============================================================================= Reading config file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/configfile.txt ============================================================================= ----------------------------------------------------------------------------- Warning: Non-parallel version of QRNA cannot spawn threads. Warning: More threads than cores available. Parameters to be used: Number of minimization steps (NSTEPS): 5000 Golden section step sizes: maximal (MAXSTEP): 0.0001 minimal (MINSTEP): 1e-08 Verbosity (VERBOSE): 1 Write output every: 100 steps (WRITEFREQ) Record trajectory (TRAJECTORY): disabled Pedantic treatment of molecules (PEDANTICMOL): disabled Van der Waals cutoff radius (CUTOFF): 12 Born generalized solvent (USEBORN): disabled Constraints on secondary struct. (SSCONSTR): enabled Auto-detection of secondary struct. (SSDETECT): enabled Secondary structure (SECSTRUCT): none specified Hydrogen bonds (HBONDS): enabled Electrostatics (ELECTR): enabled van der Waals interactions (VANDERWAALS): enabled Anti-blow-up protection (BLOWGUARD): enabled Occupancy as positional restraint (POSRESTRAINTS): disabled Restraints description (RESTRFILE): none Number of parallel threads: 1 ----------------------------------------------------------------------------- Internal Warning: unknown atom type(s) in bond: C2 H5 Internal Warning: unknown atom type(s) in bond: C2 N* Internal Warning: unknown atom type(s) in bond: C2 NB Internal Warning: unknown atom type(s) in bond: C C1 Internal Warning: unknown atom type(s) in bond: CA C1 Internal Warning: unknown atom type(s) in bond: C1 C1 Internal Warning: unknown atom type(s) in bond: C1 CT Internal Warning: unknown atom type(s) in bond: C1 HA Internal Warning: unknown atom type(s) in bond: C1 H4 Internal Warning: unknown atom type(s) in bond: C1 N* Internal Warning: unknown atoms in angle: H5 C2 N* Internal Warning: unknown atoms in angle: H5 C2 NB Internal Warning: unknown atoms in angle: N* C2 NB Internal Warning: unknown atoms in angle: CB N* C2 Internal Warning: unknown atoms in angle: C2 N* CT Internal Warning: unknown atoms in angle: CB NB C2 Internal Warning: unknown atoms in angle: C1 C NA Internal Warning: unknown atoms in angle: C1 C O Internal Warning: unknown atoms in angle: C1 CA N2 Internal Warning: unknown atoms in angle: C1 CA NC Internal Warning: unknown atoms in angle: C C1 C1 Internal Warning: unknown atoms in angle: C C1 CT Internal Warning: unknown atoms in angle: C C1 HA Internal Warning: unknown atoms in angle: C C1 H4 Internal Warning: unknown atoms in angle: CA C1 C1 Internal Warning: unknown atoms in angle: CA C1 HA Internal Warning: unknown atoms in angle: CA C1 H4 Internal Warning: unknown atoms in angle: C1 C1 CT Internal Warning: unknown atoms in angle: C1 C1 HA Internal Warning: unknown atoms in angle: C1 C1 H4 Internal Warning: unknown atoms in angle: C1 C1 N* Internal Warning: unknown atoms in angle: H4 C1 N* Internal Warning: unknown atoms in angle: H1 CT C1 Internal Warning: unknown atoms in angle: HC CT C1 Internal Warning: unknown atoms in angle: C N* C1 Internal Warning: unknown atoms in angle: C1 N* CT Internal Warning: unknown atom(s) in dihedral: X C2 N* X Internal Warning: unknown atom(s) in dihedral: X C2 NB X Internal Warning: unknown atom(s) in dihedral: X C C1 X Internal Warning: unknown atom(s) in dihedral: X CA C1 X Internal Warning: unknown atom(s) in dihedral: X C1 C1 X Internal Warning: unknown atom(s) in dihedral: X C1 CT X Internal Warning: unknown atom(s) in dihedral: X C1 N* X Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in improper: C C1 N* CT Internal Warning: unknown atom(s) in improper: C C1 C1 CT Internal Warning: unknown atom(s) in improper: C1 N2 CA NC Initializing... Generic atom descriptions read: 47 Generic bond descriptions read: 199 Generic angle descriptions read: 567 Generic dihedral descriptions read: 812 Generic improper descriptions read: 116 Generic vdW descriptions read: 47 ----------------------------------------------------------------------------- ============================================================================= Reading PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref.pdb ============================================================================= Atom's 3506 H3' residue renamed to RU3 Atom's 3505 HO'2 residue renamed to RU3 Atom's 3504 H2' residue renamed to RU3 Atom's 3503 H5 residue renamed to RU3 Atom's 3502 H3 residue renamed to RU3 Atom's 3501 H6 residue renamed to RU3 Atom's 3500 H1' residue renamed to RU3 Atom's 3499 H4' residue renamed to RU3 Atom's 3498 H5'2 residue renamed to RU3 Atom's 3497 H5'1 residue renamed to RU3 Atom's 3496 C6 residue renamed to RU3 Atom's 3495 C5 residue renamed to RU3 Atom's 3494 O4 residue renamed to RU3 Atom's 3493 C4 residue renamed to RU3 Atom's 3492 N3 residue renamed to RU3 Atom's 3491 O2 residue renamed to RU3 Atom's 3490 C2 residue renamed to RU3 Atom's 3489 N1 residue renamed to RU3 Atom's 3488 O2' residue renamed to RU3 Atom's 3487 C2' residue renamed to RU3 Atom's 3486 C1' residue renamed to RU3 Atom's 3485 O4' residue renamed to RU3 Atom's 3484 P residue renamed to RU3 Atom's 3483 OP2 residue renamed to RU3 Atom's 3482 OP1 residue renamed to RU3 Atom's 3481 O3' residue renamed to RU3 Atom's 3480 C3' residue renamed to RU3 Atom's 3479 C4' residue renamed to RU3 Atom's 3478 C5' residue renamed to RU3 Atom's 3477 O5' residue renamed to RU3 Missing atom added: ATOM 31 H3T RU3 A 110 35.471 -0.132 52.274 1.00 0.00 H Missing atom added: ATOM 7 OP3 G A 1 38.152 -16.304 46.689 1.00 0.00 Number of atoms: 3508 Number of residues: 110 Building intraresidual bonds... Building intraresidual angles... Building intraresidual dihedrals... Building intraresidual impropers... Building interresidual bonds... Building interresidual angles... Internal Warning: unknown atoms in angle: H5 C2 N* Internal Warning: unknown atoms in angle: H5 C2 NB Internal Warning: unknown atoms in angle: N* C2 NB Internal Warning: unknown atoms in angle: CB N* C2 Internal Warning: unknown atoms in angle: C2 N* CT Internal Warning: unknown atoms in angle: CB NB C2 Internal Warning: unknown atoms in angle: C1 C NA Internal Warning: unknown atoms in angle: C1 C O Internal Warning: unknown atoms in angle: C1 CA N2 Internal Warning: unknown atoms in angle: C1 CA NC Internal Warning: unknown atoms in angle: C C1 C1 Internal Warning: unknown atoms in angle: C C1 CT Internal Warning: unknown atoms in angle: C C1 HA Internal Warning: unknown atoms in angle: C C1 H4 Internal Warning: unknown atoms in angle: CA C1 C1 Internal Warning: unknown atoms in angle: CA C1 HA Internal Warning: unknown atoms in angle: CA C1 H4 Internal Warning: unknown atoms in angle: C1 C1 CT Internal Warning: unknown atoms in angle: C1 C1 HA Internal Warning: unknown atoms in angle: C1 C1 H4 Internal Warning: unknown atoms in angle: C1 C1 N* Internal Warning: unknown atoms in angle: H4 C1 N* Internal Warning: unknown atoms in angle: H1 CT C1 Internal Warning: unknown atoms in angle: HC CT C1 Internal Warning: unknown atoms in angle: C N* C1 Internal Warning: unknown atoms in angle: C1 N* CT Building interresidual dihedrals... Internal Warning: unknown atom(s) in dihedral: X C2 N* X Internal Warning: unknown atom(s) in dihedral: X C2 NB X Internal Warning: unknown atom(s) in dihedral: X C C1 X Internal Warning: unknown atom(s) in dihedral: X CA C1 X Internal Warning: unknown atom(s) in dihedral: X C1 C1 X Internal Warning: unknown atom(s) in dihedral: X C1 CT X Internal Warning: unknown atom(s) in dihedral: X C1 N* X Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: HC CT C1 C1 Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: C1 C1 C O Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C2 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Internal Warning: unknown atom(s) in dihedral: OS CT N* C1 Number of bonds built: 3777 Number of angles built: 6765 Number of dihedrals built: 10303 Number of impropers built: 739 ----------------------------------------------------------------------------- End of molecule (chain) ----------------------------------------------------------------------------- ----------------------------------------------------------------------------- Building interresidual nonbonded pairs & H-bonds (it may take a while)... Number of electrostatic pairs: 6140736 Number of van der Waals pairs: 417497 Number of H-bonds built: 117 Number of spring restraints: 0 Number of positional restraints: 0 Number of base pairs built: 36 Number of molecules (chains) read: 1 ----------------------------------------------------------------------------- Performing minimization step: 1. Total energy = 112395.4844 kcal/mol (112357.0827 without restraints) Performing minimization step: 2. Total energy = 112300.5851 kcal/mol (112262.1948 without restraints) Performing minimization step: 3. Total energy = 112205.7559 kcal/mol (112167.3769 without restraints) Performing minimization step: 4. Total energy = 112110.9960 kcal/mol (112072.6284 without restraints) Performing minimization step: 5. Total energy = 112016.3055 kcal/mol (111977.9491 without restraints) Performing minimization step: 6. Total energy = 111921.6835 kcal/mol (111883.3385 without restraints) Performing minimization step: 7. Total energy = 111827.1313 kcal/mol (111788.7975 without restraints) Performing minimization step: 8. Total energy = 111732.6484 kcal/mol (111694.3261 without restraints) Performing minimization step: 9. Total energy = 111638.2344 kcal/mol (111599.9235 without restraints) Performing minimization step: 10. Total energy = 111543.8905 kcal/mol (111505.5909 without restraints) Performing minimization step: 11. Total energy = 111449.6152 kcal/mol (111411.3269 without restraints) Performing minimization step: 12. Total energy = 111355.4094 kcal/mol (111317.1324 without restraints) Performing minimization step: 13. Total energy = 111261.2727 kcal/mol (111223.0070 without restraints) Performing minimization step: 14. Total energy = 111167.2049 kcal/mol (111128.9506 without restraints) Performing minimization step: 15. Total energy = 111073.2065 kcal/mol (111034.9635 without restraints) Performing minimization step: 16. Total energy = 110979.2773 kcal/mol (110941.0456 without restraints) Performing minimization step: 17. Total energy = 110885.4169 kcal/mol (110847.1965 without restraints) Performing minimization step: 18. Total energy = 110791.6258 kcal/mol (110753.4167 without restraints) Performing minimization step: 19. Total energy = 110697.9039 kcal/mol (110659.7061 without restraints) Performing minimization step: 20. Total energy = 110604.2510 kcal/mol (110566.0646 without restraints) Performing minimization step: 21. Total energy = 110510.6671 kcal/mol (110472.4919 without restraints) Performing minimization step: 22. Total energy = 110417.1521 kcal/mol (110378.9882 without restraints) Performing minimization step: 23. Total energy = 110323.7060 kcal/mol (110285.5534 without restraints) Performing minimization step: 24. Total energy = 110230.3286 kcal/mol (110192.1871 without restraints) Performing minimization step: 25. Total energy = 110137.0202 kcal/mol (110098.8900 without restraints) Performing minimization step: 26. Total energy = 110043.7807 kcal/mol (110005.6619 without restraints) Performing minimization step: 27. Total energy = 109950.6103 kcal/mol (109912.5028 without restraints) Performing minimization step: 28. Total energy = 109857.5089 kcal/mol (109819.4126 without restraints) Performing minimization step: 29. Total energy = 109764.4762 kcal/mol (109726.3912 without restraints) Performing minimization step: 30. Total energy = 109671.5125 kcal/mol (109633.4387 without restraints) Performing minimization step: 31. Total energy = 109578.6171 kcal/mol (109540.5546 without restraints) Performing minimization step: 32. Total energy = 109485.7909 kcal/mol (109447.7397 without restraints) Performing minimization step: 33. Total energy = 109393.0338 kcal/mol (109354.9939 without restraints) Performing minimization step: 34. Total energy = 109300.3445 kcal/mol (109262.3158 without restraints) Performing minimization step: 35. Total energy = 109207.7243 kcal/mol (109169.7068 without restraints) Performing minimization step: 36. Total energy = 109115.1731 kcal/mol (109077.1669 without restraints) Performing minimization step: 37. Total energy = 109022.6906 kcal/mol (108984.6956 without restraints) Performing minimization step: 38. Total energy = 108930.2768 kcal/mol (108892.2930 without restraints) Performing minimization step: 39. Total energy = 108837.9318 kcal/mol (108799.9592 without restraints) Performing minimization step: 40. Total energy = 108745.6547 kcal/mol (108707.6934 without restraints) Performing minimization step: 41. Total energy = 108653.4467 kcal/mol (108615.4966 without restraints) Performing minimization step: 42. Total energy = 108561.3076 kcal/mol (108523.3687 without restraints) Performing minimization step: 43. Total energy = 108469.2369 kcal/mol (108431.3093 without restraints) Performing minimization step: 44. Total energy = 108377.2349 kcal/mol (108339.3184 without restraints) Performing minimization step: 45. Total energy = 108285.3007 kcal/mol (108247.3953 without restraints) Performing minimization step: 46. Total energy = 108193.4353 kcal/mol (108155.5412 without restraints) Performing minimization step: 47. Total energy = 108101.6384 kcal/mol (108063.7554 without restraints) Performing minimization step: 48. Total energy = 108009.9097 kcal/mol (107972.0380 without restraints) Performing minimization step: 49. Total energy = 107918.2496 kcal/mol (107880.3890 without restraints) Performing minimization step: 50. Total energy = 107826.6581 kcal/mol (107788.8088 without restraints) Performing minimization step: 51. Total energy = 107735.1352 kcal/mol (107697.2971 without restraints) Performing minimization step: 52. Total energy = 107643.6806 kcal/mol (107605.8536 without restraints) Performing minimization step: 53. Total energy = 107552.2942 kcal/mol (107514.4784 without restraints) Performing minimization step: 54. Total energy = 107460.9763 kcal/mol (107423.1716 without restraints) Performing minimization step: 55. Total energy = 107369.7271 kcal/mol (107331.9336 without restraints) Performing minimization step: 56. Total energy = 107278.5457 kcal/mol (107240.7634 without restraints) Performing minimization step: 57. Total energy = 107187.4324 kcal/mol (107149.6613 without restraints) Performing minimization step: 58. Total energy = 107096.3876 kcal/mol (107058.6276 without restraints) Performing minimization step: 59. Total energy = 107005.4110 kcal/mol (106967.6621 without restraints) Performing minimization step: 60. Total energy = 106914.5025 kcal/mol (106876.7649 without restraints) Performing minimization step: 61. Total energy = 106823.6624 kcal/mol (106785.9358 without restraints) Performing minimization step: 62. Total energy = 106732.8899 kcal/mol (106695.1745 without restraints) Performing minimization step: 63. Total energy = 106642.1855 kcal/mol (106604.4811 without restraints) Performing minimization step: 64. Total energy = 106551.5497 kcal/mol (106513.8565 without restraints) Performing minimization step: 65. Total energy = 106460.9817 kcal/mol (106423.2997 without restraints) Performing minimization step: 66. Total energy = 106370.4819 kcal/mol (106332.8108 without restraints) Performing minimization step: 67. Total energy = 106280.0502 kcal/mol (106242.3903 without restraints) Performing minimization step: 68. Total energy = 106189.6861 kcal/mol (106152.0374 without restraints) Performing minimization step: 69. Total energy = 106099.3908 kcal/mol (106061.7533 without restraints) Performing minimization step: 70. Total energy = 106009.1636 kcal/mol (105971.5371 without restraints) Performing minimization step: 71. Total energy = 105919.0040 kcal/mol (105881.3886 without restraints) Performing minimization step: 72. Total energy = 105828.9125 kcal/mol (105791.3082 without restraints) Performing minimization step: 73. Total energy = 105738.8887 kcal/mol (105701.2955 without restraints) Performing minimization step: 74. Total energy = 105648.9330 kcal/mol (105611.3509 without restraints) Performing minimization step: 75. Total energy = 105559.0451 kcal/mol (105521.4741 without restraints) Performing minimization step: 76. Total energy = 105469.2246 kcal/mol (105431.6647 without restraints) Performing minimization step: 77. Total energy = 105379.4726 kcal/mol (105341.9238 without restraints) Performing minimization step: 78. Total energy = 105289.7881 kcal/mol (105252.2504 without restraints) Performing minimization step: 79. Total energy = 105200.1716 kcal/mol (105162.6451 without restraints) Performing minimization step: 80. Total energy = 105110.6234 kcal/mol (105073.1080 without restraints) Performing minimization step: 81. Total energy = 105021.1424 kcal/mol (104983.6378 without restraints) Performing minimization step: 82. Total energy = 104931.7290 kcal/mol (104894.2355 without restraints) Performing minimization step: 83. Total energy = 104842.3834 kcal/mol (104804.9010 without restraints) Performing minimization step: 84. Total energy = 104753.1057 kcal/mol (104715.6344 without restraints) Performing minimization step: 85. Total energy = 104663.8955 kcal/mol (104626.4353 without restraints) Performing minimization step: 86. Total energy = 104574.7535 kcal/mol (104537.3042 without restraints) Performing minimization step: 87. Total energy = 104485.6787 kcal/mol (104448.2405 without restraints) Performing minimization step: 88. Total energy = 104396.6714 kcal/mol (104359.2442 without restraints) Performing minimization step: 89. Total energy = 104307.7318 kcal/mol (104270.3157 without restraints) Performing minimization step: 90. Total energy = 104218.8595 kcal/mol (104181.4543 without restraints) Performing minimization step: 91. Total energy = 104130.0549 kcal/mol (104092.6610 without restraints) Performing minimization step: 92. Total energy = 104041.3182 kcal/mol (104003.9351 without restraints) Performing minimization step: 93. Total energy = 103952.6492 kcal/mol (103915.2771 without restraints) Performing minimization step: 94. Total energy = 103864.0472 kcal/mol (103826.6862 without restraints) Performing minimization step: 95. Total energy = 103775.5130 kcal/mol (103738.1629 without restraints) Performing minimization step: 96. Total energy = 103687.0458 kcal/mol (103649.7067 without restraints) Performing minimization step: 97. Total energy = 103598.6461 kcal/mol (103561.3181 without restraints) Performing minimization step: 98. Total energy = 103510.3139 kcal/mol (103472.9969 without restraints) Performing minimization step: 99. Total energy = 103422.0495 kcal/mol (103384.7436 without restraints) Performing minimization step: 100. Total energy = 103333.8522 kcal/mol (103296.5571 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 101. Total energy = 103245.7221 kcal/mol (103208.4382 without restraints) Performing minimization step: 102. Total energy = 103157.6594 kcal/mol (103120.3864 without restraints) Performing minimization step: 103. Total energy = 103069.6639 kcal/mol (103032.4018 without restraints) Performing minimization step: 104. Total energy = 102981.7357 kcal/mol (102944.4846 without restraints) Performing minimization step: 105. Total energy = 102893.8744 kcal/mol (102856.6344 without restraints) Performing minimization step: 106. Total energy = 102806.0803 kcal/mol (102768.8512 without restraints) Performing minimization step: 107. Total energy = 102718.3537 kcal/mol (102681.1355 without restraints) Performing minimization step: 108. Total energy = 102630.6942 kcal/mol (102593.4869 without restraints) Performing minimization step: 109. Total energy = 102543.1016 kcal/mol (102505.9051 without restraints) Performing minimization step: 110. Total energy = 102455.5759 kcal/mol (102418.3905 without restraints) Performing minimization step: 111. Total energy = 102368.1180 kcal/mol (102330.9436 without restraints) Performing minimization step: 112. Total energy = 102280.7271 kcal/mol (102243.5637 without restraints) Performing minimization step: 113. Total energy = 102193.4031 kcal/mol (102156.2507 without restraints) Performing minimization step: 114. Total energy = 102106.1464 kcal/mol (102069.0048 without restraints) Performing minimization step: 115. Total energy = 102018.9566 kcal/mol (101981.8260 without restraints) Performing minimization step: 116. Total energy = 101931.8335 kcal/mol (101894.7138 without restraints) Performing minimization step: 117. Total energy = 101844.7775 kcal/mol (101807.6687 without restraints) Performing minimization step: 118. Total energy = 101757.7885 kcal/mol (101720.6906 without restraints) Performing minimization step: 119. Total energy = 101670.8666 kcal/mol (101633.7796 without restraints) Performing minimization step: 120. Total energy = 101584.0113 kcal/mol (101546.9353 without restraints) Performing minimization step: 121. Total energy = 101497.2230 kcal/mol (101460.1578 without restraints) Performing minimization step: 122. Total energy = 101410.5017 kcal/mol (101373.4475 without restraints) Performing minimization step: 123. Total energy = 101323.8469 kcal/mol (101286.8035 without restraints) Performing minimization step: 124. Total energy = 101237.2590 kcal/mol (101200.2265 without restraints) Performing minimization step: 125. Total energy = 101150.7377 kcal/mol (101113.7161 without restraints) Performing minimization step: 126. Total energy = 101064.2836 kcal/mol (101027.2730 without restraints) Performing minimization step: 127. Total energy = 100977.8961 kcal/mol (100940.8963 without restraints) Performing minimization step: 128. Total energy = 100891.5753 kcal/mol (100854.5864 without restraints) Performing minimization step: 129. Total energy = 100805.3216 kcal/mol (100768.3435 without restraints) Performing minimization step: 130. Total energy = 100719.1335 kcal/mol (100682.1663 without restraints) Performing minimization step: 131. Total energy = 100633.0127 kcal/mol (100596.0564 without restraints) Performing minimization step: 132. Total energy = 100546.9586 kcal/mol (100510.0131 without restraints) Performing minimization step: 133. Total energy = 100460.9711 kcal/mol (100424.0365 without restraints) Performing minimization step: 134. Total energy = 100375.0499 kcal/mol (100338.1261 without restraints) Performing minimization step: 135. Total energy = 100289.1952 kcal/mol (100252.2823 without restraints) Performing minimization step: 136. Total energy = 100203.4071 kcal/mol (100166.5051 without restraints) Performing minimization step: 137. Total energy = 100117.6857 kcal/mol (100080.7945 without restraints) Performing minimization step: 138. Total energy = 100032.0309 kcal/mol (99995.1505 without restraints) Performing minimization step: 139. Total energy = 99946.4424 kcal/mol (99909.5729 without restraints) Performing minimization step: 140. Total energy = 99860.9206 kcal/mol (99824.0619 without restraints) Performing minimization step: 141. Total energy = 99775.4650 kcal/mol (99738.6172 without restraints) Performing minimization step: 142. Total energy = 99690.0757 kcal/mol (99653.2386 without restraints) Performing minimization step: 143. Total energy = 99604.7531 kcal/mol (99567.9268 without restraints) Performing minimization step: 144. Total energy = 99519.4964 kcal/mol (99482.6810 without restraints) Performing minimization step: 145. Total energy = 99434.3062 kcal/mol (99397.5016 without restraints) Performing minimization step: 146. Total energy = 99349.1818 kcal/mol (99312.3880 without restraints) Performing minimization step: 147. Total energy = 99264.1242 kcal/mol (99227.3410 without restraints) Performing minimization step: 148. Total energy = 99179.1327 kcal/mol (99142.3605 without restraints) Performing minimization step: 149. Total energy = 99094.2075 kcal/mol (99057.4460 without restraints) Performing minimization step: 150. Total energy = 99009.3487 kcal/mol (98972.5980 without restraints) Performing minimization step: 151. Total energy = 98924.5561 kcal/mol (98887.8161 without restraints) Performing minimization step: 152. Total energy = 98839.8295 kcal/mol (98803.1004 without restraints) Performing minimization step: 153. Total energy = 98755.1691 kcal/mol (98718.4507 without restraints) Performing minimization step: 154. Total energy = 98670.5747 kcal/mol (98633.8673 without restraints) Performing minimization step: 155. Total energy = 98586.0465 kcal/mol (98549.3497 without restraints) Performing minimization step: 156. Total energy = 98501.5840 kcal/mol (98464.8980 without restraints) Performing minimization step: 157. Total energy = 98417.1875 kcal/mol (98380.5122 without restraints) Performing minimization step: 158. Total energy = 98332.8577 kcal/mol (98296.1932 without restraints) Performing minimization step: 159. Total energy = 98248.5935 kcal/mol (98211.9398 without restraints) Performing minimization step: 160. Total energy = 98164.3954 kcal/mol (98127.7524 without restraints) Performing minimization step: 161. Total energy = 98080.2629 kcal/mol (98043.6307 without restraints) Performing minimization step: 162. Total energy = 97996.1963 kcal/mol (97959.5748 without restraints) Performing minimization step: 163. Total energy = 97912.1960 kcal/mol (97875.5853 without restraints) Performing minimization step: 164. Total energy = 97828.2612 kcal/mol (97791.6610 without restraints) Performing minimization step: 165. Total energy = 97744.3926 kcal/mol (97707.8033 without restraints) Performing minimization step: 166. Total energy = 97660.5897 kcal/mol (97624.0111 without restraints) Performing minimization step: 167. Total energy = 97576.8528 kcal/mol (97540.2849 without restraints) Performing minimization step: 168. Total energy = 97493.1817 kcal/mol (97456.6245 without restraints) Performing minimization step: 169. Total energy = 97409.5763 kcal/mol (97373.0299 without restraints) Performing minimization step: 170. Total energy = 97326.0368 kcal/mol (97289.5010 without restraints) Performing minimization step: 171. Total energy = 97242.5627 kcal/mol (97206.0376 without restraints) Performing minimization step: 172. Total energy = 97159.1543 kcal/mol (97122.6400 without restraints) Performing minimization step: 173. Total energy = 97075.8118 kcal/mol (97039.3082 without restraints) Performing minimization step: 174. Total energy = 96992.5352 kcal/mol (96956.0422 without restraints) Performing minimization step: 175. Total energy = 96909.3234 kcal/mol (96872.8410 without restraints) Performing minimization step: 176. Total energy = 96826.1774 kcal/mol (96789.7058 without restraints) Performing minimization step: 177. Total energy = 96743.0972 kcal/mol (96706.6362 without restraints) Performing minimization step: 178. Total energy = 96660.0828 kcal/mol (96623.6325 without restraints) Performing minimization step: 179. Total energy = 96577.1337 kcal/mol (96540.6941 without restraints) Performing minimization step: 180. Total energy = 96494.2502 kcal/mol (96457.8213 without restraints) Performing minimization step: 181. Total energy = 96411.4321 kcal/mol (96375.0138 without restraints) Performing minimization step: 182. Total energy = 96328.6795 kcal/mol (96292.2719 without restraints) Performing minimization step: 183. Total energy = 96245.9921 kcal/mol (96209.5951 without restraints) Performing minimization step: 184. Total energy = 96163.3698 kcal/mol (96126.9833 without restraints) Performing minimization step: 185. Total energy = 96080.8131 kcal/mol (96044.4373 without restraints) Performing minimization step: 186. Total energy = 95998.3218 kcal/mol (95961.9567 without restraints) Performing minimization step: 187. Total energy = 95915.8960 kcal/mol (95879.5414 without restraints) Performing minimization step: 188. Total energy = 95833.5354 kcal/mol (95797.1916 without restraints) Performing minimization step: 189. Total energy = 95751.2403 kcal/mol (95714.9071 without restraints) Performing minimization step: 190. Total energy = 95669.0105 kcal/mol (95632.6880 without restraints) Performing minimization step: 191. Total energy = 95586.8459 kcal/mol (95550.5342 without restraints) Performing minimization step: 192. Total energy = 95504.7465 kcal/mol (95468.4452 without restraints) Performing minimization step: 193. Total energy = 95422.7118 kcal/mol (95386.4208 without restraints) Performing minimization step: 194. Total energy = 95340.7422 kcal/mol (95304.4620 without restraints) Performing minimization step: 195. Total energy = 95258.8379 kcal/mol (95222.5683 without restraints) Performing minimization step: 196. Total energy = 95176.9990 kcal/mol (95140.7401 without restraints) Performing minimization step: 197. Total energy = 95095.2250 kcal/mol (95058.9766 without restraints) Performing minimization step: 198. Total energy = 95013.5160 kcal/mol (94977.2783 without restraints) Performing minimization step: 199. Total energy = 94931.8725 kcal/mol (94895.6453 without restraints) Performing minimization step: 200. Total energy = 94850.2938 kcal/mol (94814.0772 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 201. Total energy = 94768.7798 kcal/mol (94732.5738 without restraints) Performing minimization step: 202. Total energy = 94687.3310 kcal/mol (94651.1354 without restraints) Performing minimization step: 203. Total energy = 94605.9470 kcal/mol (94569.7621 without restraints) Performing minimization step: 204. Total energy = 94524.6278 kcal/mol (94488.4535 without restraints) Performing minimization step: 205. Total energy = 94443.3736 kcal/mol (94407.2097 without restraints) Performing minimization step: 206. Total energy = 94362.1841 kcal/mol (94326.0308 without restraints) Performing minimization step: 207. Total energy = 94281.0598 kcal/mol (94244.9171 without restraints) Performing minimization step: 208. Total energy = 94200.0001 kcal/mol (94163.8679 without restraints) Performing minimization step: 209. Total energy = 94119.0052 kcal/mol (94082.8835 without restraints) Performing minimization step: 210. Total energy = 94038.0751 kcal/mol (94001.9640 without restraints) Performing minimization step: 211. Total energy = 93957.2096 kcal/mol (93921.1091 without restraints) Performing minimization step: 212. Total energy = 93876.4090 kcal/mol (93840.3190 without restraints) Performing minimization step: 213. Total energy = 93795.6731 kcal/mol (93759.5936 without restraints) Performing minimization step: 214. Total energy = 93715.0019 kcal/mol (93678.9329 without restraints) Performing minimization step: 215. Total energy = 93634.3954 kcal/mol (93598.3369 without restraints) Performing minimization step: 216. Total energy = 93553.8534 kcal/mol (93517.8055 without restraints) Performing minimization step: 217. Total energy = 93473.3760 kcal/mol (93437.3386 without restraints) Performing minimization step: 218. Total energy = 93392.9630 kcal/mol (93356.9360 without restraints) Performing minimization step: 219. Total energy = 93312.6141 kcal/mol (93276.5977 without restraints) Performing minimization step: 220. Total energy = 93232.3307 kcal/mol (93196.3246 without restraints) Performing minimization step: 221. Total energy = 93152.1112 kcal/mol (93116.1157 without restraints) Performing minimization step: 222. Total energy = 93071.9562 kcal/mol (93035.9711 without restraints) Performing minimization step: 223. Total energy = 92991.8657 kcal/mol (92955.8912 without restraints) Performing minimization step: 224. Total energy = 92911.8395 kcal/mol (92875.8754 without restraints) Performing minimization step: 225. Total energy = 92831.8771 kcal/mol (92795.9234 without restraints) Performing minimization step: 226. Total energy = 92751.9791 kcal/mol (92716.0359 without restraints) Performing minimization step: 227. Total energy = 92672.1458 kcal/mol (92636.2132 without restraints) Performing minimization step: 228. Total energy = 92592.3772 kcal/mol (92556.4549 without restraints) Performing minimization step: 229. Total energy = 92512.6729 kcal/mol (92476.7611 without restraints) Performing minimization step: 230. Total energy = 92433.0328 kcal/mol (92397.1315 without restraints) Performing minimization step: 231. Total energy = 92353.4569 kcal/mol (92317.5660 without restraints) Performing minimization step: 232. Total energy = 92273.9450 kcal/mol (92238.0645 without restraints) Performing minimization step: 233. Total energy = 92194.4975 kcal/mol (92158.6275 without restraints) Performing minimization step: 234. Total energy = 92115.1141 kcal/mol (92079.2545 without restraints) Performing minimization step: 235. Total energy = 92035.7949 kcal/mol (91999.9457 without restraints) Performing minimization step: 236. Total energy = 91956.5398 kcal/mol (91920.7010 without restraints) Performing minimization step: 237. Total energy = 91877.3487 kcal/mol (91841.5202 without restraints) Performing minimization step: 238. Total energy = 91798.2217 kcal/mol (91762.4038 without restraints) Performing minimization step: 239. Total energy = 91719.1587 kcal/mol (91683.3511 without restraints) Performing minimization step: 240. Total energy = 91640.1597 kcal/mol (91604.3627 without restraints) Performing minimization step: 241. Total energy = 91561.2247 kcal/mol (91525.4381 without restraints) Performing minimization step: 242. Total energy = 91482.3538 kcal/mol (91446.5774 without restraints) Performing minimization step: 243. Total energy = 91403.5464 kcal/mol (91367.7805 without restraints) Performing minimization step: 244. Total energy = 91324.8032 kcal/mol (91289.0476 without restraints) Performing minimization step: 245. Total energy = 91246.1238 kcal/mol (91210.3786 without restraints) Performing minimization step: 246. Total energy = 91167.5081 kcal/mol (91131.7733 without restraints) Performing minimization step: 247. Total energy = 91088.9564 kcal/mol (91053.2320 without restraints) Performing minimization step: 248. Total energy = 91010.4683 kcal/mol (90974.7542 without restraints) Performing minimization step: 249. Total energy = 90932.0441 kcal/mol (90896.3404 without restraints) Performing minimization step: 250. Total energy = 90853.6834 kcal/mol (90817.9900 without restraints) Performing minimization step: 251. Total energy = 90775.3867 kcal/mol (90739.7037 without restraints) Performing minimization step: 252. Total energy = 90697.1537 kcal/mol (90661.4811 without restraints) Performing minimization step: 253. Total energy = 90618.9841 kcal/mol (90583.3218 without restraints) Performing minimization step: 254. Total energy = 90540.8783 kcal/mol (90505.2264 without restraints) Performing minimization step: 255. Total energy = 90462.8362 kcal/mol (90427.1946 without restraints) Performing minimization step: 256. Total energy = 90384.8577 kcal/mol (90349.2264 without restraints) Performing minimization step: 257. Total energy = 90306.9425 kcal/mol (90271.3215 without restraints) Performing minimization step: 258. Total energy = 90229.0910 kcal/mol (90193.4803 without restraints) Performing minimization step: 259. Total energy = 90151.3031 kcal/mol (90115.7027 without restraints) Performing minimization step: 260. Total energy = 90073.5787 kcal/mol (90037.9886 without restraints) Performing minimization step: 261. Total energy = 89995.9175 kcal/mol (89960.3378 without restraints) Performing minimization step: 262. Total energy = 89918.3193 kcal/mol (89882.7496 without restraints) Performing minimization step: 263. Total energy = 89840.7846 kcal/mol (89805.2255 without restraints) Performing minimization step: 264. Total energy = 89763.3138 kcal/mol (89727.7649 without restraints) Performing minimization step: 265. Total energy = 89685.9058 kcal/mol (89650.3671 without restraints) Performing minimization step: 266. Total energy = 89608.5612 kcal/mol (89573.0328 without restraints) Performing minimization step: 267. Total energy = 89531.2800 kcal/mol (89495.7620 without restraints) Performing minimization step: 268. Total energy = 89454.0620 kcal/mol (89418.5543 without restraints) Performing minimization step: 269. Total energy = 89376.9079 kcal/mol (89341.4105 without restraints) Performing minimization step: 270. Total energy = 89299.8169 kcal/mol (89264.3298 without restraints) Performing minimization step: 271. Total energy = 89222.7887 kcal/mol (89187.3118 without restraints) Performing minimization step: 272. Total energy = 89145.8239 kcal/mol (89110.3573 without restraints) Performing minimization step: 273. Total energy = 89068.9223 kcal/mol (89033.4658 without restraints) Performing minimization step: 274. Total energy = 88992.0834 kcal/mol (88956.6373 without restraints) Performing minimization step: 275. Total energy = 88915.3083 kcal/mol (88879.8724 without restraints) Performing minimization step: 276. Total energy = 88838.5958 kcal/mol (88803.1700 without restraints) Performing minimization step: 277. Total energy = 88761.9466 kcal/mol (88726.5313 without restraints) Performing minimization step: 278. Total energy = 88685.3606 kcal/mol (88649.9553 without restraints) Performing minimization step: 279. Total energy = 88608.8371 kcal/mol (88573.4421 without restraints) Performing minimization step: 280. Total energy = 88532.3766 kcal/mol (88496.9918 without restraints) Performing minimization step: 281. Total energy = 88455.9790 kcal/mol (88420.6045 without restraints) Performing minimization step: 282. Total energy = 88379.6441 kcal/mol (88344.2797 without restraints) Performing minimization step: 283. Total energy = 88303.3722 kcal/mol (88268.0180 without restraints) Performing minimization step: 284. Total energy = 88227.1629 kcal/mol (88191.8189 without restraints) Performing minimization step: 285. Total energy = 88151.0167 kcal/mol (88115.6829 without restraints) Performing minimization step: 286. Total energy = 88074.9332 kcal/mol (88039.6096 without restraints) Performing minimization step: 287. Total energy = 87998.9124 kcal/mol (87963.5989 without restraints) Performing minimization step: 288. Total energy = 87922.9542 kcal/mol (87887.6510 without restraints) Performing minimization step: 289. Total energy = 87847.0591 kcal/mol (87811.7662 without restraints) Performing minimization step: 290. Total energy = 87771.2266 kcal/mol (87735.9437 without restraints) Performing minimization step: 291. Total energy = 87695.4566 kcal/mol (87660.1839 without restraints) Performing minimization step: 292. Total energy = 87619.7490 kcal/mol (87584.4865 without restraints) Performing minimization step: 293. Total energy = 87544.1043 kcal/mol (87508.8520 without restraints) Performing minimization step: 294. Total energy = 87468.5225 kcal/mol (87433.2803 without restraints) Performing minimization step: 295. Total energy = 87393.0030 kcal/mol (87357.7709 without restraints) Performing minimization step: 296. Total energy = 87317.5460 kcal/mol (87282.3241 without restraints) Performing minimization step: 297. Total energy = 87242.1513 kcal/mol (87206.9397 without restraints) Performing minimization step: 298. Total energy = 87166.8192 kcal/mol (87131.6176 without restraints) Performing minimization step: 299. Total energy = 87091.5488 kcal/mol (87056.3573 without restraints) Performing minimization step: 300. Total energy = 87016.3413 kcal/mol (86981.1600 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 301. Total energy = 86941.1964 kcal/mol (86906.0251 without restraints) Performing minimization step: 302. Total energy = 86866.1140 kcal/mol (86830.9529 without restraints) Performing minimization step: 303. Total energy = 86791.0940 kcal/mol (86755.9430 without restraints) Performing minimization step: 304. Total energy = 86716.1356 kcal/mol (86680.9948 without restraints) Performing minimization step: 305. Total energy = 86641.2401 kcal/mol (86606.1093 without restraints) Performing minimization step: 306. Total energy = 86566.4068 kcal/mol (86531.2861 without restraints) Performing minimization step: 307. Total energy = 86491.6357 kcal/mol (86456.5251 without restraints) Performing minimization step: 308. Total energy = 86416.9267 kcal/mol (86381.8262 without restraints) Performing minimization step: 309. Total energy = 86342.2794 kcal/mol (86307.1889 without restraints) Performing minimization step: 310. Total energy = 86267.6946 kcal/mol (86232.6143 without restraints) Performing minimization step: 311. Total energy = 86193.1719 kcal/mol (86158.1018 without restraints) Performing minimization step: 312. Total energy = 86118.7115 kcal/mol (86083.6514 without restraints) Performing minimization step: 313. Total energy = 86044.3132 kcal/mol (86009.2632 without restraints) Performing minimization step: 314. Total energy = 85969.9768 kcal/mol (85934.9368 without restraints) Performing minimization step: 315. Total energy = 85895.7022 kcal/mol (85860.6722 without restraints) Performing minimization step: 316. Total energy = 85821.4894 kcal/mol (85786.4694 without restraints) Performing minimization step: 317. Total energy = 85747.3387 kcal/mol (85712.3288 without restraints) Performing minimization step: 318. Total energy = 85673.2501 kcal/mol (85638.2503 without restraints) Performing minimization step: 319. Total energy = 85599.2231 kcal/mol (85564.2333 without restraints) Performing minimization step: 320. Total energy = 85525.2582 kcal/mol (85490.2783 without restraints) Performing minimization step: 321. Total energy = 85451.3552 kcal/mol (85416.3854 without restraints) Performing minimization step: 322. Total energy = 85377.5139 kcal/mol (85342.5542 without restraints) Performing minimization step: 323. Total energy = 85303.7340 kcal/mol (85268.7843 without restraints) Performing minimization step: 324. Total energy = 85230.0162 kcal/mol (85195.0765 without restraints) Performing minimization step: 325. Total energy = 85156.3607 kcal/mol (85121.4310 without restraints) Performing minimization step: 326. Total energy = 85082.7664 kcal/mol (85047.8467 without restraints) Performing minimization step: 327. Total energy = 85009.2337 kcal/mol (84974.3239 without restraints) Performing minimization step: 328. Total energy = 84935.7626 kcal/mol (84900.8629 without restraints) Performing minimization step: 329. Total energy = 84862.3533 kcal/mol (84827.4635 without restraints) Performing minimization step: 330. Total energy = 84789.0050 kcal/mol (84754.1253 without restraints) Performing minimization step: 331. Total energy = 84715.7185 kcal/mol (84680.8488 without restraints) Performing minimization step: 332. Total energy = 84642.4938 kcal/mol (84607.6340 without restraints) Performing minimization step: 333. Total energy = 84569.3302 kcal/mol (84534.4804 without restraints) Performing minimization step: 334. Total energy = 84496.2281 kcal/mol (84461.3882 without restraints) Performing minimization step: 335. Total energy = 84423.1876 kcal/mol (84388.3577 without restraints) Performing minimization step: 336. Total energy = 84350.2090 kcal/mol (84315.3890 without restraints) Performing minimization step: 337. Total energy = 84277.2913 kcal/mol (84242.4814 without restraints) Performing minimization step: 338. Total energy = 84204.4351 kcal/mol (84169.6351 without restraints) Performing minimization step: 339. Total energy = 84131.6400 kcal/mol (84096.8499 without restraints) Performing minimization step: 340. Total energy = 84058.9064 kcal/mol (84024.1262 without restraints) Performing minimization step: 341. Total energy = 83986.2339 kcal/mol (83951.4638 without restraints) Performing minimization step: 342. Total energy = 83913.6226 kcal/mol (83878.8623 without restraints) Performing minimization step: 343. Total energy = 83841.0724 kcal/mol (83806.3221 without restraints) Performing minimization step: 344. Total energy = 83768.5831 kcal/mol (83733.8427 without restraints) Performing minimization step: 345. Total energy = 83696.1555 kcal/mol (83661.4250 without restraints) Performing minimization step: 346. Total energy = 83623.7890 kcal/mol (83589.0684 without restraints) Performing minimization step: 347. Total energy = 83551.4834 kcal/mol (83516.7727 without restraints) Performing minimization step: 348. Total energy = 83479.2393 kcal/mol (83444.5385 without restraints) Performing minimization step: 349. Total energy = 83407.0561 kcal/mol (83372.3652 without restraints) Performing minimization step: 350. Total energy = 83334.9340 kcal/mol (83300.2530 without restraints) Performing minimization step: 351. Total energy = 83262.8729 kcal/mol (83228.2019 without restraints) Performing minimization step: 352. Total energy = 83190.8727 kcal/mol (83156.2114 without restraints) Performing minimization step: 353. Total energy = 83118.9332 kcal/mol (83084.2819 without restraints) Performing minimization step: 354. Total energy = 83047.0545 kcal/mol (83012.4130 without restraints) Performing minimization step: 355. Total energy = 82975.2368 kcal/mol (82940.6052 without restraints) Performing minimization step: 356. Total energy = 82903.4801 kcal/mol (82868.8583 without restraints) Performing minimization step: 357. Total energy = 82831.7841 kcal/mol (82797.1721 without restraints) Performing minimization step: 358. Total energy = 82760.1486 kcal/mol (82725.5463 without restraints) Performing minimization step: 359. Total energy = 82688.5739 kcal/mol (82653.9817 without restraints) Performing minimization step: 360. Total energy = 82617.0598 kcal/mol (82582.4772 without restraints) Performing minimization step: 361. Total energy = 82545.6064 kcal/mol (82511.0337 without restraints) Performing minimization step: 362. Total energy = 82474.2140 kcal/mol (82439.6512 without restraints) Performing minimization step: 363. Total energy = 82402.8822 kcal/mol (82368.3293 without restraints) Performing minimization step: 364. Total energy = 82331.6106 kcal/mol (82297.0675 without restraints) Performing minimization step: 365. Total energy = 82260.3999 kcal/mol (82225.8665 without restraints) Performing minimization step: 366. Total energy = 82189.2496 kcal/mol (82154.7261 without restraints) Performing minimization step: 367. Total energy = 82118.1596 kcal/mol (82083.6458 without restraints) Performing minimization step: 368. Total energy = 82047.1304 kcal/mol (82012.6266 without restraints) Performing minimization step: 369. Total energy = 81976.1616 kcal/mol (81941.6675 without restraints) Performing minimization step: 370. Total energy = 81905.2533 kcal/mol (81870.7690 without restraints) Performing minimization step: 371. Total energy = 81834.4058 kcal/mol (81799.9313 without restraints) Performing minimization step: 372. Total energy = 81763.6185 kcal/mol (81729.1538 without restraints) Performing minimization step: 373. Total energy = 81692.8915 kcal/mol (81658.4366 without restraints) Performing minimization step: 374. Total energy = 81622.2251 kcal/mol (81587.7799 without restraints) Performing minimization step: 375. Total energy = 81551.6188 kcal/mol (81517.1835 without restraints) Performing minimization step: 376. Total energy = 81481.0728 kcal/mol (81446.6474 without restraints) Performing minimization step: 377. Total energy = 81410.5869 kcal/mol (81376.1710 without restraints) Performing minimization step: 378. Total energy = 81340.1611 kcal/mol (81305.7549 without restraints) Performing minimization step: 379. Total energy = 81269.7952 kcal/mol (81235.3987 without restraints) Performing minimization step: 380. Total energy = 81199.4897 kcal/mol (81165.1031 without restraints) Performing minimization step: 381. Total energy = 81129.2445 kcal/mol (81094.8676 without restraints) Performing minimization step: 382. Total energy = 81059.0591 kcal/mol (81024.6920 without restraints) Performing minimization step: 383. Total energy = 80988.9340 kcal/mol (80954.5766 without restraints) Performing minimization step: 384. Total energy = 80918.8689 kcal/mol (80884.5212 without restraints) Performing minimization step: 385. Total energy = 80848.8638 kcal/mol (80814.5259 without restraints) Performing minimization step: 386. Total energy = 80778.9186 kcal/mol (80744.5903 without restraints) Performing minimization step: 387. Total energy = 80709.0334 kcal/mol (80674.7149 without restraints) Performing minimization step: 388. Total energy = 80639.2082 kcal/mol (80604.8994 without restraints) Performing minimization step: 389. Total energy = 80569.4429 kcal/mol (80535.1437 without restraints) Performing minimization step: 390. Total energy = 80499.7373 kcal/mol (80465.4477 without restraints) Performing minimization step: 391. Total energy = 80430.0915 kcal/mol (80395.8118 without restraints) Performing minimization step: 392. Total energy = 80360.5056 kcal/mol (80326.2356 without restraints) Performing minimization step: 393. Total energy = 80290.9795 kcal/mol (80256.7191 without restraints) Performing minimization step: 394. Total energy = 80221.5130 kcal/mol (80187.2624 without restraints) Performing minimization step: 395. Total energy = 80152.1065 kcal/mol (80117.8654 without restraints) Performing minimization step: 396. Total energy = 80082.7597 kcal/mol (80048.5283 without restraints) Performing minimization step: 397. Total energy = 80013.4722 kcal/mol (79979.2503 without restraints) Performing minimization step: 398. Total energy = 79944.2442 kcal/mol (79910.0321 without restraints) Performing minimization step: 399. Total energy = 79875.0759 kcal/mol (79840.8735 without restraints) Performing minimization step: 400. Total energy = 79805.9674 kcal/mol (79771.7746 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 401. Total energy = 79736.9183 kcal/mol (79702.7352 without restraints) Performing minimization step: 402. Total energy = 79667.9289 kcal/mol (79633.7554 without restraints) Performing minimization step: 403. Total energy = 79598.9989 kcal/mol (79564.8350 without restraints) Performing minimization step: 404. Total energy = 79530.1282 kcal/mol (79495.9740 without restraints) Performing minimization step: 405. Total energy = 79461.3170 kcal/mol (79427.1723 without restraints) Performing minimization step: 406. Total energy = 79392.5653 kcal/mol (79358.4303 without restraints) Performing minimization step: 407. Total energy = 79323.8726 kcal/mol (79289.7472 without restraints) Performing minimization step: 408. Total energy = 79255.2389 kcal/mol (79221.1231 without restraints) Performing minimization step: 409. Total energy = 79186.6652 kcal/mol (79152.5590 without restraints) Performing minimization step: 410. Total energy = 79118.1503 kcal/mol (79084.0537 without restraints) Performing minimization step: 411. Total energy = 79049.6949 kcal/mol (79015.6079 without restraints) Performing minimization step: 412. Total energy = 78981.2990 kcal/mol (78947.2216 without restraints) Performing minimization step: 413. Total energy = 78912.9620 kcal/mol (78878.8941 without restraints) Performing minimization step: 414. Total energy = 78844.6839 kcal/mol (78810.6255 without restraints) Performing minimization step: 415. Total energy = 78776.4650 kcal/mol (78742.4163 without restraints) Performing minimization step: 416. Total energy = 78708.3051 kcal/mol (78674.2659 without restraints) Performing minimization step: 417. Total energy = 78640.2043 kcal/mol (78606.1747 without restraints) Performing minimization step: 418. Total energy = 78572.1626 kcal/mol (78538.1425 without restraints) Performing minimization step: 419. Total energy = 78504.1799 kcal/mol (78470.1693 without restraints) Performing minimization step: 420. Total energy = 78436.2561 kcal/mol (78402.2552 without restraints) Performing minimization step: 421. Total energy = 78368.3913 kcal/mol (78334.3999 without restraints) Performing minimization step: 422. Total energy = 78300.5857 kcal/mol (78266.6038 without restraints) Performing minimization step: 423. Total energy = 78232.8389 kcal/mol (78198.8668 without restraints) Performing minimization step: 424. Total energy = 78165.1510 kcal/mol (78131.1881 without restraints) Performing minimization step: 425. Total energy = 78097.5212 kcal/mol (78063.5679 without restraints) Performing minimization step: 426. Total energy = 78029.9507 kcal/mol (77996.0069 without restraints) Performing minimization step: 427. Total energy = 77962.4389 kcal/mol (77928.5046 without restraints) Performing minimization step: 428. Total energy = 77894.9858 kcal/mol (77861.0610 without restraints) Performing minimization step: 429. Total energy = 77827.5912 kcal/mol (77793.6757 without restraints) Performing minimization step: 430. Total energy = 77760.2553 kcal/mol (77726.3495 without restraints) Performing minimization step: 431. Total energy = 77692.9779 kcal/mol (77659.0816 without restraints) Performing minimization step: 432. Total energy = 77625.7594 kcal/mol (77591.8725 without restraints) Performing minimization step: 433. Total energy = 77558.5993 kcal/mol (77524.7219 without restraints) Performing minimization step: 434. Total energy = 77491.4979 kcal/mol (77457.6300 without restraints) Performing minimization step: 435. Total energy = 77424.4547 kcal/mol (77390.5963 without restraints) Performing minimization step: 436. Total energy = 77357.4702 kcal/mol (77323.6212 without restraints) Performing minimization step: 437. Total energy = 77290.5443 kcal/mol (77256.7049 without restraints) Performing minimization step: 438. Total energy = 77223.6767 kcal/mol (77189.8467 without restraints) Performing minimization step: 439. Total energy = 77156.8675 kcal/mol (77123.0469 without restraints) Performing minimization step: 440. Total energy = 77090.1165 kcal/mol (77056.3053 without restraints) Performing minimization step: 441. Total energy = 77023.4237 kcal/mol (76989.6220 without restraints) Performing minimization step: 442. Total energy = 76956.7893 kcal/mol (76922.9970 without restraints) Performing minimization step: 443. Total energy = 76890.2134 kcal/mol (76856.4305 without restraints) Performing minimization step: 444. Total energy = 76823.6955 kcal/mol (76789.9220 without restraints) Performing minimization step: 445. Total energy = 76757.2359 kcal/mol (76723.4719 without restraints) Performing minimization step: 446. Total energy = 76690.8344 kcal/mol (76657.0797 without restraints) Performing minimization step: 447. Total energy = 76624.4913 kcal/mol (76590.7461 without restraints) Performing minimization step: 448. Total energy = 76558.2061 kcal/mol (76524.4703 without restraints) Performing minimization step: 449. Total energy = 76491.9792 kcal/mol (76458.2528 without restraints) Performing minimization step: 450. Total energy = 76425.8101 kcal/mol (76392.0931 without restraints) Performing minimization step: 451. Total energy = 76359.6994 kcal/mol (76325.9920 without restraints) Performing minimization step: 452. Total energy = 76293.6467 kcal/mol (76259.9482 without restraints) Performing minimization step: 453. Total energy = 76227.6515 kcal/mol (76193.9626 without restraints) Performing minimization step: 454. Total energy = 76161.7144 kcal/mol (76128.0349 without restraints) Performing minimization step: 455. Total energy = 76095.8350 kcal/mol (76062.1646 without restraints) Performing minimization step: 456. Total energy = 76030.0133 kcal/mol (75996.3525 without restraints) Performing minimization step: 457. Total energy = 75964.2499 kcal/mol (75930.5985 without restraints) Performing minimization step: 458. Total energy = 75898.5440 kcal/mol (75864.9019 without restraints) Performing minimization step: 459. Total energy = 75832.8963 kcal/mol (75799.2636 without restraints) Performing minimization step: 460. Total energy = 75767.3061 kcal/mol (75733.6827 without restraints) Performing minimization step: 461. Total energy = 75701.7734 kcal/mol (75668.1592 without restraints) Performing minimization step: 462. Total energy = 75636.2983 kcal/mol (75602.6935 without restraints) Performing minimization step: 463. Total energy = 75570.8811 kcal/mol (75537.2857 without restraints) Performing minimization step: 464. Total energy = 75505.5214 kcal/mol (75471.9352 without restraints) Performing minimization step: 465. Total energy = 75440.2191 kcal/mol (75406.6422 without restraints) Performing minimization step: 466. Total energy = 75374.9746 kcal/mol (75341.4071 without restraints) Performing minimization step: 467. Total energy = 75309.7873 kcal/mol (75276.2291 without restraints) Performing minimization step: 468. Total energy = 75244.6575 kcal/mol (75211.1086 without restraints) Performing minimization step: 469. Total energy = 75179.5852 kcal/mol (75146.0456 without restraints) Performing minimization step: 470. Total energy = 75114.5705 kcal/mol (75081.0402 without restraints) Performing minimization step: 471. Total energy = 75049.6132 kcal/mol (75016.0922 without restraints) Performing minimization step: 472. Total energy = 74984.7138 kcal/mol (74951.2021 without restraints) Performing minimization step: 473. Total energy = 74919.8713 kcal/mol (74886.3688 without restraints) Performing minimization step: 474. Total energy = 74855.0863 kcal/mol (74821.5931 without restraints) Performing minimization step: 475. Total energy = 74790.3588 kcal/mol (74756.8748 without restraints) Performing minimization step: 476. Total energy = 74725.6881 kcal/mol (74692.2134 without restraints) Performing minimization step: 477. Total energy = 74661.0750 kcal/mol (74627.6096 without restraints) Performing minimization step: 478. Total energy = 74596.5191 kcal/mol (74563.0629 without restraints) Performing minimization step: 479. Total energy = 74532.0203 kcal/mol (74498.5734 without restraints) Performing minimization step: 480. Total energy = 74467.5784 kcal/mol (74434.1407 without restraints) Performing minimization step: 481. Total energy = 74403.1938 kcal/mol (74369.7652 without restraints) Performing minimization step: 482. Total energy = 74338.8656 kcal/mol (74305.4463 without restraints) Performing minimization step: 483. Total energy = 74274.5949 kcal/mol (74241.1849 without restraints) Performing minimization step: 484. Total energy = 74210.3815 kcal/mol (74176.9805 without restraints) Performing minimization step: 485. Total energy = 74146.2243 kcal/mol (74112.8328 without restraints) Performing minimization step: 486. Total energy = 74082.1243 kcal/mol (74048.7418 without restraints) Performing minimization step: 487. Total energy = 74018.0816 kcal/mol (73984.7084 without restraints) Performing minimization step: 488. Total energy = 73954.0956 kcal/mol (73920.7316 without restraints) Performing minimization step: 489. Total energy = 73890.1660 kcal/mol (73856.8112 without restraints) Performing minimization step: 490. Total energy = 73826.2937 kcal/mol (73792.9481 without restraints) Performing minimization step: 491. Total energy = 73762.4776 kcal/mol (73729.1410 without restraints) Performing minimization step: 492. Total energy = 73698.7187 kcal/mol (73665.3914 without restraints) Performing minimization step: 493. Total energy = 73635.0166 kcal/mol (73601.6984 without restraints) Performing minimization step: 494. Total energy = 73571.3710 kcal/mol (73538.0620 without restraints) Performing minimization step: 495. Total energy = 73507.7821 kcal/mol (73474.4822 without restraints) Performing minimization step: 496. Total energy = 73444.2493 kcal/mol (73410.9585 without restraints) Performing minimization step: 497. Total energy = 73380.7735 kcal/mol (73347.4920 without restraints) Performing minimization step: 498. Total energy = 73317.3546 kcal/mol (73284.0822 without restraints) Performing minimization step: 499. Total energy = 73253.9919 kcal/mol (73220.7286 without restraints) Performing minimization step: 500. Total energy = 73190.6859 kcal/mol (73157.4318 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 501. Total energy = 73127.4366 kcal/mol (73094.1916 without restraints) Performing minimization step: 502. Total energy = 73064.2437 kcal/mol (73031.0078 without restraints) Performing minimization step: 503. Total energy = 73001.1070 kcal/mol (72967.8803 without restraints) Performing minimization step: 504. Total energy = 72938.0266 kcal/mol (72904.8089 without restraints) Performing minimization step: 505. Total energy = 72875.0025 kcal/mol (72841.7938 without restraints) Performing minimization step: 506. Total energy = 72812.0348 kcal/mol (72778.8353 without restraints) Performing minimization step: 507. Total energy = 72749.1234 kcal/mol (72715.9330 without restraints) Performing minimization step: 508. Total energy = 72686.2682 kcal/mol (72653.0869 without restraints) Performing minimization step: 509. Total energy = 72623.4695 kcal/mol (72590.2973 without restraints) Performing minimization step: 510. Total energy = 72560.7268 kcal/mol (72527.5637 without restraints) Performing minimization step: 511. Total energy = 72498.0403 kcal/mol (72464.8862 without restraints) Performing minimization step: 512. Total energy = 72435.4096 kcal/mol (72402.2646 without restraints) Performing minimization step: 513. Total energy = 72372.8352 kcal/mol (72339.6993 without restraints) Performing minimization step: 514. Total energy = 72310.3169 kcal/mol (72277.1900 without restraints) Performing minimization step: 515. Total energy = 72247.8544 kcal/mol (72214.7366 without restraints) Performing minimization step: 516. Total energy = 72185.4481 kcal/mol (72152.3393 without restraints) Performing minimization step: 517. Total energy = 72123.0975 kcal/mol (72089.9978 without restraints) Performing minimization step: 518. Total energy = 72060.8027 kcal/mol (72027.7120 without restraints) Performing minimization step: 519. Total energy = 71998.5638 kcal/mol (71965.4821 without restraints) Performing minimization step: 520. Total energy = 71936.3810 kcal/mol (71903.3084 without restraints) Performing minimization step: 521. Total energy = 71874.2542 kcal/mol (71841.1906 without restraints) Performing minimization step: 522. Total energy = 71812.1829 kcal/mol (71779.1283 without restraints) Performing minimization step: 523. Total energy = 71750.1677 kcal/mol (71717.1221 without restraints) Performing minimization step: 524. Total energy = 71688.2077 kcal/mol (71655.1711 without restraints) Performing minimization step: 525. Total energy = 71626.3039 kcal/mol (71593.2763 without restraints) Performing minimization step: 526. Total energy = 71564.4558 kcal/mol (71531.4371 without restraints) Performing minimization step: 527. Total energy = 71502.6630 kcal/mol (71469.6534 without restraints) Performing minimization step: 528. Total energy = 71440.9258 kcal/mol (71407.9252 without restraints) Performing minimization step: 529. Total energy = 71379.2448 kcal/mol (71346.2531 without restraints) Performing minimization step: 530. Total energy = 71317.6188 kcal/mol (71284.6361 without restraints) Performing minimization step: 531. Total energy = 71256.0483 kcal/mol (71223.0745 without restraints) Performing minimization step: 532. Total energy = 71194.5327 kcal/mol (71161.5678 without restraints) Performing minimization step: 533. Total energy = 71133.0735 kcal/mol (71100.1177 without restraints) Performing minimization step: 534. Total energy = 71071.6696 kcal/mol (71038.7227 without restraints) Performing minimization step: 535. Total energy = 71010.3210 kcal/mol (70977.3831 without restraints) Performing minimization step: 536. Total energy = 70949.0278 kcal/mol (70916.0989 without restraints) Performing minimization step: 537. Total energy = 70887.7900 kcal/mol (70854.8700 without restraints) Performing minimization step: 538. Total energy = 70826.6075 kcal/mol (70793.6962 without restraints) Performing minimization step: 539. Total energy = 70765.4800 kcal/mol (70732.5778 without restraints) Performing minimization step: 540. Total energy = 70704.4078 kcal/mol (70671.5146 without restraints) Performing minimization step: 541. Total energy = 70643.3907 kcal/mol (70610.5063 without restraints) Performing minimization step: 542. Total energy = 70582.4289 kcal/mol (70549.5534 without restraints) Performing minimization step: 543. Total energy = 70521.5223 kcal/mol (70488.6557 without restraints) Performing minimization step: 544. Total energy = 70460.6710 kcal/mol (70427.8133 without restraints) Performing minimization step: 545. Total energy = 70399.8743 kcal/mol (70367.0255 without restraints) Performing minimization step: 546. Total energy = 70339.1328 kcal/mol (70306.2929 without restraints) Performing minimization step: 547. Total energy = 70278.4459 kcal/mol (70245.6149 without restraints) Performing minimization step: 548. Total energy = 70217.8144 kcal/mol (70184.9923 without restraints) Performing minimization step: 549. Total energy = 70157.2380 kcal/mol (70124.4248 without restraints) Performing minimization step: 550. Total energy = 70096.7164 kcal/mol (70063.9119 without restraints) Performing minimization step: 551. Total energy = 70036.2494 kcal/mol (70003.4538 without restraints) Performing minimization step: 552. Total energy = 69975.8373 kcal/mol (69943.0505 without restraints) Performing minimization step: 553. Total energy = 69915.4800 kcal/mol (69882.7022 without restraints) Performing minimization step: 554. Total energy = 69855.1776 kcal/mol (69822.4085 without restraints) Performing minimization step: 555. Total energy = 69794.9299 kcal/mol (69762.1697 without restraints) Performing minimization step: 556. Total energy = 69734.7372 kcal/mol (69701.9859 without restraints) Performing minimization step: 557. Total energy = 69674.5990 kcal/mol (69641.8565 without restraints) Performing minimization step: 558. Total energy = 69614.5152 kcal/mol (69581.7815 without restraints) Performing minimization step: 559. Total energy = 69554.4860 kcal/mol (69521.7611 without restraints) Performing minimization step: 560. Total energy = 69494.5116 kcal/mol (69461.7955 without restraints) Performing minimization step: 561. Total energy = 69434.5915 kcal/mol (69401.8843 without restraints) Performing minimization step: 562. Total energy = 69374.7262 kcal/mol (69342.0278 without restraints) Performing minimization step: 563. Total energy = 69314.9154 kcal/mol (69282.2258 without restraints) Performing minimization step: 564. Total energy = 69255.1588 kcal/mol (69222.4778 without restraints) Performing minimization step: 565. Total energy = 69195.4567 kcal/mol (69162.7846 without restraints) Performing minimization step: 566. Total energy = 69135.8090 kcal/mol (69103.1457 without restraints) Performing minimization step: 567. Total energy = 69076.2156 kcal/mol (69043.5610 without restraints) Performing minimization step: 568. Total energy = 69016.6765 kcal/mol (68984.0306 without restraints) Performing minimization step: 569. Total energy = 68957.1918 kcal/mol (68924.5548 without restraints) Performing minimization step: 570. Total energy = 68897.7617 kcal/mol (68865.1334 without restraints) Performing minimization step: 571. Total energy = 68838.3855 kcal/mol (68805.7660 without restraints) Performing minimization step: 572. Total energy = 68779.0640 kcal/mol (68746.4533 without restraints) Performing minimization step: 573. Total energy = 68719.7963 kcal/mol (68687.1942 without restraints) Performing minimization step: 574. Total energy = 68660.5826 kcal/mol (68627.9893 without restraints) Performing minimization step: 575. Total energy = 68601.4229 kcal/mol (68568.8383 without restraints) Performing minimization step: 576. Total energy = 68542.3173 kcal/mol (68509.7415 without restraints) Performing minimization step: 577. Total energy = 68483.2658 kcal/mol (68450.6988 without restraints) Performing minimization step: 578. Total energy = 68424.2685 kcal/mol (68391.7101 without restraints) Performing minimization step: 579. Total energy = 68365.3251 kcal/mol (68332.7754 without restraints) Performing minimization step: 580. Total energy = 68306.4349 kcal/mol (68273.8939 without restraints) Performing minimization step: 581. Total energy = 68247.5991 kcal/mol (68215.0668 without restraints) Performing minimization step: 582. Total energy = 68188.8174 kcal/mol (68156.2938 without restraints) Performing minimization step: 583. Total energy = 68130.0892 kcal/mol (68097.5743 without restraints) Performing minimization step: 584. Total energy = 68071.4150 kcal/mol (68038.9087 without restraints) Performing minimization step: 585. Total energy = 68012.7947 kcal/mol (67980.2973 without restraints) Performing minimization step: 586. Total energy = 67954.2279 kcal/mol (67921.7390 without restraints) Performing minimization step: 587. Total energy = 67895.7150 kcal/mol (67863.2347 without restraints) Performing minimization step: 588. Total energy = 67837.2554 kcal/mol (67804.7838 without restraints) Performing minimization step: 589. Total energy = 67778.8497 kcal/mol (67746.3867 without restraints) Performing minimization step: 590. Total energy = 67720.4973 kcal/mol (67688.0430 without restraints) Performing minimization step: 591. Total energy = 67662.1991 kcal/mol (67629.7534 without restraints) Performing minimization step: 592. Total energy = 67603.9537 kcal/mol (67571.5166 without restraints) Performing minimization step: 593. Total energy = 67545.7621 kcal/mol (67513.3338 without restraints) Performing minimization step: 594. Total energy = 67487.6239 kcal/mol (67455.2042 without restraints) Performing minimization step: 595. Total energy = 67429.5394 kcal/mol (67397.1283 without restraints) Performing minimization step: 596. Total energy = 67371.5078 kcal/mol (67339.1052 without restraints) Performing minimization step: 597. Total energy = 67313.5300 kcal/mol (67281.1361 without restraints) Performing minimization step: 598. Total energy = 67255.6056 kcal/mol (67223.2203 without restraints) Performing minimization step: 599. Total energy = 67197.7346 kcal/mol (67165.3579 without restraints) Performing minimization step: 600. Total energy = 67139.9168 kcal/mol (67107.5487 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 601. Total energy = 67082.1520 kcal/mol (67049.7925 without restraints) Performing minimization step: 602. Total energy = 67024.4407 kcal/mol (66992.0899 without restraints) Performing minimization step: 603. Total energy = 66966.7827 kcal/mol (66934.4404 without restraints) Performing minimization step: 604. Total energy = 66909.1775 kcal/mol (66876.8437 without restraints) Performing minimization step: 605. Total energy = 66851.6258 kcal/mol (66819.3006 without restraints) Performing minimization step: 606. Total energy = 66794.1268 kcal/mol (66761.8101 without restraints) Performing minimization step: 607. Total energy = 66736.6806 kcal/mol (66704.3725 without restraints) Performing minimization step: 608. Total energy = 66679.2877 kcal/mol (66646.9882 without restraints) Performing minimization step: 609. Total energy = 66621.9478 kcal/mol (66589.6566 without restraints) Performing minimization step: 610. Total energy = 66564.6610 kcal/mol (66532.3785 without restraints) Performing minimization step: 611. Total energy = 66507.4271 kcal/mol (66475.1530 without restraints) Performing minimization step: 612. Total energy = 66450.2458 kcal/mol (66417.9804 without restraints) Performing minimization step: 613. Total energy = 66393.1177 kcal/mol (66360.8608 without restraints) Performing minimization step: 614. Total energy = 66336.0424 kcal/mol (66303.7940 without restraints) Performing minimization step: 615. Total energy = 66279.0198 kcal/mol (66246.7800 without restraints) Performing minimization step: 616. Total energy = 66222.0500 kcal/mol (66189.8187 without restraints) Performing minimization step: 617. Total energy = 66165.1330 kcal/mol (66132.9102 without restraints) Performing minimization step: 618. Total energy = 66108.2686 kcal/mol (66076.0543 without restraints) Performing minimization step: 619. Total energy = 66051.4566 kcal/mol (66019.2507 without restraints) Performing minimization step: 620. Total energy = 65994.6965 kcal/mol (65962.4989 without restraints) Performing minimization step: 621. Total energy = 65937.9898 kcal/mol (65905.8009 without restraints) Performing minimization step: 622. Total energy = 65881.3356 kcal/mol (65849.1552 without restraints) Performing minimization step: 623. Total energy = 65824.7338 kcal/mol (65792.5618 without restraints) Performing minimization step: 624. Total energy = 65768.1849 kcal/mol (65736.0214 without restraints) Performing minimization step: 625. Total energy = 65711.6883 kcal/mol (65679.5332 without restraints) Performing minimization step: 626. Total energy = 65655.2443 kcal/mol (65623.0977 without restraints) Performing minimization step: 627. Total energy = 65598.8529 kcal/mol (65566.7148 without restraints) Performing minimization step: 628. Total energy = 65542.5132 kcal/mol (65510.3835 without restraints) Performing minimization step: 629. Total energy = 65486.2265 kcal/mol (65454.1052 without restraints) Performing minimization step: 630. Total energy = 65429.9916 kcal/mol (65397.8788 without restraints) Performing minimization step: 631. Total energy = 65373.8093 kcal/mol (65341.7049 without restraints) Performing minimization step: 632. Total energy = 65317.6791 kcal/mol (65285.5831 without restraints) Performing minimization step: 633. Total energy = 65261.6012 kcal/mol (65229.5136 without restraints) Performing minimization step: 634. Total energy = 65205.5750 kcal/mol (65173.4958 without restraints) Performing minimization step: 635. Total energy = 65149.6013 kcal/mol (65117.5305 without restraints) Performing minimization step: 636. Total energy = 65093.6796 kcal/mol (65061.6173 without restraints) Performing minimization step: 637. Total energy = 65037.8102 kcal/mol (65005.7562 without restraints) Performing minimization step: 638. Total energy = 64981.9928 kcal/mol (64949.9472 without restraints) Performing minimization step: 639. Total energy = 64926.2274 kcal/mol (64894.1902 without restraints) Performing minimization step: 640. Total energy = 64870.5139 kcal/mol (64838.4849 without restraints) Performing minimization step: 641. Total energy = 64814.8522 kcal/mol (64782.8317 without restraints) Performing minimization step: 642. Total energy = 64759.2426 kcal/mol (64727.2305 without restraints) Performing minimization step: 643. Total energy = 64703.6845 kcal/mol (64671.6808 without restraints) Performing minimization step: 644. Total energy = 64648.1785 kcal/mol (64616.1831 without restraints) Performing minimization step: 645. Total energy = 64592.7243 kcal/mol (64560.7372 without restraints) Performing minimization step: 646. Total energy = 64537.3217 kcal/mol (64505.3430 without restraints) Performing minimization step: 647. Total energy = 64481.9711 kcal/mol (64450.0007 without restraints) Performing minimization step: 648. Total energy = 64426.6724 kcal/mol (64394.7104 without restraints) Performing minimization step: 649. Total energy = 64371.4250 kcal/mol (64339.4712 without restraints) Performing minimization step: 650. Total energy = 64316.2297 kcal/mol (64284.2842 without restraints) Performing minimization step: 651. Total energy = 64261.0854 kcal/mol (64229.1482 without restraints) Performing minimization step: 652. Total energy = 64205.9928 kcal/mol (64174.0641 without restraints) Performing minimization step: 653. Total energy = 64150.9519 kcal/mol (64119.0314 without restraints) Performing minimization step: 654. Total energy = 64095.9624 kcal/mol (64064.0503 without restraints) Performing minimization step: 655. Total energy = 64041.0242 kcal/mol (64009.1202 without restraints) Performing minimization step: 656. Total energy = 63986.1378 kcal/mol (63954.2423 without restraints) Performing minimization step: 657. Total energy = 63931.3028 kcal/mol (63899.4154 without restraints) Performing minimization step: 658. Total energy = 63876.5188 kcal/mol (63844.6398 without restraints) Performing minimization step: 659. Total energy = 63821.7863 kcal/mol (63789.9154 without restraints) Performing minimization step: 660. Total energy = 63767.1047 kcal/mol (63735.2422 without restraints) Performing minimization step: 661. Total energy = 63712.4752 kcal/mol (63680.6208 without restraints) Performing minimization step: 662. Total energy = 63657.8965 kcal/mol (63626.0505 without restraints) Performing minimization step: 663. Total energy = 63603.3690 kcal/mol (63571.5312 without restraints) Performing minimization step: 664. Total energy = 63548.8925 kcal/mol (63517.0630 without restraints) Performing minimization step: 665. Total energy = 63494.4674 kcal/mol (63462.6462 without restraints) Performing minimization step: 666. Total energy = 63440.0934 kcal/mol (63408.2804 without restraints) Performing minimization step: 667. Total energy = 63385.7707 kcal/mol (63353.9660 without restraints) Performing minimization step: 668. Total energy = 63331.4988 kcal/mol (63299.7021 without restraints) Performing minimization step: 669. Total energy = 63277.2780 kcal/mol (63245.4897 without restraints) Performing minimization step: 670. Total energy = 63223.1082 kcal/mol (63191.3280 without restraints) Performing minimization step: 671. Total energy = 63168.9895 kcal/mol (63137.2175 without restraints) Performing minimization step: 672. Total energy = 63114.9212 kcal/mol (63083.1575 without restraints) Performing minimization step: 673. Total energy = 63060.9042 kcal/mol (63029.1486 without restraints) Performing minimization step: 674. Total energy = 63006.9379 kcal/mol (62975.1905 without restraints) Performing minimization step: 675. Total energy = 62953.0222 kcal/mol (62921.2829 without restraints) Performing minimization step: 676. Total energy = 62899.1570 kcal/mol (62867.4260 without restraints) Performing minimization step: 677. Total energy = 62845.3430 kcal/mol (62813.6202 without restraints) Performing minimization step: 678. Total energy = 62791.5793 kcal/mol (62759.8646 without restraints) Performing minimization step: 679. Total energy = 62737.8665 kcal/mol (62706.1599 without restraints) Performing minimization step: 680. Total energy = 62684.2045 kcal/mol (62652.5061 without restraints) Performing minimization step: 681. Total energy = 62630.5928 kcal/mol (62598.9025 without restraints) Performing minimization step: 682. Total energy = 62577.0322 kcal/mol (62545.3501 without restraints) Performing minimization step: 683. Total energy = 62523.5223 kcal/mol (62491.8484 without restraints) Performing minimization step: 684. Total energy = 62470.0629 kcal/mol (62438.3973 without restraints) Performing minimization step: 685. Total energy = 62416.6541 kcal/mol (62384.9964 without restraints) Performing minimization step: 686. Total energy = 62363.2950 kcal/mol (62331.6453 without restraints) Performing minimization step: 