy = 13670.3411 kcal/mol (13644.8040 without restraints) Performing minimization step: 3119. Total energy = 13663.1086 kcal/mol (13637.5732 without restraints) Performing minimization step: 3120. Total energy = 13655.8784 kcal/mol (13630.3446 without restraints) Performing minimization step: 3121. Total energy = 13648.6502 kcal/mol (13623.1181 without restraints) Performing minimization step: 3122. Total energy = 13641.4242 kcal/mol (13615.8938 without restraints) Performing minimization step: 3123. Total energy = 13634.2004 kcal/mol (13608.6717 without restraints) Performing minimization step: 3124. Total energy = 13626.9787 kcal/mol (13601.4516 without restraints) Performing minimization step: 3125. Total energy = 13619.7589 kcal/mol (13594.2335 without restraints) Performing minimization step: 3126. Total energy = 13612.5415 kcal/mol (13587.0178 without restraints) Performing minimization step: 3127. Total energy = 13605.3263 kcal/mol (13579.8043 without restraints) Performing minimization step: 3128. Total energy = 13598.1134 kcal/mol (13572.5930 without restraints) Performing minimization step: 3129. Total energy = 13590.9025 kcal/mol (13565.3838 without restraints) Performing minimization step: 3130. Total energy = 13583.6937 kcal/mol (13558.1767 without restraints) Performing minimization step: 3131. Total energy = 13576.4876 kcal/mol (13550.9722 without restraints) Performing minimization step: 3132. Total energy = 13569.2830 kcal/mol (13543.7694 without restraints) Performing minimization step: 3133. Total energy = 13562.0809 kcal/mol (13536.5690 without restraints) Performing minimization step: 3134. Total energy = 13554.8809 kcal/mol (13529.3706 without restraints) Performing minimization step: 3135. Total energy = 13547.6830 kcal/mol (13522.1744 without restraints) Performing minimization step: 3136. Total energy = 13540.4872 kcal/mol (13514.9802 without restraints) Performing minimization step: 3137. Total energy = 13533.2936 kcal/mol (13507.7883 without restraints) Performing minimization step: 3138. Total energy = 13526.1022 kcal/mol (13500.5986 without restraints) Performing minimization step: 3139. Total energy = 13518.9127 kcal/mol (13493.4108 without restraints) Performing minimization step: 3140. Total energy = 13511.7257 kcal/mol (13486.2255 without restraints) Performing minimization step: 3141. Total energy = 13504.5406 kcal/mol (13479.0420 without restraints) Performing minimization step: 3142. Total energy = 13497.3579 kcal/mol (13471.8611 without restraints) Performing minimization step: 3143. Total energy = 13490.1776 kcal/mol (13464.6824 without restraints) Performing minimization step: 3144. Total energy = 13482.9992 kcal/mol (13457.5057 without restraints) Performing minimization step: 3145. Total energy = 13475.8230 kcal/mol (13450.3312 without restraints) Performing minimization step: 3146. Total energy = 13468.6490 kcal/mol (13443.1589 without restraints) Performing minimization step: 3147. Total energy = 13461.4772 kcal/mol (13435.9887 without restraints) Performing minimization step: 3148. Total energy = 13454.3075 kcal/mol (13428.8207 without restraints) Performing minimization step: 3149. Total energy = 13447.1397 kcal/mol (13421.6544 without restraints) Performing minimization step: 3150. Total energy = 13439.9741 kcal/mol (13414.4906 without restraints) Performing minimization step: 3151. Total energy = 13432.8112 kcal/mol (13407.3294 without restraints) Performing minimization step: 3152. Total energy = 13425.6506 kcal/mol (13400.1706 without restraints) Performing minimization step: 3153. Total energy = 13418.4919 kcal/mol (13393.0134 without restraints) Performing minimization step: 3154. Total energy = 13411.3352 kcal/mol (13385.8585 without restraints) Performing minimization step: 3155. Total energy = 13404.1808 kcal/mol (13378.7057 without restraints) Performing minimization step: 3156. Total energy = 13397.0282 kcal/mol (13371.5549 without restraints) Performing minimization step: 3157. Total energy = 13389.8783 kcal/mol (13364.4066 without restraints) Performing minimization step: 3158. Total energy = 13382.7304 kcal/mol (13357.2603 without restraints) Performing minimization step: 3159. Total energy = 13375.5846 kcal/mol (13350.1163 without restraints) Performing minimization step: 3160. Total energy = 13368.4411 kcal/mol (13342.9745 without restraints) Performing minimization step: 3161. Total energy = 13361.2997 kcal/mol (13335.8347 without restraints) Performing minimization step: 3162. Total energy = 13354.1605 kcal/mol (13328.6971 without restraints) Performing minimization step: 3163. Total energy = 13347.0234 kcal/mol (13321.5618 without restraints) Performing minimization step: 3164. Total energy = 13339.8887 kcal/mol (13314.4288 without restraints) Performing minimization step: 3165. Total energy = 13332.7563 kcal/mol (13307.2981 without restraints) Performing minimization step: 3166. Total energy = 13325.6261 kcal/mol (13300.1694 without restraints) Performing minimization step: 3167. Total energy = 13318.4978 kcal/mol (13293.0429 without restraints) Performing minimization step: 3168. Total energy = 13311.3722 kcal/mol (13285.9190 without restraints) Performing minimization step: 3169. Total energy = 13304.2486 kcal/mol (13278.7972 without restraints) Performing minimization step: 3170. Total energy = 13297.1272 kcal/mol (13271.6774 without restraints) Performing minimization step: 3171. Total energy = 13290.0081 kcal/mol (13264.5600 without restraints) Performing minimization step: 3172. Total energy = 13282.8910 kcal/mol (13257.4445 without restraints) Performing minimization step: 3173. Total energy = 13275.7761 kcal/mol (13250.3313 without restraints) Performing minimization step: 3174. Total energy = 13268.6635 kcal/mol (13243.2204 without restraints) Performing minimization step: 3175. Total energy = 13261.5531 kcal/mol (13236.1116 without restraints) Performing minimization step: 3176. Total energy = 13254.4449 kcal/mol (13229.0053 without restraints) Performing minimization step: 3177. Total energy = 13247.3389 kcal/mol (13221.9008 without restraints) Performing minimization step: 3178. Total energy = 13240.2348 kcal/mol (13214.7984 without restraints) Performing minimization step: 3179. Total energy = 13233.1330 kcal/mol (13207.6983 without restraints) Performing minimization step: 3180. Total energy = 13226.0339 kcal/mol (13200.6008 without restraints) Performing minimization step: 3181. Total energy = 13218.9366 kcal/mol (13193.5053 without restraints) Performing minimization step: 3182. Total energy = 13211.8416 kcal/mol (13186.4119 without restraints) Performing minimization step: 3183. Total energy = 13204.7485 kcal/mol (13179.3204 without restraints) Performing minimization step: 3184. Total energy = 13197.6577 kcal/mol (13172.2314 without restraints) Performing minimization step: 3185. Total energy = 13190.5694 kcal/mol (13165.1447 without restraints) Performing minimization step: 3186. Total energy = 13183.4832 kcal/mol (13158.0602 without restraints) Performing minimization step: 3187. Total energy = 13176.3992 kcal/mol (13150.9780 without restraints) Performing minimization step: 3188. Total energy = 13169.3175 kcal/mol (13143.8979 without restraints) Performing minimization step: 3189. Total energy = 13162.2380 kcal/mol (13136.8201 without restraints) Performing minimization step: 3190. Total energy = 13155.1607 kcal/mol (13129.7445 without restraints) Performing minimization step: 3191. Total energy = 13148.0857 kcal/mol (13122.6712 without restraints) Performing minimization step: 3192. Total energy = 13141.0132 kcal/mol (13115.6004 without restraints) Performing minimization step: 3193. Total energy = 13133.9427 kcal/mol (13108.5315 without restraints) Performing minimization step: 3194. Total energy = 13126.8743 kcal/mol (13101.4648 without restraints) Performing minimization step: 3195. Total energy = 13119.8091 kcal/mol (13094.4013 without restraints) Performing minimization step: 3196. Total energy = 13112.7454 kcal/mol (13087.3393 without restraints) Performing minimization step: 3197. Total energy = 13105.6837 kcal/mol (13080.2793 without restraints) Performing minimization step: 3198. Total energy = 13098.6244 kcal/mol (13073.2217 without restraints) Performing minimization step: 3199. Total energy = 13091.5673 kcal/mol (13066.1662 without restraints) Performing minimization step: 3200. Total energy = 13084.5123 kcal/mol (13059.1129 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3201. Total energy = 13077.4595 kcal/mol (13052.0618 without restraints) Performing minimization step: 3202. Total energy = 13070.4090 kcal/mol (13045.0130 without restraints) Performing minimization step: 3203. Total energy = 13063.3607 kcal/mol (13037.9664 without restraints) Performing minimization step: 3204. Total energy = 13056.3147 kcal/mol (13030.9221 without restraints) Performing minimization step: 3205. Total energy = 13049.2713 kcal/mol (13023.8803 without restraints) Performing minimization step: 3206. Total energy = 13042.2298 kcal/mol (13016.8406 without restraints) Performing minimization step: 3207. Total energy = 13035.1909 kcal/mol (13009.8034 without restraints) Performing minimization step: 3208. Total energy = 13028.1544 kcal/mol (13002.7685 without restraints) Performing minimization step: 3209. Total energy = 13021.1196 kcal/mol (12995.7354 without restraints) Performing minimization step: 3210. Total energy = 13014.0869 kcal/mol (12988.7043 without restraints) Performing minimization step: 3211. Total energy = 13007.0567 kcal/mol (12981.6759 without restraints) Performing minimization step: 3212. Total energy = 13000.0287 kcal/mol (12974.6495 without restraints) Performing minimization step: 3213. Total energy = 12993.0028 kcal/mol (12967.6253 without restraints) Performing minimization step: 3214. Total energy = 12985.9792 kcal/mol (12960.6034 without restraints) Performing minimization step: 3215. Total energy = 12978.9582 kcal/mol (12953.5841 without restraints) Performing minimization step: 3216. Total energy = 12971.9394 kcal/mol (12946.5670 without restraints) Performing minimization step: 3217. Total energy = 12964.9227 kcal/mol (12939.5519 without restraints) Performing minimization step: 3218. Total energy = 12957.9082 kcal/mol (12932.5392 without restraints) Performing minimization step: 3219. Total energy = 12950.8960 kcal/mol (12925.5287 without restraints) Performing minimization step: 3220. Total energy = 12943.8863 kcal/mol (12918.5206 without restraints) Performing minimization step: 3221. Total energy = 12936.8785 kcal/mol (12911.5145 without restraints) Performing minimization step: 3222. Total energy = 12929.8731 kcal/mol (12904.5108 without restraints) Performing minimization step: 3223. Total energy = 12922.8699 kcal/mol (12897.5092 without restraints) Performing minimization step: 3224. Total energy = 12915.8689 kcal/mol (12890.5100 without restraints) Performing minimization step: 3225. Total energy = 12908.8704 kcal/mol (12883.5131 without restraints) Performing minimization step: 3226. Total energy = 12901.8741 kcal/mol (12876.5187 without restraints) Performing minimization step: 3227. Total energy = 12894.8803 kcal/mol (12869.5265 without restraints) Performing minimization step: 3228. Total energy = 12887.8887 kcal/mol (12862.5366 without restraints) Performing minimization step: 3229. Total energy = 12880.8992 kcal/mol (12855.5487 without restraints) Performing minimization step: 3230. Total energy = 12873.9121 kcal/mol (12848.5633 without restraints) Performing minimization step: 3231. Total energy = 12866.9273 kcal/mol (12841.5803 without restraints) Performing minimization step: 3232. Total energy = 12859.9447 kcal/mol (12834.5993 without restraints) Performing minimization step: 3233. Total energy = 12852.9643 kcal/mol (12827.6206 without restraints) Performing minimization step: 3234. Total energy = 12845.9863 kcal/mol (12820.6442 without restraints) Performing minimization step: 3235. Total energy = 12839.0104 kcal/mol (12813.6701 without restraints) Performing minimization step: 3236. Total energy = 12832.0372 kcal/mol (12806.6986 without restraints) Performing minimization step: 3237. Total energy = 12825.0660 kcal/mol (12799.7290 without restraints) Performing minimization step: 3238. Total energy = 12818.0971 kcal/mol (12792.7618 without restraints) Performing minimization step: 3239. Total energy = 12811.1302 kcal/mol (12785.7966 without restraints) Performing minimization step: 3240. Total energy = 12804.1658 kcal/mol (12778.8338 without restraints) Performing minimization step: 3241. Total energy = 12797.2037 kcal/mol (12771.8734 without restraints) Performing minimization step: 3242. Total energy = 12790.2441 kcal/mol (12764.9156 without restraints) Performing minimization step: 3243. Total energy = 12783.2869 kcal/mol (12757.9603 without restraints) Performing minimization step: 3244. Total energy = 12776.3321 kcal/mol (12751.0070 without restraints) Performing minimization step: 3245. Total energy = 12769.3792 kcal/mol (12744.0558 without restraints) Performing minimization step: 3246. Total energy = 12762.4286 kcal/mol (12737.1069 without restraints) Performing minimization step: 3247. Total energy = 12755.4804 kcal/mol (12730.1603 without restraints) Performing minimization step: 3248. Total energy = 12748.5344 kcal/mol (12723.2160 without restraints) Performing minimization step: 3249. Total energy = 12741.5907 kcal/mol (12716.2740 without restraints) Performing minimization step: 3250. Total energy = 12734.6495 kcal/mol (12709.3345 without restraints) Performing minimization step: 3251. Total energy = 12727.7105 kcal/mol (12702.3972 without restraints) Performing minimization step: 3252. Total energy = 12720.7739 kcal/mol (12695.4623 without restraints) Performing minimization step: 3253. Total energy = 12713.8397 kcal/mol (12688.5298 without restraints) Performing minimization step: 3254. Total energy = 12706.9076 kcal/mol (12681.5994 without restraints) Performing minimization step: 3255. Total energy = 12699.9778 kcal/mol (12674.6712 without restraints) Performing minimization step: 3256. Total energy = 12693.0504 kcal/mol (12667.7457 without restraints) Performing minimization step: 3257. Total energy = 12686.1255 kcal/mol (12660.8224 without restraints) Performing minimization step: 3258. Total energy = 12679.2029 kcal/mol (12653.9015 without restraints) Performing minimization step: 3259. Total energy = 12672.2824 kcal/mol (12646.9826 without restraints) Performing minimization step: 3260. Total energy = 12665.3643 kcal/mol (12640.0663 without restraints) Performing minimization step: 3261. Total energy = 12658.4484 kcal/mol (12633.1521 without restraints) Performing minimization step: 3262. Total energy = 12651.5349 kcal/mol (12626.2403 without restraints) Performing minimization step: 3263. Total energy = 12644.6237 kcal/mol (12619.3307 without restraints) Performing minimization step: 3264. Total energy = 12637.7148 kcal/mol (12612.4235 without restraints) Performing minimization step: 3265. Total energy = 12630.8083 kcal/mol (12605.5187 without restraints) Performing minimization step: 3266. Total energy = 12623.9041 kcal/mol (12598.6162 without restraints) Performing minimization step: 3267. Total energy = 12617.0022 kcal/mol (12591.7160 without restraints) Performing minimization step: 3268. Total energy = 12610.1027 kcal/mol (12584.8182 without restraints) Performing minimization step: 3269. Total energy = 12603.2055 kcal/mol (12577.9227 without restraints) Performing minimization step: 3270. Total energy = 12596.3106 kcal/mol (12571.0296 without restraints) Performing minimization step: 3271. Total energy = 12589.4182 kcal/mol (12564.1388 without restraints) Performing minimization step: 3272. Total energy = 12582.5280 kcal/mol (12557.2503 without restraints) Performing minimization step: 3273. Total energy = 12575.6401 kcal/mol (12550.3640 without restraints) Performing minimization step: 3274. Total energy = 12568.7546 kcal/mol (12543.4802 without restraints) Performing minimization step: 3275. Total energy = 12561.8716 kcal/mol (12536.5990 without restraints) Performing minimization step: 3276. Total energy = 12554.9909 kcal/mol (12529.7201 without restraints) Performing minimization step: 3277. Total energy = 12548.1126 kcal/mol (12522.8434 without restraints) Performing minimization step: 3278. Total energy = 12541.2365 kcal/mol (12515.9690 without restraints) Performing minimization step: 3279. Total energy = 12534.3629 kcal/mol (12509.0972 without restraints) Performing minimization step: 3280. Total energy = 12527.4917 kcal/mol (12502.2276 without restraints) Performing minimization step: 3281. Total energy = 12520.6227 kcal/mol (12495.3602 without restraints) Performing minimization step: 3282. Total energy = 12513.7558 kcal/mol (12488.4951 without restraints) Performing minimization step: 3283. Total energy = 12506.8914 kcal/mol (12481.6324 without restraints) Performing minimization step: 3284. Total energy = 12500.0298 kcal/mol (12474.7724 without restraints) Performing minimization step: 3285. Total energy = 12493.1703 kcal/mol (12467.9146 without restraints) Performing minimization step: 3286. Total energy = 12486.3127 kcal/mol (12461.0587 without restraints) Performing minimization step: 3287. Total energy = 12479.4585 kcal/mol (12454.2063 without restraints) Performing minimization step: 3288. Total energy = 12472.6060 kcal/mol (12447.3555 without restraints) Performing minimization step: 3289. Total energy = 12465.7560 kcal/mol (12440.5072 without restraints) Performing minimization step: 3290. Total energy = 12458.9084 kcal/mol (12433.6612 without restraints) Performing minimization step: 3291. Total energy = 12452.0631 kcal/mol (12426.8176 without restraints) Performing minimization step: 3292. Total energy = 12445.2205 kcal/mol (12419.9767 without restraints) Performing minimization step: 3293. Total energy = 12438.3800 kcal/mol (12413.1379 without restraints) Performing minimization step: 3294. Total energy = 12431.5416 kcal/mol (12406.3013 without restraints) Performing minimization step: 3295. Total energy = 12424.7059 kcal/mol (12399.4673 without restraints) Performing minimization step: 3296. Total energy = 12417.8725 kcal/mol (12392.6356 without restraints) Performing minimization step: 3297. Total energy = 12411.0415 kcal/mol (12385.8063 without restraints) Performing minimization step: 3298. Total energy = 12404.2131 kcal/mol (12378.9796 without restraints) Performing minimization step: 3299. Total energy = 12397.3869 kcal/mol (12372.1551 without restraints) Performing minimization step: 3300. Total energy = 12390.5632 kcal/mol (12365.3332 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3301. Total energy = 12383.7416 kcal/mol (12358.5132 without restraints) Performing minimization step: 3302. Total energy = 12376.9226 kcal/mol (12351.6959 without restraints) Performing minimization step: 3303. Total energy = 12370.1060 kcal/mol (12344.8810 without restraints) Performing minimization step: 3304. Total energy = 12363.2917 kcal/mol (12338.0684 without restraints) Performing minimization step: 3305. Total energy = 12356.4799 kcal/mol (12331.2583 without restraints) Performing minimization step: 3306. Total energy = 12349.6705 kcal/mol (12324.4506 without restraints) Performing minimization step: 3307. Total energy = 12342.8638 kcal/mol (12317.6456 without restraints) Performing minimization step: 3308. Total energy = 12336.0592 kcal/mol (12310.8427 without restraints) Performing minimization step: 3309. Total energy = 12329.2569 kcal/mol (12304.0423 without restraints) Performing minimization step: 3310. Total energy = 12322.4573 kcal/mol (12297.2444 without restraints) Performing minimization step: 3311. Total energy = 12315.6601 kcal/mol (12290.4487 without restraints) Performing minimization step: 3312. Total energy = 12308.8651 kcal/mol (12283.6555 without restraints) Performing minimization step: 3313. Total energy = 12302.0728 kcal/mol (12276.8649 without restraints) Performing minimization step: 3314. Total energy = 12295.2829 kcal/mol (12270.0767 without restraints) Performing minimization step: 3315. Total energy = 12288.4952 kcal/mol (12263.2907 without restraints) Performing minimization step: 3316. Total energy = 12281.7100 kcal/mol (12256.5072 without restraints) Performing minimization step: 3317. Total energy = 12274.9272 kcal/mol (12249.7261 without restraints) Performing minimization step: 3318. Total energy = 12268.1470 kcal/mol (12242.9476 without restraints) Performing minimization step: 3319. Total energy = 12261.3691 kcal/mol (12236.1714 without restraints) Performing minimization step: 3320. Total energy = 12254.5936 kcal/mol (12229.3976 without restraints) Performing minimization step: 3321. Total energy = 12247.8204 kcal/mol (12222.6262 without restraints) Performing minimization step: 3322. Total energy = 12241.0497 kcal/mol (12215.8572 without restraints) Performing minimization step: 3323. Total energy = 12234.2815 kcal/mol (12209.0907 without restraints) Performing minimization step: 3324. Total energy = 12227.5157 kcal/mol (12202.3266 without restraints) Performing minimization step: 3325. Total energy = 12220.7524 kcal/mol (12195.5650 without restraints) Performing minimization step: 3326. Total energy = 12213.9915 kcal/mol (12188.8058 without restraints) Performing minimization step: 3327. Total energy = 12207.2330 kcal/mol (12182.0490 without restraints) Performing minimization step: 3328. Total energy = 12200.4770 kcal/mol (12175.2947 without restraints) Performing minimization step: 3329. Total energy = 12193.7235 kcal/mol (12168.5429 without restraints) Performing minimization step: 3330. Total energy = 12186.9727 kcal/mol (12161.7939 without restraints) Performing minimization step: 3331. Total energy = 12180.2239 kcal/mol (12155.0467 without restraints) Performing minimization step: 3332. Total energy = 12173.4778 kcal/mol (12148.3024 without restraints) Performing minimization step: 3333. Total energy = 12166.7342 kcal/mol (12141.5603 without restraints) Performing minimization step: 3334. Total energy = 12159.9929 kcal/mol (12134.8210 without restraints) Performing minimization step: 3335. Total energy = 12153.2542 kcal/mol (12128.0840 without restraints) Performing minimization step: 3336. Total energy = 12146.5180 kcal/mol (12121.3494 without restraints) Performing minimization step: 3337. Total energy = 12139.7841 kcal/mol (12114.6173 without restraints) Performing minimization step: 3338. Total energy = 12133.0527 kcal/mol (12107.8876 without restraints) Performing minimization step: 3339. Total energy = 12126.3237 kcal/mol (12101.1603 without restraints) Performing minimization step: 3340. Total energy = 12119.5972 kcal/mol (12094.4355 without restraints) Performing minimization step: 3341. Total energy = 12112.8732 kcal/mol (12087.7132 without restraints) Performing minimization step: 3342. Total energy = 12106.1516 kcal/mol (12080.9934 without restraints) Performing minimization step: 3343. Total energy = 12099.4326 kcal/mol (12074.2760 without restraints) Performing minimization step: 3344. Total energy = 12092.7161 kcal/mol (12067.5612 without restraints) Performing minimization step: 3345. Total energy = 12086.0017 kcal/mol (12060.8485 without restraints) Performing minimization step: 3346. Total energy = 12079.2900 kcal/mol (12054.1386 without restraints) Performing minimization step: 3347. Total energy = 12072.5807 kcal/mol (12047.4310 without restraints) Performing minimization step: 3348. Total energy = 12065.8741 kcal/mol (12040.7262 without restraints) Performing minimization step: 3349. Total energy = 12059.1699 kcal/mol (12034.0237 without restraints) Performing minimization step: 3350. Total energy = 12052.4683 kcal/mol (12027.3237 without restraints) Performing minimization step: 3351. Total energy = 12045.7691 kcal/mol (12020.6263 without restraints) Performing minimization step: 3352. Total energy = 12039.0723 kcal/mol (12013.9312 without restraints) Performing minimization step: 3353. Total energy = 12032.3781 kcal/mol (12007.2388 without restraints) Performing minimization step: 3354. Total energy = 12025.6864 kcal/mol (12000.5487 without restraints) Performing minimization step: 3355. Total energy = 12018.9972 kcal/mol (11993.8612 without restraints) Performing minimization step: 3356. Total energy = 12012.3100 kcal/mol (11987.1758 without restraints) Performing minimization step: 3357. Total energy = 12005.6258 kcal/mol (11980.4933 without restraints) Performing minimization step: 3358. Total energy = 11998.9441 kcal/mol (11973.8133 without restraints) Performing minimization step: 3359. Total energy = 11992.2649 kcal/mol (11967.1358 without restraints) Performing minimization step: 3360. Total energy = 11985.5883 kcal/mol (11960.4609 without restraints) Performing minimization step: 3361. Total energy = 11978.9141 kcal/mol (11953.7885 without restraints) Performing minimization step: 3362. Total energy = 11972.2424 kcal/mol (11947.1185 without restraints) Performing minimization step: 3363. Total energy = 11965.5733 kcal/mol (11940.4511 without restraints) Performing minimization step: 3364. Total energy = 11958.9070 kcal/mol (11933.7867 without restraints) Performing minimization step: 3365. Total energy = 11952.2430 kcal/mol (11927.1243 without restraints) Performing minimization step: 3366. Total energy = 11945.5817 kcal/mol (11920.4646 without restraints) Performing minimization step: 3367. Total energy = 11938.9227 kcal/mol (11913.8074 without restraints) Performing minimization step: 3368. Total energy = 11932.2661 kcal/mol (11907.1526 without restraints) Performing minimization step: 3369. Total energy = 11925.6123 kcal/mol (11900.5006 without restraints) Performing minimization step: 3370. Total energy = 11918.9609 kcal/mol (11893.8507 without restraints) Performing minimization step: 3371. Total energy = 11912.3119 kcal/mol (11887.2035 without restraints) Performing minimization step: 3372. Total energy = 11905.6655 kcal/mol (11880.5589 without restraints) Performing minimization step: 3373. Total energy = 11899.0216 kcal/mol (11873.9166 without restraints) Performing minimization step: 3374. Total energy = 11892.3804 kcal/mol (11867.2771 without restraints) Performing minimization step: 3375. Total energy = 11885.7418 kcal/mol (11860.6403 without restraints) Performing minimization step: 3376. Total energy = 11879.1055 kcal/mol (11854.0057 without restraints) Performing minimization step: 3377. Total energy = 11872.4720 kcal/mol (11847.3739 without restraints) Performing minimization step: 3378. Total energy = 11865.8408 kcal/mol (11840.7445 without restraints) Performing minimization step: 3379. Total energy = 11859.2122 kcal/mol (11834.1176 without restraints) Performing minimization step: 3380. Total energy = 11852.5862 kcal/mol (11827.4933 without restraints) Performing minimization step: 3381. Total energy = 11845.9629 kcal/mol (11820.8718 without restraints) Performing minimization step: 3382. Total energy = 11839.3422 kcal/mol (11814.2529 without restraints) Performing minimization step: 3383. Total energy = 11832.7237 kcal/mol (11807.6360 without restraints) Performing minimization step: 3384. Total energy = 11826.1079 kcal/mol (11801.0220 without restraints) Performing minimization step: 3385. Total energy = 11819.4947 kcal/mol (11794.4105 without restraints) Performing minimization step: 3386. Total energy = 11812.8840 kcal/mol (11787.8015 without restraints) Performing minimization step: 3387. Total energy = 11806.2760 kcal/mol (11781.1953 without restraints) Performing minimization step: 3388. Total energy = 11799.6706 kcal/mol (11774.5916 without restraints) Performing minimization step: 3389. Total energy = 11793.0679 kcal/mol (11767.9906 without restraints) Performing minimization step: 3390. Total energy = 11786.4675 kcal/mol (11761.3919 without restraints) Performing minimization step: 3391. Total energy = 11779.8699 kcal/mol (11754.7961 without restraints) Performing minimization step: 3392. Total energy = 11773.2750 kcal/mol (11748.2029 without restraints) Performing minimization step: 3393. Total energy = 11766.6826 kcal/mol (11741.6122 without restraints) Performing minimization step: 3394. Total energy = 11760.0921 kcal/mol (11735.0234 without restraints) Performing minimization step: 3395. Total energy = 11753.5045 kcal/mol (11728.4376 without restraints) Performing minimization step: 3396. Total energy = 11746.9196 kcal/mol (11721.8545 without restraints) Performing minimization step: 3397. Total energy = 11740.3373 kcal/mol (11715.2739 without restraints) Performing minimization step: 3398. Total energy = 11733.7576 kcal/mol (11708.6959 without restraints) Performing minimization step: 3399. Total energy = 11727.1806 kcal/mol (11702.1207 without restraints) Performing minimization step: 3400. Total energy = 11720.6061 kcal/mol (11695.5479 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3401. Total energy = 11714.0342 kcal/mol (11688.9777 without restraints) Performing minimization step: 3402. Total energy = 11707.4648 kcal/mol (11682.4101 without restraints) Performing minimization step: 3403. Total energy = 11700.8980 kcal/mol (11675.8451 without restraints) Performing minimization step: 3404. Total energy = 11694.3339 kcal/mol (11669.2827 without restraints) Performing minimization step: 3405. Total energy = 11687.7726 kcal/mol (11662.7230 without restraints) Performing minimization step: 3406. Total energy = 11681.2136 kcal/mol (11656.1659 without restraints) Performing minimization step: 3407. Total energy = 11674.6574 kcal/mol (11649.6114 without restraints) Performing minimization step: 3408. Total energy = 11668.1037 kcal/mol (11643.0594 without restraints) Performing minimization step: 3409. Total energy = 11661.5528 kcal/mol (11636.5103 without restraints) Performing minimization step: 3410. Total energy = 11655.0045 kcal/mol (11629.9638 without restraints) Performing minimization step: 3411. Total energy = 11648.4586 kcal/mol (11623.4195 without restraints) Performing minimization step: 3412. Total energy = 11641.9153 kcal/mol (11616.8780 without restraints) Performing minimization step: 3413. Total energy = 11635.3747 kcal/mol (11610.3391 without restraints) Performing minimization step: 3414. Total energy = 11628.8367 kcal/mol (11603.8029 without restraints) Performing minimization step: 3415. Total energy = 11622.3014 kcal/mol (11597.2693 without restraints) Performing minimization step: 3416. Total energy = 11615.7687 kcal/mol (11590.7384 without restraints) Performing minimization step: 3417. Total energy = 11609.2387 kcal/mol (11584.2100 without restraints) Performing minimization step: 3418. Total energy = 11602.7112 kcal/mol (11577.6844 without restraints) Performing minimization step: 3419. Total energy = 11596.1864 kcal/mol (11571.1613 without restraints) Performing minimization step: 3420. Total energy = 11589.6644 kcal/mol (11564.6411 without restraints) Performing minimization step: 3421. Total energy = 11583.1450 kcal/mol (11558.1233 without restraints) Performing minimization step: 3422. Total energy = 11576.6283 kcal/mol (11551.6084 without restraints) Performing minimization step: 3423. Total energy = 11570.1141 kcal/mol (11545.0959 without restraints) Performing minimization step: 3424. Total energy = 11563.6025 kcal/mol (11538.5861 without restraints) Performing minimization step: 3425. Total energy = 11557.0938 kcal/mol (11532.0792 without restraints) Performing minimization step: 3426. Total energy = 11550.5876 kcal/mol (11525.5747 without restraints) Performing minimization step: 3427. Total energy = 11544.0840 kcal/mol (11519.0729 without restraints) Performing minimization step: 3428. Total energy = 11537.5830 kcal/mol (11512.5735 without restraints) Performing minimization step: 3429. Total energy = 11531.0845 kcal/mol (11506.0768 without restraints) Performing minimization step: 3430. Total energy = 11524.5890 kcal/mol (11499.5831 without restraints) Performing minimization step: 3431. Total energy = 11518.0959 kcal/mol (11493.0917 without restraints) Performing minimization step: 3432. Total energy = 11511.6058 kcal/mol (11486.6034 without restraints) Performing minimization step: 3433. Total energy = 11505.1182 kcal/mol (11480.1175 without restraints) Performing minimization step: 3434. Total energy = 11498.6331 kcal/mol (11473.6341 without restraints) Performing minimization step: 3435. Total energy = 11492.1508 kcal/mol (11467.1536 without restraints) Performing minimization step: 3436. Total energy = 11485.6712 kcal/mol (11460.6757 without restraints) Performing minimization step: 3437. Total energy = 11479.1943 kcal/mol (11454.2006 without restraints) Performing minimization step: 3438. Total energy = 11472.7201 kcal/mol (11447.7281 without restraints) Performing minimization step: 3439. Total energy = 11466.2485 kcal/mol (11441.2584 without restraints) Performing minimization step: 3440. Total energy = 11459.7796 kcal/mol (11434.7912 without restraints) Performing minimization step: 3441. Total energy = 11453.3134 kcal/mol (11428.3267 without restraints) Performing minimization step: 3442. Total energy = 11446.8498 kcal/mol (11421.8649 without restraints) Performing minimization step: 3443. Total energy = 11440.3890 kcal/mol (11415.4059 without restraints) Performing minimization step: 3444. Total energy = 11433.9309 kcal/mol (11408.9495 without restraints) Performing minimization step: 3445. Total energy = 11427.4755 kcal/mol (11402.4959 without restraints) Performing minimization step: 3446. Total energy = 11421.0228 kcal/mol (11396.0449 without restraints) Performing minimization step: 3447. Total energy = 11414.5730 kcal/mol (11389.5968 without restraints) Performing minimization step: 3448. Total energy = 11408.1261 kcal/mol (11383.1517 without restraints) Performing minimization step: 3449. Total energy = 11401.6814 kcal/mol (11376.7088 without restraints) Performing minimization step: 3450. Total energy = 11395.2396 kcal/mol (11370.2687 without restraints) Performing minimization step: 3451. Total energy = 11388.8007 kcal/mol (11363.8316 without restraints) Performing minimization step: 3452. Total energy = 11382.3642 kcal/mol (11357.3968 without restraints) Performing minimization step: 3453. Total energy = 11375.9305 kcal/mol (11350.9649 without restraints) Performing minimization step: 3454. Total energy = 11369.4994 kcal/mol (11344.5356 without restraints) Performing minimization step: 3455. Total energy = 11363.0711 kcal/mol (11338.1090 without restraints) Performing minimization step: 3456. Total energy = 11356.6458 kcal/mol (11331.6855 without restraints) Performing minimization step: 3457. Total energy = 11350.2229 kcal/mol (11325.2644 without restraints) Performing minimization step: 3458. Total energy = 11343.8028 kcal/mol (11318.8460 without restraints) Performing minimization step: 3459. Total energy = 11337.3854 kcal/mol (11312.4303 without restraints) Performing minimization step: 3460. Total energy = 11330.9706 kcal/mol (11306.0173 without restraints) Performing minimization step: 3461. Total energy = 11324.5587 kcal/mol (11299.6072 without restraints) Performing minimization step: 3462. Total energy = 11318.1495 kcal/mol (11293.1997 without restraints) Performing minimization step: 3463. Total energy = 11311.7431 kcal/mol (11286.7952 without restraints) Performing minimization step: 3464. Total energy = 11305.3394 kcal/mol (11280.3932 without restraints) Performing minimization step: 3465. Total energy = 11298.9384 kcal/mol (11273.9940 without restraints) Performing minimization step: 3466. Total energy = 11292.5402 kcal/mol (11267.5975 without restraints) Performing minimization step: 3467. Total energy = 11286.1447 kcal/mol (11261.2038 without restraints) Performing minimization step: 3468. Total energy = 11279.7520 kcal/mol (11254.8128 without restraints) Performing minimization step: 3469. Total energy = 11273.3620 kcal/mol (11248.4246 without restraints) Performing minimization step: 3470. Total energy = 11266.9748 kcal/mol (11242.0391 without restraints) Performing minimization step: 3471. Total energy = 11260.5903 kcal/mol (11235.6564 without restraints) Performing minimization step: 3472. Total energy = 11254.2085 kcal/mol (11229.2764 without restraints) Performing minimization step: 3473. Total energy = 11247.8296 kcal/mol (11222.8993 without restraints) Performing minimization step: 3474. Total energy = 11241.4532 kcal/mol (11216.5246 without restraints) Performing minimization step: 3475. Total energy = 11235.0800 kcal/mol (11210.1532 without restraints) Performing minimization step: 3476. Total energy = 11228.7095 kcal/mol (11203.7843 without restraints) Performing minimization step: 3477. Total energy = 11222.3415 kcal/mol (11197.4182 without restraints) Performing minimization step: 3478. Total energy = 11215.9763 kcal/mol (11191.0548 without restraints) Performing minimization step: 3479. Total energy = 11209.6139 kcal/mol (11184.6941 without restraints) Performing minimization step: 3480. Total energy = 11203.2543 kcal/mol (11178.3363 without restraints) Performing minimization step: 3481. Total energy = 11196.8971 kcal/mol (11171.9810 without restraints) Performing minimization step: 3482. Total energy = 11190.5428 kcal/mol (11165.6284 without restraints) Performing minimization step: 3483. Total energy = 11184.1917 kcal/mol (11159.2790 without restraints) Performing minimization step: 3484. Total energy = 11177.8433 kcal/mol (11152.9324 without restraints) Performing minimization step: 3485. Total energy = 11171.4976 kcal/mol (11146.5885 without restraints) Performing minimization step: 3486. Total energy = 11165.1550 kcal/mol (11140.2476 without restraints) Performing minimization step: 3487. Total energy = 11158.8153 kcal/mol (11133.9098 without restraints) Performing minimization step: 3488. Total energy = 11152.4783 kcal/mol (11127.5745 without restraints) Performing minimization step: 3489. Total energy = 11146.1438 kcal/mol (11121.2418 without restraints) Performing minimization step: 3490. Total energy = 11139.8122 kcal/mol (11114.9120 without restraints) Performing minimization step: 3491. Total energy = 11133.4833 kcal/mol (11108.5848 without restraints) Performing minimization step: 3492. Total energy = 11127.1575 kcal/mol (11102.2608 without restraints) Performing minimization step: 3493. Total energy = 11120.8343 kcal/mol (11095.9394 without restraints) Performing minimization step: 3494. Total energy = 11114.5140 kcal/mol (11089.6210 without restraints) Performing minimization step: 3495. Total energy = 11108.1965 kcal/mol (11083.3052 without restraints) Performing minimization step: 3496. Total energy = 11101.8815 kcal/mol (11076.9919 without restraints) Performing minimization step: 3497. Total energy = 11095.5696 kcal/mol (11070.6818 without restraints) Performing minimization step: 3498. Total energy = 11089.2605 kcal/mol (11064.3745 without restraints) Performing minimization step: 3499. Total energy = 11082.9542 kcal/mol (11058.0700 without restraints) Performing minimization step: 3500. Total energy = 11076.6510 kcal/mol (11051.7685 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3501. Total energy = 11070.3506 kcal/mol (11045.4699 without restraints) Performing minimization step: 3502. Total energy = 11064.0529 kcal/mol (11039.1741 without restraints) Performing minimization step: 3503. Total energy = 11057.7580 kcal/mol (11032.8809 without restraints) Performing minimization step: 3504. Total energy = 11051.4660 kcal/mol (11026.5907 without restraints) Performing minimization step: 3505. Total energy = 11045.1767 kcal/mol (11020.3032 without restraints) Performing minimization step: 3506. Total energy = 11038.8901 kcal/mol (11014.0183 without restraints) Performing minimization step: 3507. Total energy = 11032.6064 kcal/mol (11007.7365 without restraints) Performing minimization step: 3508. Total energy = 11026.3256 kcal/mol (11001.4574 without restraints) Performing minimization step: 3509. Total energy = 11020.0477 kcal/mol (10995.1814 without restraints) Performing minimization step: 3510. Total energy = 11013.7730 kcal/mol (10988.9084 without restraints) Performing minimization step: 3511. Total energy = 11007.5006 kcal/mol (10982.6378 without restraints) Performing minimization step: 3512. Total energy = 11001.2315 kcal/mol (10976.3705 without restraints) Performing minimization step: 3513. Total energy = 10994.9651 kcal/mol (10970.1058 without restraints) Performing minimization step: 3514. Total energy = 10988.7014 kcal/mol (10963.8440 without restraints) Performing minimization step: 3515. Total energy = 10982.4407 kcal/mol (10957.5850 without restraints) Performing minimization step: 3516. Total energy = 10976.1828 kcal/mol (10951.3289 without restraints) Performing minimization step: 3517. Total energy = 10969.9278 kcal/mol (10945.0757 without restraints) Performing minimization step: 3518. Total energy = 10963.6756 kcal/mol (10938.8253 without restraints) Performing minimization step: 3519. Total energy = 10957.4264 kcal/mol (10932.5779 without restraints) Performing minimization step: 3520. Total energy = 10951.1800 kcal/mol (10926.3333 without restraints) Performing minimization step: 3521. Total energy = 10944.9369 kcal/mol (10920.0920 without restraints) Performing minimization step: 3522. Total energy = 10938.6965 kcal/mol (10913.8534 without restraints) Performing minimization step: 3523. Total energy = 10932.4588 kcal/mol (10907.6175 without restraints) Performing minimization step: 3524. Total energy = 10926.2240 kcal/mol (10901.3845 without restraints) Performing minimization step: 3525. Total energy = 10919.9920 kcal/mol (10895.1541 without restraints) Performing minimization step: 3526. Total energy = 10913.7630 kcal/mol (10888.9271 without restraints) Performing minimization step: 3527. Total energy = 10907.5367 kcal/mol (10882.7024 without restraints) Performing minimization step: 3528. Total energy = 10901.3132 kcal/mol (10876.4809 without restraints) Performing minimization step: 3529. Total energy = 10895.0929 kcal/mol (10870.2623 without restraints) Performing minimization step: 3530. Total energy = 10888.8755 kcal/mol (10864.0468 without restraints) Performing minimization step: 3531. Total energy = 10882.6607 kcal/mol (10857.8337 without restraints) Performing minimization step: 3532. Total energy = 10876.4491 kcal/mol (10851.6239 without restraints) Performing minimization step: 3533. Total energy = 10870.2403 kcal/mol (10845.4169 without restraints) Performing minimization step: 3534. Total energy = 10864.0344 kcal/mol (10839.2128 without restraints) Performing minimization step: 3535. Total energy = 10857.8312 kcal/mol (10833.0114 without restraints) Performing minimization step: 3536. Total energy = 10851.6312 kcal/mol (10826.8134 without restraints) Performing minimization step: 3537. Total energy = 10845.4344 kcal/mol (10820.6182 without restraints) Performing minimization step: 3538. Total energy = 10839.2400 kcal/mol (10814.4256 without restraints) Performing minimization step: 3539. Total energy = 10833.0488 kcal/mol (10808.2362 without restraints) Performing minimization step: 3540. Total energy = 10826.8604 kcal/mol (10802.0497 without restraints) Performing minimization step: 3541. Total energy = 10820.6754 kcal/mol (10795.8665 without restraints) Performing minimization step: 3542. Total energy = 10814.4931 kcal/mol (10789.6860 without restraints) Performing minimization step: 3543. Total energy = 10808.3136 kcal/mol (10783.5082 without restraints) Performing minimization step: 3544. Total energy = 10802.1368 kcal/mol (10777.3333 without restraints) Performing minimization step: 3545. Total energy = 10795.9631 kcal/mol (10771.1614 without restraints) Performing minimization step: 3546. Total energy = 10789.7924 kcal/mol (10764.9925 without restraints) Performing minimization step: 3547. Total energy = 10783.6246 kcal/mol (10758.8265 without restraints) Performing minimization step: 3548. Total energy = 10777.4597 kcal/mol (10752.6634 without restraints) Performing minimization step: 3549. Total energy = 10771.2976 kcal/mol (10746.5031 without restraints) Performing minimization step: 3550. Total energy = 10765.1387 kcal/mol (10740.3460 without restraints) Performing minimization step: 3551. Total energy = 10758.9828 kcal/mol (10734.1919 without restraints) Performing minimization step: 3552. Total energy = 10752.8297 kcal/mol (10728.0405 without restraints) Performing minimization step: 3553. Total energy = 10746.6798 kcal/mol (10721.8927 without restraints) Performing minimization step: 3554. Total energy = 10740.5325 kcal/mol (10715.7471 without restraints) Performing minimization step: 3555. Total energy = 10734.3884 kcal/mol (10709.6048 without restraints) Performing minimization step: 3556. Total energy = 10728.2474 kcal/mol (10703.4656 without restraints) Performing minimization step: 3557. Total energy = 10722.1091 kcal/mol (10697.3291 without restraints) Performing minimization step: 3558. Total energy = 10715.9739 kcal/mol (10691.1957 without restraints) Performing minimization step: 3559. Total energy = 10709.8418 kcal/mol (10685.0656 without restraints) Performing minimization step: 3560. Total energy = 10703.7127 kcal/mol (10678.9381 without restraints) Performing minimization step: 3561. Total energy = 10697.5862 kcal/mol (10672.8134 without restraints) Performing minimization step: 3562. Total energy = 10691.4627 kcal/mol (10666.6918 without restraints) Performing minimization step: 3563. Total energy = 10685.3424 kcal/mol (10660.5734 without restraints) Performing minimization step: 3564. Total energy = 10679.2252 kcal/mol (10654.4579 without restraints) Performing minimization step: 3565. Total energy = 10673.1107 kcal/mol (10648.3452 without restraints) Performing minimization step: 3566. Total energy = 10666.9993 kcal/mol (10642.2356 without restraints) Performing minimization step: 3567. Total energy = 10660.8908 kcal/mol (10636.1289 without restraints) Performing minimization step: 3568. Total energy = 10654.7854 kcal/mol (10630.0253 without restraints) Performing minimization step: 3569. Total energy = 10648.6830 kcal/mol (10623.9247 without restraints) Performing minimization step: 3570. Total energy = 10642.5836 kcal/mol (10617.8272 without restraints) Performing minimization step: 3571. Total energy = 10636.4872 kcal/mol (10611.7326 without restraints) Performing minimization step: 3572. Total energy = 10630.3939 kcal/mol (10605.6413 without restraints) Performing minimization step: 3573. Total energy = 10624.3037 kcal/mol (10599.5527 without restraints) Performing minimization step: 3574. Total energy = 10618.2163 kcal/mol (10593.4672 without restraints) Performing minimization step: 3575. Total energy = 10612.1320 kcal/mol (10587.3848 without restraints) Performing minimization step: 3576. Total energy = 10606.0507 kcal/mol (10581.3052 without restraints) Performing minimization step: 3577. Total energy = 10599.9721 kcal/mol (10575.2284 without restraints) Performing minimization step: 3578. Total energy = 10593.8966 kcal/mol (10569.1548 without restraints) Performing minimization step: 3579. Total energy = 10587.8245 kcal/mol (10563.0845 without restraints) Performing minimization step: 3580. Total energy = 10581.7556 kcal/mol (10557.0175 without restraints) Performing minimization step: 3581. Total energy = 10575.6894 kcal/mol (10550.9531 without restraints) Performing minimization step: 3582. Total energy = 10569.6260 kcal/mol (10544.8913 without restraints) Performing