687. Total energy = 62309.9861 kcal/mol (62278.3447 without restraints) Performing minimization step: 688. Total energy = 62256.7281 kcal/mol (62225.0947 without restraints) Performing minimization step: 689. Total energy = 62203.5203 kcal/mol (62171.8950 without restraints) Performing minimization step: 690. Total energy = 62150.3634 kcal/mol (62118.7462 without restraints) Performing minimization step: 691. Total energy = 62097.2563 kcal/mol (62065.6473 without restraints) Performing minimization step: 692. Total energy = 62044.1993 kcal/mol (62012.5983 without restraints) Performing minimization step: 693. Total energy = 61991.1927 kcal/mol (61959.5998 without restraints) Performing minimization step: 694. Total energy = 61938.2362 kcal/mol (61906.6514 without restraints) Performing minimization step: 695. Total energy = 61885.3298 kcal/mol (61853.7530 without restraints) Performing minimization step: 696. Total energy = 61832.4736 kcal/mol (61800.9049 without restraints) Performing minimization step: 697. Total energy = 61779.6673 kcal/mol (61748.1067 without restraints) Performing minimization step: 698. Total energy = 61726.9115 kcal/mol (61695.3589 without restraints) Performing minimization step: 699. Total energy = 61674.2053 kcal/mol (61642.6608 without restraints) Performing minimization step: 700. Total energy = 61621.5489 kcal/mol (61590.0123 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 701. Total energy = 61568.9425 kcal/mol (61537.4141 without restraints) Performing minimization step: 702. Total energy = 61516.3864 kcal/mol (61484.8659 without restraints) Performing minimization step: 703. Total energy = 61463.8802 kcal/mol (61432.3679 without restraints) Performing minimization step: 704. Total energy = 61411.4230 kcal/mol (61379.9187 without restraints) Performing minimization step: 705. Total energy = 61359.0165 kcal/mol (61327.5201 without restraints) Performing minimization step: 706. Total energy = 61306.6594 kcal/mol (61275.1711 without restraints) Performing minimization step: 707. Total energy = 61254.3523 kcal/mol (61222.8720 without restraints) Performing minimization step: 708. Total energy = 61202.0948 kcal/mol (61170.6225 without restraints) Performing minimization step: 709. Total energy = 61149.8870 kcal/mol (61118.4226 without restraints) Performing minimization step: 710. Total energy = 61097.7289 kcal/mol (61066.2726 without restraints) Performing minimization step: 711. Total energy = 61045.6208 kcal/mol (61014.1724 without restraints) Performing minimization step: 712. Total energy = 60993.5621 kcal/mol (60962.1218 without restraints) Performing minimization step: 713. Total energy = 60941.5527 kcal/mol (60910.1202 without restraints) Performing minimization step: 714. Total energy = 60889.5930 kcal/mol (60858.1685 without restraints) Performing minimization step: 715. Total energy = 60837.6826 kcal/mol (60806.2661 without restraints) Performing minimization step: 716. Total energy = 60785.8222 kcal/mol (60754.4136 without restraints) Performing minimization step: 717. Total energy = 60734.0111 kcal/mol (60702.6106 without restraints) Performing minimization step: 718. Total energy = 60682.2490 kcal/mol (60650.8564 without restraints) Performing minimization step: 719. Total energy = 60630.5365 kcal/mol (60599.1519 without restraints) Performing minimization step: 720. Total energy = 60578.8731 kcal/mol (60547.4963 without restraints) Performing minimization step: 721. Total energy = 60527.2591 kcal/mol (60495.8902 without restraints) Performing minimization step: 722. Total energy = 60475.6942 kcal/mol (60444.3333 without restraints) Performing minimization step: 723. Total energy = 60424.1786 kcal/mol (60392.8256 without restraints) Performing minimization step: 724. Total energy = 60372.7124 kcal/mol (60341.3672 without restraints) Performing minimization step: 725. Total energy = 60321.2952 kcal/mol (60289.9580 without restraints) Performing minimization step: 726. Total energy = 60269.9271 kcal/mol (60238.5978 without restraints) Performing minimization step: 727. Total energy = 60218.6086 kcal/mol (60187.2874 without restraints) Performing minimization step: 728. Total energy = 60167.3386 kcal/mol (60136.0251 without restraints) Performing minimization step: 729. Total energy = 60116.1176 kcal/mol (60084.8120 without restraints) Performing minimization step: 730. Total energy = 60064.9458 kcal/mol (60033.6480 without restraints) Performing minimization step: 731. Total energy = 60013.8229 kcal/mol (59982.5331 without restraints) Performing minimization step: 732. Total energy = 59962.7490 kcal/mol (59931.4671 without restraints) Performing minimization step: 733. Total energy = 59911.7233 kcal/mol (59880.4491 without restraints) Performing minimization step: 734. Total energy = 59860.7469 kcal/mol (59829.4806 without restraints) Performing minimization step: 735. Total energy = 59809.8194 kcal/mol (59778.5609 without restraints) Performing minimization step: 736. Total energy = 59758.9405 kcal/mol (59727.6898 without restraints) Performing minimization step: 737. Total energy = 59708.1104 kcal/mol (59676.8676 without restraints) Performing minimization step: 738. Total energy = 59657.3291 kcal/mol (59626.0941 without restraints) Performing minimization step: 739. Total energy = 59606.5963 kcal/mol (59575.3692 without restraints) Performing minimization step: 740. Total energy = 59555.9125 kcal/mol (59524.6931 without restraints) Performing minimization step: 741. Total energy = 59505.2774 kcal/mol (59474.0659 without restraints) Performing minimization step: 742. Total energy = 59454.6901 kcal/mol (59423.4865 without restraints) Performing minimization step: 743. Total energy = 59404.1520 kcal/mol (59372.9561 without restraints) Performing minimization step: 744. Total energy = 59353.6623 kcal/mol (59322.4742 without restraints) Performing minimization step: 745. Total energy = 59303.2209 kcal/mol (59272.0407 without restraints) Performing minimization step: 746. Total energy = 59252.8282 kcal/mol (59221.6557 without restraints) Performing minimization step: 747. Total energy = 59202.4839 kcal/mol (59171.3192 without restraints) Performing minimization step: 748. Total energy = 59152.1880 kcal/mol (59121.0311 without restraints) Performing minimization step: 749. Total energy = 59101.9402 kcal/mol (59070.7909 without restraints) Performing minimization step: 750. Total energy = 59051.7410 kcal/mol (59020.5997 without restraints) Performing minimization step: 751. Total energy = 59001.5902 kcal/mol (58970.4565 without restraints) Performing minimization step: 752. Total energy = 58951.4876 kcal/mol (58920.3617 without restraints) Performing minimization step: 753. Total energy = 58901.4332 kcal/mol (58870.3151 without restraints) Performing minimization step: 754. Total energy = 58851.4274 kcal/mol (58820.3170 without restraints) Performing minimization step: 755. Total energy = 58801.4691 kcal/mol (58770.3665 without restraints) Performing minimization step: 756. Total energy = 58751.5596 kcal/mol (58720.4647 without restraints) Performing minimization step: 757. Total energy = 58701.6977 kcal/mol (58670.6105 without restraints) Performing minimization step: 758. Total energy = 58651.8839 kcal/mol (58620.8045 without restraints) Performing minimization step: 759. Total energy = 58602.1179 kcal/mol (58571.0462 without restraints) Performing minimization step: 760. Total energy = 58552.4002 kcal/mol (58521.3362 without restraints) Performing minimization step: 761. Total energy = 58502.7303 kcal/mol (58471.6741 without restraints) Performing minimization step: 762. Total energy = 58453.1087 kcal/mol (58422.0601 without restraints) Performing minimization step: 763. Total energy = 58403.5345 kcal/mol (58372.4936 without restraints) Performing minimization step: 764. Total energy = 58354.0087 kcal/mol (58322.9755 without restraints) Performing minimization step: 765. Total energy = 58304.5302 kcal/mol (58273.5047 without restraints) Performing minimization step: 766. Total energy = 58255.0996 kcal/mol (58224.0818 without restraints) Performing minimization step: 767. Total energy = 58205.7170 kcal/mol (58174.7068 without restraints) Performing minimization step: 768. Total energy = 58156.3820 kcal/mol (58125.3794 without restraints) Performing minimization step: 769. Total energy = 58107.0944 kcal/mol (58076.0996 without restraints) Performing minimization step: 770. Total energy = 58057.8554 kcal/mol (58026.8680 without restraints) Performing minimization step: 771. Total energy = 58008.6629 kcal/mol (57977.6833 without restraints) Performing minimization step: 772. Total energy = 57959.5185 kcal/mol (57928.5465 without restraints) Performing minimization step: 773. Total energy = 57910.4221 kcal/mol (57879.4578 without restraints) Performing minimization step: 774. Total energy = 57861.3730 kcal/mol (57830.4164 without restraints) Performing minimization step: 775. Total energy = 57812.3713 kcal/mol (57781.4222 without restraints) Performing minimization step: 776. Total energy = 57763.4172 kcal/mol (57732.4758 without restraints) Performing minimization step: 777. Total energy = 57714.5101 kcal/mol (57683.5764 without restraints) Performing minimization step: 778. Total energy = 57665.6509 kcal/mol (57634.7248 without restraints) Performing minimization step: 779. Total energy = 57616.8388 kcal/mol (57585.9203 without restraints) Performing minimization step: 780. Total energy = 57568.0738 kcal/mol (57537.1629 without restraints) Performing minimization step: 781. Total energy = 57519.3561 kcal/mol (57488.4528 without restraints) Performing minimization step: 782. Total energy = 57470.6859 kcal/mol (57439.7901 without restraints) Performing minimization step: 783. Total energy = 57422.0627 kcal/mol (57391.1746 without restraints) Performing minimization step: 784. Total energy = 57373.4867 kcal/mol (57342.6060 without restraints) Performing minimization step: 785. Total energy = 57324.9580 kcal/mol (57294.0850 without restraints) Performing minimization step: 786. Total energy = 57276.4766 kcal/mol (57245.6111 without restraints) Performing minimization step: 787. Total energy = 57228.0422 kcal/mol (57197.1843 without restraints) Performing minimization step: 788. Total energy = 57179.6546 kcal/mol (57148.8042 without restraints) Performing minimization step: 789. Total energy = 57131.3141 kcal/mol (57100.4713 without restraints) Performing minimization step: 790. Total energy = 57083.0211 kcal/mol (57052.1858 without restraints) Performing minimization step: 791. Total energy = 57034.7749 kcal/mol (57003.9471 without restraints) Performing minimization step: 792. Total energy = 56986.5755 kcal/mol (56955.7554 without restraints) Performing minimization step: 793. Total energy = 56938.4233 kcal/mol (56907.6108 without restraints) Performing minimization step: 794. Total energy = 56890.3179 kcal/mol (56859.5128 without restraints) Performing minimization step: 795. Total energy = 56842.2592 kcal/mol (56811.4616 without restraints) Performing minimization step: 796. Total energy = 56794.2474 kcal/mol (56763.4573 without restraints) Performing minimization step: 797. Total energy = 56746.2826 kcal/mol (56715.5002 without restraints) Performing minimization step: 798. Total energy = 56698.3642 kcal/mol (56667.5891 without restraints) Performing minimization step: 799. Total energy = 56650.4926 kcal/mol (56619.7250 without restraints) Performing minimization step: 800. Total energy = 56602.6676 kcal/mol (56571.9075 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 801. Total energy = 56554.8891 kcal/mol (56524.1365 without restraints) Performing minimization step: 802. Total energy = 56507.1573 kcal/mol (56476.4121 without restraints) Performing minimization step: 803. Total energy = 56459.4721 kcal/mol (56428.7345 without restraints) Performing minimization step: 804. Total energy = 56411.8333 kcal/mol (56381.1029 without restraints) Performing minimization step: 805. Total energy = 56364.2413 kcal/mol (56333.5185 without restraints) Performing minimization step: 806. Total energy = 56316.6959 kcal/mol (56285.9806 without restraints) Performing minimization step: 807. Total energy = 56269.1967 kcal/mol (56238.4889 without restraints) Performing minimization step: 808. Total energy = 56221.7440 kcal/mol (56191.0436 without restraints) Performing minimization step: 809. Total energy = 56174.3377 kcal/mol (56143.6447 without restraints) Performing minimization step: 810. Total energy = 56126.9778 kcal/mol (56096.2923 without restraints) Performing minimization step: 811. Total energy = 56079.6644 kcal/mol (56048.9863 without restraints) Performing minimization step: 812. Total energy = 56032.3966 kcal/mol (56001.7260 without restraints) Performing minimization step: 813. Total energy = 55985.1753 kcal/mol (55954.5120 without restraints) Performing minimization step: 814. Total energy = 55938.0004 kcal/mol (55907.3446 without restraints) Performing minimization step: 815. Total energy = 55890.8720 kcal/mol (55860.2235 without restraints) Performing minimization step: 816. Total energy = 55843.7887 kcal/mol (55813.1476 without restraints) Performing minimization step: 817. Total energy = 55796.7522 kcal/mol (55766.1186 without restraints) Performing minimization step: 818. Total energy = 55749.7619 kcal/mol (55719.1357 without restraints) Performing minimization step: 819. Total energy = 55702.8174 kcal/mol (55672.1986 without restraints) Performing minimization step: 820. Total energy = 55655.9190 kcal/mol (55625.3075 without restraints) Performing minimization step: 821. Total energy = 55609.0666 kcal/mol (55578.4625 without restraints) Performing minimization step: 822. Total energy = 55562.2601 kcal/mol (55531.6634 without restraints) Performing minimization step: 823. Total energy = 55515.5000 kcal/mol (55484.9107 without restraints) Performing minimization step: 824. Total energy = 55468.7853 kcal/mol (55438.2033 without restraints) Performing minimization step: 825. Total energy = 55422.1168 kcal/mol (55391.5422 without restraints) Performing minimization step: 826. Total energy = 55375.4940 kcal/mol (55344.9267 without restraints) Performing minimization step: 827. Total energy = 55328.9171 kcal/mol (55298.3571 without restraints) Performing minimization step: 828. Total energy = 55282.3860 kcal/mol (55251.8334 without restraints) Performing minimization step: 829. Total energy = 55235.9007 kcal/mol (55205.3555 without restraints) Performing minimization step: 830. Total energy = 55189.4610 kcal/mol (55158.9230 without restraints) Performing minimization step: 831. Total energy = 55143.0665 kcal/mol (55112.5359 without restraints) Performing minimization step: 832. Total energy = 55096.7180 kcal/mol (55066.1946 without restraints) Performing minimization step: 833. Total energy = 55050.4151 kcal/mol (55019.8991 without restraints) Performing minimization step: 834. Total energy = 55004.1577 kcal/mol (54973.6490 without restraints) Performing minimization step: 835. Total energy = 54957.9460 kcal/mol (54927.4446 without restraints) Performing minimization step: 836. Total energy = 54911.7797 kcal/mol (54881.2856 without restraints) Performing minimization step: 837. Total energy = 54865.6589 kcal/mol (54835.1721 without restraints) Performing minimization step: 838. Total energy = 54819.5836 kcal/mol (54789.1041 without restraints) Performing minimization step: 839. Total energy = 54773.5534 kcal/mol (54743.0812 without restraints) Performing minimization step: 840. Total energy = 54727.5693 kcal/mol (54697.1044 without restraints) Performing minimization step: 841. Total energy = 54681.6304 kcal/mol (54651.1726 without restraints) Performing minimization step: 842. Total energy = 54635.7362 kcal/mol (54605.2858 without restraints) Performing minimization step: 843. Total energy = 54589.8876 kcal/mol (54559.4444 without restraints) Performing minimization step: 844. Total energy = 54544.0843 kcal/mol (54513.6483 without restraints) Performing minimization step: 845. Total energy = 54498.3258 kcal/mol (54467.8971 without restraints) Performing minimization step: 846. Total energy = 54452.6129 kcal/mol (54422.1914 without restraints) Performing minimization step: 847. Total energy = 54406.9452 kcal/mol (54376.5309 without restraints) Performing minimization step: 848. Total energy = 54361.3224 kcal/mol (54330.9154 without restraints) Performing minimization step: 849. Total energy = 54315.7448 kcal/mol (54285.3449 without restraints) Performing minimization step: 850. Total energy = 54270.2122 kcal/mol (54239.8196 without restraints) Performing minimization step: 851. Total energy = 54224.7245 kcal/mol (54194.3392 without restraints) Performing minimization step: 852. Total energy = 54179.2817 kcal/mol (54148.9035 without restraints) Performing minimization step: 853. Total energy = 54133.8842 kcal/mol (54103.5133 without restraints) Performing minimization step: 854. Total energy = 54088.5313 kcal/mol (54058.1675 without restraints) Performing minimization step: 855. Total energy = 54043.2237 kcal/mol (54012.8671 without restraints) Performing minimization step: 856. Total energy = 53997.9607 kcal/mol (53967.6113 without restraints) Performing minimization step: 857. Total energy = 53952.7426 kcal/mol (53922.4004 without restraints) Performing minimization step: 858. Total energy = 53907.5692 kcal/mol (53877.2342 without restraints) Performing minimization step: 859. Total energy = 53862.4407 kcal/mol (53832.1129 without restraints) Performing minimization step: 860. Total energy = 53817.3566 kcal/mol (53787.0360 without restraints) Performing minimization step: 861. Total energy = 53772.3174 kcal/mol (53742.0040 without restraints) Performing minimization step: 862. Total energy = 53727.3228 kcal/mol (53697.0164 without restraints) Performing minimization step: 863. Total energy = 53682.3729 kcal/mol (53652.0737 without restraints) Performing minimization step: 864. Total energy = 53637.4677 kcal/mol (53607.1757 without restraints) Performing minimization step: 865. Total energy = 53592.6071 kcal/mol (53562.3221 without restraints) Performing minimization step: 866. Total energy = 53547.7906 kcal/mol (53517.5128 without restraints) Performing minimization step: 867. Total energy = 53503.0189 kcal/mol (53472.7482 without restraints) Performing minimization step: 868. Total energy = 53458.2913 kcal/mol (53428.0276 without restraints) Performing minimization step: 869. Total energy = 53413.6081 kcal/mol (53383.3515 without restraints) Performing minimization step: 870. Total energy = 53368.9696 kcal/mol (53338.7202 without restraints) Performing minimization step: 871. Total energy = 53324.3757 kcal/mol (53294.1335 without restraints) Performing minimization step: 872. Total energy = 53279.8262 kcal/mol (53249.5909 without restraints) Performing minimization step: 873. Total energy = 53235.3206 kcal/mol (53205.0925 without restraints) Performing minimization step: 874. Total energy = 53190.8594 kcal/mol (53160.6384 without restraints) Performing minimization step: 875. Total energy = 53146.4422 kcal/mol (53116.2282 without restraints) Performing minimization step: 876. Total energy = 53102.0693 kcal/mol (53071.8624 without restraints) Performing minimization step: 877. Total energy = 53057.7407 kcal/mol (53027.5408 without restraints) Performing minimization step: 878. Total energy = 53013.4567 kcal/mol (52983.2640 without restraints) Performing minimization step: 879. Total energy = 52969.2165 kcal/mol (52939.0308 without restraints) Performing minimization step: 880. Total energy = 52925.0202 kcal/mol (52894.8415 without restraints) Performing minimization step: 881. Total energy = 52880.8680 kcal/mol (52850.6965 without restraints) Performing minimization step: 882. Total energy = 52836.7600 kcal/mol (52806.5954 without restraints) Performing minimization step: 883. Total energy = 52792.6957 kcal/mol (52762.5382 without restraints) Performing minimization step: 884. Total energy = 52748.6756 kcal/mol (52718.5251 without restraints) Performing minimization step: 885. Total energy = 52704.6999 kcal/mol (52674.5564 without restraints) Performing minimization step: 886. Total energy = 52660.7675 kcal/mol (52630.6311 without restraints) Performing minimization step: 887. Total energy = 52616.8791 kcal/mol (52586.7497 without restraints) Performing minimization step: 888. Total energy = 52573.0345 kcal/mol (52542.9121 without restraints) Performing minimization step: 889. Total energy = 52529.2336 kcal/mol (52499.1182 without restraints) Performing minimization step: 890. Total energy = 52485.4766 kcal/mol (52455.3682 without restraints) Performing minimization step: 891. Total energy = 52441.7632 kcal/mol (52411.6618 without restraints) Performing minimization step: 892. Total energy = 52398.0936 kcal/mol (52367.9992 without restraints) Performing minimization step: 893. Total energy = 52354.4677 kcal/mol (52324.3803 without restraints) Performing minimization step: 894. Total energy = 52310.8854 kcal/mol (52280.8049 without restraints) Performing minimization step: 895. Total energy = 52267.3466 kcal/mol (52237.2732 without restraints) Performing minimization step: 896. Total energy = 52223.8517 kcal/mol (52193.7852 without restraints) Performing minimization step: 897. Total energy = 52180.4006 kcal/mol (52150.3412 without restraints) Performing minimization step: 898. Total energy = 52136.9924 kcal/mol (52106.9398 without restraints) Performing minimization step: 899. Total energy = 52093.6278 kcal/mol (52063.5822 without restraints) Performing minimization step: 900. Total energy = 52050.3067 kcal/mol (52020.2679 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 901. Total energy = 52007.0286 kcal/mol (51976.9969 without restraints) Performing minimization step: 902. Total energy = 51963.7942 kcal/mol (51933.7694 without restraints) Performing minimization step: 903. Total energy = 51920.6028 kcal/mol (51890.5849 without restraints) Performing minimization step: 904. Total energy = 51877.4551 kcal/mol (51847.4441 without restraints) Performing minimization step: 905. Total energy = 51834.3505 kcal/mol (51804.3465 without restraints) Performing minimization step: 906. Total energy = 51791.2892 kcal/mol (51761.2921 without restraints) Performing minimization step: 907. Total energy = 51748.2712 kcal/mol (51718.2810 without restraints) Performing minimization step: 908. Total energy = 51705.2962 kcal/mol (51675.3129 without restraints) Performing minimization step: 909. Total energy = 51662.3644 kcal/mol (51632.3879 without restraints) Performing minimization step: 910. Total energy = 51619.4757 kcal/mol (51589.5061 without restraints) Performing minimization step: 911. Total energy = 51576.6299 kcal/mol (51546.6672 without restraints) Performing minimization step: 912. Total energy = 51533.8275 kcal/mol (51503.8716 without restraints) Performing minimization step: 913. Total energy = 51491.0681 kcal/mol (51461.1192 without restraints) Performing minimization step: 914. Total energy = 51448.3518 kcal/mol (51418.4098 without restraints) Performing minimization step: 915. Total energy = 51405.6782 kcal/mol (51375.7430 without restraints) Performing minimization step: 916. Total energy = 51363.0470 kcal/mol (51333.1187 without restraints) Performing minimization step: 917. Total energy = 51320.4593 kcal/mol (51290.5377 without restraints) Performing minimization step: 918. Total energy = 51277.9148 kcal/mol (51248.0002 without restraints) Performing minimization step: 919. Total energy = 51235.4126 kcal/mol (51205.5049 without restraints) Performing minimization step: 920. Total energy = 51192.9536 kcal/mol (51163.0527 without restraints) Performing minimization step: 921. Total energy = 51150.5377 kcal/mol (51120.6436 without restraints) Performing minimization step: 922. Total energy = 51108.1641 kcal/mol (51078.2768 without restraints) Performing minimization step: 923. Total energy = 51065.8333 kcal/mol (51035.9528 without restraints) Performing minimization step: 924. Total energy = 51023.5454 kcal/mol (50993.6718 without restraints) Performing minimization step: 925. Total energy = 50981.2999 kcal/mol (50951.4331 without restraints) Performing minimization step: 926. Total energy = 50939.0971 kcal/mol (50909.2371 without restraints) Performing minimization step: 927. Total energy = 50896.9366 kcal/mol (50867.0832 without restraints) Performing minimization step: 928. Total energy = 50854.8188 kcal/mol (50824.9724 without restraints) Performing minimization step: 929. Total energy = 50812.7436 kcal/mol (50782.9039 without restraints) Performing minimization step: 930. Total energy = 50770.7109 kcal/mol (50740.8781 without restraints) Performing minimization step: 931. Total energy = 50728.7207 kcal/mol (50698.8946 without restraints) Performing minimization step: 932. Total energy = 50686.7726 kcal/mol (50656.9533 without restraints) Performing minimization step: 933. Total energy = 50644.8676 kcal/mol (50615.0551 without restraints) Performing minimization step: 934. Total energy = 50603.0042 kcal/mol (50573.1984 without restraints) Performing minimization step: 935. Total energy = 50561.1834 kcal/mol (50531.3844 without restraints) Performing minimization step: 936. Total energy = 50519.4049 kcal/mol (50489.6127 without restraints) Performing minimization step: 937. Total energy = 50477.6690 kcal/mol (50447.8835 without restraints) Performing minimization step: 938. Total energy = 50435.9751 kcal/mol (50406.1963 without restraints) Performing minimization step: 939. Total energy = 50394.3234 kcal/mol (50364.5514 without restraints) Performing minimization step: 940. Total energy = 50352.7140 kcal/mol (50322.9487 without restraints) Performing minimization step: 941. Total energy = 50311.1471 kcal/mol (50281.3885 without restraints) Performing minimization step: 942. Total energy = 50269.6220 kcal/mol (50239.8702 without restraints) Performing minimization step: 943. Total energy = 50228.1389 kcal/mol (50198.3938 without restraints) Performing minimization step: 944. Total energy = 50186.6979 kcal/mol (50156.9594 without restraints) Performing minimization step: 945. Total energy = 50145.2988 kcal/mol (50115.5670 without restraints) Performing minimization step: 946. Total energy = 50103.9415 kcal/mol (50074.2166 without restraints) Performing minimization step: 947. Total energy = 50062.6265 kcal/mol (50032.9081 without restraints) Performing minimization step: 948. Total energy = 50021.3532 kcal/mol (49991.6416 without restraints) Performing minimization step: 949. Total energy = 49980.1216 kcal/mol (49950.4168 without restraints) Performing minimization step: 950. Total energy = 49938.9325 kcal/mol (49909.2343 without restraints) Performing minimization step: 951. Total energy = 49897.7849 kcal/mol (49868.0933 without restraints) Performing minimization step: 952. Total energy = 49856.6789 kcal/mol (49826.9940 without restraints) Performing minimization step: 953. Total energy = 49815.6149 kcal/mol (49785.9366 without restraints) Performing minimization step: 954. Total energy = 49774.5928 kcal/mol (49744.9214 without restraints) Performing minimization step: 955. Total energy = 49733.6127 kcal/mol (49703.9477 without restraints) Performing minimization step: 956. Total energy = 49692.6737 kcal/mol (49663.0154 without restraints) Performing minimization step: 957. Total energy = 49651.7767 kcal/mol (49622.1250 without restraints) Performing minimization step: 958. Total energy = 49610.9208 kcal/mol (49581.2758 without restraints) Performing minimization step: 959. Total energy = 49570.1067 kcal/mol (49540.4683 without restraints) Performing minimization step: 960. Total energy = 49529.3342 kcal/mol (49499.7025 without restraints) Performing minimization step: 961. Total energy = 49488.6032 kcal/mol (49458.9781 without restraints) Performing minimization step: 962. Total energy = 49447.9137 kcal/mol (49418.2952 without restraints) Performing minimization step: 963. Total energy = 49407.2656 kcal/mol (49377.6537 without restraints) Performing minimization step: 964. Total energy = 49366.6591 kcal/mol (49337.0539 without restraints) Performing minimization step: 965. Total energy = 49326.0937 kcal/mol (49296.4950 without restraints) Performing minimization step: 966. Total energy = 49285.5698 kcal/mol (49255.9776 without restraints) Performing minimization step: 967. Total energy = 49245.0872 kcal/mol (49215.5017 without restraints) Performing minimization step: 968. Total energy = 49204.6462 kcal/mol (49175.0672 without restraints) Performing minimization step: 969. Total energy = 49164.2462 kcal/mol (49134.6738 without restraints) Performing minimization step: 970. Total energy = 49123.8874 kcal/mol (49094.3216 without restraints) Performing minimization step: 971. Total energy = 49083.5695 kcal/mol (49054.0100 without restraints) Performing minimization step: 972. Total energy = 49043.2929 kcal/mol (49013.7402 without restraints) Performing minimization step: 973. Total energy = 49003.0578 kcal/mol (48973.5116 without restraints) Performing minimization step: 974. Total energy = 48962.8634 kcal/mol (48933.3238 without restraints) Performing minimization step: 975. Total energy = 48922.7101 kcal/mol (48893.1771 without restraints) Performing minimization step: 976. Total energy = 48882.5980 kcal/mol (48853.0714 without restraints) Performing minimization step: 977. Total energy = 48842.5268 kcal/mol (48813.0067 without restraints) Performing minimization step: 978. Total energy = 48802.4969 kcal/mol (48772.9835 without restraints) Performing minimization step: 979. Total energy = 48762.5081 kcal/mol (48733.0012 without restraints) Performing minimization step: 980. Total energy = 48722.5602 kcal/mol (48693.0598 without restraints) Performing minimization step: 981. Total energy = 48682.6532 kcal/mol (48653.1593 without restraints) Performing minimization step: 982. Total energy = 48642.7868 kcal/mol (48613.2994 without restraints) Performing minimization step: 983. Total energy = 48602.9613 kcal/mol (48573.4804 without restraints) Performing minimization step: 984. Total energy = 48563.1766 kcal/mol (48533.7022 without restraints) Performing minimization step: 985. Total energy = 48523.4322 kcal/mol (48493.9643 without restraints) Performing minimization step: 986. Total energy = 48483.7290 kcal/mol (48454.2676 without restraints) Performing minimization step: 987. Total energy = 48444.0666 kcal/mol (48414.6116 without restraints) Performing minimization step: 988. Total energy = 48404.4450 kcal/mol (48374.9965 without restraints) Performing minimization step: 989. Total energy = 48364.8641 kcal/mol (48335.4221 without restraints) Performing minimization step: 990. Total energy = 48325.3238 kcal/mol (48295.8883 without restraints) Performing minimization step: 991. Total energy = 48285.8238 kcal/mol (48256.3948 without restraints) Performing minimization step: 992. Total energy = 48246.3644 kcal/mol (48216.9419 without restraints) Performing minimization step: 993. Total energy = 48206.9458 kcal/mol (48177.5296 without restraints) Performing minimization step: 994. Total energy = 48167.5672 kcal/mol (48138.1576 without restraints) Performing minimization step: 995. Total energy = 48128.2291 kcal/mol (48098.8259 without restraints) Performing minimization step: 996. Total energy = 48088.9317 kcal/mol (48059.5349 without restraints) Performing minimization step: 997. Total energy = 48049.6746 kcal/mol (48020.2841 without restraints) Performing minimization step: 998. Total energy = 48010.4578 kcal/mol (47981.0739 without restraints) Performing minimization step: 999. Total energy = 47971.2813 kcal/mol (47941.9037 without restraints) Performing minimization step: 1000. Total energy = 47932.1452 kcal/mol (47902.7741 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1001. Total energy = 47893.0495 kcal/mol (47863.6847 without restraints) Performing minimization step: 1002. Total energy = 47853.9940 kcal/mol (47824.6357 without restraints) Performing minimization step: 1003. Total energy = 47814.9787 kcal/mol (47785.6268 without restraints) Performing minimization step: 1004. Total energy = 47776.0036 kcal/mol (47746.6581 without restraints) Performing minimization step: 1005. Total energy = 47737.0684 kcal/mol (47707.7293 without restraints) Performing minimization step: 1006. Total energy = 47698.1736 kcal/mol (47668.8409 without restraints) Performing minimization step: 1007. Total energy = 47659.3191 kcal/mol (47629.9928 without restraints) Performing minimization step: 1008. Total energy = 47620.5045 kcal/mol (47591.1845 without restraints) Performing minimization step: 1009. Total energy = 47581.7299 kcal/mol (47552.4163 without restraints) Performing minimization step: 1010. Total energy = 47542.9953 kcal/mol (47513.6880 without restraints) Performing minimization step: 1011. Total energy = 47504.3006 kcal/mol (47474.9997 without restraints) Performing minimization step: 1012. Total energy = 47465.6459 kcal/mol (47436.3514 without restraints) Performing minimization step: 1013. Total energy = 47427.0311 kcal/mol (47397.7429 without restraints) Performing minimization step: 1014. Total energy = 47388.4561 kcal/mol (47359.1743 without restraints) Performing minimization step: 1015. Total energy = 47349.9213 kcal/mol (47320.6458 without restraints) Performing minimization step: 1016. Total energy = 47311.4263 kcal/mol (47282.1571 without restraints) Performing minimization step: 1017. Total energy = 47272.9706 kcal/mol (47243.7077 without restraints) Performing minimization step: 1018. Total energy = 47234.5549 kcal/mol (47205.2984 without restraints) Performing minimization step: 1019. Total energy = 47196.1795 kcal/mol (47166.9293 without restraints) Performing minimization step: 1020. Total energy = 47157.8433 kcal/mol (47128.5994 without restraints) Performing minimization step: 1021. Total energy = 47119.5469 kcal/mol (47090.3093 without restraints) Performing minimization step: 1022. Total energy = 47081.2897 kcal/mol (47052.0584 without restraints) Performing minimization step: 1023. Total energy = 47043.0724 kcal/mol (47013.8474 without restraints) Performing minimization step: 1024. Total energy = 47004.8944 kcal/mol (46975.6757 without restraints) Performing minimization step: 1025. Total energy = 46966.7562 kcal/mol (46937.5437 without restraints) Performing minimization step: 1026. Total energy = 46928.6575 kcal/mol (46899.4513 without restraints) Performing minimization step: 1027. Total energy = 46890.5984 kcal/mol (46861.3985 without restraints) Performing minimization step: 1028. Total energy = 46852.5788 kcal/mol (46823.3851 without restraints) Performing minimization step: 1029. Total energy = 46814.5983 kcal/mol (46785.4110 without restraints) Performing minimization step: 1030. Total energy = 46776.6570 kcal/mol (46747.4758 without restraints) Performing minimization step: 1031. Total energy = 46738.7553 kcal/mol (46709.5804 without restraints) Performing minimization step: 1032. Total energy = 46700.8930 kcal/mol (46671.7244 without restraints) Performing minimization step: 1033. Total energy = 46663.0699 kcal/mol (46633.9076 without restraints) Performing minimization step: 1034. Total energy = 46625.2862 kcal/mol (46596.1301 without restraints) Performing minimization step: 1035. Total energy = 46587.5417 kcal/mol (46558.3918 without restraints) Performing minimization step: 1036. Total energy = 46549.8367 kcal/mol (46520.6931 without restraints) Performing minimization step: 1037. Total energy = 46512.1710 kcal/mol (46483.0336 without restraints) Performing minimization step: 1038. Total energy = 46474.5441 kcal/mol (46445.4129 without restraints) Performing minimization step: 1039. Total energy = 46436.9562 kcal/mol (46407.8313 without restraints) Performing minimization step: 1040. Total energy = 46399.4075 kcal/mol (46370.2887 without restraints) Performing minimization step: 1041. Total energy = 46361.8978 kcal/mol (46332.7852 without restraints) Performing minimization step: 1042. Total energy = 46324.4271 kcal/mol (46295.3208 without restraints) Performing minimization step: 1043. Total energy = 46286.9954 kcal/mol (46257.8953 without restraints) Performing minimization step: 1044. Total energy = 46249.6027 kcal/mol (46220.5087 without restraints) Performing minimization step: 1045. Total energy = 46212.2487 kcal/mol (46183.1609 without restraints) Performing minimization step: 1046. Total energy = 46174.9341 kcal/mol (46145.8525 without restraints) Performing minimization step: 1047. Total energy = 46137.6582 kcal/mol (46108.5827 without restraints) Performing minimization step: 1048. Total energy = 46100.4209 kcal/mol (46071.3516 without restraints) Performing minimization step: 1049. Total energy = 46063.2226 kcal/mol (46034.1594 without restraints) Performing minimization step: 1050. Total energy = 46026.0633 kcal/mol (45997.0065 without restraints) Performing minimization step: 1051. Total energy = 45988.9426 kcal/mol (45959.8917 without restraints) Performing minimization step: 1052. Total energy = 45951.8604 kcal/mol (45922.8157 without restraints) Performing minimization step: 1053. Total energy = 45914.8171 kcal/mol (45885.7786 without restraints) Performing minimization step: 1054. Total energy = 45877.8122 kcal/mol (45848.7797 without restraints) Performing minimization step: 1055. Total energy = 45840.8461 kcal/mol (45811.8198 without restraints) Performing minimization step: 1056. Total energy = 45803.9186 kcal/mol (45774.8985 without restraints) Performing minimization step: 1057. Total energy = 45767.0298 kcal/mol (45738.0157 without restraints) Performing minimization step: 1058. Total energy = 45730.1795 kcal/mol (45701.1715 without restraints) Performing minimization step: 1059. Total energy = 45693.3675 kcal/mol (45664.3657 without restraints) Performing minimization step: 1060. Total energy = 45656.5941 kcal/mol (45627.5984 without restraints) Performing minimization step: 1061. Total energy = 45619.8590 kcal/mol (45590.8694 without restraints) Performing minimization step: 1062. Total energy = 45583.1629 kcal/mol (45554.1794 without restraints) Performing minimization step: 1063. Total energy = 45546.5044 kcal/mol (45517.5270 without restraints) Performing minimization step: 1064. Total energy = 45509.8847 kcal/mol (45480.9134 without restraints) Performing minimization step: 1065. Total energy = 45473.3031 kcal/mol (45444.3379 without restraints) Performing minimization step: 1066. Total energy = 45436.7600 kcal/mol (45407.8008 without restraints) Performing minimization step: 1067. Total energy = 45400.2553 kcal/mol (45371.3023 without restraints) Performing minimization step: 1068. Total energy = 45363.7889 kcal/mol (45334.8419 without restraints) Performing minimization step: 1069. Total energy = 45327.3605 kcal/mol (45298.4195 without restraints) Performing minimization step: 1070. Total energy = 45290.9701 kcal/mol (45262.0351 without restraints) Performing minimization step: 1071. Total energy = 45254.6178 kcal/mol (45225.6887 without restraints) Performing minimization step: 1072. Total energy = 45218.3036 kcal/mol (45189.3808 without restraints) Performing minimization step: 1073. Total energy = 45182.0278 kcal/mol (45153.1112 without restraints) Performing minimization step: 1074. Total energy = 45145.7905 kcal/mol (45116.8796 without restraints) Performing minimization step: 1075. Total energy = 45109.5906 kcal/mol (45080.6859 without restraints) Performing minimization step: 1076. Total energy = 45073.4288 kcal/mol (45044.5301 without restraints) Performing minimization step: 1077. Total energy = 45037.3052 kcal/mol (45008.4125 without restraints) Performing minimization step: 1078. Total energy = 45001.2196 kcal/mol (44972.3329 without restraints) Performing minimization step: 1079. Total energy = 44965.1717 kcal/mol (44936.2911 without restraints) Performing minimization step: 1080. Total energy = 44929.1619 kcal/mol (44900.2872 without restraints) Performing minimization step: 1081. Total energy = 44893.1897 kcal/mol (44864.3212 without restraints) Performing minimization step: 1082. Total energy = 44857.2550 kcal/mol (44828.3924 without restraints) Performing minimization step: 1083. Total energy = 44821.3585 kcal/mol (44792.5018 without restraints) Performing minimization step: 1084. Total energy = 44785.4999 kcal/mol (44756.6494 without restraints) Performing minimization step: 1085. Total energy = 44749.6794 kcal/mol (44720.8347 without restraints) Performing minimization step: 1086. Total energy = 44713.8958 kcal/mol (44685.0570 without restraints) Performing minimization step: 1087. Total energy = 44678.1499 kcal/mol (44649.3170 without restraints) Performing minimization step: 1088. Total energy = 44642.4417 kcal/mol (44613.6149 without restraints) Performing minimization step: 1089. Total energy = 44606.7711 kcal/mol (44577.9503 without restraints) Performing minimization step: 1090. Total energy = 44571.1382 kcal/mol (44542.3233 without restraints) Performing minimization step: 1091. Total energy = 44535.5431 kcal/mol (44506.7341 without restraints) Performing minimization step: 1092. Total energy = 44499.9852 kcal/mol (44471.1822 without restraints) Performing minimization step: 1093. Total energy = 44464.4649 kcal/mol (44435.6678 without restraints) Performing minimization step: 1094. Total energy = 44428.9822 kcal/mol (44400.1911 without restraints) Performing minimization step: 1095. Total energy = 44393.5366 kcal/mol (44364.7513 without restraints) Performing minimization step: 1096. Total energy = 44358.1286 kcal/mol (44329.3493 without restraints) Performing minimization step: 1097. Total energy = 44322.7581 kcal/mol (44293.9847 without restraints) Performing minimization step: 1098. Total energy = 44287.4248 kcal/mol (44258.6574 without restraints) Performing minimization step: 1099. Total energy = 44252.1288 kcal/mol (44223.3672 without restraints) Performing minimization step: 1100. Total energy = 44216.8703 kcal/mol (44188.1148 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1101. Total energy = 44181.6489 kcal/mol (44152.8992 without restraints) Performing minimization step: 1102. Total energy = 44146.4647 kcal/mol (44117.7208 without restraints) Performing minimization step: 1103. Total energy = 44111.3176 kcal/mol (44082.5796 without restraints) Performing minimization step: 1104. Total energy = 44076.2077 kcal/mol (44047.4756 without restraints) Performing minimization step: 1105. Total energy = 44041.1350 kcal/mol (44012.4086 without restraints) Performing minimization step: 1106. Total energy = 44006.0994 kcal/mol (43977.3790 without restraints) Performing minimization step: 1107. Total energy = 43971.1007 kcal/mol (43942.3861 without restraints) Performing minimization step: 1108. Total energy = 43936.1390 kcal/mol (43907.4304 without restraints) Performing minimization step: 1109. Total energy = 43901.2145 kcal/mol (43872.5117 without restraints) Performing minimization step: 1110. Total energy = 43866.3271 kcal/mol (43837.6302 without restraints) Performing minimization step: 1111. Total energy = 43831.4760 kcal/mol (43802.7850 without restraints) Performing minimization step: 1112. Total energy = 43796.6624 kcal/mol (43767.9771 without restraints) Performing minimization step: 1113. Total energy = 43761.8856 kcal/mol (43733.2062 without restraints) Performing minimization step: 1114. Total energy = 43727.1456 kcal/mol (43698.4721 without restraints) Performing minimization step: 1115. Total energy = 43692.4426 kcal/mol (43663.7748 without restraints) Performing minimization step: 1116. Total energy = 43657.7763 kcal/mol (43629.1144 without restraints) Performing minimization step: 1117. Total energy = 43623.1470 kcal/mol (43594.4909 without restraints) Performing minimization step: 1118. Total energy = 43588.5542 kcal/mol (43559.9039 without restraints) Performing minimization step: 1119. Total energy = 43553.9981 kcal/mol (43525.3536 without restraints) Performing minimization step: 1120. Total energy = 43519.4789 kcal/mol (43490.8403 without restraints) Performing minimization step: 1121. Total energy = 43484.9962 kcal/mol (43456.3634 without restraints) Performing minimization step: 1122. Total energy = 43450.5502 kcal/mol (43421.9231 without restraints) Performing minimization step: 1123. Total energy = 43416.1407 kcal/mol (43387.5194 without restraints) Performing minimization step: 1124. Total energy = 43381.7675 kcal/mol (43353.1520 without restraints) Performing minimization step: 1125. Total energy = 43347.4310 kcal/mol (43318.8212 without restraints) Performing minimization step: 1126. Total energy = 43313.1311 kcal/mol (43284.5271 without restraints) Performing minimization step: 1127. Total energy = 43278.8678 kcal/mol (43250.2697 without restraints) Performing minimization step: 1128. Total energy = 43244.6409 kcal/mol (43216.0484 without restraints) Performing minimization step: 1129. Total energy = 43210.4504 kcal/mol (43181.8637 without restraints) Performing minimization step: 1130. Total energy = 43176.2965 kcal/mol (43147.7156 without restraints) Performing minimization step: 1131. Total energy = 43142.1788 kcal/mol (43113.6038 without restraints) Performing minimization step: 1132. Total energy = 43108.0975 kcal/mol (43079.5281 without restraints) Performing minimization step: 1133. Total energy = 43074.0523 kcal/mol (43045.4887 without restraints) Performing minimization step: 1134. Total energy = 43040.0435 kcal/mol (43011.4855 without restraints) Performing minimization step: 1135. Total energy = 43006.0708 kcal/mol (42977.5186 without restraints) Performing minimization step: 1136. Total energy = 42972.1344 kcal/mol (42943.5879 without restraints) Performing minimization step: 1137. Total energy = 42938.2344 kcal/mol (42909.6936 without restraints) Performing minimization step: 1138. Total energy = 42904.3702 kcal/mol (42875.8351 without restraints) Performing minimization step: 1139. Total energy = 42870.5423 kcal/mol (42842.0131 without restraints) Performing minimization step: 1140. Total energy = 42836.7505 kcal/mol (42808.2269 without restraints) Performing minimization step: 1141. Total energy = 42802.9945 kcal/mol (42774.4765 without restraints) Performing minimization step: 1142. Total energy = 42769.2747 kcal/mol (42740.7624 without restraints) Performing minimization step: 1143. Total energy = 42735.5910 kcal/mol (42707.0844 without restraints) Performing minimization step: 1144. Total energy = 42701.9432 kcal/mol (42673.4424 without restraints) Performing minimization step: 1145. Total energy = 42668.3311 kcal/mol (42639.8359 without restraints) Performing minimization step: 1146. Total energy = 42634.7549 kcal/mol (42606.2654 without restraints) Performing minimization step: 1147. Total energy = 42601.2147 kcal/mol (42572.7306 without restraints) Performing minimization step: 1148. Total energy = 42567.7102 kcal/mol (42539.2320 without restraints) Performing minimization step: 1149. Total energy = 42534.2417 kcal/mol (42505.7691 without restraints) Performing minimization step: 1150. Total energy = 42500.8091 kcal/mol (42472.3422 without restraints) Performing minimization step: 1151. Total energy = 42467.4123 kcal/mol (42438.9510 without restraints) Performing minimization step: 1152. Total energy = 42434.0514 kcal/mol (42405.5958 without restraints) Performing minimization step: 1153. Total energy = 42400.7263 kcal/mol (42372.2765 without restraints) Performing minimization step: 1154. Total energy = 42367.4375 kcal/mol (42338.9932 without restraints) Performing minimization step: 1155. Total energy = 42334.1835 kcal/mol (42305.7448 without restraints) Performing minimization step: 1156. Total energy = 42300.9649 kcal/mol (42272.5316 without restraints) Performing minimization step: 1157. Total energy = 42267.7819 kcal/mol (42239.3544 without restraints) Performing minimization step: 1158. Total energy = 42234.6346 kcal/mol (42206.2128 without restraints) Performing minimization step: 1159. Total energy = 42201.5229 kcal/mol (42173.1066 without restraints) Performing minimization step: 1160. Total energy = 42168.4467 kcal/mol (42140.0360 without restraints) Performing minimization step: 1161. Total energy = 42135.4063 kcal/mol (42107.0013 without restraints) Performing minimization step: 1162. Total energy = 42102.4013 kcal/mol (42074.0019 without restraints) Performing minimization step: 1163. Total energy = 42069.4313 kcal/mol (42041.0374 without restraints) Performing minimization step: 1164. Total energy = 42036.4972 kcal/mol (42008.1091 without restraints) Performing minimization step: 1165. Total energy = 42003.5982 kcal/mol (41975.2155 without restraints) Performing minimization step: 1166. Total energy = 41970.7340 kcal/mol (41942.3569 without restraints) Performing minimization step: 1167. Total energy = 41937.9054 kcal/mol (41909.5338 without restraints) Performing minimization step: 1168. Total energy = 41905.1121 kcal/mol (41876.7461 without restraints) Performing minimization step: 1169. Total energy = 41872.3540 kcal/mol (41843.9935 without restraints) Performing minimization step: 1170. Total energy = 41839.6311 kcal/mol (41811.2762 without restraints) Performing minimization step: 1171. Total energy = 41806.9434 kcal/mol (41778.5941 without restraints) Performing minimization step: 1172. Total energy = 41774.2910 kcal/mol (41745.9472 without restraints) Performing minimization step: 1173. Total energy = 41741.6737 kcal/mol (41713.3354 without restraints) Performing minimization step: 1174. Total energy = 41709.0914 kcal/mol (41680.7587 without restraints) Performing minimization step: 1175. Total energy = 41676.5443 kcal/mol (41648.2173 without restraints) Performing minimization step: 1176. Total energy = 41644.0325 kcal/mol (41615.7108 without restraints) Performing minimization step: 1177. Total energy = 41611.5551 kcal/mol (41583.2389 without restraints) Performing minimization step: 1178. Total energy = 41579.1128 kcal/mol (41550.8022 without restraints) Performing minimization step: 1179. Total energy = 41546.7056 kcal/mol (41518.4005 without restraints) Performing minimization step: 1180. Total energy = 41514.3333 kcal/mol (41486.0337 without restraints) Performing minimization step: 1181. Total energy = 41481.9958 kcal/mol (41453.7018 without restraints) Performing minimization step: 1182. Total energy = 41449.6932 kcal/mol (41421.4047 without restraints) Performing minimization step: 1183. Total energy = 41417.4254 kcal/mol (41389.1424 without restraints) Performing minimization step: 1184. Total energy = 41385.1923 kcal/mol (41356.9147 without restraints) Performing minimization step: 1185. Total energy = 41352.9941 kcal/mol (41324.7220 without restraints) Performing minimization step: 1186. Total energy = 41320.8307 kcal/mol (41292.5641 without restraints) Performing minimization step: 1187. Total energy = 41288.7019 kcal/mol (41260.4406 without restraints) Performing minimization step: 1188. Total energy = 41256.6075 kcal/mol (41228.3518 without restraints) Performing minimization step: 1189. Total energy = 41224.5483 kcal/mol (41196.2980 without restraints) Performing minimization step: 1190. Total energy = 41192.5234 kcal/mol (41164.2787 without restraints) Performing minimization step: 1191. Total energy = 41160.5330 kcal/mol (41132.2937 without restraints) Performing minimization step: 1192. Total energy = 41128.5776 kcal/mol (41100.3437 without restraints) Performing minimization step: 1193. Total energy = 41096.6564 kcal/mol (41068.4280 without restraints) Performing minimization step: 1194. Total energy = 41064.7693 kcal/mol (41036.5462 without restraints) Performing minimization step: 1195. Total energy = 41032.9170 kcal/mol (41004.6995 without restraints) Performing minimization step: 1196. Total energy = 41001.0993 kcal/mol (40972.8872 without restraints) Performing minimization step: 1197. Total energy = 40969.3159 kcal/mol (40941.1091 without restraints) Performing minimization step: 1198. Total energy = 40937.5670 kcal/mol (40909.3658 without restraints) Performing minimization step: 1199. Total energy = 40905.8528 kcal/mol (40877.6569 without restraints) Performing minimization step: 1200. Total energy = 40874.1723 kcal/mol (40845.9818 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1201. Total energy = 40842.5263 kcal/mol (40814.3412 without restraints) Performing minimization step: 1202. Total energy = 40810.9145 kcal/mol (40782.7350 without restraints) Performing minimization step: 1203. Total energy = 40779.3373 kcal/mol (40751.1630 without restraints) Performing minimization step: 1204. Total energy = 40747.7942 kcal/mol (40719.6254 without restraints) Performing minimization step: 1205. Total energy = 40716.2851 kcal/mol (40688.1217 without restraints) Performing minimization step: 1206. Total energy = 40684.8102 kcal/mol (40656.6521 without restraints) Performing minimization step: 1207. Total energy = 40653.3695 kcal/mol (40625.2167 without restraints) Performing minimization step: 1208. Total energy = 40621.9629 kcal/mol (40593.8156 without restraints) Performing minimization step: 1209. Total energy = 40590.5902 kcal/mol (40562.4482 without restraints) Performing minimization step: 1210. Total energy = 40559.2514 kcal/mol (40531.1148 without restraints) Performing minimization step: 1211. Total energy = 40527.9469 kcal/mol (40499.8156 without restraints) Performing minimization step: 1212. Total energy = 40496.6761 kcal/mol (40468.5501 without restraints) Performing minimization step: 1213. Total energy = 40465.4395 kcal/mol (40437.3189 without restraints) Performing minimization step: 1214. Total energy = 40434.2368 kcal/mol (40406.1215 without restraints) Performing minimization step: 1215. Total energy = 40403.0681 kcal/mol (40374.9582 without restraints) Performing minimization step: 1216. Total energy = 40371.9331 kcal/mol (40343.8285 without restraints) Performing minimization step: 1217. Total energy = 40340.8318 kcal/mol (40312.7324 without restraints) Performing minimization step: 1218. Total energy = 40309.7643 kcal/mol (40281.6702 without restraints) Performing minimization step: 1219. Total energy = 40278.7304 kcal/mol (40250.6418 without restraints) Performing minimization step: 1220. Total energy = 40247.7305 kcal/mol (40219.6472 without restraints) Performing minimization step: 1221. Total energy = 40216.7642 kcal/mol (40188.6862 without restraints) Performing minimization step: 1222. Total energy = 40185.8319 kcal/mol (40157.7593 without restraints) Performing minimization step: 1223. Total energy = 40154.9331 kcal/mol (40126.8656 without restraints) Performing minimization step: 1224. Total energy = 40124.0678 kcal/mol (40096.0058 without restraints) Performing minimization step: 1225. Total energy = 40093.2365 kcal/mol (40065.1797 without restraints) Performing minimization step: 1226. Total energy = 40062.4385 kcal/mol (40034.3870 without restraints) Performing minimization step: 1227. Total energy = 40031.6740 kcal/mol (40003.6278 without restraints) Performing minimization step: 1228. Total energy = 40000.9433 kcal/mol (39972.9023 without restraints) Performing minimization step: 1229. Total energy = 39970.2461 kcal/mol (39942.2104 without restraints) Performing minimization step: 1230. Total energy = 39939.5825 kcal/mol (39911.5521 without restraints) Performing minimization step: 1231. Total energy = 39908.9521 kcal/mol (39880.9269 without restraints) Performing minimization step: 1232. Total energy = 39878.3550 kcal/mol (39850.3351 without restraints) Performing minimization step: 1233. Total energy = 39847.7912 kcal/mol (39819.7766 without restraints) Performing minimization step: 1234. Total energy = 39817.2609 kcal/mol (39789.2515 without restraints) Performing minimization step: 1235. Total energy = 39786.7634 kcal/mol (39758.7593 without restraints) Performing minimization step: 1236. Total energy = 39756.2995 kcal/mol (39728.3005 without restraints) Performing minimization step: 1237. Total energy = 39725.8687 kcal/mol (39697.8749 without restraints) Performing minimization step: 1238. Total energy = 39695.4712 kcal/mol (39667.4827 without restraints) Performing minimization step: 1239. Total energy = 39665.1071 kcal/mol (39637.1238 without restraints) Performing minimization step: 1240. Total energy = 39634.7759 kcal/mol (39606.7978 without restraints) Performing minimization step: 1241. Total energy = 39604.4778 kcal/mol (39576.5049 without restraints) Performing minimization step: 1242. Total energy = 39574.2129 kcal/mol (39546.2452 without restraints) Performing minimization step: 1243. Total energy = 39543.9810 kcal/mol (39516.0185 without restraints) Performing minimization step: 1244. Total energy = 39513.7821 kcal/mol (39485.8248 without restraints) Performing minimization step: 1245. Total energy = 39483.6162 kcal/mol (39455.6641 without restraints) Performing minimization step: 1246. Total energy = 39453.4836 kcal/mol (39425.5367 without restraints) Performing minimization step: 1247. Total energy = 39423.3843 kcal/mol (39395.4426 without restraints) Performing minimization step: 1248. Total energy = 39393.3173 kcal/mol (39365.3808 without restraints) Performing minimization step: 1249. Total energy = 39363.2830 kcal/mol (39335.3516 without restraints) Performing minimization step: 1250. Total energy = 39333.2818 kcal/mol (39305.3556 without restraints) Performing minimization step: 1251. Total energy = 39303.3133 kcal/mol (39275.3923 without restraints) Performing minimization step: 1252. Total energy = 39273.3778 kcal/mol (39245.4618 without restraints) Performing minimization step: 1253. Total energy = 39243.4747 kcal/mol (39215.5639 without restraints) Performing minimization step: 1254. Total energy = 39213.6046 kcal/mol (39185.6990 without restraints) Performing minimization step: 1255. Total energy = 39183.7672 kcal/mol (39155.8668 without restraints) Performing minimization step: 1256. Total energy = 39153.9625 kcal/mol (39126.0672 without restraints) Performing minimization step: 1257. Total energy = 39124.1906 kcal/mol (39096.3005 without restraints) Performing minimization step: 1258. Total energy = 39094.4513 kcal/mol (39066.5663 without restraints) Performing minimization step: 1259. Total energy = 39064.7451 kcal/mol (39036.8653 without restraints) Performing minimization step: 1260. Total energy = 39035.0707 kcal/mol (39007.1959 without restraints) Performing minimization step: 1261. Total energy = 39005.4291 kcal/mol (38977.5594 without restraints) Performing minimization step: 1262. Total energy = 38975.8199 kcal/mol (38947.9553 without restraints) Performing minimization step: 1263. Total energy = 38946.2433 kcal/mol (38918.3839 without restraints) Performing minimization step: 1264. Total energy = 38916.6991 kcal/mol (38888.8447 without restraints) Performing minimization step: 1265. Total energy = 38887.1873 kcal/mol (38859.3380 without restraints) Performing minimization step: 1266. Total energy = 38857.7078 kcal/mol (38829.8636 without restraints) Performing minimization step: 1267. Total energy = 38828.2609 kcal/mol (38800.4219 without restraints) Performing minimization step: 1268. Total energy = 38798.8463 kcal/mol (38771.0124 without restraints) Performing minimization step: 1269. Total energy = 38769.4640 kcal/mol (38741.6351 without restraints) Performing minimization step: 1270. Total energy = 38740.1136 kcal/mol (38712.2898 without restraints) Performing minimization step: 1271. Total energy = 38710.7954 kcal/mol (38682.9766 without restraints) Performing minimization step: 1272. Total energy = 38681.5096 kcal/mol (38653.6959 without restraints) Performing minimization step: 1273. Total energy = 38652.2564 kcal/mol (38624.4478 without restraints) Performing minimization step: 1274. Total energy = 38623.0350 kcal/mol (38595.2315 without restraints) Performing minimization step: 1275. Total energy = 38593.8459 kcal/mol (38566.0473 without restraints) Performing minimization step: 1276. Total energy = 38564.6887 kcal/mol (38536.8952 without restraints) Performing minimization step: 1277. Total energy = 38535.5632 kcal/mol (38507.7748 without restraints) Performing minimization step: 1278. Total energy = 38506.4704 kcal/mol (38478.6870 without restraints) Performing minimization step: 1279. Total energy = 38477.4098 kcal/mol (38449.6315 without restraints) Performing minimization step: 1280. Total energy = 38448.3809 kcal/mol (38420.6075 without restraints) Performing minimization step: 1281. Total energy = 38419.3837 kcal/mol (38391.6153 without restraints) Performing minimization step: 1282. Total energy = 38390.4186 kcal/mol (38362.6553 without restraints) Performing minimization step: 1283. Total energy = 38361.4854 kcal/mol (38333.7271 without restraints) Performing minimization step: 1284. Total energy = 38332.5844 kcal/mol (38304.8310 without restraints) Performing minimization step: 1285. Total energy = 38303.7151 kcal/mol (38275.9668 without restraints) Performing minimization step: 1286. Total energy = 38274.8775 kcal/mol (38247.1343 without restraints) Performing minimization step: 1287. Total energy = 38246.0722 kcal/mol (38218.3338 without restraints) Performing minimization step: 1288. Total energy = 38217.2984 kcal/mol (38189.5651 without restraints) Performing minimization step: 1289. Total energy = 38188.5564 kcal/mol (38160.8281 without restraints) Performing minimization step: 1290. Total energy = 38159.8457 kcal/mol (38132.1223 without restraints) Performing minimization step: 1291. Total energy = 38131.1666 kcal/mol (38103.4482 without restraints) Performing minimization step: 1292. Total energy = 38102.5194 kcal/mol (38074.8059 without restraints) Performing minimization step: 1293. Total energy = 38073.9038 kcal/mol (38046.1953 without restraints) Performing minimization step: 1294. Total energy = 38045.3195 kcal/mol (38017.6160 without restraints) Performing minimization step: 1295. Total energy = 38016.7668 kcal/mol (37989.0683 without restraints) Performing minimization step: 1296. Total energy = 37988.2458 kcal/mol (37960.5522 without restraints) Performing minimization step: 1297. Total energy = 37959.7561 kcal/mol (37932.0675 without restraints) Performing minimization step: 1298. Total energy = 37931.2979 kcal/mol (37903.6141 without restraints) Performing minimization step: 1299. Total energy = 37902.8709 kcal/mol (37875.1922 without restraints) Performing minimization step: 1300. Total energy = 37874.4756 kcal/mol (37846.8017 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1301. Total energy = 37846.1115 kcal/mol (37818.4426 without restraints) Performing minimization step: 1302. Total energy = 37817.7790 kcal/mol (37790.1150 without restraints) Performing minimization step: 1303. Total energy = 37789.4776 kcal/mol (37761.8185 without restraints) Performing minimization step: 1304. Total energy = 37761.2075 kcal/mol (37733.5533 without restraints) Performing minimization step: 1305. Total energy = 37732.9686 kcal/mol (37705.3193 without restraints) Performing minimization step: 1306. Total energy = 37704.7613 kcal/mol (37677.1169 without restraints) Performing minimization step: 1307. Total energy = 37676.5848 kcal/mol (37648.9454 without restraints) Performing minimization step: 1308. Total energy = 37648.4395 kcal/mol (37620.8049 without restraints) Performing minimization step: 1309. Total energy = 37620.3251 kcal/mol (37592.6954 without restraints) Performing minimization step: 1310. Total energy = 37592.2421 kcal/mol (37564.6172 without restraints) Performing minimization step: 1311. Total energy = 37564.1906 kcal/mol (37536.5708 without restraints) Performing minimization step: 1312. Total energy = 37536.1694 kcal/mol (37508.5543 without restraints) Performing minimization step: 1313. Total energy = 37508.1795 kcal/mol (37480.5693 without restraints) Performing minimization step: 1314. Total energy = 37480.2206 kcal/mol (37452.6153 without restraints) Performing minimization step: 1315. Total energy = 37452.2926 kcal/mol (37424.6922 without restraints) Performing minimization step: 1316. Total energy = 37424.3956 kcal/mol (37396.8001 without restraints) Performing minimization step: 1317. Total energy = 37396.5295 kcal/mol (37368.9388 without restraints) Performing minimization step: 1318. Total energy = 37368.6943 kcal/mol (37341.1084 without restraints) Performing minimization step: 1319. Total energy = 37340.8901 kcal/mol (37313.3090 without restraints) Performing minimization step: 1320. Total energy = 37313.1165 kcal/mol (37285.5403 without restraints) Performing minimization step: 1321. Total energy = 37285.3739 kcal/mol (37257.8025 without restraints) Performing minimization step: 1322. Total energy = 37257.6619 kcal/mol (37230.0953 without restraints) Performing minimization step: 1323. Total energy = 37229.9806 kcal/mol (37202.4188 without restraints) Performing minimization step: 1324. Total energy = 37202.3299 kcal/mol (37174.7730 without restraints) Performing minimization step: 1325. Total energy = 37174.7099 kcal/mol (37147.1577 without restraints) Performing minimization step: 1326. Total energy = 37147.1204 kcal/mol (37119.5731 without restraints) Performing minimization step: 1327. Total energy = 37119.5618 kcal/mol (37092.0192 without restraints) Performing minimization step: 1328. Total energy = 37092.0335 kcal/mol (37064.4959 without restraints) Performing minimization step: 1329. Total energy = 37064.5359 kcal/mol (37037.0030 without restraints) Performing minimization step: 1330. Total energy = 37037.0689 kcal/mol (37009.5408 without restraints) Performing minimization step: 1331. Total energy = 37009.6321 kcal/mol (36982.1088 without restraints) Performing minimization step: 1332. Total energy = 36982.2261 kcal/mol (36954.7077 without restraints) Performing minimization step: 1333. Total energy = 36954.8504 kcal/mol (36927.3366 without restraints) Performing minimization step: 1334. Total energy = 36927.5049 kcal/mol (36899.9959 without restraints) Performing minimization step: 1335. Total energy = 36900.1901 kcal/mol (36872.6859 without restraints) Performing minimization step: 1336. Total energy = 36872.9057 kcal/mol (36845.4063 without restraints) Performing minimization step: 1337. Total energy = 36845.6521 kcal/mol (36818.1574 without restraints) Performing minimization step: 1338. Total energy = 36818.4284 kcal/mol (36790.9385 without restraints) Performing minimization step: 1339. Total energy = 36791.2348 kcal/mol (36763.7495 without restraints) Performing minimization step: 1340. Total energy = 36764.0715 kcal/mol (36736.5910 without restraints) Performing minimization step: 1341. Total energy = 36736.9383 kcal/mol (36709.4625 without restraints) Performing minimization step: 1342. Total energy = 36709.8354 kcal/mol (36682.3644 without restraints) Performing minimization step: 1343. Total energy = 36682.7624 kcal/mol (36655.2961 without restraints) Performing minimization step: 1344. Total energy = 36655.7195 kcal/mol (36628.2580 without restraints) Performing minimization step: 1345. Total energy = 36628.7068 kcal/mol (36601.2500 without restraints) Performing minimization step: 1346. Total energy = 36601.7242 kcal/mol (36574.2720 without restraints) Performing minimization step: 1347. Total energy = 36574.7711 kcal/mol (36547.3237 without restraints) Performing minimization step: 1348. Total energy = 36547.8487 kcal/mol (36520.4060 without restraints) Performing minimization step: 1349. Total energy = 36520.9562 kcal/mol (36493.5182 without restraints) Performing minimization step: 1350. Total energy = 36494.0932 kcal/mol (36466.6599 without restraints) Performing minimization step: 1351. Total energy = 36467.2603 kcal/mol (36439.8317 without restraints) Performing minimization step: 1352. Total energy = 36440.4571 kcal/mol (36413.0332 without restraints) Performing minimization step: 1353. Total energy = 36413.6837 kcal/mol (36386.2645 without restraints) Performing minimization step: 1354. Total energy = 36386.9404 kcal/mol (36359.5259 without restraints) Performing minimization step: 1355. Total energy = 36360.2264 kcal/mol (36332.8166 without restraints) Performing minimization step: 1356. Total energy = 36333.5427 kcal/mol (36306.1375 without restraints) Performing minimization step: 1357. Total energy = 36306.8885 kcal/mol (36279.4879 without restraints) Performing minimization step: 1358. Total energy = 36280.2642 kcal/mol (36252.8685 without restraints) Performing minimization step: 1359. Total energy = 36253.6699 kcal/mol (36226.2787 without restraints) Performing minimization step: 1360. Total energy = 36227.1044 kcal/mol (36199.7179 without restraints) Performing minimization step: 1361. Total energy = 36200.5691 kcal/mol (36173.1872 without restraints) Performing minimization step: 1362. Total energy = 36174.0632 kcal/mol (36146.6859 without restraints) Performing minimization step: 1363. Total energy = 36147.5866 kcal/mol (36120.2139 without restraints) Performing minimization step: 1364. Total energy = 36121.1399 kcal/mol (36093.7720 without restraints) Performing minimization step: 1365. Total energy = 36094.7228 kcal/mol (36067.3595 without restraints) Performing minimization step: 1366. Total energy = 36068.3351 kcal/mol (36040.9763 without restraints) Performing minimization step: 1367. Total energy = 36041.9769 kcal/mol (36014.6228 without restraints) Performing minimization step: 1368. Total energy = 36015.6480 kcal/mol (35988.2985 without restraints) Performing minimization step: 1369. Total energy = 35989.3484 kcal/mol (35962.0035 without restraints) Performing minimization step: 1370. Total energy = 35963.0782 kcal/mol (35935.7379 without restraints) Performing minimization step: 1371. Total energy = 35936.8366 kcal/mol (35909.5009 without restraints) Performing minimization step: 1372. Total energy = 35910.6253 kcal/mol (35883.2942 without restraints) Performing minimization step: 1373. Total energy = 35884.4429 kcal/mol (35857.1164 without restraints) Performing minimization step: 1374. Total energy = 35858.2897 kcal/mol (35830.9678 without restraints) Performing minimization step: 1375. Total energy = 35832.1660 kcal/mol (35804.8487 without restraints) Performing minimization step: 1376. Total energy = 35806.0713 kcal/mol (35778.7586 without restraints) Performing minimization step: 1377. Total energy = 35780.0057 kcal/mol (35752.6976 without restraints) Performing minimization step: 1378. Total energy = 35753.9695 kcal/mol (35726.6659 without restraints) Performing minimization step: 1379. Total energy = 35727.9625 kcal/mol (35700.6635 without restraints) Performing minimization step: 1380. Total energy = 35701.9842 kcal/mol (35674.6897 without restraints) Performing minimization step: 1381. Total energy = 35676.0349 kcal/mol (35648.7450 without restraints) Performing minimization step: 1382. Total energy = 35650.1148 kcal/mol (35622.8295 without restraints) Performing minimization step: 1383. Total energy = 35624.2233 kcal/mol (35596.9425 without restraints) Performing minimization step: 1384. Total energy = 35598.3611 kcal/mol (35571.0848 without restraints) Performing minimization step: 1385. Total energy = 35572.5276 kcal/mol (35545.2559 without restraints) Performing minimization step: 1386. Total energy = 35546.7232 kcal/mol (35519.4560 without restraints) Performing minimization step: 1387. Total energy = 35520.9473 kcal/mol (35493.6846 without restraints) Performing minimization step: 1388. Total energy = 35495.2005 kcal/mol (35467.9424 without restraints) Performing minimization step: 1389. Total energy = 35469.4822 kcal/mol (35442.2285 without restraints) Performing minimization step: 1390. Total energy = 35443.7926 kcal/mol (35416.5434 without restraints) Performing minimization step: 1391. Total energy = 35418.1316 kcal/mol (35390.8870 without restraints) Performing minimization step: 1392. Total energy = 35392.4997 kcal/mol (35365.2596 without restraints) Performing minimization step: 1393. Total energy = 35366.8962 kcal/mol (35339.6606 without restraints) Performing minimization step: 1394. Total energy = 35341.3216 kcal/mol (35314.0905 without restraints) Performing minimization step: 1395. Total energy = 35315.7755 kcal/mol (35288.5489 without restraints) Performing minimization step: 1396. Total energy = 35290.2583 kcal/mol (35263.0362 without restraints) Performing minimization step: 1397. Total energy = 35264.7694 kcal/mol (35237.5517 without restraints) Performing minimization step: 1398. Total energy = 35239.3093 kcal/mol (35212.0961 without restraints) Performing minimization step: 1399. Total energy = 35213.8774 kcal/mol (35186.6687 without restraints) Performing minimization step: 1400. Total energy = 35188.4739 kcal/mol (35161.2696 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1401. Total energy = 35163.0990 kcal/mol (35135.8993 without restraints) Performing minimization step: 1402. Total energy = 35137.7525 kcal/mol (35110.5572 without restraints) Performing minimization step: 1403. Total energy = 35112.4341 kcal/mol (35085.2433 without restraints) Performing minimization step: 1404. Total energy = 35087.1445 kcal/mol (35059.9581 without restraints) Performing minimization step: 1405. Total energy = 35061.8829 kcal/mol (35034.7009 without restraints) Performing minimization step: 1406. Total energy = 35036.6497 kcal/mol (35009.4722 without restraints) Performing minimization step: 1407. Total energy = 35011.4448 kcal/mol (34984.2717 without restraints) Performing minimization step: 1408. Total energy = 34986.2681 kcal/mol (34959.0994 without restraints) Performing minimization step: 1409. Total energy = 34961.1196 kcal/mol (34933.9554 without restraints) Performing minimization step: 1410. Total energy = 34935.9989 kcal/mol (34908.8391 without restraints) Performing minimization step: 1411. Total energy = 34910.9066 kcal/mol (34883.7512 without restraints) Performing minimization step: 1412. Total energy = 34885.8425 kcal/mol (34858.6916 without restraints) Performing minimization step: 1413. Total energy = 34860.8066 kcal/mol (34833.6601 without restraints) Performing minimization step: 1414. Total energy = 34835.7987 kcal/mol (34808.6566 without restraints) Performing minimization step: 1415. Total energy = 34810.8186 kcal/mol (34783.6809 without restraints) Performing minimization step: 1416. Total energy = 34785.8666 kcal/mol (34758.7334 without restraints) Performing minimization step: 1417. Total energy = 34760.9431 kcal/mol (34733.8141 without restraints) Performing minimization step: 1418. Total energy = 34736.0471 kcal/mol (34708.9225 without restraints) Performing minimization step: 1419. Total energy = 34711.1791 kcal/mol (34684.0589 without restraints) Performing minimization step: 1420. Total energy = 34686.3388 kcal/mol (34659.2230 without restraints) Performing minimization step: 1421. Total energy = 34661.5263 kcal/mol (34634.4149 without restraints) Performing minimization step: 1422. Total energy = 34636.7419 kcal/mol (34609.6349 without restraints) Performing minimization step: 1423. Total energy = 34611.9853 kcal/mol (34584.8826 without restraints) Performing minimization step: 1424. Total energy = 34587.2562 kcal/mol (34560.1580 without restraints) Performing minimization step: 1425. Total energy = 34562.5552 kcal/mol (34535.4612 without restraints) Performing minimization step: 1426. Total energy = 34537.8819 kcal/mol (34510.7923 without restraints) Performing minimization step: 1427. Total energy = 34513.2362 kcal/mol (34486.1510 without restraints) Performing minimization step: 1428. Total energy = 34488.6181 kcal/mol (34461.5372 without restraints) Performing minimization step: 1429. Total energy = 34464.0276 kcal/mol (34436.9510 without restraints) Performing minimization step: 1430. Total energy = 34439.4643 kcal/mol (34412.3919 without restraints) Performing minimization step: 1431. Total energy = 34414.9288 kcal/mol (34387.8609 without restraints) Performing minimization step: 1432. Total energy = 34390.4212 kcal/mol (34363.3576 without restraints) Performing minimization step: 1433. Total energy = 34365.9406 kcal/mol (34338.8813 without restraints) Performing minimization step: 1434. Total energy = 34341.4875 kcal/mol (34314.4326 without restraints) Performing minimization step: 1435. Total energy = 34317.0621 kcal/mol (34290.0115 without restraints) Performing minimization step: 1436. Total energy = 34292.6644 kcal/mol (34265.6183 without restraints) Performing minimization step: 1437. Total energy = 34268.2942 kcal/mol (34241.2522 without restraints) Performing minimization step: 1438. Total energy = 34243.9510 kcal/mol (34216.9133 without restraints) Performing minimization step: 1439. Total energy = 34219.6350 kcal/mol (34192.6016 without restraints) Performing minimization step: 1440. Total energy = 34195.3464 kcal/mol (34168.3173 without restraints) Performing minimization step: 1441. Total energy = 34171.0850 kcal/mol (34144.0602 without restraints) Performing minimization step: 1442. Total energy = 34146.8509 kcal/mol (34119.8303 without restraints) Performing minimization step: 1443. Total energy = 34122.6442 kcal/mol (34095.6279 without restraints) Performing minimization step: 1444. Total energy = 34098.4645 kcal/mol (34071.4524 without restraints) Performing minimization step: 1445. Total energy = 34074.3117 kcal/mol (34047.3041 without restraints) Performing minimization step: 1446. Total energy = 34050.1862 kcal/mol (34023.1826 without restraints) Performing minimization step: 1447. Total energy = 34026.0879 kcal/mol (33999.0887 without restraints) Performing minimization step: 1448. Total energy = 34002.0165 kcal/mol (33975.0216 without restraints) Performing minimization step: 1449. Total energy = 33977.9724 kcal/mol (33950.9816 without restraints) Performing minimization step: 1450. Total energy = 33953.9550 kcal/mol (33926.9686 without restraints) Performing minimization step: 1451. Total energy = 33929.9642 kcal/mol (33902.9820 without restraints) Performing minimization step: 1452. Total energy = 33906.0006 kcal/mol (33879.0226 without restraints) Performing minimization step: 1453. Total energy = 33882.0642 kcal/mol (33855.0904 without restraints) Performing minimization step: 1454. Total energy = 33858.1544 kcal/mol (33831.1848 without restraints) Performing minimization step: 1455. Total energy = 33834.2718 kcal/mol (33807.3065 without restraints) Performing