minimization step: 3583. Total energy = 10563.5659 kcal/mol (10538.8333 without restraints) Performing minimization step: 3584. Total energy = 10557.5087 kcal/mol (10532.7778 without restraints) Performing minimization step: 3585. Total energy = 10551.4547 kcal/mol (10526.7256 without restraints) Performing minimization step: 3586. Total energy = 10545.4036 kcal/mol (10520.6764 without restraints) Performing minimization step: 3587. Total energy = 10539.3554 kcal/mol (10514.6300 without restraints) Performing minimization step: 3588. Total energy = 10533.3102 kcal/mol (10508.5867 without restraints) Performing minimization step: 3589. Total energy = 10527.2682 kcal/mol (10502.5465 without restraints) Performing minimization step: 3590. Total energy = 10521.2294 kcal/mol (10496.5095 without restraints) Performing minimization step: 3591. Total energy = 10515.1940 kcal/mol (10490.4759 without restraints) Performing minimization step: 3592. Total energy = 10509.1613 kcal/mol (10484.4451 without restraints) Performing minimization step: 3593. Total energy = 10503.1314 kcal/mol (10478.4170 without restraints) Performing minimization step: 3594. Total energy = 10497.1047 kcal/mol (10472.3922 without restraints) Performing minimization step: 3595. Total energy = 10491.0812 kcal/mol (10466.3704 without restraints) Performing minimization step: 3596. Total energy = 10485.0607 kcal/mol (10460.3518 without restraints) Performing minimization step: 3597. Total energy = 10479.0433 kcal/mol (10454.3362 without restraints) Performing minimization step: 3598. Total energy = 10473.0289 kcal/mol (10448.3237 without restraints) Performing minimization step: 3599. Total energy = 10467.0176 kcal/mol (10442.3143 without restraints) Performing minimization step: 3600. Total energy = 10461.0094 kcal/mol (10436.3081 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3601. Total energy = 10455.0045 kcal/mol (10430.3048 without restraints) Performing minimization step: 3602. Total energy = 10449.0025 kcal/mol (10424.3046 without restraints) Performing minimization step: 3603. Total energy = 10443.0035 kcal/mol (10418.3075 without restraints) Performing minimization step: 3604. Total energy = 10437.0079 kcal/mol (10412.3137 without restraints) Performing minimization step: 3605. Total energy = 10431.0152 kcal/mol (10406.3228 without restraints) Performing minimization step: 3606. Total energy = 10425.0252 kcal/mol (10400.3346 without restraints) Performing minimization step: 3607. Total energy = 10419.0383 kcal/mol (10394.3497 without restraints) Performing minimization step: 3608. Total energy = 10413.0549 kcal/mol (10388.3681 without restraints) Performing minimization step: 3609. Total energy = 10407.0748 kcal/mol (10382.3899 without restraints) Performing minimization step: 3610. Total energy = 10401.0974 kcal/mol (10376.4143 without restraints) Performing minimization step: 3611. Total energy = 10395.1231 kcal/mol (10370.4418 without restraints) Performing minimization step: 3612. Total energy = 10389.1516 kcal/mol (10364.4722 without restraints) Performing minimization step: 3613. Total energy = 10383.1836 kcal/mol (10358.5060 without restraints) Performing minimization step: 3614. Total energy = 10377.2188 kcal/mol (10352.5431 without restraints) Performing minimization step: 3615. Total energy = 10371.2572 kcal/mol (10346.5833 without restraints) Performing minimization step: 3616. Total energy = 10365.2986 kcal/mol (10340.6265 without restraints) Performing minimization step: 3617. Total energy = 10359.3431 kcal/mol (10334.6729 without restraints) Performing minimization step: 3618. Total energy = 10353.3908 kcal/mol (10328.7224 without restraints) Performing minimization step: 3619. Total energy = 10347.4415 kcal/mol (10322.7750 without restraints) Performing minimization step: 3620. Total energy = 10341.4954 kcal/mol (10316.8308 without restraints) Performing minimization step: 3621. Total energy = 10335.5527 kcal/mol (10310.8899 without restraints) Performing minimization step: 3622. Total energy = 10329.6129 kcal/mol (10304.9520 without restraints) Performing minimization step: 3623. Total energy = 10323.6762 kcal/mol (10299.0172 without restraints) Performing minimization step: 3624. Total energy = 10317.7429 kcal/mol (10293.0857 without restraints) Performing minimization step: 3625. Total energy = 10311.8127 kcal/mol (10287.1574 without restraints) Performing minimization step: 3626. Total energy = 10305.8855 kcal/mol (10281.2320 without restraints) Performing minimization step: 3627. Total energy = 10299.9612 kcal/mol (10275.3095 without restraints) Performing minimization step: 3628. Total energy = 10294.0402 kcal/mol (10269.3904 without restraints) Performing minimization step: 3629. Total energy = 10288.1224 kcal/mol (10263.4744 without restraints) Performing minimization step: 3630. Total energy = 10282.2077 kcal/mol (10257.5616 without restraints) Performing minimization step: 3631. Total energy = 10276.2962 kcal/mol (10251.6520 without restraints) Performing minimization step: 3632. Total energy = 10270.3879 kcal/mol (10245.7456 without restraints) Performing minimization step: 3633. Total energy = 10264.4828 kcal/mol (10239.8423 without restraints) Performing minimization step: 3634. Total energy = 10258.5808 kcal/mol (10233.9422 without restraints) Performing minimization step: 3635. Total energy = 10252.6820 kcal/mol (10228.0453 without restraints) Performing minimization step: 3636. Total energy = 10246.7865 kcal/mol (10222.1517 without restraints) Performing minimization step: 3637. Total energy = 10240.8941 kcal/mol (10216.2610 without restraints) Performing minimization step: 3638. Total energy = 10235.0048 kcal/mol (10210.3736 without restraints) Performing minimization step: 3639. Total energy = 10229.1187 kcal/mol (10204.4894 without restraints) Performing minimization step: 3640. Total energy = 10223.2358 kcal/mol (10198.6083 without restraints) Performing minimization step: 3641. Total energy = 10217.3561 kcal/mol (10192.7305 without restraints) Performing minimization step: 3642. Total energy = 10211.4795 kcal/mol (10186.8558 without restraints) Performing minimization step: 3643. Total energy = 10205.6064 kcal/mol (10180.9846 without restraints) Performing minimization step: 3644. Total energy = 10199.7361 kcal/mol (10175.1161 without restraints) Performing minimization step: 3645. Total energy = 10193.8689 kcal/mol (10169.2508 without restraints) Performing minimization step: 3646. Total energy = 10188.0050 kcal/mol (10163.3887 without restraints) Performing minimization step: 3647. Total energy = 10182.1446 kcal/mol (10157.5302 without restraints) Performing minimization step: 3648. Total energy = 10176.2871 kcal/mol (10151.6746 without restraints) Performing minimization step: 3649. Total energy = 10170.4329 kcal/mol (10145.8223 without restraints) Performing minimization step: 3650. Total energy = 10164.5821 kcal/mol (10139.9734 without restraints) Performing minimization step: 3651. Total energy = 10158.7344 kcal/mol (10134.1275 without restraints) Performing minimization step: 3652. Total energy = 10152.8900 kcal/mol (10128.2851 without restraints) Performing minimization step: 3653. Total energy = 10147.0488 kcal/mol (10122.4456 without restraints) Performing minimization step: 3654. Total energy = 10141.2107 kcal/mol (10116.6096 without restraints) Performing minimization step: 3655. Total energy = 10135.3760 kcal/mol (10110.7766 without restraints) Performing minimization step: 3656. Total energy = 10129.5443 kcal/mol (10104.9468 without restraints) Performing minimization step: 3657. Total energy = 10123.7157 kcal/mol (10099.1200 without restraints) Performing minimization step: 3658. Total energy = 10117.8903 kcal/mol (10093.2966 without restraints) Performing minimization step: 3659. Total energy = 10112.0684 kcal/mol (10087.4766 without restraints) Performing minimization step: 3660. Total energy = 10106.2500 kcal/mol (10081.6601 without restraints) Performing minimization step: 3661. Total energy = 10100.4350 kcal/mol (10075.8469 without restraints) Performing minimization step: 3662. Total energy = 10094.6229 kcal/mol (10070.0367 without restraints) Performing minimization step: 3663. Total energy = 10088.8139 kcal/mol (10064.2296 without restraints) Performing minimization step: 3664. Total energy = 10083.0081 kcal/mol (10058.4256 without restraints) Performing minimization step: 3665. Total energy = 10077.2061 kcal/mol (10052.6257 without restraints) Performing minimization step: 3666. Total energy = 10071.4075 kcal/mol (10046.8288 without restraints) Performing minimization step: 3667. Total energy = 10065.6114 kcal/mol (10041.0346 without restraints) Performing minimization step: 3668. Total energy = 10059.8186 kcal/mol (10035.2437 without restraints) Performing minimization step: 3669. Total energy = 10054.0292 kcal/mol (10029.4562 without restraints) Performing minimization step: 3670. Total energy = 10048.2432 kcal/mol (10023.6720 without restraints) Performing minimization step: 3671. Total energy = 10042.4601 kcal/mol (10017.8908 without restraints) Performing minimization step: 3672. Total energy = 10036.6806 kcal/mol (10012.1132 without restraints) Performing minimization step: 3673. Total energy = 10030.9041 kcal/mol (10006.3386 without restraints) Performing minimization step: 3674. Total energy = 10025.1312 kcal/mol (10000.5676 without restraints) Performing minimization step: 3675. Total energy = 10019.3612 kcal/mol (9994.7995 without restraints) Performing minimization step: 3676. Total energy = 10013.5947 kcal/mol (9989.0349 without restraints) Performing minimization step: 3677. Total energy = 10007.8314 kcal/mol (9983.2734 without restraints) Performing minimization step: 3678. Total energy = 10002.0710 kcal/mol (9977.5149 without restraints) Performing minimization step: 3679. Total energy = 9996.3142 kcal/mol (9971.7601 without restraints) Performing minimization step: 3680. Total energy = 9990.5605 kcal/mol (9966.0083 without restraints) Performing minimization step: 3681. Total energy = 9984.8103 kcal/mol (9960.2599 without restraints) Performing minimization step: 3682. Total energy = 9979.0633 kcal/mol (9954.5149 without restraints) Performing minimization step: 3683. Total energy = 9973.3197 kcal/mol (9948.7731 without restraints) Performing minimization step: 3684. Total energy = 9967.5793 kcal/mol (9943.0347 without restraints) Performing minimization step: 3685. Total energy = 9961.8420 kcal/mol (9937.2993 without restraints) Performing minimization step: 3686. Total energy = 9956.1083 kcal/mol (9931.5674 without restraints) Performing minimization step: 3687. Total energy = 9950.3780 kcal/mol (9925.8391 without restraints) Performing minimization step: 3688. Total energy = 9944.6512 kcal/mol (9920.1141 without restraints) Performing minimization step: 3689. Total energy = 9938.9275 kcal/mol (9914.3924 without restraints) Performing minimization step: 3690. Total energy = 9933.2071 kcal/mol (9908.6738 without restraints) Performing minimization step: 3691. Total energy = 9927.4898 kcal/mol (9902.9585 without restraints) Performing minimization step: 3692. Total energy = 9921.7761 kcal/mol (9897.2467 without restraints) Performing minimization step: 3693. Total energy = 9916.0655 kcal/mol (9891.5380 without restraints) Performing minimization step: 3694. Total energy = 9910.3584 kcal/mol (9885.8328 without restraints) Performing minimization step: 3695. Total energy = 9904.6542 kcal/mol (9880.1305 without restraints) Performing minimization step: 3696. Total energy = 9898.9541 kcal/mol (9874.4323 without restraints) Performing minimization step: 3697. Total energy = 9893.2573 kcal/mol (9868.7374 without restraints) Performing minimization step: 3698. Total energy = 9887.5634 kcal/mol (9863.0454 without restraints) Performing minimization step: 3699. Total energy = 9881.8728 kcal/mol (9857.3567 without restraints) Performing minimization step: 3700. Total energy = 9876.1858 kcal/mol (9851.6716 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3701. Total energy = 9870.5017 kcal/mol (9845.9896 without restraints) Performing minimization step: 3702. Total energy = 9864.8213 kcal/mol (9840.3109 without restraints) Performing minimization step: 3703. Total energy = 9859.1440 kcal/mol (9834.6356 without restraints) Performing minimization step: 3704. Total energy = 9853.4701 kcal/mol (9828.9636 without restraints) Performing minimization step: 3705. Total energy = 9847.7999 kcal/mol (9823.2954 without restraints) Performing minimization step: 3706. Total energy = 9842.1332 kcal/mol (9817.6305 without restraints) Performing minimization step: 3707. Total energy = 9836.4692 kcal/mol (9811.9684 without restraints) Performing minimization step: 3708. Total energy = 9830.8087 kcal/mol (9806.3098 without restraints) Performing minimization step: 3709. Total energy = 9825.1516 kcal/mol (9800.6546 without restraints) Performing minimization step: 3710. Total energy = 9819.4977 kcal/mol (9795.0026 without restraints) Performing minimization step: 3711. Total energy = 9813.8474 kcal/mol (9789.3543 without restraints) Performing minimization step: 3712. Total energy = 9808.2005 kcal/mol (9783.7094 without restraints) Performing minimization step: 3713. Total energy = 9802.5568 kcal/mol (9778.0675 without restraints) Performing minimization step: 3714. Total energy = 9796.9166 kcal/mol (9772.4293 without restraints) Performing minimization step: 3715. Total energy = 9791.2798 kcal/mol (9766.7944 without restraints) Performing minimization step: 3716. Total energy = 9785.6463 kcal/mol (9761.1628 without restraints) Performing minimization step: 3717. Total energy = 9780.0165 kcal/mol (9755.5349 without restraints) Performing minimization step: 3718. Total energy = 9774.3898 kcal/mol (9749.9102 without restraints) Performing minimization step: 3719. Total energy = 9768.7664 kcal/mol (9744.2887 without restraints) Performing minimization step: 3720. Total energy = 9763.1468 kcal/mol (9738.6711 without restraints) Performing minimization step: 3721. Total energy = 9757.5303 kcal/mol (9733.0564 without restraints) Performing minimization step: 3722. Total energy = 9751.9172 kcal/mol (9727.4453 without restraints) Performing minimization step: 3723. Total energy = 9746.3075 kcal/mol (9721.8375 without restraints) Performing minimization step: 3724. Total energy = 9740.7011 kcal/mol (9716.2331 without restraints) Performing minimization step: 3725. Total energy = 9735.0982 kcal/mol (9710.6320 without restraints) Performing minimization step: 3726. Total energy = 9729.4987 kcal/mol (9705.0345 without restraints) Performing minimization step: 3727. Total energy = 9723.9025 kcal/mol (9699.4402 without restraints) Performing minimization step: 3728. Total energy = 9718.3098 kcal/mol (9693.8494 without restraints) Performing minimization step: 3729. Total energy = 9712.7204 kcal/mol (9688.2620 without restraints) Performing minimization step: 3730. Total energy = 9707.1346 kcal/mol (9682.6781 without restraints) Performing minimization step: 3731. Total energy = 9701.5523 kcal/mol (9677.0978 without restraints) Performing minimization step: 3732. Total energy = 9695.9732 kcal/mol (9671.5207 without restraints) Performing minimization step: 3733. Total energy = 9690.3979 kcal/mol (9665.9475 without restraints) Performing minimization step: 3734. Total energy = 9684.8259 kcal/mol (9660.3772 without restraints) Performing minimization step: 3735. Total energy = 9679.2573 kcal/mol (9654.8106 without restraints) Performing minimization step: 3736. Total energy = 9673.6920 kcal/mol (9649.2472 without restraints) Performing minimization step: 3737. Total energy = 9668.1301 kcal/mol (9643.6872 without restraints) Performing minimization step: 3738. Total energy = 9662.5714 kcal/mol (9638.1304 without restraints) Performing minimization step: 3739. Total energy = 9657.0163 kcal/mol (9632.5773 without restraints) Performing minimization step: 3740. Total energy = 9651.4647 kcal/mol (9627.0276 without restraints) Performing minimization step: 3741. Total energy = 9645.9165 kcal/mol (9621.4814 without restraints) Performing minimization step: 3742. Total energy = 9640.3724 kcal/mol (9615.9394 without restraints) Performing minimization step: 3743. Total energy = 9634.8317 kcal/mol (9610.4004 without restraints) Performing minimization step: 3744. Total energy = 9629.2938 kcal/mol (9604.8645 without restraints) Performing minimization step: 3745. Total energy = 9623.7597 kcal/mol (9599.3324 without restraints) Performing minimization step: 3746. Total energy = 9618.2291 kcal/mol (9593.8037 without restraints) Performing minimization step: 3747. Total energy = 9612.7014 kcal/mol (9588.2780 without restraints) Performing minimization step: 3748. Total energy = 9607.1774 kcal/mol (9582.7559 without restraints) Performing minimization step: 3749. Total energy = 9601.6569 kcal/mol (9577.2373 without restraints) Performing minimization step: 3750. Total energy = 9596.1397 kcal/mol (9571.7222 without restraints) Performing minimization step: 3751. Total energy = 9590.6262 kcal/mol (9566.2105 without restraints) Performing minimization step: 3752. Total energy = 9585.1161 kcal/mol (9560.7024 without restraints) Performing minimization step: 3753. Total energy = 9579.6094 kcal/mol (9555.1977 without restraints) Performing minimization step: 3754. Total energy = 9574.1065 kcal/mol (9549.6967 without restraints) Performing minimization step: 3755. Total energy = 9568.6068 kcal/mol (9544.1990 without restraints) Performing minimization step: 3756. Total energy = 9563.1109 kcal/mol (9538.7050 without restraints) Performing minimization step: 3757. Total energy = 9557.6180 kcal/mol (9533.2142 without restraints) Performing minimization step: 3758. Total energy = 9552.1289 kcal/mol (9527.7270 without restraints) Performing minimization step: 3759. Total energy = 9546.6432 kcal/mol (9522.2432 without restraints) Performing minimization step: 3760. Total energy = 9541.1610 kcal/mol (9516.7630 without restraints) Performing minimization step: 3761. Total energy = 9535.6824 kcal/mol (9511.2865 without restraints) Performing minimization step: 3762. Total energy = 9530.2073 kcal/mol (9505.8132 without restraints) Performing minimization step: 3763. Total energy = 9524.7356 kcal/mol (9500.3435 without restraints) Performing minimization step: 3764. Total energy = 9519.2674 kcal/mol (9494.8773 without restraints) Performing minimization step: 3765. Total energy = 9513.8028 kcal/mol (9489.4146 without restraints) Performing minimization step: 3766. Total energy = 9508.3416 kcal/mol (9483.9554 without restraints) Performing minimization step: 3767. Total energy = 9502.8842 kcal/mol (9478.4999 without restraints) Performing minimization step: 3768. Total energy = 9497.4302 kcal/mol (9473.0479 without restraints) Performing minimization step: 3769. Total energy = 9491.9797 kcal/mol (9467.5994 without restraints) Performing minimization step: 3770. Total energy = 9486.5326 kcal/mol (9462.1543 without restraints) Performing minimization step: 3771. Total energy = 9481.0890 kcal/mol (9456.7127 without restraints) Performing minimization step: 3772. Total energy = 9475.6488 kcal/mol (9451.2744 without restraints) Performing minimization step: 3773. Total energy = 9470.2127 kcal/mol (9445.8402 without restraints) Performing minimization step: 3774. Total energy = 9464.7796 kcal/mol (9440.4092 without restraints) Performing minimization step: 3775. Total energy = 9459.3502 kcal/mol (9434.9817 without restraints) Performing minimization step: 3776. Total energy = 9453.9243 kcal/mol (9429.5578 without restraints) Performing minimization step: 3777. Total energy = 9448.5017 kcal/mol (9424.1371 without restraints) Performing minimization step: 3778. Total energy = 9443.0828 kcal/mol (9418.7202 without restraints) Performing minimization step: 3779. Total energy = 9437.6675 kcal/mol (9413.3069 without restraints) Performing minimization step: 3780. Total energy = 9432.2557 kcal/mol (9407.8971 without restraints) Performing minimization step: 3781. Total energy = 9426.8475 kcal/mol (9402.4909 without restraints) Performing minimization step: 3782. Total energy = 9421.4428 kcal/mol (9397.0882 without restraints) Performing minimization step: 3783. Total energy = 9416.0417 kcal/mol (9391.6891 without restraints) Performing minimization step: 3784. Total energy = 9410.6439 kcal/mol (9386.2933 without restraints) Performing minimization step: 3785. Total energy = 9405.2500 kcal/mol (9380.9013 without restraints) Performing minimization step: 3786. Total energy = 9399.8595 kcal/mol (9375.5128 without restraints) Performing minimization step: 3787. Total energy = 9394.4724 kcal/mol (9370.1277 without restraints) Performing minimization step: 3788. Total energy = 9389.0891 kcal/mol (9364.7463 without restraints) Performing minimization step: 3789. Total energy = 9383.7094 kcal/mol (9359.3686 without restraints) Performing minimization step: 3790. Total energy = 9378.3332 kcal/mol (9353.9945 without restraints) Performing minimization step: 3791. Total energy = 9372.9605 kcal/mol (9348.6238 without restraints) Performing minimization step: 3792. Total energy = 9367.5915 kcal/mol (9343.2568 without restraints) Performing minimization step: 3793. Total energy = 9362.2260 kcal/mol (9337.8933 without restraints) Performing minimization step: 3794. Total energy = 9356.8641 kcal/mol (9332.5334 without restraints) Performing minimization step: 3795. Total energy = 9351.5058 kcal/mol (9327.1770 without restraints) Performing minimization step: 3796. Total energy = 9346.1511 kcal/mol (9321.8243 without restraints) Performing minimization step: 3797. Total energy = 9340.8002 kcal/mol (9316.4755 without restraints) Performing minimization step: 3798. Total energy = 9335.4528 kcal/mol (9311.1301 without restraints) Performing minimization step: 3799. Total energy = 9330.1083 kcal/mol (9305.7875 without restraints) Performing minimization step: 3800. Total energy = 9324.7682 kcal/mol (9300.4494 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3801. Total energy = 9319.4315 kcal/mol (9295.1147 without restraints) Performing minimization step: 3802. Total energy = 9314.0983 kcal/mol (9289.7835 without restraints) Performing minimization step: 3803. Total energy = 9308.7690 kcal/mol (9284.4562 without restraints) Performing minimization step: 3804. Total energy = 9303.4433 kcal/mol (9279.1325 without restraints) Performing minimization step: 3805. Total energy = 9298.1210 kcal/mol (9273.8122 without restraints) Performing minimization step: 3806. Total energy = 9292.8025 kcal/mol (9268.4957 without restraints) Performing minimization step: 3807. Total energy = 9287.4874 kcal/mol (9263.1826 without restraints) Performing minimization step: 3808. Total energy = 9282.1759 kcal/mol (9257.8731 without restraints) Performing minimization step: 3809. Total energy = 9276.8678 kcal/mol (9252.5671 without restraints) Performing minimization step: 3810. Total energy = 9271.5636 kcal/mol (9247.2648 without restraints) Performing minimization step: 3811. Total energy = 9266.2632 kcal/mol (9241.9664 without restraints) Performing minimization step: 3812. Total energy = 9260.9663 kcal/mol (9236.6717 without restraints) Performing minimization step: 3813. Total energy = 9255.6732 kcal/mol (9231.3805 without restraints) Performing minimization step: 3814. Total energy = 9250.3833 kcal/mol (9226.0926 without restraints) Performing minimization step: 3815. Total energy = 9245.0972 kcal/mol (9220.8084 without restraints) Performing minimization step: 3816. Total energy = 9239.8147 kcal/mol (9215.5280 without restraints) Performing minimization step: 3817. Total energy = 9234.5359 kcal/mol (9210.2512 without restraints) Performing minimization