minimization step: 1456. Total energy = 33810.4159 kcal/mol (33783.4548 without restraints) Performing minimization step: 1457. Total energy = 33786.5873 kcal/mol (33759.6303 without restraints) Performing minimization step: 1458. Total energy = 33762.7849 kcal/mol (33735.8322 without restraints) Performing minimization step: 1459. Total energy = 33739.0093 kcal/mol (33712.0608 without restraints) Performing minimization step: 1460. Total energy = 33715.2603 kcal/mol (33688.3160 without restraints) Performing minimization step: 1461. Total energy = 33691.5381 kcal/mol (33664.5980 without restraints) Performing minimization step: 1462. Total energy = 33667.8427 kcal/mol (33640.9068 without restraints) Performing minimization step: 1463. Total energy = 33644.1742 kcal/mol (33617.2425 without restraints) Performing minimization step: 1464. Total energy = 33620.5317 kcal/mol (33593.6042 without restraints) Performing minimization step: 1465. Total energy = 33596.9161 kcal/mol (33569.9928 without restraints) Performing minimization step: 1466. Total energy = 33573.3269 kcal/mol (33546.4077 without restraints) Performing minimization step: 1467. Total energy = 33549.7641 kcal/mol (33522.8491 without restraints) Performing minimization step: 1468. Total energy = 33526.2279 kcal/mol (33499.3170 without restraints) Performing minimization step: 1469. Total energy = 33502.7178 kcal/mol (33475.8111 without restraints) Performing minimization step: 1470. Total energy = 33479.2346 kcal/mol (33452.3321 without restraints) Performing minimization step: 1471. Total energy = 33455.7775 kcal/mol (33428.8790 without restraints) Performing minimization step: 1472. Total energy = 33432.3469 kcal/mol (33405.4526 without restraints) Performing minimization step: 1473. Total energy = 33408.9425 kcal/mol (33382.0524 without restraints) Performing minimization step: 1474. Total energy = 33385.5646 kcal/mol (33358.6787 without restraints) Performing minimization step: 1475. Total energy = 33362.2128 kcal/mol (33335.3310 without restraints) Performing minimization step: 1476. Total energy = 33338.8875 kcal/mol (33312.0099 without restraints) Performing minimization step: 1477. Total energy = 33315.5882 kcal/mol (33288.7147 without restraints) Performing minimization step: 1478. Total energy = 33292.3156 kcal/mol (33265.4461 without restraints) Performing minimization step: 1479. Total energy = 33269.0684 kcal/mol (33242.2030 without restraints) Performing minimization step: 1480. Total energy = 33245.8474 kcal/mol (33218.9863 without restraints) Performing minimization step: 1481. Total energy = 33222.6529 kcal/mol (33195.7958 without restraints) Performing minimization step: 1482. Total energy = 33199.4841 kcal/mol (33172.6311 without restraints) Performing minimization step: 1483. Total energy = 33176.3412 kcal/mol (33149.4923 without restraints) Performing minimization step: 1484. Total energy = 33153.2245 kcal/mol (33126.3798 without restraints) Performing minimization step: 1485. Total energy = 33130.1339 kcal/mol (33103.2932 without restraints) Performing minimization step: 1486. Total energy = 33107.0694 kcal/mol (33080.2329 without restraints) Performing minimization step: 1487. Total energy = 33084.0307 kcal/mol (33057.1982 without restraints) Performing minimization step: 1488. Total energy = 33061.0177 kcal/mol (33034.1893 without restraints) Performing minimization step: 1489. Total energy = 33038.0304 kcal/mol (33011.2060 without restraints) Performing minimization step: 1490. Total energy = 33015.0691 kcal/mol (32988.2488 without restraints) Performing minimization step: 1491. Total energy = 32992.1337 kcal/mol (32965.3174 without restraints) Performing minimization step: 1492. Total energy = 32969.2240 kcal/mol (32942.4118 without restraints) Performing minimization step: 1493. Total energy = 32946.3403 kcal/mol (32919.5322 without restraints) Performing minimization step: 1494. Total energy = 32923.4825 kcal/mol (32896.6785 without restraints) Performing minimization step: 1495. Total energy = 32900.6501 kcal/mol (32873.8499 without restraints) Performing minimization step: 1496. Total energy = 32877.8430 kcal/mol (32851.0470 without restraints) Performing minimization step: 1497. Total energy = 32855.0622 kcal/mol (32828.2703 without restraints) Performing minimization step: 1498. Total energy = 32832.3067 kcal/mol (32805.5188 without restraints) Performing minimization step: 1499. Total energy = 32809.5766 kcal/mol (32782.7927 without restraints) Performing minimization step: 1500. Total energy = 32786.8722 kcal/mol (32760.0923 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1501. Total energy = 32764.1931 kcal/mol (32737.4173 without restraints) Performing minimization step: 1502. Total energy = 32741.5396 kcal/mol (32714.7678 without restraints) Performing minimization step: 1503. Total energy = 32718.9117 kcal/mol (32692.1439 without restraints) Performing minimization step: 1504. Total energy = 32696.3090 kcal/mol (32669.5453 without restraints) Performing minimization step: 1505. Total energy = 32673.7318 kcal/mol (32646.9720 without restraints) Performing minimization step: 1506. Total energy = 32651.1797 kcal/mol (32624.4239 without restraints) Performing minimization step: 1507. Total energy = 32628.6531 kcal/mol (32601.9014 without restraints) Performing minimization step: 1508. Total energy = 32606.1519 kcal/mol (32579.4042 without restraints) Performing minimization step: 1509. Total energy = 32583.6759 kcal/mol (32556.9321 without restraints) Performing minimization step: 1510. Total energy = 32561.2252 kcal/mol (32534.4854 without restraints) Performing minimization step: 1511. Total energy = 32538.7997 kcal/mol (32512.0639 without restraints) Performing minimization step: 1512. Total energy = 32516.3992 kcal/mol (32489.6673 without restraints) Performing minimization step: 1513. Total energy = 32494.0244 kcal/mol (32467.2966 without restraints) Performing minimization step: 1514. Total energy = 32471.6744 kcal/mol (32444.9505 without restraints) Performing minimization step: 1515. Total energy = 32449.3496 kcal/mol (32422.6297 without restraints) Performing minimization step: 1516. Total energy = 32427.0498 kcal/mol (32400.3338 without restraints) Performing minimization step: 1517. Total energy = 32404.7753 kcal/mol (32378.0634 without restraints) Performing minimization step: 1518. Total energy = 32382.5258 kcal/mol (32355.8177 without restraints) Performing minimization step: 1519. Total energy = 32360.3009 kcal/mol (32333.5968 without restraints) Performing minimization step: 1520. Total energy = 32338.1011 kcal/mol (32311.4010 without restraints) Performing minimization step: 1521. Total energy = 32315.9260 kcal/mol (32289.2297 without restraints) Performing minimization step: 1522. Total energy = 32293.7761 kcal/mol (32267.0837 without restraints) Performing minimization step: 1523. Total energy = 32271.6510 kcal/mol (32244.9627 without restraints) Performing minimization step: 1524. Total energy = 32249.5509 kcal/mol (32222.8665 without restraints) Performing minimization step: 1525. Total energy = 32227.4754 kcal/mol (32200.7948 without restraints) Performing minimization step: 1526. Total energy = 32205.4248 kcal/mol (32178.7482 without restraints) Performing minimization step: 1527. Total energy = 32183.3986 kcal/mol (32156.7259 without restraints) Performing minimization step: 1528. Total energy = 32161.3973 kcal/mol (32134.7286 without restraints) Performing minimization step: 1529. Total energy = 32139.4209 kcal/mol (32112.7562 without restraints) Performing minimization step: 1530. Total energy = 32117.4692 kcal/mol (32090.8082 without restraints) Performing minimization step: 1531. Total energy = 32095.5419 kcal/mol (32068.8848 without restraints) Performing minimization step: 1532. Total energy = 32073.6395 kcal/mol (32046.9863 without restraints) Performing minimization step: 1533. Total energy = 32051.7614 kcal/mol (32025.1121 without restraints) Performing minimization step: 1534. Total energy = 32029.9079 kcal/mol (32003.2625 without restraints) Performing minimization step: 1535. Total energy = 32008.0790 kcal/mol (31981.4374 without restraints) Performing minimization step: 1536. Total energy = 31986.2745 kcal/mol (31959.6368 without restraints) Performing minimization step: 1537. Total energy = 31964.4945 kcal/mol (31937.8607 without restraints) Performing minimization step: 1538. Total energy = 31942.7389 kcal/mol (31916.1090 without restraints) Performing minimization step: 1539. Total energy = 31921.0078 kcal/mol (31894.3817 without restraints) Performing minimization step: 1540. Total energy = 31899.3009 kcal/mol (31872.6786 without restraints) Performing minimization step: 1541. Total energy = 31877.6184 kcal/mol (31851.0000 without restraints) Performing minimization step: 1542. Total energy = 31855.9603 kcal/mol (31829.3458 without restraints) Performing minimization step: 1543. Total energy = 31834.3260 kcal/mol (31807.7154 without restraints) Performing minimization step: 1544. Total energy = 31812.7169 kcal/mol (31786.1101 without restraints) Performing minimization step: 1545. Total energy = 31791.1315 kcal/mol (31764.5286 without restraints) Performing minimization step: 1546. Total energy = 31769.5704 kcal/mol (31742.9713 without restraints) Performing minimization step: 1547. Total energy = 31748.0332 kcal/mol (31721.4379 without restraints) Performing minimization step: 1548. Total energy = 31726.5204 kcal/mol (31699.9289 without restraints) Performing minimization step: 1549. Total energy = 31705.0315 kcal/mol (31678.4439 without restraints) Performing minimization step: 1550. Total energy = 31683.5669 kcal/mol (31656.9831 without restraints) Performing minimization step: 1551. Total energy = 31662.1266 kcal/mol (31635.5465 without restraints) Performing minimization step: 1552. Total energy = 31640.7103 kcal/mol (31614.1341 without restraints) Performing minimization step: 1553. Total energy = 31619.3178 kcal/mol (31592.7454 without restraints) Performing minimization step: 1554. Total energy = 31597.9493 kcal/mol (31571.3807 without restraints) Performing minimization step: 1555. Total energy = 31576.6047 kcal/mol (31550.0399 without restraints) Performing minimization step: 1556. Total energy = 31555.2840 kcal/mol (31528.7230 without restraints) Performing minimization step: 1557. Total energy = 31533.9872 kcal/mol (31507.4300 without restraints) Performing minimization step: 1558. Total energy = 31512.7143 kcal/mol (31486.1609 without restraints) Performing minimization step: 1559. Total energy = 31491.4651 kcal/mol (31464.9154 without restraints) Performing minimization step: 1560. Total energy = 31470.2396 kcal/mol (31443.6937 without restraints) Performing minimization step: 1561. Total energy = 31449.0380 kcal/mol (31422.4959 without restraints) Performing minimization step: 1562. Total energy = 31427.8606 kcal/mol (31401.3222 without restraints) Performing minimization step: 1563. Total energy = 31406.7065 kcal/mol (31380.1719 without restraints) Performing minimization step: 1564. Total energy = 31385.5761 kcal/mol (31359.0452 without restraints) Performing minimization step: 1565. Total energy = 31364.4691 kcal/mol (31337.9420 without restraints) Performing minimization step: 1566. Total energy = 31343.3859 kcal/mol (31316.8626 without restraints) Performing minimization step: 1567. Total energy = 31322.3265 kcal/mol (31295.8069 without restraints) Performing minimization step: 1568. Total energy = 31301.2907 kcal/mol (31274.7749 without restraints) Performing minimization step: 1569. Total energy = 31280.2785 kcal/mol (31253.7665 without restraints) Performing minimization step: 1570. Total energy = 31259.2900 kcal/mol (31232.7816 without restraints) Performing minimization step: 1571. Total energy = 31238.3246 kcal/mol (31211.8200 without restraints) Performing minimization step: 1572. Total energy = 31217.3827 kcal/mol (31190.8818 without restraints) Performing minimization step: 1573. Total energy = 31196.4644 kcal/mol (31169.9673 without restraints) Performing minimization step: 1574. Total energy = 31175.5695 kcal/mol (31149.0760 without restraints) Performing minimization step: 1575. Total energy = 31154.6979 kcal/mol (31128.2082 without restraints) Performing minimization step: 1576. Total energy = 31133.8498 kcal/mol (31107.3638 without restraints) Performing minimization step: 1577. Total energy = 31113.0247 kcal/mol (31086.5424 without restraints) Performing minimization step: 1578. Total energy = 31092.2230 kcal/mol (31065.7443 without restraints) Performing minimization step: 1579. Total energy = 31071.4444 kcal/mol (31044.9695 without restraints) Performing minimization step: 1580. Total energy = 31050.6891 kcal/mol (31024.2179 without restraints) Performing minimization step: 1581. Total energy = 31029.9570 kcal/mol (31003.4895 without restraints) Performing minimization step: 1582. Total energy = 31009.2479 kcal/mol (30982.7841 without restraints) Performing minimization step: 1583. Total energy = 30988.5619 kcal/mol (30962.1018 without restraints) Performing minimization step: 1584. Total energy = 30967.8995 kcal/mol (30941.4430 without restraints) Performing minimization step: 1585. Total energy = 30947.2600 kcal/mol (30920.8072 without restraints) Performing minimization step: 1586. Total energy = 30926.6435 kcal/mol (30900.1943 without restraints) Performing minimization step: 1587. Total energy = 30906.0501 kcal/mol (30879.6047 without restraints) Performing minimization step: 1588. Total energy = 30885.4797 kcal/mol (30859.0378 without restraints) Performing minimization step: 1589. Total energy = 30864.9324 kcal/mol (30838.4942 without restraints) Performing minimization step: 1590. Total energy = 30844.4078 kcal/mol (30817.9733 without restraints) Performing minimization step: 1591. Total energy = 30823.9061 kcal/mol (30797.4751 without restraints) Performing minimization step: 1592. Total energy = 30803.4270 kcal/mol (30776.9998 without restraints) Performing minimization step: 1593. Total energy = 30782.9710 kcal/mol (30756.5474 without restraints) Performing minimization step: 1594. Total energy = 30762.5378 kcal/mol (30736.1178 without restraints) Performing minimization step: 1595. Total energy = 30742.1280 kcal/mol (30715.7117 without restraints) Performing minimization step: 1596. Total energy = 30721.7405 kcal/mol (30695.3279 without restraints) Performing minimization step: 1597. Total energy = 30701.3757 kcal/mol (30674.9667 without restraints) Performing minimization step: 1598. Total energy = 30681.0335 kcal/mol (30654.6281 without restraints) Performing minimization step: 1599. Total energy = 30660.7145 kcal/mol (30634.3127 without restraints) Performing minimization step: 1600. Total energy = 30640.4181 kcal/mol (30614.0201 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1601. Total energy = 30620.1443 kcal/mol (30593.7498 without restraints) Performing minimization step: 1602. Total energy = 30599.8929 kcal/mol (30573.5019 without restraints) Performing minimization step: 1603. Total energy = 30579.6642 kcal/mol (30553.2768 without restraints) Performing minimization step: 1604. Total energy = 30559.4581 kcal/mol (30533.0743 without restraints) Performing minimization step: 1605. Total energy = 30539.2743 kcal/mol (30512.8940 without restraints) Performing minimization step: 1606. Total energy = 30519.1128 kcal/mol (30492.7362 without restraints) Performing minimization step: 1607. Total energy = 30498.9742 kcal/mol (30472.6012 without restraints) Performing minimization step: 1608. Total energy = 30478.8577 kcal/mol (30452.4883 without restraints) Performing minimization step: 1609. Total energy = 30458.7634 kcal/mol (30432.3976 without restraints) Performing minimization step: 1610. Total energy = 30438.6918 kcal/mol (30412.3295 without restraints) Performing minimization step: 1611. Total energy = 30418.6428 kcal/mol (30392.2841 without restraints) Performing minimization step: 1612. Total energy = 30398.6160 kcal/mol (30372.2608 without restraints) Performing minimization step: 1613. Total energy = 30378.6114 kcal/mol (30352.2598 without restraints) Performing minimization step: 1614. Total energy = 30358.6291 kcal/mol (30332.2812 without restraints) Performing minimization step: 1615. Total energy = 30338.6690 kcal/mol (30312.3246 without restraints) Performing minimization step: 1616. Total energy = 30318.7310 kcal/mol (30292.3901 without restraints) Performing minimization step: 1617. Total energy = 30298.8151 kcal/mol (30272.4777 without restraints) Performing minimization step: 1618. Total energy = 30278.9214 kcal/mol (30252.5875 without restraints) Performing minimization step: 1619. Total energy = 30259.0500 kcal/mol (30232.7197 without restraints) Performing minimization step: 1620. Total energy = 30239.2005 kcal/mol (30212.8738 without restraints) Performing minimization step: 1621. Total energy = 30219.3727 kcal/mol (30193.0495 without restraints) Performing minimization step: 1622. Total energy = 30199.5674 kcal/mol (30173.2477 without restraints) Performing minimization step: 1623. Total energy = 30179.7841 kcal/mol (30153.4680 without restraints) Performing minimization step: 1624. Total energy = 30160.0228 kcal/mol (30133.7101 without restraints) Performing minimization step: 1625. Total energy = 30140.2836 kcal/mol (30113.9745 without restraints) Performing minimization step: 1626. Total energy = 30120.5660 kcal/mol (30094.2604 without restraints) Performing minimization step: 1627. Total energy = 30100.8703 kcal/mol (30074.5682 without restraints) Performing minimization step: 1628. Total energy = 30081.1966 kcal/mol (30054.8981 without restraints) Performing minimization step: 1629. Total energy = 30061.5448 kcal/mol (30035.2497 without restraints) Performing minimization step: 1630. Total energy = 30041.9148 kcal/mol (30015.6233 without restraints) Performing minimization step: 1631. Total energy = 30022.3068 kcal/mol (29996.0188 without restraints) Performing minimization step: 1632. Total energy = 30002.7204 kcal/mol (29976.4358 without restraints) Performing minimization step: 1633. Total energy = 29983.1553 kcal/mol (29956.8742 without restraints) Performing minimization step: 1634. Total energy = 29963.6122 kcal/mol (29937.3347 without restraints) Performing minimization step: 1635. Total energy = 29944.0910 kcal/mol (29917.8168 without restraints) Performing minimization step: 1636. Total energy = 29924.5913 kcal/mol (29898.3206 without restraints) Performing minimization step: 1637. Total energy = 29905.1130 kcal/mol (29878.8458 without restraints) Performing minimization step: 1638. Total energy = 29885.6565 kcal/mol (29859.3928 without restraints) Performing minimization step: 1639. Total energy = 29866.2216 kcal/mol (29839.9613 without restraints) Performing minimization step: 1640. Total energy = 29846.8082 kcal/mol (29820.5514 without restraints) Performing minimization step: 1641. Total energy = 29827.4161 kcal/mol (29801.1627 without restraints) Performing minimization step: 1642. Total energy = 29808.0458 kcal/mol (29781.7960 without restraints) Performing minimization step: 1643. Total energy = 29788.6970 kcal/mol (29762.4504 without restraints) Performing minimization step: 1644. Total energy = 29769.3692 kcal/mol (29743.1261 without restraints) Performing minimization step: 1645. Total energy = 29750.0634 kcal/mol (29723.8242 without restraints) Performing minimization step: 1646. Total energy = 29730.7791 kcal/mol (29704.5432 without restraints) Performing minimization step: 1647. Total energy = 29711.5164 kcal/mol (29685.2838 without restraints) Performing minimization step: 1648. Total energy = 29692.2744 kcal/mol (29666.0452 without restraints) Performing minimization step: 1649. Total energy = 29673.0537 kcal/mol (29646.8278 without restraints) Performing minimization step: 1650. Total energy = 29653.8541 kcal/mol (29627.6317 without restraints) Performing minimization step: 1651. Total energy = 29634.6760 kcal/mol (29608.4570 without restraints) Performing minimization step: 1652. Total energy = 29615.5191 kcal/mol (29589.3035 without restraints) Performing minimization step: 1653. Total energy = 29596.3828 kcal/mol (29570.1705 without restraints) Performing minimization step: 1654. Total energy = 29577.2680 kcal/mol (29551.0592 without restraints) Performing minimization step: 1655. Total energy = 29558.1744 kcal/mol (29531.9692 without restraints) Performing minimization step: 1656. Total energy = 29539.1020 kcal/mol (29512.9000 without restraints) Performing minimization step: 1657. Total energy = 29520.0505 kcal/mol (29493.8519 without restraints) Performing minimization step: 1658. Total energy = 29501.0205 kcal/mol (29474.8255 without restraints) Performing minimization step: 1659. Total energy = 29482.0107 kcal/mol (29455.8189 without restraints) Performing minimization step: 1660. Total energy = 29463.0228 kcal/mol (29436.8344 without restraints) Performing minimization step: 1661. Total energy = 29444.0556 kcal/mol (29417.8705 without restraints) Performing minimization step: 1662. Total energy = 29425.1092 kcal/mol (29398.9276 without restraints) Performing minimization step: 1663. Total energy = 29406.1835 kcal/mol (29380.0052 without restraints) Performing minimization step: 1664. Total energy = 29387.2786 kcal/mol (29361.1038 without restraints) Performing minimization step: 1665. Total energy = 29368.3947 kcal/mol (29342.2232 without restraints) Performing minimization step: 1666. Total energy = 29349.5317 kcal/mol (29323.3637 without restraints) Performing minimization step: 1667. Total energy = 29330.6894 kcal/mol (29304.5247 without restraints) Performing minimization step: 1668. Total energy = 29311.8680 kcal/mol (29285.7065 without restraints) Performing minimization step: 1669. Total energy = 29293.0672 kcal/mol (29266.9091 without restraints) Performing minimization step: 1670. Total energy = 29274.2871 kcal/mol (29248.1324 without restraints) Performing minimization step: 1671. Total energy = 29255.5277 kcal/mol (29229.3763 without restraints) Performing minimization step: 1672. Total energy = 29236.7889 kcal/mol (29210.6407 without restraints) Performing minimization step: 1673. Total energy = 29218.0707 kcal/mol (29191.9260 without restraints) Performing minimization step: 1674. Total energy = 29199.3735 kcal/mol (29173.2322 without restraints) Performing minimization step: 1675. Total energy = 29180.6967 kcal/mol (29154.5586 without restraints) Performing minimization step: 1676. Total energy = 29162.0404 kcal/mol (29135.9058 without restraints) Performing minimization step: 1677. Total energy = 29143.4047 kcal/mol (29117.2733 without restraints) Performing minimization step: 1678. Total energy = 29124.7893 kcal/mol (29098.6611 without restraints) Performing minimization step: 1679. Total energy = 29106.1943 kcal/mol (29080.0695 without restraints) Performing minimization step: 1680. Total energy = 29087.6203 kcal/mol (29061.4988 without restraints) Performing minimization step: 1681. Total energy = 29069.0662 kcal/mol (29042.9480 without restraints) Performing minimization step: 1682. Total energy = 29050.5327 kcal/mol (29024.4181 without restraints) Performing minimization step: 1683. Total energy = 29032.0199 kcal/mol (29005.9084 without restraints) Performing minimization step: 1684. Total energy = 29013.5270 kcal/mol (28987.4187 without restraints) Performing minimization step: 1685. Total energy = 28995.0545 kcal/mol (28968.9496 without restraints) Performing minimization step: 1686. Total energy = 28976.6022 kcal/mol (28950.5005 without restraints) Performing minimization step: 1687. Total energy = 28958.1702 kcal/mol (28932.0719 without restraints) Performing minimization step: 1688. Total energy = 28939.7588 kcal/mol (28913.6637 without restraints) Performing minimization step: 1689. Total energy = 28921.3673 kcal/mol (28895.2755 without restraints) Performing minimization step: 1690. Total energy = 28902.9958 kcal/mol (28876.9073 without restraints) Performing minimization step: 1691. Total energy = 28884.6444 kcal/mol (28858.5591 without restraints) Performing minimization step: 1692. Total energy = 28866.3132 kcal/mol (28840.2311 without restraints) Performing minimization step: 1693. Total energy = 28848.0020 kcal/mol (28821.9233 without restraints) Performing minimization step: 1694. Total energy = 28829.7107 kcal/mol (28803.6353 without restraints) Performing minimization step: 1695. Total energy = 28811.4394 kcal/mol (28785.3672 without restraints) Performing minimization step: 1696. Total energy = 28793.1884 kcal/mol (28767.1195 without restraints) Performing minimization step: 1697. Total energy = 28774.9572 kcal/mol (28748.8914 without restraints) Performing minimization step: 1698. Total energy = 28756.7462 kcal/mol (28730.6838 without restraints) Performing minimization step: 1699. Total energy = 28738.5552 kcal/mol (28712.4960 without restraints) Performing minimization step: 1700. Total energy = 28720.3839 kcal/mol (28694.3280 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1701. Total energy = 28702.2327 kcal/mol (28676.1800 without restraints) Performing minimization step: 1702. Total energy = 28684.1007 kcal/mol (28658.0513 without restraints) Performing minimization step: 1703. Total energy = 28665.9888 kcal/mol (28639.9426 without restraints) Performing minimization step: 1704. Total energy = 28647.8969 kcal/mol (28621.8539 without restraints) Performing minimization step: 1705. Total energy = 28629.8248 kcal/mol (28603.7850 without restraints) Performing minimization step: 1706. Total energy = 28611.7724 kcal/mol (28585.7358 without restraints) Performing minimization step: 1707. Total energy = 28593.7398 kcal/mol (28567.7064 without restraints) Performing minimization step: 1708. Total energy = 28575.7266 kcal/mol (28549.6965 without restraints) Performing minimization step: 1709. Total energy = 28557.7331 kcal/mol (28531.7062 without restraints) Performing minimization step: 1710. Total energy = 28539.7596 kcal/mol (28513.7359 without restraints) Performing minimization step: 1711. Total energy = 28521.8056 kcal/mol (28495.7851 without restraints) Performing minimization step: 1712. Total energy = 28503.8716 kcal/mol (28477.8543 without restraints) Performing minimization step: 1713. Total energy = 28485.9565 kcal/mol (28459.9424 without restraints) Performing minimization step: 1714. Total energy = 28468.0608 kcal/mol (28442.0500 without restraints) Performing minimization step: 1715. Total energy = 28450.1852 kcal/mol (28424.1775 without restraints) Performing minimization step: 1716. Total energy = 28432.3286 kcal/mol (28406.3241 without restraints) Performing minimization step: 1717. Total energy = 28414.4916 kcal/mol (28388.4903 without restraints) Performing minimization step: 1718. Total energy = 28396.6742 kcal/mol (28370.6760 without restraints) Performing minimization step: 1719. Total energy = 28378.8761 kcal/mol (28352.8811 without restraints) Performing minimization step: 1720. Total energy = 28361.0974 kcal/mol (28335.1056 without restraints) Performing minimization step: 1721. Total energy = 28343.3380 kcal/mol (28317.3494 without restraints) Performing minimization step: 1722. Total energy = 28325.5981 kcal/mol (28299.6127 without restraints) Performing minimization step: 1723. Total energy = 28307.8776 kcal/mol (28281.8953 without restraints) Performing minimization step: 1724. Total energy = 28290.1761 kcal/mol (28264.1969 without restraints) Performing minimization step: 1725. Total energy = 28272.4936 kcal/mol (28246.5175 without restraints) Performing minimization step: 1726. Total energy = 28254.8305 kcal/mol (28228.8577 without restraints) Performing minimization step: 1727. Total energy = 28237.1868 kcal/mol (28211.2171 without restraints) Performing minimization step: 1728. Total energy = 28219.5621 kcal/mol (28193.5956 without restraints) Performing minimization step: 1729. Total energy = 28201.9566 kcal/mol (28175.9932 without restraints) Performing minimization step: 1730. Total energy = 28184.3702 kcal/mol (28158.4099 without restraints) Performing minimization step: 1731. Total energy = 28166.8029 kcal/mol (28140.8457 without restraints) Performing minimization step: 1732. Total energy = 28149.2546 kcal/mol (28123.3006 without restraints) Performing minimization step: 1733. Total energy = 28131.7253 kcal/mol (28105.7743 without restraints) Performing minimization step: 1734. Total energy = 28114.2149 kcal/mol (28088.2670 without restraints) Performing minimization step: 1735. Total energy = 28096.7234 kcal/mol (28070.7787 without restraints) Performing minimization step: 1736. Total energy = 28079.2511 kcal/mol (28053.3096 without restraints) Performing minimization step: 1737. Total energy = 28061.7976 kcal/mol (28035.8592 without restraints) Performing minimization step: 1738. Total energy = 28044.3632 kcal/mol (28018.4279 without restraints) Performing minimization step: 1739. Total energy = 28026.9481 kcal/mol (28001.0159 without restraints) Performing minimization step: 1740. Total energy = 28009.5513 kcal/mol (27983.6222 without restraints) Performing minimization step: 1741. Total energy = 27992.1736 kcal/mol (27966.2476 without restraints) Performing minimization step: 1742. Total energy = 27974.8145 kcal/mol (27948.8916 without restraints) Performing minimization step: 1743. Total energy = 27957.4744 kcal/mol (27931.5547 without restraints) Performing minimization step: 1744. Total energy = 27940.1531 kcal/mol (27914.2364 without restraints) Performing minimization step: 1745. Total energy = 27922.8503 kcal/mol (27896.9367 without restraints) Performing minimization step: 1746. Total energy = 27905.5662 kcal/mol (27879.6557 without restraints) Performing minimization step: 1747. Total energy = 27888.3007 kcal/mol (27862.3933 without restraints) Performing minimization step: 1748. Total energy = 27871.0542 kcal/mol (27845.1498 without restraints) Performing minimization step: 1749. Total energy = 27853.8260 kcal/mol (27827.9248 without restraints) Performing minimization step: 1750. Total energy = 27836.6165 kcal/mol (27810.7183 without restraints) Performing minimization step: 1751. Total energy = 27819.4255 kcal/mol (27793.5304 without restraints) Performing minimization step: 1752. Total energy = 27802.2531 kcal/mol (27776.3610 without restraints) Performing minimization step: 1753. Total energy = 27785.0991 kcal/mol (27759.2101 without restraints) Performing minimization step: 1754. Total energy = 27767.9639 kcal/mol (27742.0780 without restraints) Performing minimization step: 1755. Total energy = 27750.8468 kcal/mol (27724.9639 without restraints) Performing minimization step: 1756. Total energy = 27733.7485 kcal/mol (27707.8686 without restraints) Performing minimization step: 1757. Total energy = 27716.6689 kcal/mol (27690.7921 without restraints) Performing minimization step: 1758. Total energy = 27699.6074 kcal/mol (27673.7337 without restraints) Performing minimization step: 1759. Total energy = 27682.5641 kcal/mol (27656.6934 without restraints) Performing minimization step: 1760. Total energy = 27665.5392 kcal/mol (27639.6716 without restraints) Performing minimization step: 1761. Total energy = 27648.5324 kcal/mol (27622.6677 without restraints) Performing minimization step: 1762. Total energy = 27631.5438 kcal/mol (27605.6822 without restraints) Performing minimization step: 1763. Total energy = 27614.5741 kcal/mol (27588.7156 without restraints) Performing minimization step: 1764. Total energy = 27597.6226 kcal/mol (27571.7671 without restraints) Performing minimization step: 1765. Total energy = 27580.6885 kcal/mol (27554.8360 without restraints) Performing minimization step: 1766. Total energy = 27563.7730 kcal/mol (27537.9235 without restraints) Performing minimization step: 1767. Total energy = 27546.8758 kcal/mol (27521.0293 without restraints) Performing minimization step: 1768. Total energy = 27529.9967 kcal/mol (27504.1532 without restraints) Performing minimization step: 1769. Total energy = 27513.1356 kcal/mol (27487.2952 without restraints) Performing minimization step: 1770. Total energy = 27496.2928 kcal/mol (27470.4555 without restraints) Performing minimization step: 1771. Total energy = 27479.4683 kcal/mol (27453.6339 without restraints) Performing minimization step: 1772. Total energy = 27462.6617 kcal/mol (27436.8302 without restraints) Performing minimization step: 1773. Total energy = 27445.8726 kcal/mol (27420.0442 without restraints) Performing minimization step: 1774. Total energy = 27429.1021 kcal/mol (27403.2768 without restraints) Performing minimization step: 1775. Total energy = 27412.3493 kcal/mol (27386.5269 without restraints) Performing minimization step: 1776. Total energy = 27395.6144 kcal/mol (27369.7950 without restraints) Performing minimization step: 1777. Total energy = 27378.8974 kcal/mol (27353.0810 without restraints) Performing minimization step: 1778. Total energy = 27362.1988 kcal/mol (27336.3855 without restraints) Performing minimization step: 1779. Total energy = 27345.5177 kcal/mol (27319.7072 without restraints) Performing minimization step: 1780. Total energy = 27328.8543 kcal/mol (27303.0469 without restraints) Performing minimization step: 1781. Total energy = 27312.2086 kcal/mol (27286.4041 without restraints) Performing minimization step: 1782. Total energy = 27295.5809 kcal/mol (27269.7795 without restraints) Performing minimization step: 1783. Total energy = 27278.9710 kcal/mol (27253.1725 without restraints) Performing minimization step: 1784. Total energy = 27262.3788 kcal/mol (27236.5832 without restraints) Performing minimization step: 1785. Total energy = 27245.8043 kcal/mol (27220.0118 without restraints) Performing minimization step: 1786. Total energy = 27229.2475 kcal/mol (27203.4579 without restraints) Performing minimization step: 1787. Total energy = 27212.7085 kcal/mol (27186.9218 without restraints) Performing minimization step: 1788. Total energy = 27196.1871 kcal/mol (27170.4033 without restraints) Performing minimization step: 1789. Total energy = 27179.6832 kcal/mol (27153.9024 without restraints) Performing minimization step: 1790. Total energy = 27163.1966 kcal/mol (27137.4187 without restraints) Performing minimization step: 1791. Total energy = 27146.7282 kcal/mol (27120.9534 without restraints) Performing minimization step: 1792. Total energy = 27130.2773 kcal/mol (27104.5054 without restraints) Performing minimization step: 1793. Total energy = 27113.8438 kcal/mol (27088.0748 without restraints) Performing minimization step: 1794. Total energy = 27097.4276 kcal/mol (27071.6615 without restraints) Performing minimization step: 1795. Total energy = 27081.0290 kcal/mol (27055.2659 without restraints) Performing minimization step: 1796. Total energy = 27064.6478 kcal/mol (27038.8876 without restraints) Performing minimization step: 1797. Total energy = 27048.2839 kcal/mol (27022.5264 without restraints) Performing minimization step: 1798. Total energy = 27031.9373 kcal/mol (27006.1829 without restraints) Performing minimization step: 1799. Total energy = 27015.6085 kcal/mol (26989.8570 without restraints) Performing minimization step: 1800. Total energy = 26999.2971 kcal/mol (26973.5486 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1801. Total energy = 26983.0027 kcal/mol (26957.2571 without restraints) Performing minimization step: 1802. Total energy = 26966.7259 kcal/mol (26940.9833 without restraints) Performing minimization step: 1803. Total energy = 26950.4664 kcal/mol (26924.7265 without restraints) Performing minimization step: 1804. Total energy = 26934.2242 kcal/mol (26908.4873 without restraints) Performing minimization step: 1805. Total energy = 26917.9988 kcal/mol (26892.2648 without restraints) Performing minimization step: 1806. Total energy = 26901.7906 kcal/mol (26876.0595 without restraints) Performing minimization step: 1807. Total energy = 26885.5997 kcal/mol (26859.8715 without restraints) Performing minimization step: 1808. Total energy = 26869.4256 kcal/mol (26843.7003 without restraints) Performing minimization step: 1809. Total energy = 26853.2687 kcal/mol (26827.5463 without restraints) Performing minimization step: 1810. Total energy = 26837.1295 kcal/mol (26811.4099 without restraints) Performing minimization step: 1811. Total energy = 26821.0065 kcal/mol (26795.2899 without restraints) Performing minimization step: 1812. Total energy = 26804.9013 kcal/mol (26779.1876 without restraints) Performing minimization step: 1813. Total energy = 26788.8126 kcal/mol (26763.1017 without restraints) Performing minimization step: 1814. Total energy = 26772.7409 kcal/mol (26747.0329 without restraints) Performing minimization step: 1815. Total energy = 26756.6865 kcal/mol (26730.9814 without restraints) Performing minimization step: 1816. Total energy = 26740.6490 kcal/mol (26714.9466 without restraints) Performing minimization step: 1817. Total energy = 26724.6283 kcal/mol (26698.9289 without restraints) Performing minimization step: 1818. Total energy = 26708.6249 kcal/mol (26682.9283 without restraints) Performing minimization step: 1819. Total energy = 26692.6381 kcal/mol (26666.9444 without restraints) Performing minimization step: 1820. Total energy = 26676.6684 kcal/mol (26650.9777 without restraints) Performing minimization step: 1821. Total energy = 26660.7155 kcal/mol (26635.0275 without restraints) Performing minimization step: 1822. Total energy = 26644.7793 kcal/mol (26619.0942 without restraints) Performing minimization step: 1823. Total energy = 26628.8604 kcal/mol (26603.1781 without restraints) Performing minimization step: 1824. Total energy = 26612.9577 kcal/mol (26587.2783 without restraints) Performing minimization step: 1825. Total energy = 26597.0720 kcal/mol (26571.3955 without restraints) Performing minimization step: 1826. Total energy = 26581.2032 kcal/mol (26555.5293 without restraints) Performing minimization step: 1827. Total energy = 26565.3504 kcal/mol (26539.6795 without restraints) Performing minimization step: 1828. Total energy = 26549.5146 kcal/mol (26523.8465 without restraints) Performing minimization step: 1829. Total energy = 26533.6952 kcal/mol (26508.0300 without restraints) Performing minimization step: 1830. Total energy = 26517.8926 kcal/mol (26492.2303 without restraints) Performing minimization step: 1831. Total energy = 26502.1067 kcal/mol (26476.4472 without restraints) Performing minimization step: 1832. Total energy = 26486.3374 kcal/mol (26460.6807 without restraints) Performing minimization step: 1833. Total energy = 26470.5850 kcal/mol (26444.9311 without restraints) Performing minimization step: 1834. Total energy = 26454.8488 kcal/mol (26429.1977 without restraints) Performing minimization step: 1835. Total energy = 26439.1291 kcal/mol (26413.4808 without restraints) Performing minimization step: 1836. Total energy = 26423.4262 kcal/mol (26397.7807 without restraints) Performing minimization step: 1837. Total energy = 26407.7397 kcal/mol (26382.0971 without restraints) Performing minimization step: 1838. Total energy = 26392.0692 kcal/mol (26366.4293 without restraints) Performing minimization step: 1839. Total energy = 26376.4152 kcal/mol (26350.7782 without restraints) Performing minimization step: 1840. Total energy = 26360.7777 kcal/mol (26335.1435 without restraints) Performing minimization step: 1841. Total energy = 26345.1567 kcal/mol (26319.5254 without restraints) Performing minimization step: 1842. Total energy = 26329.5519 kcal/mol (26303.9233 without restraints) Performing minimization step: 1843. Total energy = 26313.9634 kcal/mol (26288.3376 without restraints) Performing minimization step: 1844. Total energy = 26298.3912 kcal/mol (26272.7682 without restraints) Performing minimization step: 1845. Total energy = 26282.8351 kcal/mol (26257.2149 without restraints) Performing minimization step: 1846. Total energy = 26267.2955 kcal/mol (26241.6780 without restraints) Performing minimization step: 1847. Total energy = 26251.7721 kcal/mol (26226.1574 without restraints) Performing minimization step: 1848. Total energy = 26236.2648 kcal/mol (26210.6529 without restraints) Performing minimization step: 1849. Total energy = 26220.7736 kcal/mol (26195.1644 without restraints) Performing minimization step: 1850. Total energy = 26205.2987 kcal/mol (26179.6923 without restraints) Performing minimization step: 1851. Total energy = 26189.8397 kcal/mol (26164.2361 without restraints) Performing minimization step: 1852. Total energy = 26174.3972 kcal/mol (26148.7964 without restraints) Performing minimization step: 1853. Total energy = 26158.9710 kcal/mol (26133.3730 without restraints) Performing minimization step: 1854. Total energy = 26143.5606 kcal/mol (26117.9653 without restraints) Performing minimization step: 1855. Total energy = 26128.1662 kcal/mol (26102.5737 without restraints) Performing minimization step: 1856. Total energy = 26112.7878 kcal/mol (26087.1981 without restraints) Performing minimization step: 1857. Total energy = 26097.4254 kcal/mol (26071.8384 without restraints) Performing minimization step: 1858. Total energy = 26082.0795 kcal/mol (26056.4954 without restraints) Performing minimization step: 1859. Total energy = 26066.7491 kcal/mol (26041.1676 without restraints) Performing minimization step: 1860. Total energy = 26051.4347 kcal/mol (26025.8559 without restraints) Performing minimization step: 1861. Total energy = 26036.1360 kcal/mol (26010.5600 without restraints) Performing minimization step: 1862. Total energy = 26020.8532 kcal/mol (25995.2799 without restraints) Performing minimization step: 1863. Total energy = 26005.5858 kcal/mol (25980.0153 without restraints) Performing minimization step: 1864. Total energy = 25990.3347 kcal/mol (25964.7669 without restraints) Performing minimization step: 1865. Total energy = 25975.0996 kcal/mol (25949.5346 without restraints) Performing minimization step: 1866. Total energy = 25959.8801 kcal/mol (25934.3178 without restraints) Performing minimization step: 1867. Total energy = 25944.6765 kcal/mol (25919.1169 without restraints) Performing minimization step: 1868. Total energy = 25929.4889 kcal/mol (25903.9321 without restraints) Performing minimization step: 1869. Total energy = 25914.3168 kcal/mol (25888.7627 without restraints) Performing minimization step: 1870. Total energy = 25899.1603 kcal/mol (25873.6089 without restraints) Performing minimization step: 1871. Total energy = 25884.0194 kcal/mol (25858.4707 without restraints) Performing minimization step: 1872. Total energy = 25868.8946 kcal/mol (25843.3488 without restraints) Performing minimization step: 1873. Total energy = 25853.7852 kcal/mol (25828.2419 without restraints) Performing minimization step: 1874. Total energy = 25838.6910 kcal/mol (25813.1503 without restraints) Performing minimization step: 1875. Total energy = 25823.6125 kcal/mol (25798.0746 without restraints) Performing minimization step: 1876. Total energy = 25808.5500 kcal/mol (25783.0149 without restraints) Performing minimization step: 1877. Total energy = 25793.5027 kcal/mol (25767.9702 without restraints) Performing minimization step: 1878. Total energy = 25778.4708 kcal/mol (25752.9411 without restraints) Performing minimization step: 1879. Total energy = 25763.4544 kcal/mol (25737.9274 without restraints) Performing minimization step: 1880. Total energy = 25748.4536 kcal/mol (25722.9293 without restraints) Performing minimization step: 1881. Total energy = 25733.4680 kcal/mol (25707.9464 without restraints) Performing minimization step: 1882. Total energy = 25718.4980 kcal/mol (25692.9791 without restraints) Performing minimization step: 1883. Total energy = 25703.5436 kcal/mol (25678.0273 without restraints) Performing minimization step: 1884. Total energy = 25688.6044 kcal/mol (25663.0909 without restraints) Performing minimization step: 1885. Total energy = 25673.6805 kcal/mol (25648.1695 without restraints) Performing minimization step: 1886. Total energy = 25658.7725 kcal/mol (25633.2643 without restraints) Performing minimization step: 1887. Total energy = 25643.8790 kcal/mol (25618.3735 without restraints) Performing minimization step: 1888. Total energy = 25629.0012 kcal/mol (25603.4983 without restraints) Performing minimization step: 1889. Total energy = 25614.1388 kcal/mol (25588.6386 without restraints) Performing minimization step: 1890. Total energy = 25599.2914 kcal/mol (25573.7939 without restraints) Performing minimization step: 1891. Total energy = 25584.4595 kcal/mol (25558.9647 without restraints) Performing minimization step: 1892. Total energy = 25569.6426 kcal/mol (25544.1505 without restraints) Performing minimization step: 1893. Total energy = 25554.8410 kcal/mol (25529.3517 without restraints) Performing minimization step: 1894. Total energy = 25540.0546 kcal/mol (25514.5677 without restraints) Performing minimization step: 1895. Total energy = 25525.2835 kcal/mol (25499.7994 without restraints) Performing minimization step: 1896. Total energy = 25510.5276 kcal/mol (25485.0461 without restraints) Performing minimization step: 1897. Total energy = 25495.7866 kcal/mol (25470.3077 without restraints) Performing minimization step: 1898. Total energy = 25481.0612 kcal/mol (25455.5850 without restraints) Performing minimization step: 1899. Total energy = 25466.3504 kcal/mol (25440.8768 without restraints) Performing minimization step: 1900. Total energy = 25451.6544 kcal/mol (25426.1834 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 1901. Total energy = 25436.9735 kcal/mol (25411.5053 without restraints) Performing minimization step: 1902. Total energy = 25422.3072 kcal/mol (25396.8416 without restraints) Performing minimization step: 1903. Total energy = 25407.6562 kcal/mol (25382.1932 without restraints) Performing minimization step: 1904. Total energy = 25393.0200 kcal/mol (25367.5596 without restraints) Performing minimization step: 1905. Total energy = 25378.3989 kcal/mol (25352.9411 without restraints) Performing minimization step: 1906. Total energy = 25363.7921 kcal/mol (25338.3369 without restraints) Performing minimization step: 1907. Total energy = 25349.2008 kcal/mol (25323.7483 without restraints) Performing minimization step: 1908. Total energy = 25334.6242 kcal/mol (25309.1744 without restraints) Performing minimization step: 1909. Total energy = 25320.0626 kcal/mol (25294.6153 without restraints) Performing minimization step: 1910. Total energy = 25305.5155 kcal/mol (25280.0709 without restraints) Performing minimization step: 1911. Total energy = 25290.9833 kcal/mol (25265.5413 without restraints) Performing minimization step: 1912. Total energy = 25276.4656 kcal/mol (25251.0263 without restraints) Performing minimization step: 1913. Total energy = 25261.9632 kcal/mol (25236.5265 without restraints) Performing minimization step: 1914. Total energy = 25247.4753 kcal/mol (25222.0413 without restraints) Performing minimization step: 1915. Total energy = 25233.0026 kcal/mol (25207.5711 without restraints) Performing minimization step: 1916. Total energy = 25218.5440 kcal/mol (25193.1151 without restraints) Performing minimization step: 1917. Total energy = 25204.1003 kcal/mol (25178.6739 without restraints) Performing minimization step: 1918. Total energy = 25189.6710 kcal/mol (25164.2473 without restraints) Performing minimization step: 1919. Total energy = 25175.2564 kcal/mol (25149.8353 without restraints) Performing minimization step: 1920. Total energy = 25160.8565 kcal/mol (25135.4380 without restraints) Performing minimization step: 1921. Total energy = 25146.4712 kcal/mol (25121.0553 without restraints) Performing minimization step: 1922. Total energy = 25132.1006 kcal/mol (25106.6873 without restraints) Performing minimization step: 1923. Total energy = 25117.7442 kcal/mol (25092.3335 without restraints) Performing minimization step: 1924. Total energy = 25103.4021 kcal/mol (25077.9939 without restraints) Performing minimization step: 1925. Total energy = 25089.0746 kcal/mol (25063.6690 without restraints) Performing minimization step: 1926. Total energy = 25074.7616 kcal/mol (25049.3586 without restraints) Performing minimization step: 1927. Total energy = 25060.4631 kcal/mol (25035.0628 without restraints) Performing minimization step: 1928. Total energy = 25046.1789 kcal/mol (25020.7811 without restraints) Performing minimization step: 1929. Total energy = 25031.9093 kcal/mol (25006.5142 without restraints) Performing minimization step: 1930. Total energy = 25017.6541 kcal/mol (24992.2614 without restraints) Performing minimization step: 1931. Total energy = 25003.4131 kcal/mol (24978.0230 without restraints) Performing minimization step: 1932. Total energy = 24989.1864 kcal/mol (24963.7989 without restraints) Performing minimization step: 1933. Total energy = 24974.9741 kcal/mol (24949.5891 without restraints) Performing minimization step: 1934. Total energy = 24960.7760 kcal/mol (24935.3936 without restraints) Performing minimization step: 1935. Total energy = 24946.5922 kcal/mol (24921.2124 without restraints) Performing minimization step: 1936. Total energy = 24932.4227 kcal/mol (24907.0454 without restraints) Performing minimization step: 1937. Total energy = 24918.2676 kcal/mol (24892.8928 without restraints) Performing minimization step: 1938. Total energy = 24904.1265 kcal/mol (24878.7543 without restraints) Performing minimization step: 1939. Total energy = 24889.9997 kcal/mol (24864.6301 without restraints) Performing minimization step: 1940. Total energy = 24875.8870 kcal/mol (24850.5200 without restraints) Performing minimization step: 1941. Total energy = 24861.7885 kcal/mol (24836.4239 without restraints) Performing minimization step: 1942. Total energy = 24847.7041 kcal/mol (24822.3421 without restraints) Performing minimization step: 1943. Total energy = 24833.6337 kcal/mol (24808.2742 without restraints) Performing minimization step: 1944. Total energy = 24819.5773 kcal/mol (24794.2204 without restraints) Performing minimization step: 1945. Total energy = 24805.5355 kcal/mol (24780.1811 without restraints) Performing minimization step: 1946. Total energy = 24791.5075 kcal/mol (24766.1556 without restraints) Performing minimization step: 1947. Total energy = 24777.4931 kcal/mol (24752.1438 without restraints) Performing minimization step: 1948. Total energy = 24763.4931 kcal/mol (24738.1464 without restraints) Performing minimization step: 1949. Total energy = 24749.5070 kcal/mol (24724.1629 without restraints) Performing minimization step: 1950. Total energy = 24735.5348 kcal/mol (24710.1932 without restraints) Performing minimization step: 1951. Total energy = 24721.5767 kcal/mol (24696.2375 without restraints) Performing minimization step: 1952. Total energy = 24707.6322 kcal/mol (24682.2956 without restraints) Performing minimization step: 1953. Total energy = 24693.7013 kcal/mol (24668.3671 without restraints) Performing minimization step: 1954. Total energy = 24679.7846 kcal/mol (24654.4531 without restraints) Performing minimization step: 1955. Total energy = 24665.8818 kcal/mol (24640.5527 without restraints) Performing minimization step: 1956. Total energy = 24651.9929 kcal/mol (24626.6664 without restraints) Performing minimization step: 1957. Total energy = 24638.1181 kcal/mol (24612.7942 without restraints) Performing minimization step: 1958. Total energy = 24624.2566 kcal/mol (24598.9350 without restraints) Performing minimization step: 1959. Total energy = 24610.4093 kcal/mol (24585.0903 without restraints) Performing minimization step: 1960. Total energy = 24596.5754 kcal/mol (24571.2589 without restraints) Performing minimization step: 1961. Total energy = 24582.7552 kcal/mol (24557.4412 without restraints) Performing minimization step: 1962. Total energy = 24568.9485 kcal/mol (24543.6370 without restraints) Performing minimization step: 1963. Total energy = 24555.1560 kcal/mol (24529.8469 without restraints) Performing minimization step: 1964. Total energy = 24541.3768 kcal/mol (24516.0703 without restraints) Performing minimization step: 1965. Total energy = 24527.6115 kcal/mol (24502.3075 without restraints) Performing minimization step: 1966. Total energy = 24513.8598 kcal/mol (24488.5581 without restraints) Performing minimization step: 1967. Total energy = 24500.1216 kcal/mol (24474.8226 without restraints) Performing minimization step: 1968. Total energy = 24486.3974 kcal/mol (24461.1008 without restraints) Performing minimization step: 1969. Total energy = 24472.6865 kcal/mol (24447.3925 without restraints) Performing minimization step: 1970. Total energy = 24458.9887 kcal/mol (24433.6969 without restraints) Performing minimization step: 1971. Total energy = 24445.3044 kcal/mol (24420.0153 without restraints) Performing minimization step: 1972. Total energy = 24431.6339 kcal/mol (24406.3473 without restraints) Performing minimization step: 1973. Total energy = 24417.9773 kcal/mol (24392.6931 without restraints) Performing minimization step: 1974. Total energy = 24404.3328 kcal/mol (24379.0511 without restraints) Performing minimization step: 1975. Total energy = 24390.7026 kcal/mol (24365.4234 without restraints) Performing minimization step: 1976. Total energy = 24377.0858 kcal/mol (24351.8091 without restraints) Performing minimization step: 1977. Total energy = 24363.4824 kcal/mol (24338.2081 without restraints) Performing minimization step: 1978. Total energy = 24349.8924 kcal/mol (24324.6206 without restraints) Performing minimization step: 1979. Total energy = 24336.3158 kcal/mol (24311.0464 without restraints) Performing minimization step: 1980. Total energy = 24322.7520 kcal/mol (24297.4851 without restraints) Performing minimization step: 1981. Total energy = 24309.2020 kcal/mol (24283.9376 without restraints) Performing minimization step: 1982. Total energy = 24295.6655 kcal/mol (24270.4035 without restraints) Performing minimization step: 1983. Total energy = 24282.1419 kcal/mol (24256.8824 without restraints) Performing minimization step: 1984. Total energy = 24268.6316 kcal/mol (24243.3746 without restraints) Performing minimization step: 1985. Total energy = 24255.1345 kcal/mol (24229.8799 without restraints) Performing minimization step: 1986. Total energy = 24241.6507 kcal/mol (24216.3986 without restraints) Performing minimization step: 1987. Total energy = 24228.1802 kcal/mol (24202.9305 without restraints) Performing minimization step: 1988. Total energy = 24214.7228 kcal/mol (24189.4756 without restraints) Performing minimization step: 1989. Total energy = 24201.2786 kcal/mol (24176.0338 without restraints) Performing minimization step: 1990. Total energy = 24187.8477 kcal/mol (24162.6054 without restraints) Performing minimization step: 1991. Total energy = 24174.4300 kcal/mol (24149.1901 without restraints) Performing minimization step: 1992. Total energy = 24161.0252 kcal/mol (24135.7877 without restraints) Performing minimization step: 1993. Total energy = 24147.6334 kcal/mol (24122.3983 without restraints) Performing minimization step: 1994. Total energy = 24134.2547 kcal/mol (24109.0221 without restraints) Performing minimization step: 1995. Total energy = 24120.8890 kcal/mol (24095.6588 without restraints) Performing minimization step: 1996. Total energy = 24107.5363 kcal/mol (24082.3086 without restraints) Performing minimization step: 1997. Total energy = 24094.1963 kcal/mol (24068.9710 without restraints) Performing minimization step: 1998. Total energy = 24080.8696 kcal/mol (24055.6467 without restraints) Performing minimization step: 1999. Total energy = 24067.5562 kcal/mol (24042.3358 without restraints) Performing minimization step: 2000. Total energy = 24054.2554 kcal/mol (24029.0373 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2001. Total energy = 24040.9678 kcal/mol (24015.7522 without restraints) Performing minimization step: 2002. Total energy = 24027.6927 kcal/mol (24002.4795 without restraints) Performing minimization step: 2003. Total energy = 24014.4305 kcal/mol (23989.2197 without restraints) Performing minimization step: 2004. Total energy = 24001.1810 kcal/mol (23975.9725 without restraints) Performing minimization step: 2005. Total energy = 23987.9443 kcal/mol (23962.7384 without restraints) Performing minimization step: 2006. Total energy = 23974.7206 kcal/mol (23949.5170 without restraints) Performing minimization step: 2007. Total energy = 23961.5097 kcal/mol (23936.3085 without restraints) Performing minimization step: 2008. Total energy = 23948.3114 kcal/mol (23923.1125 without restraints) Performing minimization step: 2009. Total energy = 23935.1259 kcal/mol (23909.9295 without restraints) Performing minimization step: 2010. Total energy = 23921.9534 kcal/mol (23896.7595 without restraints) Performing minimization step: 2011. Total energy = 23908.7935 kcal/mol (23883.6018 without restraints) Performing minimization step: 2012. Total energy = 23895.6461 kcal/mol (23870.4570 without restraints) Performing minimization step: 2013. Total energy = 23882.5117 kcal/mol (23857.3250 without restraints) Performing minimization step: 2014. Total energy = 23869.3905 kcal/mol (23844.2062 without restraints) Performing minimization step: 2015. Total energy = 23856.2813 kcal/mol (23831.0993 without restraints) Performing minimization step: 2016. Total energy = 23843.1847 kcal/mol (23818.0050 without restraints) Performing minimization step: 2017. Total energy = 23830.1006 kcal/mol (23804.9234 without restraints) Performing minimization step: 2018. Total energy = 23817.0290 kcal/mol (23791.8542 without restraints) Performing minimization step: 2019. Total energy = 23803.9701 kcal/mol (23778.7976 without restraints) Performing minimization step: 2020. Total energy = 23790.9235 kcal/mol (23765.7534 without restraints) Performing minimization step: 2021. Total energy = 23777.8896 kcal/mol (23752.7219 without restraints) Performing minimization step: 2022. Total energy = 23764.8685 kcal/mol (23739.7032 without restraints) Performing minimization step: 2023. Total energy = 23751.8598 kcal/mol (23726.6969 without restraints) Performing minimization step: 2024. Total energy = 23738.8634 kcal/mol (23713.7028 without restraints) Performing minimization step: 2025. Total energy = 23725.8792 kcal/mol (23700.7210 without restraints) Performing minimization step: 2026. Total energy = 23712.9076 kcal/mol (23687.7518 without restraints) Performing minimization step: 2027. Total energy = 23699.9484 kcal/mol (23674.7951 without restraints) Performing minimization step: 2028. Total energy = 23687.0016 kcal/mol (23661.8505 without restraints) Performing minimization step: 2029. Total energy = 23674.0673 kcal/mol (23648.9186 without restraints) Performing minimization step: 2030. Total energy = 23661.1452 kcal/mol (23635.9988 without restraints) Performing minimization step: 2031. Total energy = 23648.2354 kcal/mol (23623.0913 without restraints) Performing minimization step: 2032. Total energy = 23635.3379 kcal/mol (23610.1963 without restraints) Performing minimization step: 2033. Total energy = 23622.4532 kcal/mol (23597.3139 without restraints) Performing minimization step: 2034. Total energy = 23609.5804 kcal/mol (23584.4434 without restraints) Performing minimization step: 2035. Total energy = 23596.7197 kcal/mol (23571.5851 without restraints) Performing minimization step: 2036. Total energy = 23583.8713 kcal/mol (23558.7391 without restraints) Performing minimization step: 2037. Total energy = 23571.0353 kcal/mol (23545.9054 without restraints) Performing minimization step: 2038. Total energy = 23558.2112 kcal/mol (23533.0837 without restraints) Performing minimization step: 2039. Total energy = 23545.3993 kcal/mol (23520.2741 without restraints) Performing minimization step: 2040. Total energy = 23532.5993 kcal/mol (23507.4764 without restraints) Performing minimization step: 2041. Total energy = 23519.8117 kcal/mol (23494.6911 without restraints) Performing minimization step: 2042. Total energy = 23507.0362 kcal/mol (23481.9180 without restraints) Performing minimization step: 2043. Total energy = 23494.2733 kcal/mol (23469.1574 without restraints) Performing minimization step: 2044. Total energy = 23481.5218 kcal/mol (23456.4082 without restraints) Performing minimization step: 2045. Total energy = 23468.7826 kcal/mol (23443.6714 without restraints) Performing minimization step: 2046. Total energy = 23456.0552 kcal/mol (23430.9462 without restraints) Performing minimization step: 2047. Total energy = 23443.3398 kcal/mol (23418.2332 without restraints) Performing minimization step: 2048. Total energy = 23430.6366 kcal/mol (23405.5325 without restraints) Performing minimization step: 2049. Total energy = 23417.9455 kcal/mol (23392.8436 without restraints) Performing minimization step: 2050. Total energy = 23405.2662 kcal/mol (23380.1666 without restraints) Performing minimization step: 2051. Total energy = 23392.5988 kcal/mol (23367.5015 without restraints) Performing minimization step: 2052. Total energy = 23379.9433 kcal/mol (23354.8484 without restraints) Performing minimization step: 2053. Total energy = 23367.2999 kcal/mol (23342.2073 without restraints) Performing minimization step: 2054. Total energy = 23354.6682 kcal/mol (23329.5780 without restraints) Performing minimization step: 2055. Total energy = 23342.0484 kcal/mol (23316.9604 without restraints) Performing minimization step: 2056. Total energy = 23329.4405 kcal/mol (23304.3548 without restraints) Performing minimization step: 2057. Total energy = 23316.8439 kcal/mol (23291.7604 without restraints) Performing minimization step: 2058. Total energy = 23304.2596 kcal/mol (23279.1787 without restraints) Performing minimization step: 2059. Total energy = 23291.6872 kcal/mol (23266.6084 without restraints) Performing minimization step: 2060. Total energy = 23279.1264 kcal/mol (23254.0499 without restraints) Performing minimization step: 2061. Total energy = 23266.5774 kcal/mol (23241.5032 without restraints) Performing minimization step: 2062. Total energy = 23254.0402 kcal/mol (23228.9684 without restraints) Performing minimization step: 2063. Total energy = 23241.5146 kcal/mol (23216.4451 without restraints) Performing minimization step: 2064. Total energy = 23229.0006 kcal/mol (23203.9334 without restraints) Performing minimization step: 2065. Total energy = 23216.4986 kcal/mol (23191.4336 without restraints) Performing minimization step: 2066. Total energy = 23204.0087 kcal/mol (23178.9461 without restraints) Performing minimization step: 2067. Total energy = 23191.5300 kcal/mol (23166.4698 without restraints) Performing minimization step: 2068. Total energy = 23179.0628 kcal/mol (23154.0047 without restraints) Performing minimization step: 2069. Total energy = 23166.6071 kcal/mol (23141.5513 without restraints) Performing minimization step: 2070. Total energy = 23154.1626 kcal/mol (23129.1091 without restraints) Performing minimization step: 2071. Total energy = 23141.7300 kcal/mol (23116.6787 without restraints) Performing minimization step: 2072. Total energy = 23129.3092 kcal/mol (23104.2604 without restraints) Performing minimization step: 2073. Total energy = 23116.9001 kcal/mol (23091.8534 without restraints) Performing minimization step: 2074. Total energy = 23104.5020 kcal/mol (23079.4576 without restraints) Performing minimization step: 2075. Total energy = 23092.1154 kcal/mol (23067.0733 without restraints) Performing minimization step: 2076. Total energy = 23079.7407 kcal/mol (23054.7009 without restraints) Performing minimization step: 2077. Total energy = 23067.3768 kcal/mol (23042.3393 without restraints) Performing minimization step: 2078. Total energy = 23055.0249 kcal/mol (23029.9896 without restraints) Performing minimization step: 2079. Total energy = 23042.6836 kcal/mol (23017.6506 without restraints) Performing minimization step: 2080. Total energy = 23030.3542 kcal/mol (23005.3234 without restraints) Performing minimization step: 2081. Total energy = 23018.0361 kcal/mol (22993.0077 without restraints) Performing minimization step: 2082. Total energy = 23005.7290 kcal/mol (22980.7028 without restraints) Performing minimization step: 2083. Total energy = 22993.4336 kcal/mol (22968.4097 without restraints) Performing minimization step: 2084. Total energy = 22981.1496 kcal/mol (22956.1279 without restraints) Performing minimization step: 2085. Total energy = 22968.8769 kcal/mol (22943.8574 without restraints) Performing minimization step: 2086. Total energy = 22956.6153 kcal/mol (22931.5981 without restraints) Performing minimization step: 2087. Total energy = 22944.3652 kcal/mol (22919.3503 without restraints) Performing minimization step: 2088. Total energy = 22932.1261 kcal/mol (22907.1133 without restraints) Performing minimization step: 2089. Total energy = 22919.8982 kcal/mol (22894.8878 without restraints) Performing minimization step: 2090. Total energy = 22907.6816 kcal/mol (22882.6734 without restraints) Performing minimization step: 2091. Total energy = 22895.4762 kcal/mol (22870.4703 without restraints) Performing minimization step: 2092. Total energy = 22883.2819 kcal/mol (22858.2782 without restraints) Performing minimization step: 2093. Total energy = 22871.0991 kcal/mol (22846.0976 without restraints) Performing minimization step: 2094. Total energy = 22858.9273 kcal/mol (22833.9281 without restraints) Performing minimization step: 2095. Total energy = 22846.7666 kcal/mol (22821.7696 without restraints) Performing minimization step: 2096. Total energy = 22834.6169 kcal/mol (22809.6222 without restraints) Performing minimization step: 2097. Total energy = 22822.4784 kcal/mol (22797.4860 without restraints) Performing minimization step: 2098. Total energy = 22810.3511 kcal/mol (22785.3609 without restraints) Performing minimization step: 2099. Total energy = 22798.2343 kcal/mol (22773.2462 without restraints) Performing minimization step: 2100. Total energy = 22786.1289 kcal/mol (22761.1431 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2101. Total energy = 22774.0349 kcal/mol (22749.0513 without restraints) Performing minimization step: 2102. Total energy = 22761.9514 kcal/mol (22736.9701 without restraints) Performing minimization step: 2103. Total energy = 22749.8789 kcal/mol (22724.8998 without restraints) Performing minimization step: 2104. Total energy = 22737.8172 kcal/mol (22712.8402 without restraints) Performing minimization step: 2105. Total energy = 22725.7664 kcal/mol (22700.7918 without restraints) Performing minimization step: 2106. Total energy = 22713.7269 kcal/mol (22688.7545 without restraints) Performing minimization step: 2107. Total energy = 22701.6980 kcal/mol (22676.7278 without restraints) Performing minimization step: 2108. Total energy = 22689.6801 kcal/mol (22664.7121 without restraints) Performing minimization step: 2109. Total energy = 22677.6730 kcal/mol (22652.7073 without restraints) Performing minimization step: 2110. Total energy = 22665.6769 kcal/mol (22640.7134 without restraints) Performing minimization step: 2111. Total energy = 22653.6915 kcal/mol (22628.7302 without restraints) Performing minimization step: 2112. Total energy = 22641.7172 kcal/mol (22616.7581 without restraints) Performing minimization step: 2113. Total energy = 22629.7534 kcal/mol (22604.7965 without restraints) Performing minimization step: 2114. Total energy = 22617.8002 kcal/mol (22592.8455 without restraints) Performing minimization step: 2115. Total energy = 22605.8577 kcal/mol (22580.9052 without restraints) Performing minimization step: 2116. Total energy = 22593.9262 kcal/mol (22568.9760 without restraints) Performing minimization step: 2117. Total energy = 22582.0056 kcal/mol (22557.0575 without restraints) Performing minimization step: 2118. Total energy = 22570.0960 kcal/mol (22545.1502 without restraints) Performing minimization step: 2119. Total energy = 22558.1968 kcal/mol (22533.2531 without restraints) Performing minimization step: 2120. Total energy = 22546.3077 kcal/mol (22521.3662 without restraints) Performing minimization step: 2121. Total energy = 22534.4295 kcal/mol (22509.4902 without restraints) Performing minimization step: 2122. Total energy = 22522.5623 kcal/mol (22497.6251 without restraints) Performing minimization step: 2123. Total energy = 22510.7053 kcal/mol (22485.7703 without restraints) Performing minimization step: 2124. Total energy = 22498.8593 kcal/mol (22473.9265 without restraints) Performing minimization step: 2125. Total energy = 22487.0234 kcal/mol (22462.0929 without restraints) Performing minimization step: 2126. Total energy = 22475.1981 kcal/mol (22450.2700 without restraints) Performing minimization step: 2127. Total energy = 22463.3835 kcal/mol (22438.4573 without restraints) Performing minimization step: 2128. Total energy = 22451.5793 kcal/mol (22426.6553 without restraints) Performing minimization step: 2129. Total energy = 22439.7857 kcal/mol (22414.8639 without restraints) Performing minimization step: 2130. Total energy = 22428.0024 kcal/mol (22403.0828 without restraints) Performing minimization step: 2131. Total energy = 22416.2296 kcal/mol (22391.3121 without restraints) Performing minimization step: 2132. Total energy = 22404.4673 kcal/mol (22379.5520 without restraints) Performing minimization step: 2133. Total energy = 22392.7157 kcal/mol (22367.8028 without restraints) Performing minimization step: 2134. Total energy = 22380.9745 kcal/mol (22356.0635 without restraints) Performing minimization step: 2135. Total energy = 22369.2428 kcal/mol (22344.3340 without restraints) Performing minimization step: 2136. Total energy = 22357.5219 kcal/mol (22332.6153 without restraints) Performing minimization step: 2137. Total energy = 22345.8112 kcal/mol (22320.9068 without restraints) Performing minimization step: 2138. Total energy = 22334.1107 kcal/mol (22309.2084 without restraints) Performing minimization step: 2139. Total energy = 22322.4211 kcal/mol (22297.5210 without restraints) Performing minimization step: 2140. Total energy = 22310.7419 kcal/mol (22285.8440 without restraints) Performing minimization step: 2141. Total energy = 22299.0728 kcal/mol (22274.1772 without restraints) Performing minimization step: 2142. Total energy = 22287.4146 kcal/mol (22262.5210 without restraints) Performing minimization step: 2143. Total energy = 22275.7659 kcal/mol (22250.8745 without restraints) Performing minimization step: 2144. Total energy = 22264.1278 kcal/mol (22239.2386 without restraints) Performing minimization step: 2145. Total energy = 22252.4996 kcal/mol (22227.6125 without restraints) Performing minimization step: 2146. Total energy = 22240.8816 kcal/mol (22215.9967 without restraints) Performing minimization step: 2147. Total energy = 22229.2738 kcal/mol (22204.3910 without restraints) Performing minimization step: 2148. Total energy = 22217.6764 kcal/mol (22192.7959 without restraints) Performing minimization step: 2149. Total energy = 22206.0891 kcal/mol (22181.2105 without restraints) Performing minimization step: 2150. Total energy = 22194.5118 kcal/mol (22169.6354 without restraints) Performing minimization step: 2151. Total energy = 22182.9447 kcal/mol (22158.0705 without restraints) Performing minimization step: 2152. Total energy = 22171.3877 kcal/mol (22146.5156 without restraints) Performing minimization step: 2153. Total energy = 22159.8405 kcal/mol (22134.9706 without restraints) Performing minimization step: 2154. Total energy = 22148.3036 kcal/mol (22123.4358 without restraints) Performing minimization step: 2155. Total energy = 22136.7767 kcal/mol (22111.9111 without restraints) Performing minimization step: 2156. Total energy = 22125.2597 kcal/mol (22100.3962 without restraints) Performing minimization step: 2157. Total energy = 22113.7527 kcal/mol (22088.8913 without restraints) Performing minimization step: 2158. Total energy = 22102.2554 kcal/mol (22077.3962 without restraints) Performing minimization step: 2159. Total energy = 22090.7683 kcal/mol (22065.9111 without restraints) Performing minimization step: 2160. Total energy = 22079.2911 kcal/mol (22054.4362 without restraints) Performing minimization step: 2161. Total energy = 22067.8240 kcal/mol (22042.9712 without restraints) Performing minimization step: 2162. Total energy = 22056.3670 kcal/mol (22031.5163 without restraints) Performing minimization step: 2163. Total energy = 22044.9196 kcal/mol (22020.0710 without restraints) Performing minimization step: 2164. Total energy = 22033.4823 kcal/mol (22008.6358 without restraints) Performing minimization step: 2165. Total energy = 22022.0542 kcal/mol (21997.2099 without restraints) Performing minimization step: 2166. Total energy = 22010.6364 kcal/mol (21985.7941 without restraints) Performing minimization step: 2167. Total energy = 21999.2284 kcal/mol (21974.3882 without restraints) Performing minimization step: 2168. Total energy = 21987.8304 kcal/mol (21962.9924 without restraints) Performing minimization step: 2169. Total energy = 21976.4423 kcal/mol (21951.6064 without restraints) Performing minimization step: 2170. Total energy = 21965.0638 kcal/mol (21940.2300 without restraints) Performing minimization step: 2171. Total energy = 21953.6950 kcal/mol (21928.8635 without restraints) Performing minimization step: 2172. Total energy = 21942.3362 kcal/mol (21917.5067 without restraints) Performing minimization step: 2173. Total energy = 21930.9868 kcal/mol (21906.1595 without restraints) Performing minimization step: 2174. Total energy = 21919.6474 kcal/mol (21894.8221 without restraints) Performing minimization step: 2175. Total energy = 21908.3173 kcal/mol (21883.4941 without restraints) Performing minimization step: 2176. Total energy = 21896.9969 kcal/mol (21872.1758 without restraints) Performing minimization step: 2177. Total energy = 21885.6862 kcal/mol (21860.8672 without restraints) Performing minimization step: 2178. Total energy = 21874.3854 kcal/mol (21849.5685 without restraints) Performing minimization step: 2179. Total energy = 21863.0942 kcal/mol (21838.2794 without restraints) Performing minimization step: 2180. Total energy = 21851.8123 kcal/mol (21826.9996 without restraints) Performing minimization step: 2181. Total energy = 21840.5401 kcal/mol (21815.7294 without restraints) Performing minimization step: 2182. Total energy = 21829.2771 kcal/mol (21804.4688 without restraints) Performing minimization step: 2183. Total energy = 21818.0242 kcal/mol (21793.2178 without restraints) Performing minimization step: 2184. Total energy = 21806.7809 kcal/mol (21781.9766 without restraints) Performing minimization step: 2185. Total energy = 21795.5468 kcal/mol (21770.7446 without restraints) Performing minimization step: 2186. Total energy = 21784.3226 kcal/mol (21759.5225 without restraints) Performing minimization step: 2187. Total energy = 21773.1077 kcal/mol (21748.3095 without restraints) Performing minimization step: 2188. Total energy = 21761.9023 kcal/mol (21737.1065 without restraints) Performing minimization step: 2189. Total energy = 21750.7064 kcal/mol (21725.9125 without restraints) Performing minimization step: 2190. Total energy = 21739.5196 kcal/mol (21714.7278 without restraints) Performing minimization step: 2191. Total energy = 21728.3425 kcal/mol (21703.5528 without restraints) Performing minimization step: 2192. Total energy = 21717.1747 kcal/mol (21692.3870 without restraints) Performing minimization step: 2193. Total energy = 21706.0162 kcal/mol (21681.2307 without restraints) Performing minimization step: 2194. Total energy = 21694.8669 kcal/mol (21670.0834 without restraints) Performing minimization step: 2195. Total energy = 21683.7269 kcal/mol (21658.9455 without restraints) Performing minimization step: 2196. Total energy = 21672.5964 kcal/mol (21647.8171 without restraints) Performing minimization step: 2197. Total energy = 21661.4751 kcal/mol (21636.6978 without restraints) Performing minimization step: 2198. Total energy = 21650.3631 kcal/mol (21625.5880 without restraints) Performing minimization step: 2199. Total energy = 21639.2607 kcal/mol (21614.4876 without restraints) Performing minimization step: 2200. Total energy = 21628.1673 kcal/mol (21603.3962 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2201. Total energy = 21617.0831 kcal/mol (21592.3141 without restraints) Performing minimization step: 2202. Total energy = 21606.0082 kcal/mol (21581.2413 without restraints) Performing minimization step: 2203. Total energy = 21594.9430 kcal/mol (21570.1783 without restraints) Performing minimization step: 2204. Total energy = 21583.8868 kcal/mol (21559.1240 without restraints) Performing minimization step: 2205. Total energy = 21572.8394 kcal/mol (21548.0786 without restraints) Performing minimization step: 2206. Total energy = 21561.8011 kcal/mol (21537.0425 without restraints) Performing minimization step: 2207. Total energy = 21550.7723 kcal/mol (21526.0157 without restraints) Performing minimization step: 2208. Total energy = 21539.7525 kcal/mol (21514.9980 without restraints) Performing minimization step: 2209. Total energy = 21528.7417 kcal/mol (21503.9892 without restraints) Performing minimization step: 2210. Total energy = 21517.7400 kcal/mol (21492.9895 without restraints) Performing minimization step: 2211. Total energy = 21506.7475 kcal/mol (21481.9991 without restraints) Performing minimization step: 2212. Total energy = 21495.7639 kcal/mol (21471.0175 without restraints) Performing minimization step: 2213. Total energy = 21484.7892 kcal/mol (21460.0449 without restraints) Performing minimization step: 2214. Total energy = 21473.8236 kcal/mol (21449.0814 without restraints) Performing minimization step: 2215. Total energy = 21462.8669 kcal/mol (21438.1266 without restraints) Performing minimization step: 2216. Total energy = 21451.9195 kcal/mol (21427.1814 without restraints) Performing minimization step: 2217. Total energy = 21440.9808 kcal/mol (21416.2447 without restraints) Performing minimization step: 2218. Total energy = 21430.0512 kcal/mol (21405.3170 without restraints) Performing minimization step: 2219. Total energy = 21419.1303 kcal/mol (21394.3981 without restraints) Performing minimization step: 2220. Total energy = 21408.2184 kcal/mol (21383.4884 without restraints) Performing minimization step: 2221. Total energy = 21397.3156 kcal/mol (21372.5876 without