step: 3818. Total energy = 9229.2607 kcal/mol (9204.9781 without restraints) Performing minimization step: 3819. Total energy = 9223.9889 kcal/mol (9199.7082 without restraints) Performing minimization step: 3820. Total energy = 9218.7209 kcal/mol (9194.4423 without restraints) Performing minimization step: 3821. Total energy = 9213.4567 kcal/mol (9189.1801 without restraints) Performing minimization step: 3822. Total energy = 9208.1962 kcal/mol (9183.9218 without restraints) Performing minimization step: 3823. Total energy = 9202.9395 kcal/mol (9178.6669 without restraints) Performing minimization step: 3824. Total energy = 9197.6866 kcal/mol (9173.4161 without restraints) Performing minimization step: 3825. Total energy = 9192.4373 kcal/mol (9168.1688 without restraints) Performing minimization step: 3826. Total energy = 9187.1912 kcal/mol (9162.9247 without restraints) Performing minimization step: 3827. Total energy = 9181.9490 kcal/mol (9157.6846 without restraints) Performing minimization step: 3828. Total energy = 9176.7104 kcal/mol (9152.4480 without restraints) Performing minimization step: 3829. Total energy = 9171.4755 kcal/mol (9147.2151 without restraints) Performing minimization step: 3830. Total energy = 9166.2442 kcal/mol (9141.9859 without restraints) Performing minimization step: 3831. Total energy = 9161.0168 kcal/mol (9136.7605 without restraints) Performing minimization step: 3832. Total energy = 9155.7929 kcal/mol (9131.5386 without restraints) Performing minimization step: 3833. Total energy = 9150.5727 kcal/mol (9126.3204 without restraints) Performing minimization step: 3834. Total energy = 9145.3559 kcal/mol (9121.1056 without restraints) Performing minimization step: 3835. Total energy = 9140.1430 kcal/mol (9115.8948 without restraints) Performing minimization step: 3836. Total energy = 9134.9338 kcal/mol (9110.6877 without restraints) Performing minimization step: 3837. Total energy = 9129.7285 kcal/mol (9105.4844 without restraints) Performing minimization step: 3838. Total energy = 9124.5265 kcal/mol (9100.2844 without restraints) Performing minimization step: 3839. Total energy = 9119.3279 kcal/mol (9095.0878 without restraints) Performing minimization step: 3840. Total energy = 9114.1335 kcal/mol (9089.8954 without restraints) Performing minimization step: 3841. Total energy = 9108.9428 kcal/mol (9084.7068 without restraints) Performing minimization step: 3842. Total energy = 9103.7558 kcal/mol (9079.5218 without restraints) Performing minimization step: 3843. Total energy = 9098.5725 kcal/mol (9074.3406 without restraints) Performing minimization step: 3844. Total energy = 9093.3927 kcal/mol (9069.1628 without restraints) Performing minimization step: 3845. Total energy = 9088.2166 kcal/mol (9063.9888 without restraints) Performing minimization step: 3846. Total energy = 9083.0446 kcal/mol (9058.8189 without restraints) Performing minimization step: 3847. Total energy = 9077.8764 kcal/mol (9053.6528 without restraints) Performing minimization step: 3848. Total energy = 9072.7118 kcal/mol (9048.4901 without restraints) Performing minimization step: 3849. Total energy = 9067.5508 kcal/mol (9043.3312 without restraints) Performing minimization step: 3850. Total energy = 9062.3937 kcal/mol (9038.1761 without restraints) Performing minimization step: 3851. Total energy = 9057.2401 kcal/mol (9033.0245 without restraints) Performing minimization step: 3852. Total energy = 9052.0903 kcal/mol (9027.8769 without restraints) Performing minimization step: 3853. Total energy = 9046.9441 kcal/mol (9022.7327 without restraints) Performing minimization step: 3854. Total energy = 9041.8020 kcal/mol (9017.5926 without restraints) Performing minimization step: 3855. Total energy = 9036.6633 kcal/mol (9012.4560 without restraints) Performing minimization step: 3856. Total energy = 9031.5284 kcal/mol (9007.3231 without restraints) Performing minimization step: 3857. Total energy = 9026.3972 kcal/mol (9002.1940 without restraints) Performing minimization step: 3858. Total energy = 9021.2698 kcal/mol (8997.0686 without restraints) Performing minimization step: 3859. Total energy = 9016.1461 kcal/mol (8991.9470 without restraints) Performing minimization step: 3860. Total energy = 9011.0261 kcal/mol (8986.8290 without restraints) Performing minimization step: 3861. Total energy = 9005.9100 kcal/mol (8981.7152 without restraints) Performing minimization step: 3862. Total energy = 9000.7976 kcal/mol (8976.6047 without restraints) Performing minimization step: 3863. Total energy = 8995.6890 kcal/mol (8971.4981 without restraints) Performing minimization step: 3864. Total energy = 8990.5840 kcal/mol (8966.3952 without restraints) Performing minimization step: 3865. Total energy = 8985.4827 kcal/mol (8961.2960 without restraints) Performing minimization step: 3866. Total energy = 8980.3851 kcal/mol (8956.2005 without restraints) Performing minimization step: 3867. Total energy = 8975.2914 kcal/mol (8951.1088 without restraints) Performing minimization step: 3868. Total energy = 8970.2012 kcal/mol (8946.0207 without restraints) Performing minimization step: 3869. Total energy = 8965.1149 kcal/mol (8940.9365 without restraints) Performing minimization step: 3870. Total energy = 8960.0326 kcal/mol (8935.8562 without restraints) Performing minimization step: 3871. Total energy = 8954.9541 kcal/mol (8930.7798 without restraints) Performing minimization step: 3872. Total energy = 8949.8793 kcal/mol (8925.7071 without restraints) Performing minimization step: 3873. Total energy = 8944.8083 kcal/mol (8920.6381 without restraints) Performing minimization step: 3874. Total energy = 8939.7415 kcal/mol (8915.5735 without restraints) Performing minimization step: 3875. Total energy = 8934.6782 kcal/mol (8910.5122 without restraints) Performing minimization step: 3876. Total energy = 8929.6187 kcal/mol (8905.4547 without restraints) Performing minimization step: 3877. Total energy = 8924.5630 kcal/mol (8900.4011 without restraints) Performing minimization step: 3878. Total energy = 8919.5108 kcal/mol (8895.3511 without restraints) Performing minimization step: 3879. Total energy = 8914.4625 kcal/mol (8890.3048 without restraints) Performing minimization step: 3880. Total energy = 8909.4180 kcal/mol (8885.2624 without restraints) Performing minimization step: 3881. Total energy = 8904.3773 kcal/mol (8880.2237 without restraints) Performing minimization step: 3882. Total energy = 8899.3404 kcal/mol (8875.1890 without restraints) Performing minimization step: 3883. Total energy = 8894.3073 kcal/mol (8870.1580 without restraints) Performing minimization step: 3884. Total energy = 8889.2779 kcal/mol (8865.1307 without restraints) Performing minimization step: 3885. Total energy = 8884.2529 kcal/mol (8860.1077 without restraints) Performing minimization step: 3886. Total energy = 8879.2311 kcal/mol (8855.0880 without restraints) Performing minimization step: 3887. Total energy = 8874.2131 kcal/mol (8850.0721 without restraints) Performing minimization step: 3888. Total energy = 8869.1990 kcal/mol (8845.0601 without restraints) Performing minimization step: 3889. Total energy = 8864.1887 kcal/mol (8840.0519 without restraints) Performing minimization step: 3890. Total energy = 8859.1822 kcal/mol (8835.0475 without restraints) Performing minimization step: 3891. Total energy = 8854.1796 kcal/mol (8830.0470 without restraints) Performing minimization step: 3892. Total energy = 8849.1807 kcal/mol (8825.0502 without restraints) Performing minimization step: 3893. Total energy = 8844.1850 kcal/mol (8820.0565 without restraints) Performing minimization step: 3894. Total energy = 8839.1941 kcal/mol (8815.0678 without restraints) Performing minimization step: 3895. Total energy = 8834.2068 kcal/mol (8810.0826 without restraints) Performing minimization step: 3896. Total energy = 8829.2236 kcal/mol (8805.1014 without restraints) Performing minimization step: 3897. Total energy = 8824.2439 kcal/mol (8800.1239 without restraints) Performing minimization step: 3898. Total energy = 8819.2680 kcal/mol (8795.1501 without restraints) Performing minimization step: 3899. Total energy = 8814.2960 kcal/mol (8790.1802 without restraints) Performing minimization step: 3900. Total energy = 8809.3279 kcal/mol (8785.2142 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 3901. Total energy = 8804.3641 kcal/mol (8780.2524 without restraints) Performing minimization step: 3902. Total energy = 8799.4036 kcal/mol (8775.2942 without restraints) Performing minimization step: 3903. Total energy = 8794.4470 kcal/mol (8770.3396 without restraints) Performing minimization step: 3904. Total energy = 8789.4943 kcal/mol (8765.3890 without restraints) Performing minimization step: 3905. Total energy = 8784.5453 kcal/mol (8760.4421 without restraints) Performing minimization step: 3906. Total energy = 8779.6002 kcal/mol (8755.4992 without restraints) Performing minimization step: 3907. Total energy = 8774.6592 kcal/mol (8750.5603 without restraints) Performing minimization step: 3908. Total energy = 8769.7218 kcal/mol (8745.6250 without restraints) Performing minimization step: 3909. Total energy = 8764.7884 kcal/mol (8740.6936 without restraints) Performing minimization step: 3910. Total energy = 8759.8587 kcal/mol (8735.7661 without restraints) Performing minimization step: 3911. Total energy = 8754.9330 kcal/mol (8730.8425 without restraints) Performing minimization step: 3912. Total energy = 8750.0112 kcal/mol (8725.9229 without restraints) Performing minimization step: 3913. Total energy = 8745.0932 kcal/mol (8721.0069 without restraints) Performing minimization step: 3914. Total energy = 8740.1789 kcal/mol (8716.0948 without restraints) Performing minimization step: 3915. Total energy = 8735.2687 kcal/mol (8711.1867 without restraints) Performing minimization step: 3916. Total energy = 8730.3624 kcal/mol (8706.2825 without restraints) Performing minimization step: 3917. Total energy = 8725.4598 kcal/mol (8701.3819 without restraints) Performing minimization step: 3918. Total energy = 8720.5610 kcal/mol (8696.4854 without restraints) Performing minimization step: 3919. Total energy = 8715.6662 kcal/mol (8691.5926 without restraints) Performing minimization step: 3920. Total energy = 8710.7752 kcal/mol (8686.7038 without restraints) Performing minimization step: 3921. Total energy = 8705.8880 kcal/mol (8681.8187 without restraints) Performing minimization step: 3922. Total energy = 8701.0054 kcal/mol (8676.9383 without restraints) Performing minimization step: 3923. Total energy = 8696.1265 kcal/mol (8672.0615 without restraints) Performing minimization step: 3924. Total energy = 8691.2510 kcal/mol (8667.1881 without restraints) Performing minimization step: 3925. Total energy = 8686.3796 kcal/mol (8662.3189 without restraints) Performing minimization step: 3926. Total energy = 8681.5122 kcal/mol (8657.4537 without restraints) Performing minimization step: 3927. Total energy = 8676.6487 kcal/mol (8652.5922 without restraints) Performing minimization step: 3928. Total energy = 8671.7887 kcal/mol (8647.7344 without restraints) Performing minimization step: 3929. Total energy = 8666.9329 kcal/mol (8642.8807 without restraints) Performing minimization step: 3930. Total energy = 8662.0810 kcal/mol (8638.0310 without restraints) Performing minimization step: 3931. Total energy = 8657.2330 kcal/mol (8633.1852 without restraints) Performing minimization step: 3932. Total energy = 8652.3890 kcal/mol (8628.3432 without restraints) Performing minimization step: 3933. Total energy = 8647.5492 kcal/mol (8623.5057 without restraints) Performing minimization step: 3934. Total energy = 8642.7130 kcal/mol (8618.6715 without restraints) Performing minimization step: 3935. Total energy = 8637.8814 kcal/mol (8613.8421 without restraints) Performing minimization step: 3936. Total energy = 8633.0528 kcal/mol (8609.0157 without restraints) Performing minimization step: 3937. Total energy = 8628.2284 kcal/mol (8604.1934 without restraints) Performing minimization step: 3938. Total energy = 8623.4076 kcal/mol (8599.3746 without restraints) Performing minimization step: 3939. Total energy = 8618.5909 kcal/mol (8594.5602 without restraints) Performing minimization step: 3940. Total energy = 8613.7780 kcal/mol (8589.7495 without restraints) Performing minimization step: 3941. Total energy = 8608.9693 kcal/mol (8584.9429 without restraints) Performing minimization step: 3942. Total energy = 8604.1645 kcal/mol (8580.1403 without restraints) Performing minimization step: 3943. Total energy = 8599.3638 kcal/mol (8575.3418 without restraints) Performing minimization step: 3944. Total energy = 8594.5671 kcal/mol (8570.5471 without restraints) Performing minimization step: 3945. Total energy = 8589.7740 kcal/mol (8565.7563 without restraints) Performing minimization step: 3946. Total energy = 8584.9845 kcal/mol (8560.9689 without restraints) Performing minimization step: 3947. Total energy = 8580.1994 kcal/mol (8556.1859 without restraints) Performing minimization step: 3948. Total energy = 8575.4182 kcal/mol (8551.4069 without restraints) Performing minimization step: 3949. Total energy = 8570.6410 kcal/mol (8546.6320 without restraints) Performing minimization step: 3950. Total energy = 8565.8678 kcal/mol (8541.8609 without restraints) Performing minimization step: 3951. Total energy = 8561.0985 kcal/mol (8537.0938 without restraints) Performing minimization step: 3952. Total energy = 8556.3332 kcal/mol (8532.3306 without restraints) Performing minimization step: 3953. Total energy = 8551.5718 kcal/mol (8527.5713 without restraints) Performing minimization step: 3954. Total energy = 8546.8146 kcal/mol (8522.8164 without restraints) Performing minimization step: 3955. Total energy = 8542.0613 kcal/mol (8518.0652 without restraints) Performing minimization step: 3956. Total energy = 8537.3118 kcal/mol (8513.3179 without restraints) Performing minimization step: 3957. Total energy = 8532.5662 kcal/mol (8508.5745 without restraints) Performing minimization step: 3958. Total energy = 8527.8251 kcal/mol (8503.8355 without restraints) Performing minimization step: 3959. Total energy = 8523.0876 kcal/mol (8499.1002 without restraints) Performing minimization step: 3960. Total energy = 8518.3539 kcal/mol (8494.3687 without restraints) Performing minimization step: 3961. Total energy = 8513.6242 kcal/mol (8489.6410 without restraints) Performing minimization step: 3962. Total energy = 8508.8984 kcal/mol (8484.9175 without restraints) Performing minimization step: 3963. Total energy = 8504.1768 kcal/mol (8480.1982 without restraints) Performing minimization step: 3964. Total energy = 8499.4593 kcal/mol (8475.4829 without restraints) Performing minimization step: 3965. Total energy = 8494.7456 kcal/mol (8470.7713 without restraints) Performing minimization step: 3966. Total energy = 8490.0359 kcal/mol (8466.0638 without restraints) Performing minimization step: 3967. Total energy = 8485.3302 kcal/mol (8461.3602 without restraints) Performing minimization step: 3968. Total energy = 8480.6282 kcal/mol (8456.6605 without restraints) Performing minimization step: 3969. Total energy = 8475.9305 kcal/mol (8451.9649 without restraints) Performing minimization step: 3970. Total energy = 8471.2370 kcal/mol (8447.2736 without restraints) Performing minimization step: 3971. Total energy = 8466.5475 kcal/mol (8442.5863 without restraints) Performing minimization step: 3972. Total energy = 8461.8619 kcal/mol (8437.9029 without restraints) Performing minimization step: 3973. Total energy = 8457.1801 kcal/mol (8433.2234 without restraints) Performing minimization step: 3974. Total energy = 8452.5023 kcal/mol (8428.5477 without restraints) Performing minimization step: 3975. Total energy = 8447.8290 kcal/mol (8423.8766 without restraints) Performing minimization step: 3976. Total energy = 8443.1593 kcal/mol (8419.2091 without restraints) Performing minimization step: 3977. Total energy = 8438.4935 kcal/mol (8414.5456 without restraints) Performing minimization step: 3978. Total energy = 8433.8310 kcal/mol (8409.8852 without restraints) Performing minimization step: 3979. Total energy = 8429.1733 kcal/mol (8405.2297 without restraints) Performing minimization step: 3980. Total energy = 8424.5196 kcal/mol (8400.5782 without restraints) Performing minimization step: 3981. Total energy = 8419.8701 kcal/mol (8395.9310 without restraints) Performing minimization step: 3982. Total energy = 8415.2245 kcal/mol (8391.2875 without restraints) Performing minimization step: 3983. Total energy = 8410.5830 kcal/mol (8386.6483 without restraints) Performing minimization step: 3984. Total energy = 8405.9454 kcal/mol (8382.0128 without restraints) Performing minimization step: 3985. Total energy = 8401.3120 kcal/mol (8377.3817 without restraints) Performing minimization step: 3986. Total energy = 8396.6825 kcal/mol (8372.7544 without restraints) Performing minimization step: 3987. Total energy = 8392.0569 kcal/mol (8368.1310 without restraints) Performing minimization step: 3988. Total energy = 8387.4356 kcal/mol (8363.5120 without restraints) Performing minimization step: 3989. Total energy = 8382.8184 kcal/mol (8358.8969 without restraints) Performing minimization step: 3990. Total energy = 8378.2051 kcal/mol (8354.2859 without restraints) Performing minimization step: 3991. Total energy = 8373.5953 kcal/mol (8349.6783 without restraints) Performing minimization step: 3992. Total energy = 8368.9902 kcal/mol (8345.0754 without restraints) Performing minimization step: 3993. Total energy = 8364.3888 kcal/mol (8340.4763 without restraints) Performing minimization step: 3994. Total energy = 8359.7916 kcal/mol (8335.8812 without restraints) Performing minimization step: 3995. Total energy = 8355.1981 kcal/mol (8331.2900 without restraints) Performing minimization step: 3996. Total energy = 8350.6091 kcal/mol (8326.7032 without restraints) Performing minimization step: 3997. Total energy = 8346.0240 kcal/mol (8322.1203 without restraints) Performing minimization step: 3998. Total energy = 8341.4429 kcal/mol (8317.5414 without restraints) Performing minimization step: 3999. Total energy = 8336.8658 kcal/mol (8312.9667 without restraints) Performing minimization step: 4000. Total energy = 8332.2929 kcal/mol (8308.3959 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4001. Total energy = 8327.7240 kcal/mol (8303.8292 without restraints) Performing minimization step: 4002. Total energy = 8323.1593 kcal/mol (8299.2669 without restraints) Performing minimization step: 4003. Total energy = 8318.5992 kcal/mol (8294.7092 without restraints) Performing minimization step: 4004. Total energy = 8314.0427 kcal/mol (8290.1547 without restraints) Performing minimization step: 4005. Total energy = 8309.4901 kcal/mol (8285.6043 without restraints) Performing minimization step: 4006. Total energy = 8304.9415 kcal/mol (8281.0580 without restraints) Performing minimization step: 4007. Total energy = 8300.3966 kcal/mol (8276.5153 without restraints) Performing minimization step: 4008. Total energy = 8295.8562 kcal/mol (8271.9773 without restraints) Performing minimization step: 4009. Total energy = 8291.3201 kcal/mol (8267.4434 without restraints) Performing minimization step: 4010. Total energy = 8286.7879 kcal/mol (8262.9134 without restraints) Performing minimization step: 4011. Total energy = 8282.2597 kcal/mol (8258.3874 without restraints) Performing minimization step: 4012. Total energy = 8277.7356 kcal/mol (8253.8656 without restraints) Performing minimization step: 4013. Total energy = 8273.2156 kcal/mol (8249.3478 without restraints) Performing minimization step: 4014. Total energy = 8268.6996 kcal/mol (8244.8341 without restraints) Performing minimization step: 4015. Total energy = 8264.1880 kcal/mol (8240.3247 without restraints) Performing minimization step: 4016. Total energy = 8259.6801 kcal/mol (8235.8190 without restraints) Performing minimization step: 4017. Total energy = 8255.1763 kcal/mol (8231.3175 without restraints) Performing minimization step: 4018. Total energy = 8250.6769 kcal/mol (8226.8203 without restraints) Performing minimization step: 4019. Total energy = 8246.1815 kcal/mol (8222.3272 without restraints) Performing minimization step: 4020. Total energy = 8241.6900 kcal/mol (8217.8380 without restraints) Performing minimization step: 4021. Total energy = 8237.2026 kcal/mol (8213.3529 without restraints) Performing minimization step: 4022. Total energy = 8232.7191 kcal/mol (8208.8716 without restraints) Performing minimization step: 4023. Total energy = 8228.2401 kcal/mol (8204.3948 without restraints) Performing minimization step: 4024. Total energy = 8223.7652 kcal/mol (8199.9223 without restraints) Performing minimization step: 4025. Total energy = 8219.2944 kcal/mol (8195.4538 without restraints) Performing minimization step: 4026. Total energy = 8214.8275 kcal/mol (8190.9891 without restraints) Performing minimization step: 4027. Total energy = 8210.3648 kcal/mol (8186.5288 without restraints) Performing minimization step: 4028. Total energy = 8205.9067 kcal/mol (8182.0728 without restraints) Performing minimization step: 4029. Total energy = 8201.4528 kcal/mol (8177.6212 without restraints) Performing minimization step: 4030. Total energy = 8197.0023 kcal/mol (8173.1730 without restraints) Performing minimization step: 4031. Total energy = 8192.5562 kcal/mol (8168.7292 without restraints) Performing minimization step: 4032. Total energy = 8188.1140 kcal/mol (8164.2894 without restraints) Performing minimization step: 4033. Total energy = 8183.6759 kcal/mol (8159.8535 without restraints) Performing minimization step: 4034. Total energy = 8179.2419 kcal/mol (8155.4217 without restraints) Performing minimization step: 4035. Total energy = 8174.8121 kcal/mol (8150.9942 without restraints) Performing minimization step: 4036. Total energy = 8170.3863 kcal/mol (8146.5708 without restraints) Performing minimization step: 4037. Total energy = 8165.9652 kcal/mol (8142.1519 without restraints) Performing minimization step: 4038. Total energy = 8161.5478 kcal/mol (8137.7369 without restraints) Performing minimization step: 4039. Total energy = 8157.1349 kcal/mol (8133.3261 without restraints) Performing minimization step: 4040. Total energy = 8152.7257 kcal/mol (8128.9192 without restraints) Performing minimization step: 4041. Total energy = 8148.3211 kcal/mol (8124.5170 without restraints) Performing minimization step: 4042. Total energy = 8143.9202 kcal/mol (8120.1183 without restraints) Performing minimization step: 4043. Total energy = 8139.5234 kcal/mol (8115.7238 without restraints) Performing minimization step: 4044. Total energy = 8135.1303 kcal/mol (8111.3330 without restraints) Performing minimization step: 4045. Total energy = 8130.7417 kcal/mol (8106.9467 without restraints) Performing minimization step: 4046. Total energy = 8126.3573 kcal/mol (8102.5647 without restraints) Performing minimization step: 4047. Total energy = 8121.9776 kcal/mol (8098.1872 without restraints) Performing minimization step: 4048. Total energy = 8117.6014 kcal/mol (8093.8133 without restraints) Performing minimization step: 4049. Total energy = 8113.2295 kcal/mol (8089.4437 without restraints) Performing minimization step: 4050. Total energy = 8108.8618 kcal/mol (8085.0783 without restraints) Performing minimization step: 4051. Total energy = 8104.4981 kcal/mol (8080.7170 without restraints) Performing minimization step: 4052. Total energy = 8100.1384 kcal/mol (8076.3595 without restraints) Performing minimization step: 4053. Total energy = 8095.7830 kcal/mol (8072.0065 without restraints) Performing minimization step: 4054. Total energy = 8091.4322 kcal/mol (8067.6580 without restraints) Performing