restraints) Performing minimization step: 2222. Total energy = 21386.4218 kcal/mol (21361.6958 without restraints) Performing minimization step: 2223. Total energy = 21375.5367 kcal/mol (21350.8127 without restraints) Performing minimization step: 2224. Total energy = 21364.6603 kcal/mol (21339.9384 without restraints) Performing minimization step: 2225. Total energy = 21353.7929 kcal/mol (21329.0731 without restraints) Performing minimization step: 2226. Total energy = 21342.9344 kcal/mol (21318.2165 without restraints) Performing minimization step: 2227. Total energy = 21332.0853 kcal/mol (21307.3695 without restraints) Performing minimization step: 2228. Total energy = 21321.2443 kcal/mol (21296.5306 without restraints) Performing minimization step: 2229. Total energy = 21310.4121 kcal/mol (21285.7004 without restraints) Performing minimization step: 2230. Total energy = 21299.5881 kcal/mol (21274.8784 without restraints) Performing minimization step: 2231. Total energy = 21288.7733 kcal/mol (21264.0656 without restraints) Performing minimization step: 2232. Total energy = 21277.9673 kcal/mol (21253.2616 without restraints) Performing minimization step: 2233. Total energy = 21267.1701 kcal/mol (21242.4664 without restraints) Performing minimization step: 2234. Total energy = 21256.3815 kcal/mol (21231.6798 without restraints) Performing minimization step: 2235. Total energy = 21245.6015 kcal/mol (21220.9019 without restraints) Performing minimization step: 2236. Total energy = 21234.8305 kcal/mol (21210.1328 without restraints) Performing minimization step: 2237. Total energy = 21224.0681 kcal/mol (21199.3725 without restraints) Performing minimization step: 2238. Total energy = 21213.3140 kcal/mol (21188.6204 without restraints) Performing minimization step: 2239. Total energy = 21202.5686 kcal/mol (21177.8770 without restraints) Performing minimization step: 2240. Total energy = 21191.8322 kcal/mol (21167.1426 without restraints) Performing minimization step: 2241. Total energy = 21181.1040 kcal/mol (21156.4164 without restraints) Performing minimization step: 2242. Total energy = 21170.3844 kcal/mol (21145.6988 without restraints) Performing minimization step: 2243. Total energy = 21159.6731 kcal/mol (21134.9895 without restraints) Performing minimization step: 2244. Total energy = 21148.9704 kcal/mol (21124.2889 without restraints) Performing minimization step: 2245. Total energy = 21138.2764 kcal/mol (21113.5968 without restraints) Performing minimization step: 2246. Total energy = 21127.5906 kcal/mol (21102.9128 without restraints) Performing minimization step: 2247. Total energy = 21116.9136 kcal/mol (21092.2380 without restraints) Performing minimization step: 2248. Total energy = 21106.2451 kcal/mol (21081.5715 without restraints) Performing minimization step: 2249. Total energy = 21095.5852 kcal/mol (21070.9136 without restraints) Performing minimization step: 2250. Total energy = 21084.9336 kcal/mol (21060.2642 without restraints) Performing minimization step: 2251. Total energy = 21074.2903 kcal/mol (21049.6227 without restraints) Performing minimization step: 2252. Total energy = 21063.6554 kcal/mol (21038.9898 without restraints) Performing minimization step: 2253. Total energy = 21053.0289 kcal/mol (21028.3653 without restraints) Performing minimization step: 2254. Total energy = 21042.4109 kcal/mol (21017.7493 without restraints) Performing minimization step: 2255. Total energy = 21031.8010 kcal/mol (21007.1413 without restraints) Performing minimization step: 2256. Total energy = 21021.1994 kcal/mol (20996.5417 without restraints) Performing minimization step: 2257. Total energy = 21010.6059 kcal/mol (20985.9501 without restraints) Performing minimization step: 2258. Total energy = 21000.0208 kcal/mol (20975.3671 without restraints) Performing minimization step: 2259. Total energy = 20989.4445 kcal/mol (20964.7927 without restraints) Performing minimization step: 2260. Total energy = 20978.8760 kcal/mol (20954.2262 without restraints) Performing minimization step: 2261. Total energy = 20968.3158 kcal/mol (20943.6680 without restraints) Performing minimization step: 2262. Total energy = 20957.7638 kcal/mol (20933.1180 without restraints) Performing minimization step: 2263. Total energy = 20947.2201 kcal/mol (20922.5762 without restraints) Performing minimization step: 2264. Total energy = 20936.6845 kcal/mol (20912.0427 without restraints) Performing minimization step: 2265. Total energy = 20926.1571 kcal/mol (20901.5170 without restraints) Performing minimization step: 2266. Total energy = 20915.6377 kcal/mol (20890.9998 without restraints) Performing minimization step: 2267. Total energy = 20905.1270 kcal/mol (20880.4911 without restraints) Performing minimization step: 2268. Total energy = 20894.6242 kcal/mol (20869.9902 without restraints) Performing minimization step: 2269. Total energy = 20884.1295 kcal/mol (20859.4975 without restraints) Performing minimization step: 2270. Total energy = 20873.6429 kcal/mol (20849.0128 without restraints) Performing minimization step: 2271. Total energy = 20863.1646 kcal/mol (20838.5366 without restraints) Performing minimization step: 2272. Total energy = 20852.6942 kcal/mol (20828.0680 without restraints) Performing minimization step: 2273. Total energy = 20842.2319 kcal/mol (20817.6078 without restraints) Performing minimization step: 2274. Total energy = 20831.7780 kcal/mol (20807.1558 without restraints) Performing minimization step: 2275. Total energy = 20821.3317 kcal/mol (20796.7112 without restraints) Performing minimization step: 2276. Total energy = 20810.8931 kcal/mol (20786.2748 without restraints) Performing minimization step: 2277. Total energy = 20800.4627 kcal/mol (20775.8463 without restraints) Performing minimization step: 2278. Total energy = 20790.0404 kcal/mol (20765.4260 without restraints) Performing minimization step: 2279. Total energy = 20779.6258 kcal/mol (20755.0134 without restraints) Performing minimization step: 2280. Total energy = 20769.2194 kcal/mol (20744.6089 without restraints) Performing minimization step: 2281. Total energy = 20758.8208 kcal/mol (20734.2122 without restraints) Performing minimization step: 2282. Total energy = 20748.4299 kcal/mol (20723.8233 without restraints) Performing minimization step: 2283. Total energy = 20738.0470 kcal/mol (20713.4421 without restraints) Performing minimization step: 2284. Total energy = 20727.6719 kcal/mol (20703.0691 without restraints) Performing minimization step: 2285. Total energy = 20717.3049 kcal/mol (20692.7040 without restraints) Performing minimization step: 2286. Total energy = 20706.9459 kcal/mol (20682.3470 without restraints) Performing minimization step: 2287. Total energy = 20696.5945 kcal/mol (20671.9976 without restraints) Performing minimization step: 2288. Total energy = 20686.2508 kcal/mol (20661.6558 without restraints) Performing minimization step: 2289. Total energy = 20675.9149 kcal/mol (20651.3218 without restraints) Performing minimization step: 2290. Total energy = 20665.5873 kcal/mol (20640.9962 without restraints) Performing minimization step: 2291. Total energy = 20655.2673 kcal/mol (20630.6781 without restraints) Performing minimization step: 2292. Total energy = 20644.9549 kcal/mol (20620.3676 without restraints) Performing minimization step: 2293. Total energy = 20634.6504 kcal/mol (20610.0651 without restraints) Performing minimization step: 2294. Total energy = 20624.3532 kcal/mol (20599.7698 without restraints) Performing minimization step: 2295. Total energy = 20614.0640 kcal/mol (20589.4825 without restraints) Performing minimization step: 2296. Total energy = 20603.7820 kcal/mol (20579.2025 without restraints) Performing minimization step: 2297. Total energy = 20593.5081 kcal/mol (20568.9305 without restraints) Performing minimization step: 2298. Total energy = 20583.2419 kcal/mol (20558.6662 without restraints) Performing minimization step: 2299. Total energy = 20572.9833 kcal/mol (20548.4095 without restraints) Performing minimization step: 2300. Total energy = 20562.7321 kcal/mol (20538.1603 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2301. Total energy = 20552.4886 kcal/mol (20527.9186 without restraints) Performing minimization step: 2302. Total energy = 20542.2528 kcal/mol (20517.6847 without restraints) Performing minimization step: 2303. Total energy = 20532.0246 kcal/mol (20507.4585 without restraints) Performing minimization step: 2304. Total energy = 20521.8037 kcal/mol (20497.2395 without restraints) Performing minimization step: 2305. Total energy = 20511.5908 kcal/mol (20487.0285 without restraints) Performing minimization step: 2306. Total energy = 20501.3853 kcal/mol (20476.8249 without restraints) Performing minimization step: 2307. Total energy = 20491.1877 kcal/mol (20466.6293 without restraints) Performing minimization step: 2308. Total energy = 20480.9973 kcal/mol (20456.4407 without restraints) Performing minimization step: 2309. Total energy = 20470.8145 kcal/mol (20446.2598 without restraints) Performing minimization step: 2310. Total energy = 20460.6390 kcal/mol (20436.0863 without restraints) Performing minimization step: 2311. Total energy = 20450.4710 kcal/mol (20425.9201 without restraints) Performing minimization step: 2312. Total energy = 20440.3101 kcal/mol (20415.7612 without restraints) Performing minimization step: 2313. Total energy = 20430.1572 kcal/mol (20405.6101 without restraints) Performing minimization step: 2314. Total energy = 20420.0112 kcal/mol (20395.4660 without restraints) Performing minimization step: 2315. Total energy = 20409.8728 kcal/mol (20385.3297 without restraints) Performing minimization step: 2316. Total energy = 20399.7421 kcal/mol (20375.2008 without restraints) Performing minimization step: 2317. Total energy = 20389.6185 kcal/mol (20365.0790 without restraints) Performing minimization step: 2318. Total energy = 20379.5020 kcal/mol (20354.9644 without restraints) Performing minimization step: 2319. Total energy = 20369.3930 kcal/mol (20344.8573 without restraints) Performing minimization step: 2320. Total energy = 20359.2915 kcal/mol (20334.7578 without restraints) Performing minimization step: 2321. Total energy = 20349.1972 kcal/mol (20324.6655 without restraints) Performing minimization step: 2322. Total energy = 20339.1103 kcal/mol (20314.5802 without restraints) Performing minimization step: 2323. Total energy = 20329.0307 kcal/mol (20304.5026 without restraints) Performing minimization step: 2324. Total energy = 20318.9582 kcal/mol (20294.4320 without restraints) Performing minimization step: 2325. Total energy = 20308.8929 kcal/mol (20284.3686 without restraints) Performing minimization step: 2326. Total energy = 20298.8349 kcal/mol (20274.3125 without restraints) Performing minimization step: 2327. Total energy = 20288.7841 kcal/mol (20264.2635 without restraints) Performing minimization step: 2328. Total energy = 20278.7407 kcal/mol (20254.2219 without restraints) Performing minimization step: 2329. Total energy = 20268.7042 kcal/mol (20244.1874 without restraints) Performing minimization step: 2330. Total energy = 20258.6756 kcal/mol (20234.1606 without restraints) Performing minimization step: 2331. Total energy = 20248.6536 kcal/mol (20224.1406 without restraints) Performing minimization step: 2332. Total energy = 20238.6384 kcal/mol (20214.1272 without restraints) Performing minimization step: 2333. Total energy = 20228.6306 kcal/mol (20204.1212 without restraints) Performing minimization step: 2334. Total energy = 20218.6298 kcal/mol (20194.1224 without restraints) Performing minimization step: 2335. Total energy = 20208.6362 kcal/mol (20184.1307 without restraints) Performing minimization step: 2336. Total energy = 20198.6496 kcal/mol (20174.1460 without restraints) Performing minimization step: 2337. Total energy = 20188.6704 kcal/mol (20164.1686 without restraints) Performing minimization step: 2338. Total energy = 20178.6981 kcal/mol (20154.1983 without restraints) Performing minimization step: 2339. Total energy = 20168.7329 kcal/mol (20144.2349 without restraints) Performing minimization step: 2340. Total energy = 20158.7742 kcal/mol (20134.2780 without restraints) Performing minimization step: 2341. Total energy = 20148.8228 kcal/mol (20124.3284 without restraints) Performing minimization step: 2342. Total energy = 20138.8785 kcal/mol (20114.3862 without restraints) Performing minimization step: 2343. Total energy = 20128.9412 kcal/mol (20104.4507 without restraints) Performing minimization step: 2344. Total energy = 20119.0108 kcal/mol (20094.5220 without restraints) Performing minimization step: 2345. Total energy = 20109.0872 kcal/mol (20084.6002 without restraints) Performing minimization step: 2346. Total energy = 20099.1705 kcal/mol (20074.6854 without restraints) Performing minimization step: 2347. Total energy = 20089.2607 kcal/mol (20064.7775 without restraints) Performing minimization step: 2348. Total energy = 20079.3578 kcal/mol (20054.8764 without restraints) Performing minimization step: 2349. Total energy = 20069.4619 kcal/mol (20044.9825 without restraints) Performing minimization step: 2350. Total energy = 20059.5731 kcal/mol (20035.0954 without restraints) Performing minimization step: 2351. Total energy = 20049.6910 kcal/mol (20025.2153 without restraints) Performing minimization step: 2352. Total energy = 20039.8155 kcal/mol (20015.3415 without restraints) Performing minimization step: 2353. Total energy = 20029.9469 kcal/mol (20005.4748 without restraints) Performing minimization step: 2354. Total energy = 20020.0851 kcal/mol (19995.6148 without restraints) Performing minimization step: 2355. Total energy = 20010.2301 kcal/mol (19985.7617 without restraints) Performing minimization step: 2356. Total energy = 20000.3819 kcal/mol (19975.9153 without restraints) Performing minimization step: 2357. Total energy = 19990.5406 kcal/mol (19966.0759 without restraints) Performing minimization step: 2358. Total energy = 19980.7057 kcal/mol (19956.2428 without restraints) Performing minimization step: 2359. Total energy = 19970.8781 kcal/mol (19946.4171 without restraints) Performing minimization step: 2360. Total energy = 19961.0569 kcal/mol (19936.5976 without restraints) Performing minimization step: 2361. Total energy = 19951.2427 kcal/mol (19926.7853 without restraints) Performing minimization step: 2362. Total energy = 19941.4351 kcal/mol (19916.9795 without restraints) Performing minimization step: 2363. Total energy = 19931.6341 kcal/mol (19907.1804 without restraints) Performing minimization step: 2364. Total energy = 19921.8394 kcal/mol (19897.3875 without restraints) Performing minimization step: 2365. Total energy = 19912.0516 kcal/mol (19887.6015 without restraints) Performing minimization step: 2366. Total energy = 19902.2704 kcal/mol (19877.8221 without restraints) Performing minimization step: 2367. Total energy = 19892.4962 kcal/mol (19868.0498 without restraints) Performing minimization step: 2368. Total energy = 19882.7282 kcal/mol (19858.2836 without restraints) Performing minimization step: 2369. Total energy = 19872.9668 kcal/mol (19848.5240 without restraints) Performing minimization step: 2370. Total energy = 19863.2119 kcal/mol (19838.7710 without restraints) Performing minimization step: 2371. Total energy = 19853.4638 kcal/mol (19829.0248 without restraints) Performing minimization step: 2372. Total energy = 19843.7223 kcal/mol (19819.2849 without restraints) Performing minimization step: 2373. Total energy = 19833.9873 kcal/mol (19809.5518 without restraints) Performing minimization step: 2374. Total energy = 19824.2586 kcal/mol (19799.8249 without restraints) Performing minimization step: 2375. Total energy = 19814.5364 kcal/mol (19790.1045 without restraints) Performing minimization step: 2376. Total energy = 19804.8206 kcal/mol (19780.3906 without restraints) Performing minimization step: 2377. Total energy = 19795.1115 kcal/mol (19770.6832 without restraints) Performing minimization step: 2378. Total energy = 19785.4085 kcal/mol (19760.9821 without restraints) Performing minimization step: 2379. Total energy = 19775.7122 kcal/mol (19751.2875 without restraints) Performing minimization step: 2380. Total energy = 19766.0222 kcal/mol (19741.5993 without restraints) Performing minimization step: 2381. Total energy = 19756.3386 kcal/mol (19731.9176 without restraints) Performing minimization step: 2382. Total energy = 19746.6616 kcal/mol (19722.2423 without restraints) Performing minimization step: 2383. Total energy = 19736.9908 kcal/mol (19712.5734 without restraints) Performing minimization step: 2384. Total energy = 19727.3265 kcal/mol (19702.9110 without restraints) Performing minimization step: 2385. Total energy = 19717.6688 kcal/mol (19693.2550 without restraints) Performing minimization step: 2386. Total energy = 19708.0172 kcal/mol (19683.6052 without restraints) Performing minimization step: 2387. Total energy = 19698.3722 kcal/mol (19673.9620 without restraints) Performing minimization step: 2388. Total energy = 19688.7329 kcal/mol (19664.3245 without restraints) Performing minimization step: 2389. Total energy = 19679.1003 kcal/mol (19654.6937 without restraints) Performing minimization step: 2390. Total energy = 19669.4740 kcal/mol (19645.0692 without restraints) Performing minimization step: 2391. Total energy = 19659.8542 kcal/mol (19635.4511 without restraints) Performing minimization step: 2392. Total energy = 19650.2405 kcal/mol (19625.8393 without restraints) Performing minimization step: 2393. Total energy = 19640.6329 kcal/mol (19616.2335 without restraints) Performing minimization step: 2394. Total energy = 19631.0315 kcal/mol (19606.6339 without restraints) Performing minimization step: 2395. Total energy = 19621.4360 kcal/mol (19597.0401 without restraints) Performing minimization step: 2396. Total energy = 19611.8472 kcal/mol (19587.4531 without restraints) Performing minimization step: 2397. Total energy = 19602.2648 kcal/mol (19577.8725 without restraints) Performing minimization step: 2398. Total energy = 19592.6882 kcal/mol (19568.2977 without restraints) Performing minimization step: 2399. Total energy = 19583.1179 kcal/mol (19558.7292 without restraints) Performing minimization step: 2400. Total energy = 19573.5536 kcal/mol (19549.1667 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2401. Total energy = 19563.9955 kcal/mol (19539.6104 without restraints) Performing minimization step: 2402. Total energy = 19554.4433 kcal/mol (19530.0600 without restraints) Performing minimization step: 2403. Total energy = 19544.8974 kcal/mol (19520.5158 without restraints) Performing minimization step: 2404. Total energy = 19535.3576 kcal/mol (19510.9778 without restraints) Performing minimization step: 2405. Total energy = 19525.8240 kcal/mol (19501.4461 without restraints) Performing minimization step: 2406. Total energy = 19516.2967 kcal/mol (19491.9204 without restraints) Performing minimization step: 2407. Total energy = 19506.7756 kcal/mol (19482.4011 without restraints) Performing minimization step: 2408. Total energy = 19497.2600 kcal/mol (19472.8873 without restraints) Performing minimization step: 2409. Total energy = 19487.7502 kcal/mol (19463.3791 without restraints) Performing minimization step: 2410. Total energy = 19478.2466 kcal/mol (19453.8774 without restraints) Performing minimization step: 2411. Total energy = 19468.7488 kcal/mol (19444.3815 without restraints) Performing minimization step: 2412. Total energy = 19459.2574 kcal/mol (19434.8919 without restraints) Performing minimization step: 2413. Total energy = 19449.7719 kcal/mol (19425.4080 without restraints) Performing minimization step: 2414. Total energy = 19440.2921 kcal/mol (19415.9300 without restraints) Performing minimization step: 2415. Total energy = 19430.8186 kcal/mol (19406.4584 without restraints) Performing minimization step: 2416. Total energy = 19421.3509 kcal/mol (19396.9924 without restraints) Performing minimization step: 2417. Total energy = 19411.8893 kcal/mol (19387.5325 without restraints) Performing minimization step: 2418. Total energy = 19402.4331 kcal/mol (19378.0781 without restraints) Performing minimization step: 2419. Total energy = 19392.9831 kcal/mol (19368.6299 without restraints) Performing minimization step: 2420. Total energy = 19383.5393 kcal/mol (19359.1877 without restraints) Performing minimization step: 2421. Total energy = 19374.1012 kcal/mol (19349.7514 without restraints) Performing minimization step: 2422. Total energy = 19364.6688 kcal/mol (19340.3207 without restraints) Performing minimization step: 2423. Total energy = 19355.2421 kcal/mol (19330.8958 without restraints) Performing minimization step: 2424. Total energy = 19345.8213 kcal/mol (19321.4767 without restraints) Performing minimization step: 2425. Total energy = 19336.4062 kcal/mol (19312.0634 without restraints) Performing minimization step: 2426. Total energy = 19326.9970 kcal/mol (19302.6560 without restraints) Performing minimization step: 2427. Total energy = 19317.5935 kcal/mol (19293.2542 without restraints) Performing minimization step: 2428. Total energy = 19308.1958 kcal/mol (19283.8583 without restraints) Performing minimization step: 2429. Total energy = 19298.8041 kcal/mol (19274.4684 without restraints) Performing minimization step: 2430. Total energy = 19289.4180 kcal/mol (19265.0839 without restraints) Performing minimization step: 2431. Total energy = 19280.0376 kcal/mol (19255.7054 without restraints) Performing minimization step: 2432. Total energy = 19270.6630 kcal/mol (19246.3324 without restraints) Performing minimization step: 2433. Total energy = 19261.2941 kcal/mol (19236.9653 without restraints) Performing minimization step: 2434. Total energy = 19251.9308 kcal/mol (19227.6037 without restraints) Performing minimization step: 2435. Total energy = 19242.5731 kcal/mol (19218.2479 without restraints) Performing minimization step: 2436. Total energy = 19233.2215 kcal/mol (19208.8978 without restraints) Performing minimization step: 2437. Total energy = 19223.8757 kcal/mol (19199.5539 without restraints) Performing minimization step: 2438. Total energy = 19214.5354 kcal/mol (19190.2152 without restraints) Performing minimization step: 2439. Total energy = 19205.2005 kcal/mol (19180.8821 without restraints) Performing minimization step: 2440. Total energy = 19195.8711 kcal/mol (19171.5544 without restraints) Performing minimization step: 2441. Total energy = 19186.5469 kcal/mol (19162.2319 without restraints) Performing minimization step: 2442. Total energy = 19177.2284 kcal/mol (19152.9152 without restraints) Performing minimization step: 2443. Total energy = 19167.9152 kcal/mol (19143.6037 without restraints) Performing minimization step: 2444. Total energy = 19158.6080 kcal/mol (19134.2982 without restraints) Performing minimization step: 2445. Total energy = 19149.3066 kcal/mol (19124.9986 without restraints) Performing minimization step: 2446. Total energy = 19140.0105 kcal/mol (19115.7042 without restraints) Performing minimization step: 2447. Total energy = 19130.7200 kcal/mol (19106.4155 without restraints) Performing minimization step: 2448. Total energy = 19121.4349 kcal/mol (19097.1321 without restraints) Performing minimization step: 2449. Total energy = 19112.1553 kcal/mol (19087.8542 without restraints) Performing minimization step: 2450. Total energy = 19102.8811 kcal/mol (19078.5817 without restraints) Performing minimization step: 2451. Total energy = 19093.6125 kcal/mol (19069.3148 without restraints) Performing minimization step: 2452. Total energy = 19084.3493 kcal/mol (19060.0533 without restraints) Performing minimization step: 2453. Total energy = 19075.0919 kcal/mol (19050.7977 without restraints) Performing minimization step: 2454. Total energy = 19065.8397 kcal/mol (19041.5471 without restraints) Performing minimization step: 2455. Total energy = 19056.5929 kcal/mol (19032.3021 without restraints) Performing minimization step: 2456. Total energy = 19047.3514 kcal/mol (19023.0623 without restraints) Performing minimization step: 2457. Total energy = 19038.1153 kcal/mol (19013.8278 without restraints) Performing minimization step: 2458. Total energy = 19028.8845 kcal/mol (19004.5988 without restraints) Performing minimization step: 2459. Total energy = 19019.6591 kcal/mol (18995.3751 without restraints) Performing minimization step: 2460. Total energy = 19010.4393 kcal/mol (18986.1570 without restraints) Performing minimization step: 2461. Total energy = 19001.2247 kcal/mol (18976.9441 without restraints) Performing minimization step: 2462. Total energy = 18992.0154 kcal/mol (18967.7366 without restraints) Performing minimization step: 2463. Total energy = 18982.8116 kcal/mol (18958.5344 without restraints) Performing minimization step: 2464. Total energy = 18973.6133 kcal/mol (18949.3378 without restraints) Performing minimization step: 2465. Total energy = 18964.4198 kcal/mol (18940.1460 without restraints) Performing minimization step: 2466. Total energy = 18955.2316 kcal/mol (18930.9595 without restraints) Performing minimization step: 2467. Total energy = 18946.0487 kcal/mol (18921.7783 without restraints) Performing minimization step: 2468. Total energy = 18936.8712 kcal/mol (18912.6025 without restraints) Performing minimization step: 2469. Total energy = 18927.6991 kcal/mol (18903.4322 without restraints) Performing minimization step: 2470. Total energy = 18918.5324 kcal/mol (18894.2671 without restraints) Performing minimization step: 2471. Total energy = 18909.3704 kcal/mol (18885.1068 without restraints) Performing minimization step: 2472. Total energy = 18900.2136 kcal/mol (18875.9517 without restraints) Performing minimization step: 2473. Total energy = 18891.0620 kcal/mol (18866.8017 without restraints) Performing minimization step: 2474. Total energy = 18881.9162 kcal/mol (18857.6580 without restraints) Performing minimization step: 2475. Total energy = 18872.7755 kcal/mol (18848.5187 without restraints) Performing minimization step: 2476. Total energy = 18863.6394 kcal/mol (18839.3843 without restraints) Performing minimization step: 2477. Total energy = 18854.5085 kcal/mol (18830.2550 without restraints) Performing minimization step: 2478. Total energy = 18845.3828 kcal/mol (18821.1310 without restraints) Performing minimization step: 2479. Total energy = 18836.2621 kcal/mol (18812.0119 without restraints) Performing minimization step: 2480. Total energy = 18827.1464 kcal/mol (18802.8978 without restraints) Performing minimization step: 2481. Total energy = 18818.0357 kcal/mol (18793.7889 without restraints) Performing minimization step: 2482. Total energy = 18808.9300 kcal/mol (18784.6849 without restraints) Performing minimization step: 2483. Total energy = 18799.8298 kcal/mol (18775.5864 without restraints) Performing minimization step: 2484. Total energy = 18790.7347 kcal/mol (18766.4931 without restraints) Performing minimization step: 2485. Total energy = 18781.6448 kcal/mol (18757.4048 without restraints) Performing minimization step: 2486. Total energy = 18772.5596 kcal/mol (18748.3212 without restraints) Performing minimization step: 2487. Total energy = 18763.4795 kcal/mol (18739.2428 without restraints) Performing minimization step: 2488. Total energy = 18754.4043 kcal/mol (18730.1692 without restraints) Performing minimization step: 2489. Total energy = 18745.3341 kcal/mol (18721.1007 without restraints) Performing minimization step: 2490. Total energy = 18736.2687 kcal/mol (18712.0370 without restraints) Performing minimization step: 2491. Total energy = 18727.2084 kcal/mol (18702.9784 without restraints) Performing minimization step: 2492. Total energy = 18718.1532 kcal/mol (18693.9249 without restraints) Performing minimization step: 2493. Total energy = 18709.1028 kcal/mol (18684.8761 without restraints) Performing minimization step: 2494. Total energy = 18700.0573 kcal/mol (18675.8323 without restraints) Performing minimization step: 2495. Total energy = 18691.0166 kcal/mol (18666.7933 without restraints) Performing minimization step: 2496. Total energy = 18681.9810 kcal/mol (18657.7593 without restraints) Performing minimization step: 2497. Total energy = 18672.9508 kcal/mol (18648.7308 without restraints) Performing minimization step: 2498. Total energy = 18663.9250 kcal/mol (18639.7068 without restraints) Performing minimization step: 2499. Total energy = 18654.9042 kcal/mol (18630.6875 without restraints) Performing minimization step: 2500. Total energy = 18645.8881 kcal/mol (18621.6730 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2501. Total energy = 18636.8766 kcal/mol (18612.6632 without restraints) Performing minimization step: 2502. Total energy = 18627.8703 kcal/mol (18603.6585 without restraints) Performing minimization step: 2503. Total energy = 18618.8688 kcal/mol (18594.6587 without restraints) Performing minimization step: 2504. Total energy = 18609.8721 kcal/mol (18585.6637 without restraints) Performing minimization step: 2505. Total energy = 18600.8800 kcal/mol (18576.6732 without restraints) Performing minimization step: 2506. Total energy = 18591.8923 kcal/mol (18567.6872 without restraints) Performing minimization step: 2507. Total energy = 18582.9101 kcal/mol (18558.7067 without restraints) Performing minimization step: 2508. Total energy = 18573.9325 kcal/mol (18549.7307 without restraints) Performing minimization step: 2509. Total energy = 18564.9595 kcal/mol (18540.7594 without restraints) Performing minimization step: 2510. Total energy = 18555.9914 kcal/mol (18531.7929 without restraints) Performing minimization step: 2511. Total energy = 18547.0280 kcal/mol (18522.8312 without restraints) Performing minimization step: 2512. Total energy = 18538.0697 kcal/mol (18513.8745 without restraints) Performing minimization step: 2513. Total energy = 18529.1162 kcal/mol (18504.9226 without restraints) Performing minimization step: 2514. Total energy = 18520.1670 kcal/mol (18495.9750 without restraints) Performing minimization step: 2515. Total energy = 18511.2224 kcal/mol (18487.0321 without restraints) Performing minimization step: 2516. Total energy = 18502.2826 kcal/mol (18478.0940 without restraints) Performing minimization step: 2517. Total energy = 18493.3474 kcal/mol (18469.1604 without restraints) Performing minimization step: 2518. Total energy = 18484.4169 kcal/mol (18460.2315 without restraints) Performing minimization step: 2519. Total energy = 18475.4911 kcal/mol (18451.3073 without restraints) Performing minimization step: 2520. Total energy = 18466.5700 kcal/mol (18442.3875 without restraints) Performing minimization step: 2521. Total energy = 18458.0109 kcal/mol (18433.4728 without restraints) Performing minimization step: 2522. Total energy = 18448.7415 kcal/mol (18424.5625 without restraints) Performing minimization step: 2523. Total energy = 18439.8340 kcal/mol (18415.6568 without restraints) Performing minimization step: 2524. Total energy = 18430.9311 kcal/mol (18406.7555 without restraints) Performing minimization step: 2525. Total energy = 18422.0328 kcal/mol (18397.8589 without restraints) Performing minimization step: 2526. Total energy = 18413.1391 kcal/mol (18388.9668 without restraints) Performing minimization step: 2527. Total energy = 18404.2502 kcal/mol (18380.0795 without restraints) Performing minimization step: 2528. Total energy = 18395.3658 kcal/mol (18371.1968 without restraints) Performing minimization step: 2529. Total energy = 18386.4858 kcal/mol (18362.3184 without restraints) Performing minimization step: 2530. Total energy = 18377.6103 kcal/mol (18353.4445 without restraints) Performing minimization step: 2531. Total energy = 18368.7393 kcal/mol (18344.5752 without restraints) Performing minimization step: 2532. Total energy = 18359.8726 kcal/mol (18335.7101 without restraints) Performing minimization step: 2533. Total energy = 18351.0109 kcal/mol (18326.8500 without restraints) Performing minimization step: 2534. Total energy = 18342.1537 kcal/mol (18317.9944 without restraints) Performing minimization step: 2535. Total energy = 18333.3011 kcal/mol (18309.1434 without restraints) Performing minimization step: 2536. Total energy = 18324.4526 kcal/mol (18300.2965 without restraints) Performing minimization step: 2537. Total energy = 18315.6089 kcal/mol (18291.4544 without restraints) Performing minimization step: 2538. Total energy = 18306.7690 kcal/mol (18282.6161 without restraints) Performing minimization step: 2539. Total energy = 18297.9339 kcal/mol (18273.7827 without restraints) Performing minimization step: 2540. Total energy = 18289.1031 kcal/mol (18264.9534 without restraints) Performing minimization step: 2541. Total energy = 18280.2765 kcal/mol (18256.1284 without restraints) Performing minimization step: 2542. Total energy = 18271.4543 kcal/mol (18247.3077 without restraints) Performing minimization step: 2543. Total energy = 18262.6366 kcal/mol (18238.4919 without restraints) Performing minimization step: 2544. Total energy = 18253.8234 kcal/mol (18229.6802 without restraints) Performing minimization step: 2545. Total energy = 18245.0144 kcal/mol (18220.8728 without restraints) Performing minimization step: 2546. Total energy = 18236.2100 kcal/mol (18212.0700 without restraints) Performing minimization step: 2547. Total energy = 18227.4100 kcal/mol (18203.2716 without restraints) Performing minimization step: 2548. Total energy = 18218.6140 kcal/mol (18194.4773 without restraints) Performing minimization step: 2549. Total energy = 18209.8220 kcal/mol (18185.6869 without restraints) Performing minimization step: 2550. Total energy = 18201.0352 kcal/mol (18176.9016 without restraints) Performing minimization step: 2551. Total energy = 18192.2522 kcal/mol (18168.1202 without restraints) Performing minimization step: 2552. Total energy = 18183.4738 kcal/mol (18159.3434 without restraints) Performing minimization step: 2553. Total energy = 18174.6993 kcal/mol (18150.5705 without restraints) Performing minimization step: 2554. Total energy = 18165.9297 kcal/mol (18141.8025 without restraints) Performing minimization step: 2555. Total energy = 18157.1638 kcal/mol (18133.0383 without restraints) Performing minimization step: 2556. Total energy = 18148.4022 kcal/mol (18124.2782 without restraints) Performing minimization step: 2557. Total energy = 18139.6448 kcal/mol (18115.5224 without restraints) Performing minimization step: 2558. Total energy = 18130.8918 kcal/mol (18106.7711 without restraints) Performing minimization step: 2559. Total energy = 18122.1429 kcal/mol (18098.0237 without restraints) Performing minimization step: 2560. Total energy = 18113.3981 kcal/mol (18089.2806 without restraints) Performing minimization step: 2561. Total energy = 18104.6576 kcal/mol (18080.5416 without restraints) Performing minimization step: 2562. Total energy = 18095.9215 kcal/mol (18071.8072 without restraints) Performing minimization step: 2563. Total energy = 18087.1893 kcal/mol (18063.0765 without restraints) Performing minimization step: 2564. Total energy = 18078.4613 kcal/mol (18054.3501 without restraints) Performing minimization step: 2565. Total energy = 18069.7373 kcal/mol (18045.6276 without restraints) Performing minimization step: 2566. Total energy = 18061.0173 kcal/mol (18036.9092 without restraints) Performing minimization step: 2567. Total energy = 18052.3019 kcal/mol (18028.1954 without restraints) Performing minimization step: 2568. Total energy = 18043.5905 kcal/mol (18019.4856 without restraints) Performing minimization step: 2569. Total energy = 18034.8832 kcal/mol (18010.7799 without restraints) Performing minimization step: 2570. Total energy = 18026.1800 kcal/mol (18002.0783 without restraints) Performing minimization step: 2571. Total energy = 18017.4809 kcal/mol (17993.3808 without restraints) Performing minimization step: 2572. Total energy = 18008.7859 kcal/mol (17984.6873 without restraints) Performing minimization step: 2573. Total energy = 18000.0949 kcal/mol (17975.9979 without restraints) Performing minimization step: 2574. Total energy = 17991.4077 kcal/mol (17967.3123 without restraints) Performing minimization step: 2575. Total energy = 17982.7249 kcal/mol (17958.6311 without restraints) Performing minimization step: 2576. Total energy = 17974.0459 kcal/mol (17949.9536 without restraints) Performing minimization step: 2577. Total energy = 17965.3712 kcal/mol (17941.2805 without restraints) Performing minimization step: 2578. Total energy = 17956.7006 kcal/mol (17932.6116 without restraints) Performing minimization step: 2579. Total energy = 17948.0341 kcal/mol (17923.9465 without restraints) Performing minimization step: 2580. Total energy = 17939.3714 kcal/mol (17915.2854 without restraints) Performing minimization step: 2581. Total energy = 17930.7128 kcal/mol (17906.6285 without restraints) Performing minimization step: 2582. Total energy = 17922.0584 kcal/mol (17897.9756 without restraints) Performing minimization step: 2583. Total energy = 17913.4077 kcal/mol (17889.3265 without restraints) Performing minimization step: 2584. Total energy = 17904.7610 kcal/mol (17880.6814 without restraints) Performing minimization step: 2585. Total energy = 17896.1186 kcal/mol (17872.0404 without restraints) Performing minimization step: 2586. Total energy = 17887.4798 kcal/mol (17863.4032 without restraints) Performing minimization step: 2587. Total energy = 17878.8447 kcal/mol (17854.7697 without restraints) Performing minimization step: 2588. Total energy = 17870.2137 kcal/mol (17846.1403 without restraints) Performing minimization step: 2589. Total energy = 17861.5867 kcal/mol (17837.5148 without restraints) Performing minimization step: 2590. Total energy = 17852.9636 kcal/mol (17828.8933 without restraints) Performing minimization step: 2591. Total energy = 17844.3444 kcal/mol (17820.2756 without restraints) Performing minimization step: 2592. Total energy = 17835.7290 kcal/mol (17811.6617 without restraints) Performing minimization step: 2593. Total energy = 17827.1175 kcal/mol (17803.0518 without restraints) Performing minimization step: 2594. Total energy = 17818.5099 kcal/mol (17794.4458 without restraints) Performing minimization step: 2595. Total energy = 17809.9063 kcal/mol (17785.8438 without restraints) Performing minimization step: 2596. Total energy = 17801.3067 kcal/mol (17777.2457 without restraints) Performing minimization step: 2597. Total energy = 17792.7107 kcal/mol (17768.6513 without restraints) Performing minimization step: 2598. Total energy = 17784.1185 kcal/mol (17760.0605 without restraints) Performing minimization step: 2599. Total energy = 17775.5302 kcal/mol (17751.4739 without restraints) Performing minimization step: 2600. Total energy = 17766.9456 kcal/mol (17742.8908 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2601. Total energy = 17758.3651 kcal/mol (17734.3119 without restraints) Performing minimization step: 2602. Total energy = 17749.7881 kcal/mol (17725.7365 without restraints) Performing minimization step: 2603. Total energy = 17741.2147 kcal/mol (17717.1646 without restraints) Performing minimization step: 2604. Total energy = 17732.6455 kcal/mol (17708.5969 