minimization step: 4055. Total energy = 8087.0852 kcal/mol (8063.3133 without restraints) Performing minimization step: 4056. Total energy = 8082.7426 kcal/mol (8058.9730 without restraints) Performing minimization step: 4057. Total energy = 8078.4039 kcal/mol (8054.6366 without restraints) Performing minimization step: 4058. Total energy = 8074.0693 kcal/mol (8050.3043 without restraints) Performing minimization step: 4059. Total energy = 8069.7389 kcal/mol (8045.9762 without restraints) Performing minimization step: 4060. Total energy = 8065.4127 kcal/mol (8041.6525 without restraints) Performing minimization step: 4061. Total energy = 8061.0907 kcal/mol (8037.3327 without restraints) Performing minimization step: 4062. Total energy = 8056.7727 kcal/mol (8033.0170 without restraints) Performing minimization step: 4063. Total energy = 8052.4591 kcal/mol (8028.7057 without restraints) Performing minimization step: 4064. Total energy = 8048.1494 kcal/mol (8024.3984 without restraints) Performing minimization step: 4065. Total energy = 8043.8438 kcal/mol (8020.0951 without restraints) Performing minimization step: 4066. Total energy = 8039.5423 kcal/mol (8015.7960 without restraints) Performing minimization step: 4067. Total energy = 8035.2452 kcal/mol (8011.5012 without restraints) Performing minimization step: 4068. Total energy = 8030.9522 kcal/mol (8007.2105 without restraints) Performing minimization step: 4069. Total energy = 8026.6634 kcal/mol (8002.9240 without restraints) Performing minimization step: 4070. Total energy = 8022.3788 kcal/mol (7998.6418 without restraints) Performing minimization step: 4071. Total energy = 8018.0984 kcal/mol (7994.3637 without restraints) Performing minimization step: 4072. Total energy = 8013.8221 kcal/mol (7990.0898 without restraints) Performing minimization step: 4073. Total energy = 8009.5501 kcal/mol (7985.8201 without restraints) Performing minimization step: 4074. Total energy = 8005.2823 kcal/mol (7981.5546 without restraints) Performing minimization step: 4075. Total energy = 8001.0185 kcal/mol (7977.2932 without restraints) Performing minimization step: 4076. Total energy = 7996.7590 kcal/mol (7973.0360 without restraints) Performing minimization step: 4077. Total energy = 7992.5035 kcal/mol (7968.7828 without restraints) Performing minimization step: 4078. Total energy = 7988.2523 kcal/mol (7964.5340 without restraints) Performing minimization step: 4079. Total energy = 7984.0056 kcal/mol (7960.2896 without restraints) Performing minimization step: 4080. Total energy = 7979.7630 kcal/mol (7956.0495 without restraints) Performing minimization step: 4081. Total energy = 7975.5247 kcal/mol (7951.8135 without restraints) Performing minimization step: 4082. Total energy = 7971.2902 kcal/mol (7947.5813 without restraints) Performing minimization step: 4083. Total energy = 7967.0600 kcal/mol (7943.3535 without restraints) Performing minimization step: 4084. Total energy = 7962.8340 kcal/mol (7939.1299 without restraints) Performing minimization step: 4085. Total energy = 7958.6122 kcal/mol (7934.9105 without restraints) Performing minimization step: 4086. Total energy = 7954.3947 kcal/mol (7930.6953 without restraints) Performing minimization step: 4087. Total energy = 7950.1818 kcal/mol (7926.4847 without restraints) Performing minimization step: 4088. Total energy = 7945.9726 kcal/mol (7922.2779 without restraints) Performing minimization step: 4089. Total energy = 7941.7677 kcal/mol (7918.0754 without restraints) Performing minimization step: 4090. Total energy = 7937.5667 kcal/mol (7913.8767 without restraints) Performing minimization step: 4091. Total energy = 7933.3702 kcal/mol (7909.6826 without restraints) Performing minimization step: 4092. Total energy = 7929.1778 kcal/mol (7905.4926 without restraints) Performing minimization step: 4093. Total energy = 7924.9897 kcal/mol (7901.3068 without restraints) Performing minimization step: 4094. Total energy = 7920.8057 kcal/mol (7897.1252 without restraints) Performing minimization step: 4095. Total energy = 7916.6262 kcal/mol (7892.9482 without restraints) Performing minimization step: 4096. Total energy = 7912.4508 kcal/mol (7888.7751 without restraints) Performing minimization step: 4097. Total energy = 7908.2796 kcal/mol (7884.6064 without restraints) Performing minimization step: 4098. Total energy = 7904.1129 kcal/mol (7880.4420 without restraints) Performing minimization step: 4099. Total energy = 7899.9503 kcal/mol (7876.2817 without restraints) Performing minimization step: 4100. Total energy = 7895.7917 kcal/mol (7872.1255 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4101. Total energy = 7891.6374 kcal/mol (7867.9736 without restraints) Performing minimization step: 4102. Total energy = 7887.4872 kcal/mol (7863.8258 without restraints) Performing minimization step: 4103. Total energy = 7883.3413 kcal/mol (7859.6823 without restraints) Performing minimization step: 4104. Total energy = 7879.1998 kcal/mol (7855.5432 without restraints) Performing minimization step: 4105. Total energy = 7875.0625 kcal/mol (7851.4083 without restraints) Performing minimization step: 4106. Total energy = 7870.9294 kcal/mol (7847.2775 without restraints) Performing minimization step: 4107. Total energy = 7866.8004 kcal/mol (7843.1510 without restraints) Performing minimization step: 4108. Total energy = 7862.6754 kcal/mol (7839.0283 without restraints) Performing minimization step: 4109. Total energy = 7858.5548 kcal/mol (7834.9102 without restraints) Performing minimization step: 4110. Total energy = 7854.4384 kcal/mol (7830.7962 without restraints) Performing minimization step: 4111. Total energy = 7850.3263 kcal/mol (7826.6865 without restraints) Performing minimization step: 4112. Total energy = 7846.2184 kcal/mol (7822.5810 without restraints) Performing minimization step: 4113. Total energy = 7842.1150 kcal/mol (7818.4800 without restraints) Performing minimization step: 4114. Total energy = 7838.0163 kcal/mol (7814.3838 without restraints) Performing minimization step: 4115. Total energy = 7833.9210 kcal/mol (7810.2909 without restraints) Performing minimization step: 4116. Total energy = 7829.8302 kcal/mol (7806.2024 without restraints) Performing minimization step: 4117. Total energy = 7825.7435 kcal/mol (7802.1182 without restraints) Performing minimization step: 4118. Total energy = 7821.6611 kcal/mol (7798.0381 without restraints) Performing minimization step: 4119. Total energy = 7817.5832 kcal/mol (7793.9626 without restraints) Performing minimization step: 4120. Total energy = 7813.5092 kcal/mol (7789.8911 without restraints) Performing minimization step: 4121. Total energy = 7809.4393 kcal/mol (7785.8236 without restraints) Performing minimization step: 4122. Total energy = 7805.3738 kcal/mol (7781.7606 without restraints) Performing minimization step: 4123. Total energy = 7801.3125 kcal/mol (7777.7016 without restraints) Performing minimization step: 4124. Total energy = 7797.2555 kcal/mol (7773.6471 without restraints) Performing minimization step: 4125. Total energy = 7793.2026 kcal/mol (7769.5967 without restraints) Performing minimization step: 4126. Total energy = 7789.1543 kcal/mol (7765.5508 without restraints) Performing minimization step: 4127. Total energy = 7785.1102 kcal/mol (7761.5091 without restraints) Performing minimization step: 4128. Total energy = 7781.0703 kcal/mol (7757.4717 without restraints) Performing minimization step: 4129. Total energy = 7777.0348 kcal/mol (7753.4386 without restraints) Performing minimization step: 4130. Total energy = 7773.0032 kcal/mol (7749.4094 without restraints) Performing minimization step: 4131. Total energy = 7768.9760 kcal/mol (7745.3846 without restraints) Performing minimization step: 4132. Total energy = 7764.9533 kcal/mol (7741.3644 without restraints) Performing minimization step: 4133. Total energy = 7760.9348 kcal/mol (7737.3483 without restraints) Performing minimization step: 4134. Total energy = 7756.9204 kcal/mol (7733.3364 without restraints) Performing minimization step: 4135. Total energy = 7752.9105 kcal/mol (7729.3289 without restraints) Performing minimization step: 4136. Total energy = 7748.9047 kcal/mol (7725.3255 without restraints) Performing minimization step: 4137. Total energy = 7744.9031 kcal/mol (7721.3264 without restraints) Performing minimization step: 4138. Total energy = 7740.9059 kcal/mol (7717.3316 without restraints) Performing minimization step: 4139. Total energy = 7736.9130 kcal/mol (7713.3413 without restraints) Performing minimization step: 4140. Total energy = 7732.9243 kcal/mol (7709.3550 without restraints) Performing minimization step: 4141. Total energy = 7728.9393 kcal/mol (7705.3725 without restraints) Performing minimization step: 4142. Total energy = 7724.9593 kcal/mol (7701.3949 without restraints) Performing minimization step: 4143. Total energy = 7720.9833 kcal/mol (7697.4214 without restraints) Performing minimization step: 4144. Total energy = 7717.0116 kcal/mol (7693.4521 without restraints) Performing minimization step: 4145. Total energy = 7713.0440 kcal/mol (7689.4870 without restraints) Performing minimization step: 4146. Total energy = 7709.0808 kcal/mol (7685.5261 without restraints) Performing minimization step: 4147. Total energy = 7705.1218 kcal/mol (7681.5697 without restraints) Performing minimization step: 4148. Total energy = 7701.1672 kcal/mol (7677.6176 without restraints) Performing minimization step: 4149. Total energy = 7697.2169 kcal/mol (7673.6698 without restraints) Performing minimization step: 4150. Total energy = 7693.2710 kcal/mol (7669.7264 without restraints) Performing minimization step: 4151. Total energy = 7689.3294 kcal/mol (7665.7872 without restraints) Performing minimization step: 4152. Total energy = 7685.3918 kcal/mol (7661.8521 without restraints) Performing minimization step: 4153. Total energy = 7681.4585 kcal/mol (7657.9213 without restraints) Performing minimization step: 4154. Total energy = 7677.5298 kcal/mol (7653.9950 without restraints) Performing minimization step: 4155. Total energy = 7673.6048 kcal/mol (7650.0726 without restraints) Performing minimization step: 4156. Total energy = 7669.6847 kcal/mol (7646.1549 without restraints) Performing minimization step: 4157. Total energy = 7665.7686 kcal/mol (7642.2413 without restraints) Performing minimization step: 4158. Total energy = 7661.8567 kcal/mol (7638.3318 without restraints) Performing minimization step: 4159. Total energy = 7657.9493 kcal/mol (7634.4270 without restraints) Performing minimization step: 4160. Total energy = 7654.0460 kcal/mol (7630.5262 without restraints) Performing minimization step: 4161. Total energy = 7650.1472 kcal/mol (7626.6299 without restraints) Performing minimization step: 4162. Total energy = 7646.2526 kcal/mol (7622.7378 without restraints) Performing minimization step: 4163. Total energy = 7642.3620 kcal/mol (7618.8497 without restraints) Performing minimization step: 4164. Total energy = 7638.4762 kcal/mol (7614.9664 without restraints) Performing minimization step: 4165. Total energy = 7634.5944 kcal/mol (7611.0871 without restraints) Performing minimization step: 4166. Total energy = 7630.7171 kcal/mol (7607.2124 without restraints) Performing minimization step: 4167. Total energy = 7626.8443 kcal/mol (7603.3420 without restraints) Performing minimization step: 4168. Total energy = 7622.9755 kcal/mol (7599.4757 without restraints) Performing minimization step: 4169. Total energy = 7619.1109 kcal/mol (7595.6136 without restraints) Performing minimization step: 4170. Total energy = 7615.2507 kcal/mol (7591.7559 without restraints) Performing minimization step: 4171. Total energy = 7611.3949 kcal/mol (7587.9026 without restraints) Performing minimization step: 4172. Total energy = 7607.5432 kcal/mol (7584.0534 without restraints) Performing minimization step: 4173. Total energy = 7603.6959 kcal/mol (7580.2087 without restraints) Performing minimization step: 4174. Total energy = 7599.8527 kcal/mol (7576.3680 without restraints) Performing minimization step: 4175. Total energy = 7596.0139 kcal/mol (7572.5317 without restraints) Performing minimization step: 4176. Total energy = 7592.1794 kcal/mol (7568.6997 without restraints) Performing minimization step: 4177. Total energy = 7588.3492 kcal/mol (7564.8722 without restraints) Performing minimization step: 4178. Total energy = 7584.5237 kcal/mol (7561.0491 without restraints) Performing minimization step: 4179. Total energy = 7580.7022 kcal/mol (7557.2301 without restraints) Performing minimization step: 4180. Total energy = 7576.8848 kcal/mol (7553.4152 without restraints) Performing minimization step: 4181. Total energy = 7573.0717 kcal/mol (7549.6046 without restraints) Performing minimization step: 4182. Total energy = 7569.2631 kcal/mol (7545.7986 without restraints) Performing minimization step: 4183. Total energy = 7565.4587 kcal/mol (7541.9967 without restraints) Performing minimization step: 4184. Total energy = 7561.6586 kcal/mol (7538.1992 without restraints) Performing minimization step: 4185. Total energy = 7557.8626 kcal/mol (7534.4057 without restraints) Performing minimization step: 4186. Total energy = 7554.0710 kcal/mol (7530.6167 without restraints) Performing minimization step: 4187. Total energy = 7550.2840 kcal/mol (7526.8322 without restraints) Performing minimization step: 4188. Total energy = 7546.5012 kcal/mol (7523.0520 without restraints) Performing minimization step: 4189. Total energy = 7542.7228 kcal/mol (7519.2761 without restraints) Performing minimization step: 4190. Total energy = 7538.9487 kcal/mol (7515.5045 without restraints) Performing minimization step: 4191. Total energy = 7535.1787 kcal/mol (7511.7371 without restraints) Performing minimization step: 4192. Total energy = 7531.4130 kcal/mol (7507.9740 without restraints) Performing minimization step: 4193. Total energy = 7527.6515 kcal/mol (7504.2149 without restraints) Performing minimization step: 4194. Total energy = 7523.8946 kcal/mol (7500.4607 without restraints) Performing minimization step: 4195. Total energy = 7520.1419 kcal/mol (7496.7105 without restraints) Performing minimization step: 4196. Total energy = 7516.3934 kcal/mol (7492.9646 without restraints) Performing minimization step: 4197. Total energy = 7512.6497 kcal/mol (7489.2235 without restraints) Performing minimization step: 4198. Total energy = 7508.9099 kcal/mol (7485.4862 without restraints) Performing minimization step: 4199. Total energy = 7505.1741 kcal/mol (7481.7530 without restraints) Performing minimization step: 4200. Total energy = 7501.4431 kcal/mol (7478.0245 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4201. Total energy = 7497.7161 kcal/mol (7474.3002 without restraints) Performing minimization step: 4202. Total energy = 7493.9934 kcal/mol (7470.5799 without restraints) Performing minimization step: 4203. Total energy = 7490.2752 kcal/mol (7466.8644 without restraints) Performing minimization step: 4204. Total energy = 7486.5613 kcal/mol (7463.1530 without restraints) Performing minimization step: 4205. Total energy = 7482.8517 kcal/mol (7459.4461 without restraints) Performing minimization step: 4206. Total energy = 7479.1464 kcal/mol (7455.7434 without restraints) Performing minimization step: 4207. Total energy = 7475.4456 kcal/mol (7452.0453 without restraints) Performing minimization step: 4208. Total energy = 7471.7493 kcal/mol (7448.3514 without restraints) Performing minimization step: 4209. Total energy = 7468.0570 kcal/mol (7444.6617 without restraints) Performing minimization step: 4210. Total energy = 7464.3685 kcal/mol (7440.9758 without restraints) Performing minimization step: 4211. Total energy = 7460.6848 kcal/mol (7437.2948 without restraints) Performing minimization step: 4212. Total energy = 7457.0056 kcal/mol (7433.6182 without restraints) Performing minimization step: 4213. Total energy = 7453.3308 kcal/mol (7429.9459 without restraints) Performing minimization step: 4214. Total energy = 7449.6598 kcal/mol (7426.2774 without restraints) Performing minimization step: 4215. Total energy = 7445.9933 kcal/mol (7422.6135 without restraints) Performing minimization step: 4216. Total energy = 7442.3311 kcal/mol (7418.9540 without restraints) Performing minimization step: 4217. Total energy = 7438.6735 kcal/mol (7415.2990 without restraints) Performing minimization step: 4218. Total energy = 7435.0201 kcal/mol (7411.6481 without restraints) Performing minimization step: 4219. Total energy = 7431.3708 kcal/mol (7408.0015 without restraints) Performing minimization step: 4220. Total energy = 7427.7261 kcal/mol (7404.3595 without restraints) Performing minimization step: 4221. Total energy = 7424.0855 kcal/mol (7400.7214 without restraints) Performing minimization step: 4222. Total energy = 7420.4495 kcal/mol (7397.0880 without restraints) Performing minimization step: 4223. Total energy = 7416.8177 kcal/mol (7393.4589 without restraints) Performing minimization step: 4224. Total energy = 7413.1905 kcal/mol (7389.8343 without restraints) Performing minimization step: 4225. Total energy = 7409.5672 kcal/mol (7386.2136 without restraints) Performing minimization step: 4226. Total energy = 7405.9484 kcal/mol (7382.5974 without restraints) Performing minimization step: 4227. Total energy = 7402.3338 kcal/mol (7378.9854 without restraints) Performing minimization step: 4228. Total energy = 7398.7235 kcal/mol (7375.3778 without restraints) Performing minimization step: 4229. Total energy = 7395.1172 kcal/mol (7371.7741 without restraints) Performing minimization step: 4230. Total energy = 7391.5155 kcal/mol (7368.1750 without restraints) Performing minimization step: 4231. Total energy = 7387.9181 kcal/mol (7364.5803 without restraints) Performing minimization step: 4232. Total energy = 7384.3251 kcal/mol (7360.9899 without restraints) Performing minimization step: 4233. Total energy = 7380.7364 kcal/mol (7357.4040 without restraints) Performing minimization step: 4234. Total energy = 7377.1522 kcal/mol (7353.8222 without restraints) Performing minimization step: 4235. Total energy = 7373.5724 kcal/mol (7350.2451 without restraints) Performing minimization step: 4236. Total energy = 7369.9966 kcal/mol (7346.6720 without restraints) Performing minimization step: 4237. Total energy = 7366.4253 kcal/mol (7343.1033 without restraints) Performing minimization step: 4238. Total energy = 7362.8584 kcal/mol (7339.5391 without restraints) Performing minimization step: 4239. Total energy = 7359.2957 kcal/mol (7335.9789 without restraints) Performing minimization step: 4240. Total energy = 7355.7372 kcal/mol (7332.4232 without restraints) Performing minimization step: 4241. Total energy = 7352.1831 kcal/mol (7328.8717 without restraints) Performing minimization step: 4242. Total energy = 7348.6334 kcal/mol (7325.3247 without restraints) Performing minimization step: 4243. Total energy = 7345.0879 kcal/mol (7321.7819 without restraints) Performing minimization step: 4244. Total energy = 7341.5468 kcal/mol (7318.2434 without restraints) Performing minimization step: 4245. Total energy = 7338.0100 kcal/mol (7314.7092 without restraints) Performing minimization step: 4246. Total energy = 7334.4775 kcal/mol (7311.1795 without restraints) Performing minimization step: 4247. Total energy = 7330.9495 kcal/mol (7307.6541 without restraints) Performing minimization step: 4248. Total energy = 7327.4256 kcal/mol (7304.1329 without restraints) Performing minimization step: 4249. Total energy = 7323.9063 kcal/mol (7300.6164 without restraints) Performing minimization step: 4250. Total energy = 7320.3912 kcal/mol (7297.1038 without restraints) Performing minimization step: 4251. Total energy = 7316.8802 kcal/mol (7293.5956 without restraints) Performing minimization step: 4252. Total energy = 7313.3736 kcal/mol (7290.0916 without restraints) Performing minimization step: 4253. Total energy = 7309.8713 kcal/mol (7286.5921 without restraints) Performing minimization step: 4254. Total energy = 7306.3734 kcal/mol (7283.0968 without restraints) Performing minimization step: 4255. Total energy = 7302.8797 kcal/mol (7279.6058 without restraints) Performing minimization step: 4256. Total energy = 7299.3905 kcal/mol (7276.1193 without restraints) Performing minimization step: 4257. Total energy = 7295.9055 kcal/mol (7272.6369 without restraints) Performing minimization step: 4258. Total energy = 7292.4248 kcal/mol (7269.1589 without restraints) Performing minimization step: 4259. Total energy = 7288.9490 kcal/mol (7265.6858 without restraints) Performing minimization step: 4260. Total energy = 7285.4768 kcal/mol (7262.2163 without restraints) Performing minimization step: 4261. Total energy = 7282.0090 kcal/mol (7258.7512 without restraints) Performing minimization step: 4262. Total energy = 7278.5460 kcal/mol (7255.2909 without restraints) Performing minimization step: 4263. Total energy = 7275.0868 kcal/mol (7251.8344 without restraints) Performing minimization step: 4264. Total energy = 7271.6322 kcal/mol (7248.3825 without restraints) Performing minimization step: 4265. Total energy = 7268.1817 kcal/mol (7244.9347 without restraints) Performing minimization step: 4266. Total energy = 7264.7357 kcal/mol (7241.4914 without restraints) Performing minimization step: 4267. Total energy = 7261.2943 kcal/mol (7238.0529 without restraints) Performing minimization step: 4268. Total energy = 7257.8570 kcal/mol (7234.6182 without restraints) Performing minimization step: 4269. Total energy = 7254.4237 kcal/mol (7231.1876 without restraints) Performing minimization step: 4270. Total energy = 7250.9947 kcal/mol (7227.7614 without restraints) Performing minimization step: 4271. Total energy = 7247.5701 kcal/mol (7224.3395 without restraints) Performing minimization step: 4272. Total energy = 7244.1503 kcal/mol (7220.9223 without restraints) Performing minimization step: 4273. Total energy = 7240.7345 kcal/mol (7217.5093 without restraints) Performing minimization step: 4274. Total energy = 7237.3232 kcal/mol (7214.1008 without restraints) Performing minimization step: 4275. Total energy = 7233.9160 kcal/mol (7210.6963 without restraints) Performing minimization step: 4276. Total energy = 7230.5127 kcal/mol (7207.2957 without restraints) Performing minimization step: 4277. Total energy = 7227.1139 kcal/mol (7203.8997 without restraints) Performing minimization step: 4278. Total energy = 7223.7194 kcal/mol (7200.5079 without restraints) Performing minimization step: 4279. Total energy = 7220.3293 kcal/mol (7197.1205 without restraints) Performing minimization step: 4280. Total energy = 7216.9437 kcal/mol (7193.7378 without restraints) Performing minimization step: 4281. Total energy = 7213.5624 kcal/mol (7190.3591 without restraints) Performing minimization step: 4282. Total energy = 7210.1850 kcal/mol (7186.9845 without restraints) Performing minimization step: 4283. Total energy = 7206.8122 kcal/mol (7183.6146 without restraints) Performing minimization step: 4284. Total energy = 7203.4438 kcal/mol (7180.2489 without restraints) Performing minimization step: 4285. Total energy = 7200.0797 kcal/mol (7176.8874 without restraints) Performing minimization step: 4286. Total energy = 7196.7195 kcal/mol (7173.5300 without restraints) Performing minimization step: 4287. Total energy = 7193.3640 kcal/mol (7170.1773 without restraints) Performing minimization step: 4288. Total energy = 7190.0126 kcal/mol (7166.8286 without restraints) Performing minimization step: 4289. Total energy = 7186.6653 kcal/mol (7163.4841 without restraints) Performing minimization step: 4290. Total energy = 7183.3226 kcal/mol (7160.1442 without restraints) Performing minimization step: 4291. Total energy = 7179.9841 kcal/mol (7156.8085 without restraints) Performing minimization step: 4292. Total energy = 7176.6500 kcal/mol (7153.4770 without restraints) Performing minimization step: 4293. Total energy = 7173.3201 kcal/mol (7150.1499 without restraints) Performing minimization step: 4294. Total energy = 7169.9945 kcal/mol (7146.8272 without restraints) Performing minimization step: 4295. Total energy = 7166.6735 kcal/mol (7143.5089 without restraints) Performing minimization step: 4296. Total energy = 7163.3566 kcal/mol (7140.1948 without restraints) Performing minimization step: 4297. Total energy = 7160.0440 kcal/mol (7136.8849 without restraints) Performing minimization step: 4298. Total energy = 7156.7353 kcal/mol (7133.5791 without restraints) Performing minimization step: 4299. Total energy = 7153.4313 kcal/mol (7130.2778 without restraints) Performing minimization step: 4300. Total energy = 7150.1318 kcal/mol (7126.9811 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4301. Total energy = 7146.8362 kcal/mol (7123.6884 without restraints) Performing minimization step: 4302. Total energy = 7143.5451 kcal/mol (7120.4001 without restraints) Performing minimization step: 4303. Total energy = 7140.2583 kcal/mol (7117.1161 without restraints) Performing minimization step: 4304. Total energy = 7136.9753 kcal/mol (7113.8358 without restraints) Performing minimization step: 4305. Total energy = 7133.6971 kcal/mol (7110.5604 without restraints) Performing minimization step: 4306. Total energy = 7130.4231 kcal/mol (7107.2892 without restraints) Performing minimization step: 4307. Total energy = 7127.1534 kcal/mol (7104.0223 without restraints) Performing minimization step: 4308. Total energy = 7123.8880 kcal/mol (7100.7597 without restraints) Performing minimization step: 4309. Total energy = 7120.6268 kcal/mol (7097.5014 without restraints) Performing minimization step: 4310. Total energy = 7117.3702 kcal/mol (7094.2478 without restraints) Performing minimization step: 4311. Total energy = 7114.1178 kcal/mol (7090.9980 without restraints) Performing minimization step: 4312. Total energy = 7110.8696 kcal/mol (7087.7526 without restraints) Performing minimization step: 4313. Total energy = 7107.6256 kcal/mol (7084.5115 without restraints) Performing minimization step: 4314. Total energy = 7104.3860 kcal/mol (7081.2746 without restraints) Performing minimization step: 4315. Total energy = 7101.1508 kcal/mol (7078.0423 without restraints) Performing minimization step: 4316. Total energy = 7097.9196 kcal/mol (7074.8140 without restraints) Performing minimization step: 4317. Total energy = 7094.6930 kcal/mol (7071.5901 without restraints) Performing minimization step: 4318. Total energy = 7091.4705 kcal/mol (7068.3705 without restraints) Performing minimization step: 4319. Total energy = 7088.2522 kcal/mol (7065.1551 without restraints) Performing minimization step: 4320. Total energy = 7085.0384 kcal/mol (7061.9442 without restraints) Performing minimization step: 4321. Total energy = 7081.8288 kcal/mol (7058.7372 without restraints) Performing minimization step: 4322. Total energy = 7078.6232 kcal/mol (7055.5346 without restraints) Performing minimization step: 4323. Total energy = 7075.4220 kcal/mol (7052.3363 without restraints) Performing minimization step: 4324. Total energy = 7072.2252 kcal/mol (7049.1422 without restraints) Performing minimization step: 4325. Total energy = 7069.0328 kcal/mol (7045.9528 without restraints) Performing minimization step: 4326. Total energy = 7065.8446 kcal/mol (7042.7675 without restraints) Performing minimization step: 4327. Total energy = 7062.6607 kcal/mol (7039.5863 without restraints) Performing minimization step: 4328. Total energy = 7059.4810 kcal/mol (7036.4096 without restraints) Performing minimization step: 4329. Total energy = 7056.3056 kcal/mol (7033.2371 without restraints) Performing minimization step: 4330. Total energy = 7053.1344 kcal/mol (7030.0687 without restraints) Performing minimization step: 4331. Total energy = 7049.9674 kcal/mol (7026.9045 without restraints) Performing minimization step: 4332. Total energy = 7046.8047 kcal/mol (7023.7447 without restraints) Performing minimization step: 4333. Total energy = 7043.6462 kcal/mol (7020.5890 without restraints) Performing minimization step: 4334. Total energy = 7040.4919 kcal/mol (7017.4377 without restraints) Performing minimization step: 4335. Total energy = 7037.3422 kcal/mol (7014.2908 without restraints) Performing minimization step: 4336. Total energy = 7034.1964 kcal/mol (7011.1478 without restraints) Performing minimization step: 4337. Total energy = 7031.0549 kcal/mol (7008.0093 without restraints) Performing minimization step: 4338. Total energy = 7027.9177 kcal/mol (7004.8750 without restraints) Performing minimization step: 4339. Total energy = 7024.7848 kcal/mol (7001.7449 without restraints) Performing minimization step: 4340. Total energy = 7021.6561 kcal/mol (6998.6192 without restraints) Performing minimization step: 4341. Total energy = 7018.5321 kcal/mol (6995.4980 without restraints) Performing minimization step: 4342. Total energy = 7015.4123 kcal/mol (6992.3812 without restraints) Performing minimization step: 4343. Total energy = 7012.2966 kcal/mol (6989.2684 without restraints) Performing minimization step: 4344. Total energy = 7009.1851 kcal/mol (6986.1598 without restraints) Performing minimization step: 4345. Total energy = 7006.0777 kcal/mol (6983.0553 without restraints) Performing minimization step: 4346. Total energy = 7002.9746 kcal/mol (6979.9551 without restraints) Performing minimization step: 4347. Total energy = 6999.8758 kcal/mol (6976.8592 without restraints) Performing minimization step: 4348. Total energy = 6996.7811 kcal/mol (6973.7674 without restraints) Performing minimization step: 4349. Total energy = 6993.6907 kcal/mol (6970.6800 without restraints) Performing minimization step: 4350. Total energy = 6990.6048 kcal/mol (6967.5969 without restraints) Performing minimization step: 4351. Total energy = 6987.5233 kcal/mol (6964.5183 without restraints) Performing minimization step: 4352. Total energy = 6984.4461 kcal/mol (6961.4441 without restraints) Performing minimization step: 4353. Total energy = 6981.3729 kcal/mol (6958.3737 without restraints) Performing minimization step: 4354. Total energy = 6978.3038 kcal/mol (6955.3076 without restraints) Performing minimization step: 4355. Total energy = 6975.2390 kcal/mol (6952.2457 without restraints) Performing minimization step: 4356. Total energy = 6972.1784 kcal/mol (6949.1881 without restraints) Performing minimization step: 4357. Total energy = 6969.1216 kcal/mol (6946.1342 without restraints) Performing minimization step: 4358. Total energy = 6966.0690 kcal/mol (6943.0846 without restraints) Performing minimization step: 4359. Total energy = 6963.0210 kcal/mol (6940.0395 without restraints) Performing minimization step: 4360. Total energy = 6959.9771 kcal/mol (6936.9986 without restraints) Performing minimization step: 4361. Total energy = 6956.9377 kcal/mol (6933.9621 without restraints) Performing minimization step: 4362. Total energy = 6953.9023 kcal/mol (6930.9296 without restraints) Performing minimization step: 4363. Total energy = 6950.8711 kcal/mol (6927.9014 without restraints) Performing minimization step: 4364. Total energy = 6947.8441 kcal/mol (6924.8774 without restraints) Performing minimization step: 4365. Total energy = 6944.8218 kcal/mol (6921.8580 without restraints) Performing minimization step: 4366. Total energy = 6941.8032 kcal/mol (6918.8424 without restraints) Performing minimization step: 4367. Total energy = 6938.7892 kcal/mol (6915.8314 without restraints) Performing minimization step: 4368. Total energy = 6935.7791 kcal/mol (6912.8242 without restraints) Performing minimization step: 4369. Total energy = 6932.7728 kcal/mol (6909.8208 without restraints) Performing minimization step: 4370. Total energy = 6929.7712 kcal/mol (6906.8227 without restraints) Performing minimization step: 4371. Total energy = 6926.7740 kcal/mol (6903.8280 without restraints) Performing minimization step: 4372. Total energy = 6923.7806 kcal/mol (6900.8376 without restraints) Performing minimization step: 4373. Total energy = 6920.7915 kcal/mol (6897.8515 without restraints) Performing minimization step: 4374. Total energy = 6917.8066 kcal/mol (6894.8695 without restraints) Performing minimization step: 4375. Total energy = 6914.8257 kcal/mol (6891.8917 without restraints) Performing minimization step: 4376. Total energy = 6911.8494 kcal/mol (6888.9183 without restraints) Performing minimization step: 4377. Total energy = 6908.8772 kcal/mol (6885.9492 without restraints) Performing minimization step: 4378. Total energy = 6905.9091 kcal/mol (6882.9840 without restraints) Performing minimization step: 4379. Total energy = 6902.9448 kcal/mol (6880.0228 without restraints) Performing minimization step: 4380. Total energy = 6899.9852 kcal/mol (6877.0662 without restraints) Performing minimization step: 4381. Total energy = 6897.0299 kcal/mol (6874.1141 without restraints) Performing minimization step: 4382. Total energy = 6894.0787 kcal/mol (6871.1656 without restraints) Performing minimization step: 4383. Total energy = 6891.1314 kcal/mol (6868.2214 without restraints) Performing minimization step: 4384. Total energy = 6888.1887 kcal/mol (6865.2816 without restraints) Performing minimization step: 4385. Total energy = 6885.2498 kcal/mol (6862.3458 without restraints) Performing minimization step: 4386. Total energy = 6882.3151 kcal/mol (6859.4141 without restraints) Performing minimization step: 4387. Total energy = 6879.3847 kcal/mol (6856.4869 without restraints) Performing minimization step: 4388. Total energy = 6876.4587 kcal/mol (6853.5637 without restraints) Performing minimization step: 4389. Total energy = 6873.5368 kcal/mol (6850.6450 without restraints) Performing minimization step: 4390. Total energy = 6870.6189 kcal/mol (6847.7299 without restraints) Performing minimization step: 4391. Total energy = 6867.7050 kcal/mol (6844.8191 without restraints) Performing minimization step: 4392. Total energy = 6864.7950 kcal/mol (6841.9121 without restraints) Performing minimization step: 4393. Total energy = 6861.8893 kcal/mol (6839.0095 without restraints) Performing minimization step: 4394. Total energy = 6858.9879 kcal/mol (6836.1112 without restraints) Performing minimization step: 4395. Total energy = 6856.0907 kcal/mol (6833.2170 without restraints) Performing minimization step: 4396. Total energy = 6853.1976 kcal/mol (6830.3269 without restraints) Performing minimization step: 4397. Total energy = 6850.3084 kcal/mol (6827.4407 without restraints) Performing minimization step: 4398. Total energy = 6847.4238 kcal/mol (6824.5594 without restraints) Performing minimization step: 4399. Total energy = 6844.5434 kcal/mol (6821.6819 without restraints) Performing minimization step: 4400. Total energy = 6841.6670 kcal/mol (6818.8086 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4401. Total energy = 6838.7950 kcal/mol (6815.9394 without restraints) Performing minimization step: 4402. Total energy = 6835.9267 kcal/mol (6813.0743 without restraints) Performing minimization step: 4403. Total energy = 6833.0627 kcal/mol (6810.2135 without restraints) Performing minimization step: 4404. Total energy = 6830.2028 kcal/mol (6807.3566 without restraints) Performing minimization step: 4405. Total energy = 6827.3470 kcal/mol (6804.5039 without restraints) Performing minimization step: 4406. Total energy = 6824.4953 kcal/mol (6801.6552 without restraints) Performing minimization step: 4407. Total energy = 6821.6479 kcal/mol (6798.8109 without restraints) Performing minimization step: 4408. Total energy = 6818.8044 kcal/mol (6795.9704 without restraints) Performing minimization step: 4409. Total energy = 6815.9653 kcal/mol (6793.1344 without restraints) Performing minimization step: 4410. Total energy = 6813.1298 kcal/mol (6790.3020 without restraints) Performing minimization step: 4411. Total energy = 6810.2990 kcal/mol (6787.4745 without restraints) Performing minimization step: 4412. Total energy = 6807.4720 kcal/mol (6784.6504 without restraints) Performing minimization step: 4413. Total energy = 6804.6492 kcal/mol (6781.8308 without restraints) Performing minimization step: 4414. Total energy = 6801.8306 kcal/mol (6779.0154 without restraints) Performing minimization step: 4415. Total energy = 6799.0161 kcal/mol (6776.2038 without restraints) Performing minimization step: 4416. Total energy = 6796.2056 kcal/mol (6773.3965 without restraints) Performing minimization step: 4417. Total energy = 6793.3992 kcal/mol (6770.5931 without restraints) Performing minimization step: 4418. Total energy = 6790.5970 kcal/mol (6767.7941 without restraints) Performing minimization step: 4419. Total energy = 6787.7986 kcal/mol (6764.9987 without restraints) Performing minimization step: 4420. Total energy = 6785.0044 kcal/mol (6762.2077 without restraints) Performing minimization step: 4421. Total energy = 6782.2152 kcal/mol (6759.4217 without restraints) Performing minimization step: 4422. Total energy = 6779.4293 kcal/mol (6756.6388 without restraints) Performing minimization step: 4423. Total energy = 6776.6478 kcal/mol (6753.8604 without restraints) Performing minimization step: 4424. Total energy = 6773.8698 kcal/mol (6751.0855 without restraints) Performing minimization step: 4425. Total energy = 6771.0958 kcal/mol (6748.3146 without restraints) Performing minimization step: 4426. Total energy = 6768.3261 kcal/mol (6745.5481 without restraints) Performing minimization step: 4427. Total energy = 6765.5605 kcal/mol (6742.7857 without restraints) Performing minimization step: 4428. Total energy = 6762.7988 kcal/mol (6740.0271 without restraints) Performing minimization step: 4429. Total energy = 6760.0416 kcal/mol (6737.2729 without restraints) Performing minimization step: 4430. Total energy = 6757.2881 kcal/mol (6734.5226 without restraints) Performing minimization step: 4431. Total energy = 6754.5390 kcal/mol (6731.7767 without restraints) Performing minimization step: 4432. Total energy = 6751.7939 kcal/mol (6729.0348 without restraints) Performing minimization step: 4433. Total energy = 6749.0527 kcal/mol (6726.2967 without restraints) Performing minimization step: 4434. Total energy = 6746.3156 kcal/mol (6723.5628 without restraints) Performing minimization step: 4435. Total energy = 6743.5831 kcal/mol (6720.8335 without restraints) Performing minimization step: 4436. Total energy = 6740.8545 kcal/mol (6718.1080 without restraints) Performing minimization step: 4437. Total energy = 6738.1295 kcal/mol (6715.3862 without restraints) Performing minimization step: 4438. Total energy = 6735.4085 kcal/mol (6712.6684 without restraints) Performing minimization step: 4439. Total energy = 6732.6917 kcal/mol (6709.9548 without restraints) Performing minimization step: 4440. Total energy = 6729.9790 kcal/mol (6707.2451 without restraints) Performing minimization step: 4441. Total energy = 6727.2702 kcal/mol (6704.5395 without restraints) Performing minimization step: 4442. Total energy = 6724.5652 kcal/mol (6701.8376 without restraints) Performing minimization step: 4443. Total energy = 6721.8647 kcal/mol (6699.1404 without restraints) Performing minimization step: 4444. Total energy = 6719.1683 kcal/mol (6696.4472 without restraints) Performing minimization step: 4445. Total energy = 6716.4756 kcal/mol (6693.7577 without restraints) Performing minimization step: 4446. Total energy = 6713.7869 kcal/mol (6691.0722 without restraints) Performing minimization step: 4447. Total energy = 6711.1023 kcal/mol (6688.3908 without restraints) Performing minimization step: 4448. Total energy = 6708.4218 kcal/mol (6685.7135 without restraints) Performing minimization step: 4449. Total energy = 6705.7450 kcal/mol (6683.0399 without restraints) Performing minimization step: 4450. Total energy = 6703.0735 kcal/mol (6680.3720 without restraints) Performing minimization step: 4451. Total energy = 6700.4054 kcal/mol (6677.7067 without restraints) Performing minimization step: 4452. Total energy = 6697.7409 kcal/mol (6675.0454 without restraints) Performing minimization step: 4453. Total energy = 6695.0802 kcal/mol (6672.3879 without restraints) Performing minimization step: 4454. Total energy = 6692.4235 kcal/mol (6669.7345 without restraints) Performing minimization step: 4455. Total energy = 6689.7712 kcal/mol (6667.0854 without restraints) Performing minimization step: 4456. Total energy = 6687.1225 kcal/mol (6664.4399 without restraints) Performing minimization step: 4457. Total energy = 6684.4777 kcal/mol (6661.7984 without restraints) Performing minimization step: 4458. Total energy = 6681.8373 kcal/mol (6659.1613 without restraints) Performing minimization step: 4459. Total energy = 6679.2006 kcal/mol (6656.5277 without restraints) Performing minimization step: 4460. Total energy = 6676.5682 kcal/mol (6653.8985 without restraints) Performing minimization step: 4461. Total energy = 6673.9393 kcal/mol (6651.2729 without restraints) Performing minimization step: 4462. Total energy = 6671.3145 kcal/mol (6648.6513 without restraints) Performing minimization step: 4463. Total energy = 6668.6938 kcal/mol (6646.0340 without restraints) Performing minimization step: 4464. Total energy = 6666.0770 kcal/mol (6643.4202 without restraints) Performing minimization step: 4465. Total energy = 6663.4637 kcal/mol (6640.8102 without restraints) Performing minimization step: 4466. Total energy = 6660.8548 kcal/mol (6638.2046 without restraints) Performing minimization step: 4467. Total energy = 6658.2496 kcal/mol (6635.6027 without restraints) Performing minimization step: 4468. Total energy = 6655.6485 kcal/mol (6633.0048 without restraints) Performing minimization step: 4469. Total energy = 6653.0514 kcal/mol (6630.4111 without restraints) Performing minimization step: 4470. Total energy = 6650.4582 kcal/mol (6627.8210 without restraints) Performing minimization step: 4471. Total energy = 6647.8688 kcal/mol (6625.2349 without restraints) Performing minimization step: 4472. Total energy = 6645.2833 kcal/mol (6622.6527 without restraints) Performing minimization step: 4473. Total energy = 6642.7019 kcal/mol (6620.0746 without restraints) Performing minimization step: 4474. Total energy = 6640.1242 kcal/mol (6617.5002 without restraints) Performing minimization step: 4475. Total energy = 6637.5505 kcal/mol (6614.9297 without restraints) Performing minimization step: 4476. Total energy = 6634.9807 kcal/mol (6612.3633 without restraints) Performing minimization step: 4477. Total energy = 6632.4151 kcal/mol (6609.8010 without restraints) Performing minimization step: 4478. Total energy = 6629.8536 kcal/mol (6607.2428 without restraints) Performing minimization step: 4479. Total energy = 6627.2959 kcal/mol (6604.6883 without restraints) Performing minimization step: 4480. Total energy = 6624.7419 kcal/mol (6602.1376 without restraints) Performing minimization step: 4481. Total energy = 6622.1919 kcal/mol (6599.5909 without restraints) Performing minimization step: 4482. Total energy = 6619.6459 kcal/mol (6597.0483 without restraints) Performing minimization step: 4483. Total energy = 6617.1035 kcal/mol (6594.5092 without restraints) Performing minimization step: 4484. Total energy = 6614.5650 kcal/mol (6591.9739 without restraints) Performing minimization step: 4485. Total energy = 6612.0307 kcal/mol (6589.4431 without restraints) Performing minimization step: 4486. Total energy = 6609.5002 kcal/mol (6586.9158 without restraints) Performing minimization step: 4487. Total energy = 6606.9734 kcal/mol (6584.3924 without restraints) Performing minimization step: 4488. Total energy = 6604.4504 kcal/mol (6581.8727 without restraints) Performing minimization step: 4489. Total energy = 6601.9315 kcal/mol (6579.3571 without restraints) Performing minimization step: 4490. Total energy = 6599.4159 kcal/mol (6576.8448 without restraints) Performing minimization step: 4491. Total energy = 6596.9045 kcal/mol (6574.3368 without restraints) Performing minimization step: 4492. Total energy = 6594.3968 kcal/mol (6571.8322 without restraints) Performing minimization step: 4493. Total energy = 6591.8928 kcal/mol (6569.3318 without restraints) Performing minimization step: 4494. Total energy = 6589.3936 kcal/mol (6566.8359 without restraints) Performing minimization step: 4495. Total energy = 6586.8974 kcal/mol (6564.3430 without restraints) Performing minimization step: 4496. Total energy = 6584.4052 kcal/mol (6561.8542 without restraints) Performing minimization step: 4497. Total energy = 6581.9176 kcal/mol (6559.3698 without restraints) Performing minimization step: 4498. Total energy = 6579.4332 kcal/mol (6556.8889 without restraints) Performing minimization step: 4499. Total energy = 6576.9530 kcal/mol (6554.4120 without restraints) Performing minimization step: 4500. Total energy = 6574.4764 kcal/mol (6551.9389 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4501. Total energy = 6572.0031 kcal/mol (6549.4689 without restraints) Performing minimization step: 4502. Total energy = 6569.5341 kcal/mol (6547.0035 without restraints) Performing minimization step: 4503. Total energy = 6567.0689 kcal/mol (6544.5414 without restraints) Performing minimization step: 4504. Total energy = 6564.6073 kcal/mol (6542.0832 without restraints) Performing minimization step: 4505. Total energy = 6562.1493 kcal/mol (6539.6287 without restraints) Performing minimization step: 4506. Total energy = 6559.6954 kcal/mol (6537.1781 without restraints) Performing minimization step: 4507. Total energy = 6557.2456 kcal/mol (6534.7319 without restraints) Performing minimization step: 4508. Total energy = 6554.7990 kcal/mol (6532.2885 without restraints) Performing minimization step: 4509. Total energy = 6552.3565 kcal/mol (6529.8494 without restraints) Performing minimization step: 4510. Total energy = 6549.9180 kcal/mol (6527.4145 without restraints) Performing minimization step: 4511. Total energy = 6547.4834 kcal/mol (6524.9832 without restraints) Performing minimization step: 4512. Total energy = 6545.0527 kcal/mol (6522.5558 without restraints) Performing minimization step: 4513. Total energy = 6542.6252 kcal/mol (6520.1317 without restraints) Performing minimization step: 4514. Total energy = 6540.2018 kcal/mol (6517.7118 without restraints) Performing minimization step: 4515. Total energy = 6537.7823 kcal/mol (6515.2956 without restraints) Performing minimization step: 4516. Total energy = 6535.3663 kcal/mol (6512.8831 without restraints) Performing minimization step: 4517. Total energy = 6532.9538 kcal/mol (6510.4740 without restraints) Performing minimization step: 4518. Total energy = 6530.5453 kcal/mol (6508.0689 without restraints) Performing minimization step: 4519. Total energy = 6528.1403 kcal/mol (6505.6674 without restraints) Performing minimization step: 4520. Total energy = 6525.7391 kcal/mol (6503.2696 without restraints) Performing minimization step: 4521. Total energy = 6523.3416 kcal/mol (6500.8755 without restraints) Performing minimization step: 4522. Total energy = 6520.9479 kcal/mol (6498.4853 without restraints) Performing minimization step: 4523. Total energy = 6518.5579 kcal/mol (6496.0987 without restraints) Performing minimization step: 4524. Total energy = 6516.1715 kcal/mol (6493.7158 without restraints) Performing minimization step: 4525. Total energy = 6513.7891 kcal/mol (6491.3368 without restraints) Performing minimization step: 4526. Total energy = 6511.4102 kcal/mol (6488.9614 without restraints) Performing minimization step: 4527. Total energy = 6509.0351 kcal/mol (6486.5897 without restraints) Performing minimization step: 4528. Total energy = 6506.6636 kcal/mol (6484.2217 without restraints) Performing minimization step: 4529. Total energy = 6504.2963 kcal/mol (6481.8578 without restraints) Performing minimization step: 4530. Total energy = 6501.9323 kcal/mol (6479.4973 without restraints) Performing minimization step: 4531. Total energy = 6499.5722 kcal/mol (6477.1407 without restraints) Performing minimization step: 4532. Total energy = 6497.2158 kcal/mol (6474.7877 without restraints) Performing minimization step: 4533. Total energy = 6494.8630 kcal/mol (6472.4384 without restraints) Performing minimization step: 4534. Total energy = 6492.5137 kcal/mol (6470.0926 without restraints) Performing minimization step: 4535. Total energy = 6490.1687 kcal/mol (6467.7511 without restraints) Performing minimization step: 4536. Total energy = 6487.8267 kcal/mol (6465.4126 without restraints) Performing minimization step: 4537. Total energy = 6485.4884 kcal/mol (6463.0779 without restraints) Performing minimization step: 4538. Total energy = 6483.1543 kcal/mol (6460.7474 without restraints) Performing minimization step: 4539. Total energy = 6480.8237 kcal/mol (6458.4201 without restraints) Performing minimization step: 4540. Total energy = 6478.4963 kcal/mol (6456.0962 without restraints) Performing minimization step: 4541. Total energy = 6476.1728 kcal/mol (6453.7761 without restraints) Performing minimization step: 4542. Total energy = 6473.8526 kcal/mol (6451.4595 without restraints) Performing minimization step: 4543. Total energy = 6471.5363 kcal/mol (6449.1467 without restraints) Performing minimization step: 4544. Total energy = 6469.2238 kcal/mol (6446.8378 without restraints) Performing minimization step: 4545. Total energy = 6466.9148 kcal/mol (6444.5323 without restraints) Performing minimization step: 4546. Total energy = 6464.6098 kcal/mol (6442.2308 without restraints) Performing minimization step: 4547. Total energy = 6462.3084 kcal/mol (6439.9329 without restraints) Performing minimization step: 4548. Total energy = 6460.0102 kcal/mol (6437.6383 without restraints) Performing minimization step: 4549. Total energy = 6457.7158 kcal/mol (6435.3474 without restraints) Performing minimization step: 4550. Total energy = 6455.4247 kcal/mol (6433.0598 without restraints) Performing minimization step: 4551. Total energy = 6453.1374 kcal/mol (6430.7761 without restraints) Performing minimization step: 4552. Total energy = 6450.8535 kcal/mol (6428.4957 without restraints) Performing minimization step: 4553. Total energy = 6448.5733 kcal/mol (6426.2190 without restraints) Performing minimization step: 4554. Total energy = 6446.2969 kcal/mol (6423.9462 without restraints) Performing minimization step: 4555. Total energy = 6444.0240 kcal/mol (6421.6769 without restraints) Performing minimization step: 4556. Total energy = 6441.7550 kcal/mol (6419.4114 without restraints) Performing minimization step: 4557. Total energy = 6439.4890 kcal/mol (6417.1490 without restraints) Performing minimization step: 4558. Total energy = 6437.2267 kcal/mol (6414.8902 without restraints) Performing minimization step: 4559. Total energy = 6434.9681 kcal/mol (6412.6352 without restraints) Performing minimization step: 4560. Total energy = 6432.7128 kcal/mol (6410.3834 without restraints) Performing minimization step: 4561. Total energy = 6430.4611 kcal/mol (6408.1353 without restraints) Performing minimization step: 4562. Total energy = 6428.2129 kcal/mol (6405.8907 without restraints) Performing minimization step: 4563. Total energy = 6425.9683 kcal/mol (6403.6497 without restraints) Performing minimization step: 4564. Total energy = 6423.7272 kcal/mol (6401.4122 without restraints) Performing minimization step: 4565. Total energy = 6421.4896 kcal/mol (6399.1782 without restraints) Performing minimization step: 4566. Total energy = 6419.2557 kcal/mol (6396.9478 without restraints) Performing minimization step: 4567. Total energy = 6417.0252 kcal/mol (6394.7210 without restraints) Performing minimization step: 4568. Total energy = 6414.7984 kcal/mol (6392.4978 without restraints) Performing minimization step: 4569. Total energy = 6412.5748 kcal/mol (6390.2776 without restraints) Performing minimization step: 4570. Total energy = 6410.3546 kcal/mol (6388.0612 without restraints) Performing minimization step: 4571. Total energy = 6408.1381 kcal/mol (6385.8483 without restraints) Performing minimization step: 4572. Total energy = 6405.9251 kcal/mol (6383.6390 without restraints) Performing minimization step: 4573. Total energy = 6403.7157 kcal/mol (6381.4331 without restraints) Performing minimization step: 4574. Total energy = 6401.5101 kcal/mol (6379.2311 without restraints) Performing minimization step: 4575. Total energy = 6399.3076 kcal/mol (6377.0325 without restraints) Performing minimization step: 4576. Total energy = 6397.1090 kcal/mol (6374.8373 without restraints) Performing minimization step: 4577. Total energy = 6394.9135 kcal/mol (6372.6454 without restraints) Performing minimization step: 4578. Total energy = 6392.7212 kcal/mol (6370.4568 without restraints) Performing minimization step: 4579. Total energy = 6390.5329 kcal/mol (6368.2721 without restraints) Performing minimization step: 4580. Total energy = 6388.3479 kcal/mol (6366.0907 without restraints) Performing minimization step: 4581. Total energy = 6386.1667 kcal/mol (6363.9132 without restraints) Performing minimization step: 4582. Total energy = 6383.9884 kcal/mol (6361.7386 without restraints) Performing minimization step: 4583. Total energy = 6381.8136 kcal/mol (6359.5675 without restraints) Performing minimization step: 4584. Total energy = 6379.6424 kcal/mol (6357.4001 without restraints) Performing minimization step: 4585. Total energy = 6377.4746 kcal/mol (6355.2357 without restraints) Performing minimization step: 4586. Total energy = 6375.3100 kcal/mol (6353.0749 without restraints) Performing minimization step: 4587. Total energy = 6373.1491 kcal/mol (6350.9178 without restraints) Performing minimization step: 4588. Total energy = 6370.9916 kcal/mol (6348.7637 without restraints) Performing minimization step: 4589. Total energy = 6368.8373 kcal/mol (6346.6132 without restraints) Performing minimization step: 4590. Total energy = 6366.6865 kcal/mol (6344.4660 without restraints) Performing minimization step: 4591. Total energy = 6364.5395 kcal/mol (6342.3227 without restraints) Performing minimization step: 4592. Total energy = 6362.3953 kcal/mol (6340.1822 without restraints) Performing minimization step: 4593. Total energy = 6360.2547 kcal/mol (6338.0453 without restraints) Performing minimization step: 4594. Total energy = 6358.1176 kcal/mol (6335.9119 without restraints) Performing minimization step: 4595. Total energy = 6355.9836 kcal/mol (6333.7816 without restraints) Performing minimization step: 4596. Total energy = 6353.8527 kcal/mol (6331.6545 without restraints) Performing minimization step: 4597. Total energy = 6351.7256 kcal/mol (6329.5310 without restraints) Performing minimization step: 4598. Total energy = 6349.6022 kcal/mol (6327.4114 without restraints) Performing minimization step: 4599. Total energy = 6347.4816 kcal/mol (6325.2944 without restraints) Performing minimization step: 4600. Total energy = 6345.3640 kcal/mol (6323.1806 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4601. Total energy = 6343.2502 kcal/mol (6321.0705 without restraints) Performing minimization step: 4602. Total energy = 6341.1400 kcal/mol (6318.9639 without restraints) Performing minimization step: 4603. Total energy = 6339.0330 kcal/mol (6316.8607 without restraints) Performing minimization step: 4604. Total energy = 6336.9292 kcal/mol (6314.7606 without restraints) Performing minimization step: 4605. Total energy = 6334.8287 kcal/mol (6312.6639 without restraints) Performing minimization step: 4606. Total energy = 6332.7315 kcal/mol (6310.5704 without restraints) Performing minimization step: 4607. Total energy = 6330.6375 kcal/mol (6308.4801 without restraints) Performing minimization step: 4608. Total energy = 6328.5468 kcal/mol (6306.3932 without restraints) Performing minimization step: 4609. Total energy = 6326.4598 kcal/mol (6304.3100 without restraints) Performing minimization step: 4610. Total energy = 6324.3757 kcal/mol (6302.2296 without restraints) Performing minimization step: 4611. Total energy = 6322.2951 kcal/mol (6300.1527 without restraints) Performing minimization step: 4612. Total energy = 6320.2184 kcal/mol (6298.0798 without restraints) Performing minimization step: 4613. Total energy = 6318.1443 kcal/mol (6296.0095 without restraints) Performing minimization step: 4614. Total energy = 6316.0735 kcal/mol (6293.9424 without restraints) Performing minimization step: 4615. Total energy = 6314.0060 kcal/mol (6291.8787 without restraints) Performing minimization step: 4616. Total energy = 6311.9419 kcal/mol (6289.8185 without restraints) Performing minimization step: 4617. Total energy = 6309.8809 kcal/mol (6287.7612 without restraints) Performing minimization step: 4618. Total energy = 6307.8236 kcal/mol (6285.7077 without restraints) Performing minimization step: 4619. Total energy = 6305.7691 kcal/mol (6283.6570 without restraints) Performing minimization step: 4620. Total energy = 6303.7178 kcal/mol (6281.6095 without restraints) Performing minimization step: 4621. Total energy = 6301.6701 kcal/mol (6279.5655 without restraints) Performing minimization step: 4622. Total energy = 6299.6253 kcal/mol (6277.5245 without restraints) Performing minimization step: 4623. Total energy = 6297.5839 kcal/mol (6275.4871 without restraints) Performing minimization step: 4624. Total energy = 6295.5461 kcal/mol (6273.4529 without restraints) Performing minimization step: 4625. Total energy = 6293.5110 kcal/mol (6271.4216 without restraints) Performing minimization step: 4626. Total energy = 6291.4794 kcal/mol (6269.3940 without restraints) Performing minimization step: 4627. Total energy = 6289.4510 kcal/mol (6267.3693 without restraints) Performing minimization step: 4628. Total energy = 6287.4257 kcal/mol (6265.3479 without restraints) Performing minimization step: 4629. Total energy = 6285.4039 kcal/mol (6263.3299 without restraints) Performing minimization step: 4630. Total energy = 6283.3853 kcal/mol (6261.3150 without restraints) Performing minimization step: 4631. Total energy = 6281.3693 kcal/mol (6259.3029 without restraints) Performing minimization step: 4632. Total energy = 6279.3569 kcal/mol (6257.2943 without restraints) Performing minimization step: 4633. Total energy = 6277.3476 kcal/mol (6255.2888 without restraints) Performing minimization step: 4634. Total energy = 6275.3411 kcal/mol (6253.2862 without restraints) Performing minimization step: 4635. Total energy = 6273.3376 kcal/mol (6251.2866 without restraints) Performing minimization step: 4636. Total energy = 6271.3374 kcal/mol (6249.2901 without restraints) Performing minimization step: 4637. Total energy = 6269.3403 kcal/mol (6247.2969 without restraints) Performing minimization step: 4638. Total energy = 6267.3466 kcal/mol (6245.3071 without restraints) Performing minimization step: 4639. Total energy = 6265.3561 kcal/mol (6243.3205 without restraints) Performing minimization step: 4640. Total energy = 6263.3686 kcal/mol (6241.3368 without restraints) Performing minimization step: 4641. Total energy = 6261.3842 kcal/mol (6239.3563 without restraints) Performing minimization step: 4642. Total energy = 6259.4031 kcal/mol (6237.3791 without restraints) Performing minimization step: 4643. Total energy = 6257.4251 kcal/mol (6235.4049 without restraints) Performing minimization step: 4644. Total energy = 6255.4502 kcal/mol (6233.4339 without restraints) Performing minimization step: 4645. Total energy = 6253.4790 kcal/mol (6231.4666 without restraints) Performing minimization step: 4646. Total energy = 6251.5100 kcal/mol (6229.5015 without restraints) Performing minimization step: 4647. Total energy = 6249.5444 kcal/mol (6227.5398 without restraints) Performing minimization step: 4648. Total energy = 6247.5817 kcal/mol (6225.5810 without restraints) Performing minimization step: 4649. Total energy = 6245.6216 kcal/mol (6223.6248 without restraints) Performing minimization step: 4650. Total energy = 6243.6654 kcal/mol (6221.6728 without restraints) Performing minimization step: 4651. Total energy = 6241.7123 kcal/mol (6219.7233 without restraints) Performing minimization step: 4652. Total energy = 6239.7621 kcal/mol (6217.7770 without restraints) Performing minimization step: 4653. Total energy = 6237.8143 kcal/mol (6215.8331 without restraints) Performing minimization step: 4654. Total energy = 6235.8702 kcal/mol (6213.8930 without restraints) Performing minimization step: 4655. Total energy = 6233.9288 kcal/mol (6211.9555 without restraints) Performing minimization step: 4656. Total energy = 6231.9907 kcal/mol (6210.0212 without restraints) Performing minimization step: 4657. Total energy = 6230.0555 kcal/mol (6208.0900 without restraints) Performing minimization step: 4658. Total energy = 6228.1233 kcal/mol (6206.1618 without restraints) Performing minimization step: 4659. Total energy = 6226.1944 kcal/mol (6204.2368 without restraints) Performing minimization step: 4660. Total energy = 6224.2679 kcal/mol (6202.3141 without restraints) Performing minimization step: 4661. Total energy = 6222.3448 kcal/mol (6200.3951 without restraints) Performing minimization step: 4662. Total energy = 6220.4249 kcal/mol (6198.4791 without restraints) Performing minimization step: 4663. Total energy = 6218.5082 kcal/mol (6196.5664 without restraints) Performing minimization step: 4664. Total energy = 6216.5941 kcal/mol (6194.6562 without restraints) Performing minimization step: 4665. Total energy = 6214.6835 kcal/mol (6192.7497 without restraints) Performing minimization step: 4666. Total energy = 6212.7755 kcal/mol (6190.8455 without restraints) Performing minimization step: 4667. Total energy = 6210.8704 kcal/mol (6188.9444 without restraints) Performing minimization step: 4668. Total energy = 6208.9684 kcal/mol (6187.0466 without restraints) Performing minimization step: 4669. Total energy = 6207.0694 kcal/mol (6185.1513 without restraints) Performing minimization step: 4670. Total energy = 6205.1732 kcal/mol (6183.2591 without restraints) Performing minimization step: 4671. Total energy = 6203.2799 kcal/mol (6181.3698 without restraints) Performing minimization step: 4672. Total energy = 6201.3897 kcal/mol (6179.4836 without restraints) Performing minimization step: 4673. Total energy = 6199.5025 kcal/mol (6177.6004 without restraints) Performing minimization step: 4674. Total energy = 6197.6181 kcal/mol (6175.7199 without restraints) Performing minimization step: 4675. Total energy = 6195.7365 kcal/mol (6173.8424 without restraints) Performing minimization step: 4676. Total energy = 6193.8579 kcal/mol (6171.9678 without restraints) Performing minimization step: 4677. Total energy = 6191.9822 kcal/mol (6170.0961 without restraints) Performing minimization step: 4678. Total energy = 6190.1094 kcal/mol (6168.2273 without restraints) Performing minimization step: 4679. Total energy = 6188.2395 kcal/mol (6166.3614 without restraints) Performing minimization step: 4680. Total energy = 6186.3727 kcal/mol (6164.4986 without restraints) Performing minimization step: 4681. Total energy = 6184.5087 kcal/mol (6162.6386 without restraints) Performing minimization step: 4682. Total energy = 6182.6474 kcal/mol (6160.7812 without restraints) Performing minimization step: 4683. Total energy = 6180.7893 kcal/mol (6158.9272 without restraints) Performing minimization step: 4684. Total energy = 6178.9339 kcal/mol (6157.0759 without restraints) Performing minimization step: 4685. Total energy = 6177.0812 kcal/mol (6155.2272 without restraints) Performing minimization step: 4686. Total energy = 6175.2315 kcal/mol (6153.3815 without restraints) Performing minimization step: 4687. Total energy = 6173.3848 kcal/mol (6151.5389 without restraints) Performing minimization step: 4688. Total energy = 6171.5408 kcal/mol (6149.6990 without restraints) Performing minimization step: 4689. Total energy = 6169.6997 kcal/mol (6147.8618 without restraints) Performing minimization step: 4690. Total energy = 6167.8614 kcal/mol (6146.0276 without restraints) Performing minimization step: 4691. Total energy = 6166.0259 kcal/mol (6144.1962 without restraints) Performing minimization step: 4692. Total energy = 6164.1936 kcal/mol (6142.3679 without restraints) Performing minimization step: 4693. Total energy = 6162.3638 kcal/mol (6140.5422 without restraints) Performing minimization step: 4694. Total energy = 6160.5371 kcal/mol (6138.7196 without restraints) Performing minimization step: 4695. Total energy = 6158.7131 kcal/mol (6136.8997 without restraints) Performing minimization step: 4696. Total energy = 6156.8919 kcal/mol (6135.0825 without restraints) Performing minimization step: 4697. Total energy = 6155.0734 kcal/mol (6133.2681 without restraints) Performing minimization step: 4698. Total energy = 6153.2575 kcal/mol (6131.4562 without restraints) Performing minimization step: 4699. Total energy = 6151.4447 kcal/mol (6129.6479 without restraints) Performing minimization step: 4700. Total energy = 6149.6351 kcal/mol (6127.8421 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4701. Total energy = 6147.8281 kcal/mol (6126.0392 without restraints) Performing minimization step: 4702. Total energy = 6146.0237 kcal/mol (6124.2390 without restraints) Performing minimization step: 4703. Total energy = 6144.2220 kcal/mol (6122.4413 without restraints) Performing minimization step: 4704. Total energy = 6142.4234 kcal/mol (6120.6467 without restraints) Performing minimization step: 4705. Total energy = 6140.6271 kcal/mol (6118.8546 without restraints) Performing minimization step: 4706. Total energy = 6138.8336 kcal/mol (6117.0652 without restraints) Performing minimization step: 4707. Total energy = 6137.0431 kcal/mol (6115.2787 without restraints) Performing minimization step: 4708. Total energy = 6135.2554 kcal/mol (6113.4952 without restraints) Performing minimization step: 4709. Total energy = 6133.4706 kcal/mol (6111.7145 without restraints) Performing minimization step: 4710. Total energy = 6131.6880 kcal/mol (6109.9361 without restraints) Performing minimization step: 4711. Total energy = 6129.9086 kcal/mol (6108.1607 without restraints) Performing minimization step: 4712. Total energy = 6128.1317 kcal/mol (6106.3880 without restraints) Performing minimization step: 4713. Total energy = 6126.3577 kcal/mol (6104.6181 without restraints) Performing minimization step: 4714. Total energy = 6124.5862 kcal/mol (6102.8508 without restraints) Performing minimization step: 4715. Total energy = 6122.8174 kcal/mol (6101.0861 without restraints) Performing minimization step: 4716. Total energy = 6121.0513 kcal/mol (6099.3242 without restraints) Performing minimization step: 4717. Total energy = 6119.2883 kcal/mol (6097.5654 without restraints) Performing minimization step: 4718. Total energy = 6117.5277 kcal/mol (6095.8088 without restraints) Performing minimization step: 4719. Total energy = 6115.7694 kcal/mol (6094.0547 without restraints) Performing minimization step: 4720. Total energy = 6114.0137 kcal/mol (6092.3032 without restraints) Performing minimization step: 4721. Total energy = 6112.2608 kcal/mol (6090.5545 without restraints) Performing minimization step: 4722. Total energy = 6110.5107 kcal/mol (6088.8086 without restraints) Performing minimization step: 4723. Total energy = 6108.7635 kcal/mol (6087.0653 without restraints) Performing minimization step: 4724. Total energy = 6107.0183 kcal/mol (6085.3245 without restraints) Performing minimization step: 4725. Total energy = 6105.2761 kcal/mol (6083.5866 without restraints) Performing minimization step: 4726. Total energy = 6103.5369 kcal/mol (6081.8514 without restraints) Performing minimization step: 4727. Total energy = 6101.8002 kcal/mol (6080.1189 without restraints) Performing minimization step: 4728. Total energy = 6100.0658 kcal/mol (6078.3887 without restraints) Performing minimization step: 4729. Total energy = 6098.3342 kcal/mol (6076.6613 without restraints) Performing minimization step: 4730. Total energy = 6096.6050 kcal/mol (6074.9363 without restraints) Performing minimization step: 4731. Total energy = 6094.8785 kcal/mol (6073.2140 without restraints) Performing minimization step: 4732. Total energy = 6093.1550 kcal/mol (6071.4946 without restraints) Performing minimization step: 4733. Total energy = 6091.4335 kcal/mol (6069.7774 without restraints) Performing minimization step: 4734. Total energy = 6089.7147 kcal/mol (6068.0628 without restraints) Performing minimization step: 4735. Total energy = 6087.9983 kcal/mol (6066.3506 without restraints) Performing minimization step: 4736. Total energy = 6086.2846 kcal/mol (6064.6411 without restraints) Performing minimization step: 4737. Total energy = 6084.5733 kcal/mol (6062.9341 without restraints) Performing minimization step: 4738. Total energy = 6082.8652 kcal/mol (6061.2302 without restraints) Performing minimization step: 4739. Total energy = 6081.1594 kcal/mol (6059.5286 without restraints) Performing minimization step: 4740. Total energy = 6079.4560 kcal/mol (6057.8295 without restraints) Performing minimization step: 4741. Total energy = 6077.7550 kcal/mol (6056.1327 without restraints) Performing minimization step: 4742. Total energy = 6076.0571 kcal/mol (6054.4391 without restraints) Performing minimization step: 4743. Total energy = 6074.3617 kcal/mol (6052.7480 without restraints) Performing minimization step: 4744. Total energy = 6072.6687 kcal/mol (6051.0592 without restraints) Performing minimization step: 4745. Total energy = 6070.9780 kcal/mol (6049.3727 without restraints) Performing minimization step: 4746. Total energy = 6069.2899 kcal/mol (6047.6889 without restraints) Performing minimization step: 4747. Total energy = 6067.6043 kcal/mol (6046.0075 without restraints) Performing minimization step: 4748. Total energy = 6065.9212 kcal/mol (6044.3286 without restraints) Performing minimization step: 4749. Total energy = 6064.2407 kcal/mol (6042.6524 without restraints) Performing minimization step: 4750. Total energy = 6062.5630 kcal/mol (6040.9790 without restraints) Performing minimization step: 4751. Total energy = 6060.8878 kcal/mol (6039.3083 without restraints) Performing minimization step: 4752. Total energy = 6059.2150 kcal/mol (6037.6396 without restraints) Performing minimization step: 4753. Total energy = 6057.5448 kcal/mol (6035.9736 without restraints) Performing minimization step: 4754. Total energy = 6055.8771 kcal/mol (6034.3105 without restraints) Performing minimization step: 4755. Total energy = 6054.2119 kcal/mol (6032.6494 without restraints) Performing minimization step: 4756. Total energy = 6052.5486 kcal/mol (6030.9903 without restraints) Performing minimization step: 4757. Total energy = 6050.8879 kcal/mol (6029.3339 without restraints) Performing minimization step: 4758. Total energy = 6049.2294 kcal/mol (6027.6797 without restraints) Performing minimization step: 4759. Total energy = 6047.5735 kcal/mol (6026.0281 without restraints) Performing minimization step: 4760. Total energy = 6045.9203 kcal/mol (6024.3792 without restraints) Performing minimization step: 4761. Total energy = 6044.2702 kcal/mol (6022.7335 without restraints) Performing minimization step: 4762. Total energy = 6042.6217 kcal/mol (6021.0892 without restraints) Performing minimization step: 4763. Total energy = 6040.9756 kcal/mol (6019.4475 without restraints) Performing minimization step: 4764. Total energy = 6039.3322 kcal/mol (6017.8084 without restraints) Performing minimization step: 4765. Total energy = 6037.6916 kcal/mol (6016.1720 without restraints) Performing minimization step: 4766. Total energy = 6036.0532 kcal/mol (6014.5380 without restraints) Performing minimization step: 4767. Total energy = 6034.4168 kcal/mol (6012.9060 without restraints) Performing minimization step: 4768. Total energy = 6032.7834 kcal/mol (6011.2769 without restraints) Performing minimization step: 4769. Total energy = 6031.1516 kcal/mol (6009.6494 without restraints) Performing minimization step: 4770. Total energy = 6029.5224 kcal/mol (6008.0246 without restraints) Performing minimization step: 4771. Total energy = 6027.8959 kcal/mol (6006.4025 without restraints) Performing minimization step: 4772. Total energy = 6026.2718 kcal/mol (6004.7827 without restraints) Performing minimization step: 4773. Total energy = 6024.6498 kcal/mol (6003.1650 without restraints) Performing minimization step: 4774. Total energy = 6023.0303 kcal/mol (6001.5499 without restraints) Performing minimization step: 4775. Total energy = 6021.4132 kcal/mol (5999.9372 without restraints) Performing minimization step: 4776. Total energy = 6019.7982 kcal/mol (5998.3265 without restraints) Performing minimization step: 4777. Total energy = 6018.1857 kcal/mol (5996.7183 without restraints) Performing minimization step: 4778. Total energy = 6016.5756 kcal/mol (5995.1127 without restraints) Performing minimization step: 4779. Total energy = 6014.9684 kcal/mol (5993.5098 without restraints) Performing minimization step: 4780. Total energy = 6013.3630 kcal/mol (5991.9088 without restraints) Performing minimization step: 4781. Total energy = 6011.7601 kcal/mol (5990.3103 without restraints) Performing minimization step: 4782. Total energy = 6010.1595 kcal/mol (5988.7142 without restraints) Performing minimization step: 4783. Total energy = 6008.5611 kcal/mol (5987.1200 without restraints) Performing minimization step: 4784. Total energy = 6006.9648 kcal/mol (5985.5281 without restraints) Performing minimization step: 4785. Total energy = 6005.3713 kcal/mol (5983.9391 without restraints) Performing minimization step: 4786. Total energy = 6003.7799 kcal/mol (5982.3520 without restraints) Performing minimization step: 4787. Total energy = 6002.1910 kcal/mol (5980.7676 without restraints) Performing minimization step: 4788. Total energy = 6000.6042 kcal/mol (5979.1850 without restraints) Performing minimization step: 4789. Total energy = 5999.0195 kcal/mol (5977.6049 without restraints) Performing minimization step: 4790. Total energy = 5997.4371 kcal/mol (5976.0268 without restraints) Performing minimization step: 4791. Total energy = 5995.8570 kcal/mol (5974.4512 without restraints) Performing minimization step: 4792. Total energy = 5994.2791 kcal/mol (5972.8776 without restraints) Performing minimization step: 4793. Total energy = 5992.7037 kcal/mol (5971.3066 without restraints) Performing minimization step: 4794. Total energy = 5991.1304 kcal/mol (5969.7378 without restraints) Performing minimization step: 4795. Total energy = 5989.5593 kcal/mol (5968.1711 without restraints) Performing minimization step: 4796. Total energy = 5987.9906 kcal/mol (5966.6068 without restraints) Performing minimization step: 4797. Total energy = 5986.4240 kcal/mol (5965.0446 without restraints) Performing minimization step: 4798. Total energy = 5984.8597 kcal/mol (5963.4848 without restraints) Performing minimization step: 4799. Total energy = 5983.2976 kcal/mol (5961.9271 without restraints) Performing minimization step: 4800. Total energy = 5981.7381 kcal/mol (5960.3720 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4801. Total energy = 5980.1811 kcal/mol (5958.8196 without restraints) Performing minimization step: 4802. Total energy = 5978.6255 kcal/mol (5957.2683 without restraints) Performing minimization step: 4803. Total energy = 5977.0724 kcal/mol (5955.7197 without restraints) Performing minimization step: 4804. Total energy = 5975.5217 kcal/mol (5954.1734 without restraints) Performing minimization step: 4805. Total energy = 5973.9729 kcal/mol (5952.6291 without restraints) Performing minimization step: 4806. Total energy = 5972.4263 kcal/mol (5951.0871 without restraints) Performing minimization step: 4807. Total energy = 5970.8821 kcal/mol (5949.5472 without restraints) Performing minimization step: 4808. Total energy = 5969.3402 kcal/mol (5948.0098 without restraints) Performing minimization step: 4809. Total energy = 5967.7996 kcal/mol (5946.4737 without restraints) Performing minimization step: 4810. Total energy = 5966.2621 kcal/mol (5944.9408 without restraints) Performing minimization step: 4811. Total energy = 5964.7267 kcal/mol (5943.4097 without restraints) Performing minimization step: 4812. Total energy = 5963.1932 kcal/mol (5941.8807 without restraints) Performing minimization step: 4813. Total energy = 5961.6618 kcal/mol (5940.3538 without restraints) Performing minimization step: 4814. Total energy = 5960.1330 kcal/mol (5938.8295 without restraints) Performing minimization step: 4815. Total energy = 5958.6060 kcal/mol (5937.3070 without restraints) Performing minimization step: 4816. Total energy = 5957.0811 kcal/mol (5935.7866 without restraints) Performing minimization step: 4817. Total energy = 5955.5584 kcal/mol (5934.2683 without restraints) Performing minimization step: 4818. Total energy = 5954.0383 kcal/mol (5932.7528 without restraints) Performing minimization step: 4819. Total energy = 5952.5198 kcal/mol (5931.2388 without restraints) Performing minimization step: 4820. Total energy = 5951.0031 kcal/mol (5929.7265 without restraints) Performing minimization step: 4821. Total energy = 5949.4889 kcal/mol (5928.2170 without restraints) Performing minimization step: 4822. Total energy = 5947.9769 kcal/mol (5926.7093 without restraints) Performing minimization step: 4823. Total energy = 5946.4664 kcal/mol (5925.2034 without restraints) Performing minimization step: 4824. Total energy = 5944.9586 kcal/mol (5923.7003 without restraints) Performing minimization step: 4825. Total energy = 5943.4532 kcal/mol (5922.1992 without restraints) Performing minimization step: 4826. Total energy = 5941.9499 kcal/mol (5920.7005 without restraints) Performing minimization step: 4827. Total energy = 5940.4485 kcal/mol (5919.2036 without restraints) Performing minimization step: 4828. Total energy = 5938.9490 kcal/mol (5917.7087 without restraints) Performing minimization step: 4829. Total energy = 5937.4516 kcal/mol (5916.2158 without restraints) Performing minimization step: 4830. Total energy = 5935.9567 kcal/mol (5914.7254 without restraints) Performing minimization step: 4831. Total energy = 5934.4639 kcal/mol (5913.2371 without restraints) Performing minimization step: 4832. Total energy = 5932.9727 kcal/mol (5911.7505 without restraints) Performing minimization step: 4833. Total energy = 5931.4838 kcal/mol (5910.2661 without restraints) Performing minimization step: 4834. Total energy = 5929.9969 kcal/mol (5908.7838 without restraints) Performing minimization step: 4835. Total energy = 5928.5125 kcal/mol (5907.3040 without restraints) Performing minimization step: 4836. Total energy = 5927.0296 kcal/mol (5905.8256 without restraints) Performing minimization step: 4837. Total energy = 5925.5487 kcal/mol (5904.3493 without restraints) Performing minimization step: 4838. Total energy = 5924.0701 kcal/mol (5902.8752 without restraints) Performing minimization step: 4839. Total energy = 5922.5936 kcal/mol (5901.4033 without restraints) Performing minimization step: 4840. Total energy = 5921.1194 kcal/mol (5899.9336 without restraints) Performing minimization step: 4841. Total energy = 5919.6469 kcal/mol (5898.4658 without restraints) Performing minimization step: 4842. Total energy = 5918.1764 kcal/mol (5896.9998 without restraints) Performing minimization step: 4843. Total energy = 5916.7077 kcal/mol (5895.5356 without restraints) Performing minimization step: 4844. Total energy = 5915.2411 kcal/mol (5894.0737 without restraints) Performing minimization step: 4845. Total energy = 5913.7762 kcal/mol (5892.6133 without restraints) Performing minimization step: 4846. Total energy = 5912.3138 kcal/mol (5891.1556 without restraints) Performing minimization step: 4847. Total energy = 5910.8532 kcal/mol (5889.6995 without restraints) Performing minimization step: 4848. Total energy = 5909.3947 kcal/mol (5888.2456 without restraints) Performing minimization step: 4849. Total energy = 5907.9382 kcal/mol (5886.7937 without restraints) Performing minimization step: 4850. Total energy = 5906.4830 kcal/mol (5885.3431 without restraints) Performing minimization step: 4851. Total energy = 5905.0305 kcal/mol (5883.8953 without restraints) Performing minimization step: 4852. Total energy = 5903.5799 kcal/mol (5882.4493 without restraints) Performing minimization step: 4853. Total energy = 5902.1317 kcal/mol (5881.0057 without restraints) Performing minimization step: 4854. Total energy = 5900.6849 kcal/mol (5879.5635 without restraints) Performing minimization step: 4855. Total energy = 5899.2400 kcal/mol (5878.1232 without restraints) Performing minimization step: 4856. Total energy = 5897.7971 kcal/mol (5876.6848 without restraints) Performing minimization step: 4857. Total energy = 5896.3561 kcal/mol (5875.2485 without restraints) Performing minimization step: 4858. Total energy = 5894.9173 kcal/mol (5873.8143 without restraints) Performing minimization step: 4859. Total energy = 5893.4803 kcal/mol (5872.3820 without restraints) Performing minimization step: 4860. Total energy = 5892.0456 kcal/mol (5870.9519 without restraints) Performing minimization step: 4861. Total energy = 5890.6127 kcal/mol (5869.5237 without restraints) Performing minimization step: 4862. Total energy = 5889.1819 kcal/mol (5868.0974 without restraints) Performing minimization step: 4863. Total energy = 5887.7530 kcal/mol (5866.6732 without restraints) Performing minimization step: 4864. Total energy = 5886.3262 kcal/mol (5865.2512 without restraints) Performing minimization step: 4865. Total energy = 5884.9010 kcal/mol (5863.8304 without restraints) Performing minimization step: 4866. Total energy = 5883.4778 kcal/mol (5862.4118 without restraints) Performing minimization step: 4867. Total energy = 5882.0561 kcal/mol (5860.9948 without restraints) Performing minimization step: 4868. Total energy = 5880.6369 kcal/mol (5859.5803 without restraints) Performing minimization step: 4869. Total energy = 5879.2191 kcal/mol (5858.1670 without restraints) Performing minimization step: 4870. Total energy = 5877.8026 kcal/mol (5856.7553 without restraints) Performing minimization step: 4871. Total energy = 5876.3888 kcal/mol (5855.3461 without restraints) Performing minimization step: 4872. Total energy = 5874.9770 kcal/mol (5853.9390 without restraints) Performing minimization step: 4873. Total energy = 5873.5667 kcal/mol (5852.5333 without restraints) Performing minimization step: 4874. Total energy = 5872.1584 kcal/mol (5851.1297 without restraints) Performing minimization step: 4875. Total energy = 5870.7518 kcal/mol (5849.7278 without restraints) Performing minimization step: 4876. Total energy = 5869.3471 kcal/mol (5848.3277 without restraints) Performing minimization step: 4877. Total energy = 5867.9445 kcal/mol (5846.9299 without restraints) Performing minimization step: 4878. Total energy = 5866.5438 kcal/mol (5845.5338 without restraints) Performing minimization step: 4879. Total energy = 5865.1447 kcal/mol (5844.1394 without restraints) Performing minimization step: 4880. Total energy = 5863.7474 kcal/mol (5842.7470 without restraints) Performing minimization step: 4881. Total energy = 5862.3523 kcal/mol (5841.3564 without restraints) Performing minimization step: 4882. Total energy = 5860.9592 kcal/mol (5839.9681 without restraints) Performing minimization step: 4883. Total energy = 5859.5676 kcal/mol (5838.5811 without restraints) Performing minimization step: 4884. Total energy = 5858.1775 kcal/mol (5837.1956 without restraints) Performing minimization step: 4885. Total energy = 5856.7896 kcal/mol (5835.8126 without restraints) Performing minimization step: 4886. Total energy = 5855.4045 kcal/mol (5834.4320 without restraints) Performing minimization step: 4887. Total energy = 5854.0199 kcal/mol (5833.0521 without restraints) Performing minimization step: 4888. Total energy = 5852.6373 kcal/mol (5831.6742 without restraints) Performing minimization step: 4889. Total energy = 5851.2565 kcal/mol (5830.2981 without restraints) Performing minimization step: 4890. Total energy = 5849.8776 kcal/mol (5828.9239 without restraints) Performing minimization step: 4891. Total energy = 5848.5007 kcal/mol (5827.5518 without restraints) Performing minimization step: 4892. Total energy = 5847.1255 kcal/mol (5826.1813 without restraints) Performing minimization step: 4893. Total energy = 5845.7517 kcal/mol (5824.8122 without restraints) Performing minimization step: 4894. Total energy = 5844.3799 kcal/mol (5823.4451 without restraints) Performing minimization step: 4895. Total energy = 5843.0111 kcal/mol (5822.0811 without restraints) Performing minimization step: 4896. Total energy = 5841.6434 kcal/mol (5820.7181 without restraints) Performing minimization step: 4897. Total energy = 5840.2772 kcal/mol (5819.3566 without restraints) Performing minimization step: 4898. Total energy = 5838.9128 kcal/mol (5817.9968 without restraints) Performing minimization step: 4899. Total energy = 5837.5501 kcal/mol (5816.6389 without restraints) Performing minimization step: 4900. Total energy = 5836.1895 kcal/mol (5815.2830 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. Performing minimization step: 4901. Total energy = 5834.8301 kcal/mol (5813.9283 without restraints) Performing minimization step: 4902. Total energy = 5833.4726 kcal/mol (5812.5756 without restraints) Performing minimization step: 4903. Total energy = 5832.1170 kcal/mol (5811.2247 without restraints) Performing minimization step: 4904. Total energy = 5830.7634 kcal/mol (5809.8760 without restraints) Performing minimization step: 4905. Total energy = 5829.4109 kcal/mol (5808.5281 without restraints) Performing minimization step: 4906. Total energy = 5828.0606 kcal/mol (5807.1826 without restraints) Performing minimization step: 4907. Total energy = 5826.7117 kcal/mol (5805.8384 without restraints) Performing minimization step: 4908. Total energy = 5825.3645 kcal/mol (5804.4960 without restraints) Performing minimization step: 4909. Total energy = 5824.0193 kcal/mol (5803.1556 without restraints) Performing minimization step: 4910. Total energy = 5822.6756 kcal/mol (5801.8166 without restraints) Performing minimization step: 4911. Total energy = 5821.3336 kcal/mol (5800.4793 without restraints) Performing minimization step: 4912. Total energy = 5819.9932 kcal/mol (5799.1438 without restraints) Performing minimization step: 4913. Total energy = 5818.6548 kcal/mol (5797.8100 without restraints) Performing minimization step: 4914. Total energy = 5817.3180 kcal/mol (5796.4781 without restraints) Performing minimization step: 4915. Total energy = 5815.9828 kcal/mol (5795.1476 without restraints) Performing minimization step: 4916. Total energy = 5814.6493 kcal/mol (5793.8189 without restraints) Performing minimization step: 4917. Total energy = 5813.3175 kcal/mol (5792.4919 without restraints) Performing minimization step: 4918. Total energy = 5811.9875 kcal/mol (5791.1667 without restraints) Performing minimization step: 4919. Total energy = 5810.6593 kcal/mol (5789.8431 without restraints) Performing minimization step: 4920. Total energy = 5809.3324 kcal/mol (5788.5210 without restraints) Performing minimization step: 4921. Total energy = 5808.0073 kcal/mol (5787.2007 without restraints) Performing minimization step: 4922. Total energy = 5806.6840 kcal/mol (5785.8823 without restraints) Performing minimization step: 4923. Total energy = 5805.3627 kcal/mol (5784.5657 without restraints) Performing minimization step: 4924. Total energy = 5804.0433 kcal/mol (5783.2512 without restraints) Performing minimization step: 4925. Total energy = 5802.7254 kcal/mol (5781.9380 without restraints) Performing minimization step: 4926. Total energy = 5801.4091 kcal/mol (5780.6265 without restraints) Performing minimization step: 4927. Total energy = 5800.0943 kcal/mol (5779.3165 without restraints) Performing minimization step: 4928. Total energy = 5798.7811 kcal/mol (5778.0081 without restraints) Performing minimization step: 4929. Total energy = 5797.4700 kcal/mol (5776.7018 without restraints) Performing minimization step: 4930. Total energy = 5796.1600 kcal/mol (5775.3967 without restraints) Performing minimization step: 4931. Total energy = 5794.8518 kcal/mol (5774.0932 without restraints) Performing minimization step: 4932. Total energy = 5793.5450 kcal/mol (5772.7913 without restraints) Performing minimization step: 4933. Total energy = 5792.2402 kcal/mol (5771.4912 without restraints) Performing minimization step: 4934. Total energy = 5790.9368 kcal/mol (5770.1927 without restraints) Performing minimization step: 4935. Total energy = 5789.6351 kcal/mol (5768.8958 without restraints) Performing minimization step: 4936. Total energy = 5788.3352 kcal/mol (5767.6007 without restraints) Performing minimization step: 4937. Total energy = 5787.0366 kcal/mol (5766.3068 without restraints) Performing minimization step: 4938. Total energy = 5785.7395 kcal/mol (5765.0145 without restraints) Performing minimization step: 4939. Total energy = 5784.4440 kcal/mol (5763.7238 without restraints) Performing minimization step: 4940. Total energy = 5783.1498 kcal/mol (5762.4345 without restraints) Performing minimization step: 4941. Total energy = 5781.8585 kcal/mol (5761.1480 without restraints) Performing minimization step: 4942. Total energy = 5780.5680 kcal/mol (5759.8624 without restraints) Performing minimization step: 4943. Total energy = 5779.2789 kcal/mol (5758.5781 without restraints) Performing minimization step: 4944. Total energy = 5777.9915 kcal/mol (5757.2955 without restraints) Performing minimization step: 4945. Total energy = 5776.7058 kcal/mol (5756.0148 without restraints) Performing minimization step: 4946. Total energy = 5775.4222 kcal/mol (5754.7359 without restraints) Performing minimization step: 4947. Total energy = 5774.1395 kcal/mol (5753.4580 without restraints) Performing minimization step: 4948. Total energy = 5772.8591 kcal/mol (5752.1825 without restraints) Performing minimization step: 4949. Total energy = 5771.5796 kcal/mol (5750.9078 without restraints) Performing minimization step: 4950. Total energy = 5770.3016 kcal/mol (5749.6346 without restraints) Performing minimization step: 4951. Total energy = 5769.0254 kcal/mol (5748.3633 without restraints) Performing minimization step: 4952. Total energy = 5767.7504 kcal/mol (5747.0930 without restraints) Performing minimization step: 4953. Total energy = 5766.4771 kcal/mol (5745.8247 without restraints) Performing minimization step: 4954. Total energy = 5765.2058 kcal/mol (5744.5584 without restraints) Performing minimization step: 4955. Total energy = 5763.9359 kcal/mol (5743.2931 without restraints) Performing minimization step: 4956. Total energy = 5762.6676 kcal/mol (5742.0297 without restraints) Performing minimization step: 4957. Total energy = 5761.4002 kcal/mol (5740.7671 without restraints) Performing minimization step: 4958. Total energy = 5760.1348 kcal/mol (5739.5066 without restraints) Performing minimization step: 4959. Total energy = 5758.8712 kcal/mol (5738.2479 without restraints) Performing minimization step: 4960. Total energy = 5757.6090 kcal/mol (5736.9905 without restraints) Performing minimization step: 4961. Total energy = 5756.3481 kcal/mol (5735.7346 without restraints) Performing minimization step: 4962. Total energy = 5755.0888 kcal/mol (5734.4800 without restraints) Performing minimization step: 4963. Total energy = 5753.8310 kcal/mol (5733.2272 without restraints) Performing minimization step: 4964. Total energy = 5752.5749 kcal/mol (5731.9759 without restraints) Performing minimization step: 4965. Total energy = 5751.3203 kcal/mol (5730.7260 without restraints) Performing minimization step: 4966. Total energy = 5750.0674 kcal/mol (5729.4781 without restraints) Performing minimization step: 4967. Total energy = 5748.8157 kcal/mol (5728.2314 without restraints) Performing minimization step: 4968. Total energy = 5747.5657 kcal/mol (5726.9861 without restraints) Performing minimization step: 4969. Total energy = 5746.3169 kcal/mol (5725.7423 without restraints) Performing minimization step: 4970. Total energy = 5745.0697 kcal/mol (5724.4997 without restraints) Performing minimization step: 4971. Total energy = 5743.8240 kcal/mol (5723.2590 without restraints) Performing minimization step: 4972. Total energy = 5742.5797 kcal/mol (5722.0196 without restraints) Performing minimization step: 4973. Total energy = 5741.3369 kcal/mol (5720.7817 without restraints) Performing minimization step: 4974. Total energy = 5740.0958 kcal/mol (5719.5457 without restraints) Performing minimization step: 4975. Total energy = 5738.8566 kcal/mol (5718.3112 without restraints) Performing minimization step: 4976. Total energy = 5737.6186 kcal/mol (5717.0782 without restraints) Performing minimization step: 4977. Total energy = 5736.3823 kcal/mol (5715.8466 without restraints) Performing minimization step: 4978. Total energy = 5735.1475 kcal/mol (5714.6167 without restraints) Performing minimization step: 4979. Total energy = 5733.9140 kcal/mol (5713.3881 without restraints) Performing minimization step: 4980. Total energy = 5732.6815 kcal/mol (5712.1604 without restraints) Performing minimization step: 4981. Total energy = 5731.4507 kcal/mol (5710.9345 without restraints) Performing minimization step: 4982. Total energy = 5730.2211 kcal/mol (5709.7099 without restraints) Performing minimization step: 4983. Total energy = 5728.9935 kcal/mol (5708.4871 without restraints) Performing minimization step: 4984. Total energy = 5727.7670 kcal/mol (5707.2656 without restraints) Performing minimization step: 4985. Total energy = 5726.5420 kcal/mol (5706.0454 without restraints) Performing minimization step: 4986. Total energy = 5725.3185 kcal/mol (5704.8268 without restraints) Performing minimization step: 4987. Total energy = 5724.0963 kcal/mol (5703.6095 without restraints) Performing minimization step: 4988. Total energy = 5722.8757 kcal/mol (5702.3938 without restraints) Performing minimization step: 4989. Total energy = 5721.6567 kcal/mol (5701.1797 without restraints) Performing minimization step: 4990. Total energy = 5720.4395 kcal/mol (5699.9676 without restraints) Performing minimization step: 4991. Total energy = 5719.2230 kcal/mol (5698.7557 without restraints) Performing minimization step: 4992. Total energy = 5718.0082 kcal/mol (5697.5459 without restraints) Performing minimization step: 4993. Total energy = 5716.7951 kcal/mol (5696.3377 without restraints) Performing minimization step: 4994. Total energy = 5715.5829 kcal/mol (5695.1305 without restraints) Performing minimization step: 4995. Total energy = 5714.3722 kcal/mol (5693.9247 without restraints) Performing minimization step: 4996. Total energy = 5713.1633 kcal/mol (5692.7208 without restraints) Performing minimization step: 4997. Total energy = 5711.9556 kcal/mol (5691.5179 without restraints) Performing minimization step: 4998. Total energy = 5710.7497 kcal/mol (5690.3168 without restraints) Performing minimization step: 4999. Total energy = 5709.5446 kcal/mol (5689.1169 without restraints) Performing minimization step: 5000. Total energy = 5708.3412 kcal/mol (5687.9184 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/1c3f1fa2/tmp/mir222m3ref_refx/mir222m3ref_refx.pdb ...Done. /home/ubuntu/rna-tools//opt/qrnas/ Save to mir222m3ref_refx.pdb DONE!