without restraints) Performing minimization step: 2605. Total energy = 17724.0800 kcal/mol (17700.0331 without restraints) Performing minimization step: 2606. Total energy = 17715.5185 kcal/mol (17691.4731 without restraints) Performing minimization step: 2607. Total energy = 17706.9608 kcal/mol (17682.9168 without restraints) Performing minimization step: 2608. Total energy = 17698.4066 kcal/mol (17674.3642 without restraints) Performing minimization step: 2609. Total energy = 17689.8562 kcal/mol (17665.8153 without restraints) Performing minimization step: 2610. Total energy = 17681.3095 kcal/mol (17657.2702 without restraints) Performing minimization step: 2611. Total energy = 17672.7664 kcal/mol (17648.7286 without restraints) Performing minimization step: 2612. Total energy = 17664.2271 kcal/mol (17640.1910 without restraints) Performing minimization step: 2613. Total energy = 17655.6916 kcal/mol (17631.6569 without restraints) Performing minimization step: 2614. Total energy = 17647.1596 kcal/mol (17623.1264 without restraints) Performing minimization step: 2615. Total energy = 17638.6314 kcal/mol (17614.5998 without restraints) Performing minimization step: 2616. Total energy = 17630.1068 kcal/mol (17606.0767 without restraints) Performing minimization step: 2617. Total energy = 17621.5864 kcal/mol (17597.5578 without restraints) Performing minimization step: 2618. Total energy = 17613.0694 kcal/mol (17589.0424 without restraints) Performing minimization step: 2619. Total energy = 17604.5558 kcal/mol (17580.5303 without restraints) Performing minimization step: 2620. Total energy = 17596.0459 kcal/mol (17572.0220 without restraints) Performing minimization step: 2621. Total energy = 17587.5397 kcal/mol (17563.5173 without restraints) Performing minimization step: 2622. Total energy = 17579.0371 kcal/mol (17555.0163 without restraints) Performing minimization step: 2623. Total energy = 17570.5383 kcal/mol (17546.5192 without restraints) Performing minimization step: 2624. Total energy = 17562.0432 kcal/mol (17538.0254 without restraints) Performing minimization step: 2625. Total energy = 17553.5517 kcal/mol (17529.5355 without restraints) Performing minimization step: 2626. Total energy = 17545.0638 kcal/mol (17521.0491 without restraints) Performing minimization step: 2627. Total energy = 17536.5793 kcal/mol (17512.5661 without restraints) Performing minimization step: 2628. Total energy = 17528.0983 kcal/mol (17504.0866 without restraints) Performing minimization step: 2629. Total energy = 17519.6214 kcal/mol (17495.6113 without restraints) Performing minimization step: 2630. Total energy = 17511.1476 kcal/mol (17487.1390 without restraints) Performing minimization step: 2631. Total energy = 17502.6769 kcal/mol (17478.6696 without restraints) Performing minimization step: 2632. Total energy = 17494.2102 kcal/mol (17470.2046 without restraints) Performing minimization step: 2633. Total energy = 17485.7468 kcal/mol (17461.7428 without restraints) Performing minimization step: 2634. Total energy = 17477.2872 kcal/mol (17453.2846 without restraints) Performing minimization step: 2635. Total energy = 17468.8311 kcal/mol (17444.8300 without restraints) Performing minimization step: 2636. Total energy = 17460.3784 kcal/mol (17436.3789 without restraints) Performing minimization step: 2637. Total energy = 17451.9295 kcal/mol (17427.9316 without restraints) Performing minimization step: 2638. Total energy = 17443.4835 kcal/mol (17419.4870 without restraints) Performing minimization step: 2639. Total energy = 17435.0414 kcal/mol (17411.0464 without restraints) Performing minimization step: 2640. Total energy = 17426.6027 kcal/mol (17402.6092 without restraints) Performing minimization step: 2641. Total energy = 17418.1677 kcal/mol (17394.1758 without restraints) Performing minimization step: 2642. Total energy = 17409.7357 kcal/mol (17385.7452 without restraints) Performing minimization step: 2643. Total energy = 17401.3074 kcal/mol (17377.3185 without restraints) Performing minimization step: 2644. Total energy = 17392.8827 kcal/mol (17368.8953 without restraints) Performing minimization step: 2645. Total energy = 17384.4616 kcal/mol (17360.4757 without restraints) Performing minimization step: 2646. Total energy = 17376.0437 kcal/mol (17352.0593 without restraints) Performing minimization step: 2647. Total energy = 17367.6294 kcal/mol (17343.6466 without restraints) Performing minimization step: 2648. Total energy = 17359.2184 kcal/mol (17335.2370 without restraints) Performing minimization step: 2649. Total energy = 17350.8107 kcal/mol (17326.8308 without restraints) Performing minimization step: 2650. Total energy = 17342.4064 kcal/mol (17318.4279 without restraints) Performing minimization step: 2651. Total energy = 17334.0058 kcal/mol (17310.0289 without restraints) Performing minimization step: 2652. Total energy = 17325.6084 kcal/mol (17301.6330 without restraints) Performing minimization step: 2653. Total energy = 17317.2144 kcal/mol (17293.2405 without restraints) Performing minimization step: 2654. Total energy = 17308.8237 kcal/mol (17284.8513 without restraints) Performing minimization step: 2655. Total energy = 17300.4369 kcal/mol (17276.4660 without restraints) Performing minimization step: 2656. Total energy = 17292.0528 kcal/mol (17268.0834 without restraints) Performing minimization step: 2657. Total energy = 17283.6722 kcal/mol (17259.7044 without restraints) Performing minimization step: 2658. Total energy = 17275.2950 kcal/mol (17251.3287 without restraints) Performing minimization step: 2659. Total energy = 17266.9210 kcal/mol (17242.9560 without restraints) Performing minimization step: 2660. Total energy = 17258.5502 kcal/mol (17234.5869 without restraints) Performing minimization step: 2661. Total energy = 17250.1829 kcal/mol (17226.2210 without restraints) Performing minimization step: 2662. Total energy = 17241.8191 kcal/mol (17217.8587 without restraints) Performing minimization step: 2663. Total energy = 17233.4585 kcal/mol (17209.4996 without restraints) Performing minimization step: 2664. Total energy = 17225.1014 kcal/mol (17201.1440 without restraints) Performing minimization step: 2665. Total energy = 17216.7472 kcal/mol (17192.7914 without restraints) Performing minimization step: 2666. Total energy = 17208.3969 kcal/mol (17184.4425 without restraints) Performing minimization step: 2667. Total energy = 17200.0493 kcal/mol (17176.0964 without restraints) Performing minimization step: 2668. Total energy = 17191.7051 kcal/mol (17167.7537 without restraints) Performing minimization step: 2669. Total energy = 17183.3641 kcal/mol (17159.4142 without restraints) Performing minimization step: 2670. Total energy = 17175.0264 kcal/mol (17151.0780 without restraints) Performing minimization step: 2671. Total energy = 17166.6919 kcal/mol (17142.7449 without restraints) Performing minimization step: 2672. Total energy = 17158.3604 kcal/mol (17134.4148 without restraints) Performing minimization step: 2673. Total energy = 17150.0323 kcal/mol (17126.0883 without restraints) Performing minimization step: 2674. Total energy = 17141.7075 kcal/mol (17117.7651 without restraints) Performing minimization step: 2675. Total energy = 17133.3856 kcal/mol (17109.4445 without restraints) Performing minimization step: 2676. Total energy = 17125.0674 kcal/mol (17101.1279 without restraints) Performing minimization step: 2677. Total energy = 17116.7525 kcal/mol (17092.8145 without restraints) Performing minimization step: 2678. Total energy = 17108.4411 kcal/mol (17084.5045 without restraints) Performing minimization step: 2679. Total energy = 17100.1325 kcal/mol (17076.1974 without restraints) Performing minimization step: 2680. Total energy = 17091.8269 kcal/mol (17067.8933 without restraints) Performing minimization step: 2681. Total energy = 17083.5246 kcal/mol (17059.5924 without restraints) Performing minimization step: 2682. Total energy = 17075.2254 kcal/mol (17051.2948 without restraints) Performing minimization step: 2683. Total energy = 17066.9295 kcal/mol (17043.0004 without restraints) Performing minimization step: 2684. Total energy = 17058.6366 kcal/mol (17034.7089 without restraints) Performing minimization step: 2685. Total energy = 17050.3468 kcal/mol (17026.4206 without restraints) Performing minimization step: 2686. Total energy = 17042.0605 kcal/mol (17018.1357 without restraints) Performing minimization step: 2687. Total energy = 17033.7767 kcal/mol (17009.8535 without restraints) Performing minimization step: 2688. Total energy = 17025.4964 kcal/mol (17001.5746 without restraints) Performing minimization step: 2689. Total energy = 17017.2192 kcal/mol (16993.2989 without restraints) Performing minimization step: 2690. Total energy = 17008.9452 kcal/mol (16985.0264 without restraints) Performing minimization step: 2691. Total energy = 17000.6739 kcal/mol (16976.7565 without restraints) Performing minimization step: 2692. Total energy = 16992.4060 kcal/mol (16968.4901 without restraints) Performing minimization step: 2693. Total energy = 16984.1412 kcal/mol (16960.2269 without restraints) Performing minimization step: 2694. Total energy = 16975.8798 kcal/mol (16951.9669 without restraints) Performing minimization step: 2695. Total energy = 16967.6211 kcal/mol (16943.7096 without restraints) Performing minimization step: 2696. Total energy = 16959.3653 kcal/mol (16935.4553 without restraints) Performing minimization step: 2697. Total energy = 16951.1129 kcal/mol (16927.2043 without restraints) Performing minimization step: 2698. Total energy = 16942.8635 kcal/mol (16918.9564 without restraints) Performing minimization step: 2699. Total energy = 16934.6176 kcal/mol (16910.7121 without restraints) Performing minimization step: 2700. Total energy = 16926.3746 kcal/mol (16902.4706 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2701. Total energy = 16918.1347 kcal/mol (16894.2320 without restraints) Performing minimization step: 2702. Total energy = 16909.8975 kcal/mol (16885.9962 without restraints) Performing minimization step: 2703. Total energy = 16901.6632 kcal/mol (16877.7634 without restraints) Performing minimization step: 2704. Total energy = 16893.4320 kcal/mol (16869.5338 without restraints) Performing minimization step: 2705. Total energy = 16885.2043 kcal/mol (16861.3075 without restraints) Performing minimization step: 2706. Total energy = 16876.9791 kcal/mol (16853.0838 without restraints) Performing minimization step: 2707. Total energy = 16868.7570 kcal/mol (16844.8631 without restraints) Performing minimization step: 2708. Total energy = 16860.5377 kcal/mol (16836.6453 without restraints) Performing minimization step: 2709. Total energy = 16852.3216 kcal/mol (16828.4306 without restraints) Performing minimization step: 2710. Total energy = 16844.1085 kcal/mol (16820.2190 without restraints) Performing minimization step: 2711. Total energy = 16835.8980 kcal/mol (16812.0099 without restraints) Performing minimization step: 2712. Total energy = 16827.6909 kcal/mol (16803.8043 without restraints) Performing minimization step: 2713. Total energy = 16819.4868 kcal/mol (16795.6016 without restraints) Performing minimization step: 2714. Total energy = 16811.2858 kcal/mol (16787.4021 without restraints) Performing minimization step: 2715. Total energy = 16803.0875 kcal/mol (16779.2053 without restraints) Performing minimization step: 2716. Total energy = 16794.8923 kcal/mol (16771.0115 without restraints) Performing minimization step: 2717. Total energy = 16786.6999 kcal/mol (16762.8205 without restraints) Performing minimization step: 2718. Total energy = 16778.5104 kcal/mol (16754.6325 without restraints) Performing minimization step: 2719. Total energy = 16770.3243 kcal/mol (16746.4479 without restraints) Performing minimization step: 2720. Total energy = 16762.1412 kcal/mol (16738.2663 without restraints) Performing minimization step: 2721. Total energy = 16753.9605 kcal/mol (16730.0867 without restraints) Performing minimization step: 2722. Total energy = 16745.7824 kcal/mol (16721.9103 without restraints) Performing minimization step: 2723. Total energy = 16737.6077 kcal/mol (16713.7371 without restraints) Performing minimization step: 2724. Total energy = 16729.4358 kcal/mol (16705.5666 without restraints) Performing minimization step: 2725. Total energy = 16721.2668 kcal/mol (16697.3992 without restraints) Performing minimization step: 2726. Total energy = 16713.1008 kcal/mol (16689.2345 without restraints) Performing minimization step: 2727. Total energy = 16704.9377 kcal/mol (16681.0728 without restraints) Performing minimization step: 2728. Total energy = 16696.7774 kcal/mol (16672.9140 without restraints) Performing minimization step: 2729. Total energy = 16688.6199 kcal/mol (16664.7580 without restraints) Performing minimization step: 2730. Total energy = 16680.4654 kcal/mol (16656.6048 without restraints) Performing minimization step: 2731. Total energy = 16672.3141 kcal/mol (16648.4550 without restraints) Performing minimization step: 2732. Total energy = 16664.1652 kcal/mol (16640.3076 without restraints) Performing minimization step: 2733. Total energy = 16656.0195 kcal/mol (16632.1633 without restraints) Performing minimization step: 2734. Total energy = 16647.8762 kcal/mol (16624.0215 without restraints) Performing minimization step: 2735. Total energy = 16639.7361 kcal/mol (16615.8828 without restraints) Performing minimization step: 2736. Total energy = 16631.5986 kcal/mol (16607.7467 without restraints) Performing minimization step: 2737. Total energy = 16623.4639 kcal/mol (16599.6135 without restraints) Performing minimization step: 2738. Total energy = 16615.3317 kcal/mol (16591.4827 without restraints) Performing minimization step: 2739. Total energy = 16607.2029 kcal/mol (16583.3555 without restraints) Performing minimization step: 2740. Total energy = 16599.0767 kcal/mol (16575.2306 without restraints) Performing minimization step: 2741. Total energy = 16590.9533 kcal/mol (16567.1086 without restraints) Performing minimization step: 2742. Total energy = 16582.8330 kcal/mol (16558.9897 without restraints) Performing minimization step: 2743. Total energy = 16574.7152 kcal/mol (16550.8734 without restraints) Performing minimization step: 2744. Total energy = 16566.6005 kcal/mol (16542.7603 without restraints) Performing minimization step: 2745. Total energy = 16558.4888 kcal/mol (16534.6500 without restraints) Performing minimization step: 2746. Total energy = 16550.3799 kcal/mol (16526.5426 without restraints) Performing minimization step: 2747. Total energy = 16542.2740 kcal/mol (16518.4379 without restraints) Performing minimization step: 2748. Total energy = 16534.1704 kcal/mol (16510.3358 without restraints) Performing minimization step: 2749. Total energy = 16526.0688 kcal/mol (16502.2355 without restraints) Performing minimization step: 2750. Total energy = 16517.9705 kcal/mol (16494.1388 without restraints) Performing minimization step: 2751. Total energy = 16509.8753 kcal/mol (16486.0449 without restraints) Performing minimization step: 2752. Total energy = 16501.7825 kcal/mol (16477.9536 without restraints) Performing minimization step: 2753. Total energy = 16493.6926 kcal/mol (16469.8651 without restraints) Performing minimization step: 2754. Total energy = 16485.6053 kcal/mol (16461.7792 without restraints) Performing minimization step: 2755. Total energy = 16477.5207 kcal/mol (16453.6960 without restraints) Performing minimization step: 2756. Total energy = 16469.4392 kcal/mol (16445.6160 without restraints) Performing minimization step: 2757. Total energy = 16461.3600 kcal/mol (16437.5382 without restraints) Performing minimization step: 2758. Total energy = 16453.2837 kcal/mol (16429.4633 without restraints) Performing minimization step: 2759. Total energy = 16445.2101 kcal/mol (16421.3912 without restraints) Performing minimization step: 2760. Total energy = 16437.1394 kcal/mol (16413.3219 without restraints) Performing minimization step: 2761. Total energy = 16429.0712 kcal/mol (16405.2552 without restraints) Performing minimization step: 2762. Total energy = 16421.0058 kcal/mol (16397.1911 without restraints) Performing minimization step: 2763. Total energy = 16412.9428 kcal/mol (16389.1297 without restraints) Performing minimization step: 2764. Total energy = 16404.8827 kcal/mol (16381.0709 without restraints) Performing minimization step: 2765. Total energy = 16396.8255 kcal/mol (16373.0151 without restraints) Performing minimization step: 2766. Total energy = 16388.7711 kcal/mol (16364.9622 without restraints) Performing minimization step: 2767. Total energy = 16380.7192 kcal/mol (16356.9117 without restraints) Performing minimization step: 2768. Total energy = 16372.6702 kcal/mol (16348.8640 without restraints) Performing minimization step: 2769. Total energy = 16364.6238 kcal/mol (16340.8191 without restraints) Performing minimization step: 2770. Total energy = 16356.5803 kcal/mol (16332.7771 without restraints) Performing minimization step: 2771. Total energy = 16348.5389 kcal/mol (16324.7370 without restraints) Performing minimization step: 2772. Total energy = 16340.5005 kcal/mol (16316.7001 without restraints) Performing minimization step: 2773. Total energy = 16332.4649 kcal/mol (16308.6661 without restraints) Performing minimization step: 2774. Total energy = 16324.4318 kcal/mol (16300.6342 without restraints) Performing minimization step: 2775. Total energy = 16316.4010 kcal/mol (16292.6048 without restraints) Performing minimization step: 2776. Total energy = 16308.3730 kcal/mol (16284.5782 without restraints) Performing minimization step: 2777. Total energy = 16300.3478 kcal/mol (16276.5544 without restraints) Performing minimization step: 2778. Total energy = 16292.3250 kcal/mol (16268.5330 without restraints) Performing minimization step: 2779. Total energy = 16284.3049 kcal/mol (16260.5143 without restraints) Performing minimization step: 2780. Total energy = 16276.2873 kcal/mol (16252.4982 without restraints) Performing minimization step: 2781. Total energy = 16268.2728 kcal/mol (16244.4852 without restraints) Performing minimization step: 2782. Total energy = 16260.2608 kcal/mol (16236.4745 without restraints) Performing minimization step: 2783. Total energy = 16252.2511 kcal/mol (16228.4662 without restraints) Performing minimization step: 2784. Total energy = 16244.2440 kcal/mol (16220.4606 without restraints) Performing minimization step: 2785. Total energy = 16236.2396 kcal/mol (16212.4575 without restraints) Performing minimization step: 2786. Total energy = 16228.2377 kcal/mol (16204.4571 without restraints) Performing minimization step: 2787. Total energy = 16220.2385 kcal/mol (16196.4592 without restraints) Performing minimization step: 2788. Total energy = 16212.2418 kcal/mol (16188.4639 without restraints) Performing minimization step: 2789. Total energy = 16204.2477 kcal/mol (16180.4712 without restraints) Performing minimization step: 2790. Total energy = 16196.2559 kcal/mol (16172.4809 without restraints) Performing minimization step: 2791. Total energy = 16188.2675 kcal/mol (16164.4940 without restraints) Performing minimization step: 2792. Total energy = 16180.2815 kcal/mol (16156.5093 without restraints) Performing minimization step: 2793. Total energy = 16172.2976 kcal/mol (16148.5267 without restraints) Performing minimization step: 2794. Total energy = 16164.3163 kcal/mol (16140.5469 without restraints) Performing minimization step: 2795. Total energy = 16156.3380 kcal/mol (16132.5701 without restraints) Performing minimization step: 2796. Total energy = 16148.3620 kcal/mol (16124.5955 without restraints) Performing minimization step: 2797. Total energy = 16140.3886 kcal/mol (16116.6234 without restraints) Performing minimization step: 2798. Total energy = 16132.4178 kcal/mol (16108.6540 without restraints) Performing minimization step: 2799. Total energy = 16124.4493 kcal/mol (16100.6870 without restraints) Performing minimization step: 2800. Total energy = 16116.4836 kcal/mol (16092.7225 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2801. Total energy = 16108.5201 kcal/mol (16084.7605 without restraints) Performing minimization step: 2802. Total energy = 16100.5592 kcal/mol (16076.8010 without restraints) Performing minimization step: 2803. Total energy = 16092.6012 kcal/mol (16068.8444 without restraints) Performing minimization step: 2804. Total energy = 16084.6453 kcal/mol (16060.8899 without restraints) Performing minimization step: 2805. Total energy = 16076.6922 kcal/mol (16052.9383 without restraints) Performing minimization step: 2806. Total energy = 16068.7415 kcal/mol (16044.9889 without restraints) Performing minimization step: 2807. Total energy = 16060.7932 kcal/mol (16037.0420 without restraints) Performing minimization step: 2808. Total energy = 16052.8472 kcal/mol (16029.0974 without restraints) Performing minimization step: 2809. Total energy = 16044.9039 kcal/mol (16021.1555 without restraints) Performing minimization step: 2810. Total energy = 16036.9632 kcal/mol (16013.2162 without restraints) Performing minimization step: 2811. Total energy = 16029.0252 kcal/mol (16005.2796 without restraints) Performing minimization step: 2812. Total energy = 16021.0896 kcal/mol (15997.3454 without restraints) Performing minimization step: 2813. Total energy = 16013.1564 kcal/mol (15989.4137 without restraints) Performing minimization step: 2814. Total energy = 16005.2255 kcal/mol (15981.4841 without restraints) Performing minimization step: 2815. Total energy = 15997.2973 kcal/mol (15973.5573 without restraints) Performing minimization step: 2816. Total energy = 15989.3711 kcal/mol (15965.6325 without restraints) Performing minimization step: 2817. Total energy = 15981.4475 kcal/mol (15957.7103 without restraints) Performing minimization step: 2818. Total energy = 15973.5267 kcal/mol (15949.7908 without restraints) Performing minimization step: 2819. Total energy = 15965.6083 kcal/mol (15941.8739 without restraints) Performing minimization step: 2820. Total energy = 15957.6928 kcal/mol (15933.9599 without restraints) Performing minimization step: 2821. Total energy = 15949.7795 kcal/mol (15926.0478 without restraints) Performing minimization step: 2822. Total energy = 15941.8684 kcal/mol (15918.1381 without restraints) Performing minimization step: 2823. Total energy = 15933.9603 kcal/mol (15910.2314 without restraints) Performing minimization step: 2824. Total energy = 15926.0545 kcal/mol (15902.3270 without restraints) Performing minimization step: 2825. Total energy = 15918.1509 kcal/mol (15894.4248 without restraints) Performing minimization step: 2826. Total energy = 15910.2497 kcal/mol (15886.5250 without restraints) Performing minimization step: 2827. Total energy = 15902.3510 kcal/mol (15878.6277 without restraints) Performing minimization step: 2828. Total energy = 15894.4547 kcal/mol (15870.7327 without restraints) Performing minimization step: 2829. Total energy = 15886.5610 kcal/mol (15862.8405 without restraints) Performing minimization step: 2830. Total energy = 15878.6697 kcal/mol (15854.9505 without restraints) Performing minimization step: 2831. Total energy = 15870.7806 kcal/mol (15847.0629 without restraints) Performing minimization step: 2832. Total energy = 15862.8943 kcal/mol (15839.1779 without restraints) Performing minimization step: 2833. Total energy = 15855.0102 kcal/mol (15831.2952 without restraints) Performing minimization step: 2834. Total energy = 15847.1288 kcal/mol (15823.4152 without restraints) Performing minimization step: 2835. Total energy = 15839.2496 kcal/mol (15815.5375 without restraints) Performing minimization step: 2836. Total energy = 15831.3729 kcal/mol (15807.6621 without restraints) Performing minimization step: 2837. Total energy = 15823.4983 kcal/mol (15799.7889 without restraints) Performing minimization step: 2838. Total energy = 15815.6264 kcal/mol (15791.9184 without restraints) Performing minimization step: 2839. Total energy = 15807.7568 kcal/mol (15784.0501 without restraints) Performing minimization step: 2840. Total energy = 15799.8894 kcal/mol (15776.1841 without restraints) Performing minimization step: 2841. Total energy = 15792.0246 kcal/mol (15768.3207 without restraints) Performing minimization step: 2842. Total energy = 15784.1622 kcal/mol (15760.4597 without restraints) Performing minimization step: 2843. Total energy = 15776.3018 kcal/mol (15752.6007 without restraints) Performing minimization step: 2844. Total energy = 15768.4449 kcal/mol (15744.7452 without restraints) Performing minimization step: 2845. Total energy = 15760.5896 kcal/mol (15736.8912 without restraints) Performing minimization step: 2846. Total energy = 15752.7364 kcal/mol (15729.0394 without restraints) Performing minimization step: 2847. Total energy = 15744.8859 kcal/mol (15721.1903 without restraints) Performing minimization step: 2848. Total energy = 15737.0377 kcal/mol (15713.3435 without restraints) Performing minimization step: 2849. Total energy = 15729.1919 kcal/mol (15705.4989 without restraints) Performing minimization step: 2850. Total energy = 15721.3484 kcal/mol (15697.6569 without restraints) Performing minimization step: 2851. Total energy = 15713.5072 kcal/mol (15689.8171 without restraints) Performing minimization step: 2852. Total energy = 15705.6685 kcal/mol (15681.9798 without restraints) Performing minimization step: 2853. Total energy = 15697.8325 kcal/mol (15674.1451 without restraints) Performing minimization step: 2854. Total energy = 15689.9985 kcal/mol (15666.3126 without restraints) Performing minimization step: 2855. Total energy = 15682.1671 kcal/mol (15658.4826 without restraints) Performing minimization step: 2856. Total energy = 15674.3380 kcal/mol (15650.6548 without restraints) Performing minimization step: 2857. Total energy = 15666.5112 kcal/mol (15642.8296 without restraints) Performing minimization step: 2858. Total energy = 15658.6868 kcal/mol (15635.0064 without restraints) Performing minimization step: 2859. Total energy = 15650.8647 kcal/mol (15627.1856 without restraints) Performing minimization step: 2860. Total energy = 15643.0451 kcal/mol (15619.3674 without restraints) Performing minimization step: 2861. Total energy = 15635.2276 kcal/mol (15611.5513 without restraints) Performing minimization step: 2862. Total energy = 15627.4124 kcal/mol (15603.7375 without restraints) Performing minimization step: 2863. Total energy = 15619.5996 kcal/mol (15595.9260 without restraints) Performing minimization step: 2864. Total energy = 15611.7891 kcal/mol (15588.1169 without restraints) Performing minimization step: 2865. Total energy = 15603.9811 kcal/mol (15580.3103 without restraints) Performing minimization step: 2866. Total energy = 15596.1753 kcal/mol (15572.5059 without restraints) Performing minimization step: 2867. Total energy = 15588.3718 kcal/mol (15564.7037 without restraints) Performing minimization step: 2868. Total energy = 15580.5706 kcal/mol (15556.9039 without restraints) Performing minimization step: 2869. Total energy = 15572.7719 kcal/mol (15549.1066 without restraints) Performing minimization step: 2870. Total energy = 15564.9754 kcal/mol (15541.3114 without restraints) Performing minimization step: 2871. Total energy = 15557.1811 kcal/mol (15533.5185 without restraints) Performing minimization step: 2872. Total energy = 15549.3892 kcal/mol (15525.7279 without restraints) Performing minimization step: 2873. Total energy = 15541.5996 kcal/mol (15517.9397 without restraints) Performing minimization step: 2874. Total energy = 15533.8123 kcal/mol (15510.1538 without restraints) Performing minimization step: 2875. Total energy = 15526.0272 kcal/mol (15502.3701 without restraints) Performing minimization step: 2876. Total energy = 15518.2445 kcal/mol (15494.5888 without restraints) Performing minimization step: 2877. Total energy = 15510.4642 kcal/mol (15486.8098 without restraints) Performing minimization step: 2878. Total energy = 15502.6861 kcal/mol (15479.0331 without restraints) Performing minimization step: 2879. Total energy = 15494.9104 kcal/mol (15471.2587 without restraints) Performing minimization step: 2880. Total energy = 15487.1369 kcal/mol (15463.4865 without restraints) Performing minimization step: 2881. Total energy = 15479.3658 kcal/mol (15455.7169 without restraints) Performing minimization step: 2882. Total energy = 15471.5968 kcal/mol (15447.9491 without restraints) Performing minimization step: 2883. Total energy = 15463.8301 kcal/mol (15440.1839 without restraints) Performing minimization step: 2884. Total energy = 15456.0663 kcal/mol (15432.4215 without restraints) Performing minimization step: 2885. Total energy = 15448.3043 kcal/mol (15424.6608 without restraints) Performing minimization step: 2886. Total energy = 15440.5445 kcal/mol (15416.9025 without restraints) Performing minimization step: 2887. Total energy = 15432.7870 kcal/mol (15409.1463 without restraints) Performing minimization step: 2888. Total energy = 15425.0315 kcal/mol (15401.3922 without restraints) Performing minimization step: 2889. Total energy = 15417.2784 kcal/mol (15393.6404 without restraints) Performing minimization step: 2890. Total energy = 15409.5278 kcal/mol (15385.8913 without restraints) Performing minimization step: 2891. Total energy = 15401.7795 kcal/mol (15378.1442 without restraints) Performing minimization step: 2892. Total energy = 15394.0335 kcal/mol (15370.3997 without restraints) Performing minimization step: 2893. Total energy = 15386.2899 kcal/mol (15362.6574 without restraints) Performing minimization step: 2894. Total energy = 15378.5482 kcal/mol (15354.9171 without restraints) Performing minimization step: 2895. Total energy = 15370.8088 kcal/mol (15347.1790 without restraints) Performing minimization step: 2896. Total energy = 15363.0717 kcal/mol (15339.4433 without restraints) Performing minimization step: 2897. Total energy = 15355.3369 kcal/mol (15331.7099 without restraints) Performing minimization step: 2898. Total energy = 15347.6048 kcal/mol (15323.9790 without restraints) Performing minimization step: 2899. Total energy = 15339.8744 kcal/mol (15316.2501 without restraints) Performing minimization step: 2900. Total energy = 15332.1464 kcal/mol (15308.5234 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 2901. Total energy = 15324.4207 kcal/mol (15300.7990 without restraints) Performing minimization step: 2902. Total energy = 15316.6972 kcal/mol (15293.0770 without restraints) Performing minimization step: 2903. Total energy = 15308.9759 kcal/mol (15285.3570 without restraints) Performing minimization step: 2904. Total energy = 15301.2575 kcal/mol (15277.6399 without restraints) Performing minimization step: 2905. Total energy = 15293.5406 kcal/mol (15269.9243 without restraints) Performing minimization step: 2906. Total energy = 15285.8259 kcal/mol (15262.2111 without restraints) Performing minimization step: 2907. Total energy = 15278.1137 kcal/mol (15254.5003 without restraints) Performing minimization step: 2908. Total energy = 15270.4037 kcal/mol (15246.7915 without restraints) Performing minimization step: 2909. Total energy = 15262.6958 kcal/mol (15239.0850 without restraints) Performing minimization step: 2910. Total energy = 15254.9902 kcal/mol (15231.3807 without restraints) Performing minimization step: 2911. Total energy = 15247.2869 kcal/mol (15223.6789 without restraints) Performing minimization step: 2912. Total energy = 15239.5858 kcal/mol (15215.9791 without restraints) Performing minimization step: 2913. Total energy = 15231.8867 kcal/mol (15208.2814 without restraints) Performing minimization step: 2914. Total energy = 15224.1897 kcal/mol (15200.5858 without restraints) Performing minimization step: 2915. Total energy = 15216.4952 kcal/mol (15192.8926 without restraints) Performing minimization step: 2916. Total energy = 15208.8030 kcal/mol (15185.2019 without restraints) Performing minimization step: 2917. Total energy = 15201.1134 kcal/mol (15177.5138 without restraints) Performing minimization step: 2918. Total energy = 15193.4260 kcal/mol (15169.8275 without restraints) Performing minimization step: 2919. Total energy = 15185.7406 kcal/mol (15162.1435 without restraints) Performing minimization step: 2920. Total energy = 15178.0572 kcal/mol (15154.4614 without restraints) Performing minimization step: 2921. Total energy = 15170.3761 kcal/mol (15146.7816 without restraints) Performing minimization step: 2922. Total energy = 15162.6973 kcal/mol (15139.1041 without restraints) Performing minimization step: 2923. Total energy = 15155.0205 kcal/mol (15131.4288 without restraints) Performing minimization step: 2924. Total energy = 15147.3463 kcal/mol (15123.7559 without restraints) Performing minimization step: 2925. Total energy = 15139.6738 kcal/mol (15116.0846 without restraints) Performing minimization step: 2926. Total energy = 15132.0033 kcal/mol (15108.4156 without restraints) Performing minimization step: 2927. Total energy = 15124.3353 kcal/mol (15100.7490 without restraints) Performing minimization step: 2928. Total energy = 15116.6694 kcal/mol (15093.0844 without restraints) Performing minimization step: 2929. Total energy = 15109.0059 kcal/mol (15085.4222 without restraints) Performing minimization step: 2930. Total energy = 15101.3446 kcal/mol (15077.7623 without restraints) Performing minimization step: 2931. Total energy = 15093.6859 kcal/mol (15070.1049 without restraints) Performing minimization step: 2932. Total energy = 15086.0292 kcal/mol (15062.4496 without restraints) Performing minimization step: 2933. Total energy = 15078.3744 kcal/mol (15054.7962 without restraints) Performing minimization step: 2934. Total energy = 15070.7218 kcal/mol (15047.1447 without restraints) Performing minimization step: 2935. Total energy = 15063.0715 kcal/mol (15039.4960 without restraints) Performing minimization step: 2936. Total energy = 15055.4234 kcal/mol (15031.8492 without restraints) Performing minimization step: 2937. Total energy = 15047.7775 kcal/mol (15024.2048 without restraints) Performing minimization step: 2938. Total energy = 15040.1338 kcal/mol (15016.5624 without restraints) Performing minimization step: 2939. Total energy = 15032.4922 kcal/mol (15008.9221 without restraints) Performing minimization step: 2940. Total energy = 15024.8528 kcal/mol (15001.2840 without restraints) Performing minimization step: 2941. Total energy = 15017.2159 kcal/mol (14993.6485 without restraints) Performing minimization step: 2942. Total energy = 15009.5809 kcal/mol (14986.0148 without restraints) Performing minimization step: 2943. Total energy = 15001.9481 kcal/mol (14978.3833 without restraints) Performing minimization step: 2944. Total energy = 14994.3174 kcal/mol (14970.7540 without restraints) Performing minimization step: 2945. Total energy = 14986.6892 kcal/mol (14963.1272 without restraints) Performing minimization step: 2946. Total energy = 14979.0629 kcal/mol (14955.5022 without restraints) Performing minimization step: 2947. Total energy = 14971.4392 kcal/mol (14947.8799 without restraints) Performing minimization step: 2948. Total energy = 14963.8172 kcal/mol (14940.2592 without restraints) Performing minimization step: 2949. Total energy = 14956.1975 kcal/mol (14932.6408 without restraints) Performing minimization step: 2950. Total energy = 14948.5801 kcal/mol (14925.0248 without restraints) Performing minimization step: 2951. Total energy = 14940.9647 kcal/mol (14917.4107 without restraints) Performing minimization step: 2952. Total energy = 14933.3514 kcal/mol (14909.7988 without restraints) Performing minimization step: 2953. Total energy = 14925.7399 kcal/mol (14902.1886 without restraints) Performing minimization step: 2954. Total energy = 14918.1312 kcal/mol (14894.5813 without restraints) Performing minimization step: 2955. Total energy = 14910.5245 kcal/mol (14886.9759 without restraints) Performing minimization step: 2956. Total energy = 14902.9199 kcal/mol (14879.3727 without restraints) Performing minimization step: 2957. Total energy = 14895.3176 kcal/mol (14871.7717 without restraints) Performing minimization step: 2958. Total energy = 14887.7173 kcal/mol (14864.1728 without restraints) Performing minimization step: 2959. Total energy = 14880.1192 kcal/mol (14856.5759 without restraints) Performing minimization step: 2960. Total energy = 14872.5230 kcal/mol (14848.9812 without restraints) Performing minimization step: 2961. Total energy = 14864.9293 kcal/mol (14841.3888 without restraints) Performing minimization step: 2962. Total energy = 14857.3377 kcal/mol (14833.7986 without restraints) Performing minimization step: 2963. Total energy = 14849.7483 kcal/mol (14826.2105 without restraints) Performing minimization step: 2964. Total energy = 14842.1611 kcal/mol (14818.6246 without restraints) Performing minimization step: 2965. Total energy = 14834.5759 kcal/mol (14811.0408 without restraints) Performing minimization step: 2966. Total energy = 14826.9930 kcal/mol (14803.4592 without restraints) Performing minimization step: 2967. Total energy = 14819.4122 kcal/mol (14795.8798 without restraints) Performing minimization step: 2968. Total energy = 14811.8336 kcal/mol (14788.3025 without restraints) Performing minimization step: 2969. Total energy = 14804.2571 kcal/mol (14780.7274 without restraints) Performing minimization step: 2970. Total energy = 14796.6829 kcal/mol (14773.1544 without restraints) Performing minimization step: 2971. Total energy = 14789.1107 kcal/mol (14765.5836 without restraints) Performing minimization step: 2972. Total energy = 14781.5409 kcal/mol (14758.0152 without restraints) Performing minimization step: 2973. Total energy = 14773.9731 kcal/mol (14750.4487 without restraints) Performing minimization step: 2974. Total energy = 14766.4074 kcal/mol (14742.8843 without restraints) Performing minimization step: 2975. Total energy = 14758.8438 kcal/mol (14735.3221 without restraints) Performing minimization step: 2976. Total energy = 14751.2823 kcal/mol (14727.7620 without restraints) Performing minimization step: 2977. Total energy = 14743.7230 kcal/mol (14720.2040 without restraints) Performing minimization step: 2978. Total energy = 14736.1661 kcal/mol (14712.6485 without restraints) Performing minimization step: 2979. Total energy = 14728.6112 kcal/mol (14705.0949 without restraints) Performing minimization step: 2980. Total energy = 14721.0584 kcal/mol (14697.5434 without restraints) Performing minimization step: 2981. Total energy = 14713.5078 kcal/mol (14689.9941 without restraints) Performing minimization step: 2982. Total energy = 14705.9594 kcal/mol (14682.4472 without restraints) Performing minimization step: 2983. Total energy = 14698.4131 kcal/mol (14674.9020 without restraints) Performing minimization step: 2984. Total energy = 14690.8690 kcal/mol (14667.3594 without restraints) Performing minimization step: 2985. Total energy = 14683.3270 kcal/mol (14659.8187 without restraints) Performing minimization step: 2986. Total energy = 14675.7871 kcal/mol (14652.2801 without restraints) Performing minimization step: 2987. Total energy = 14668.2492 kcal/mol (14644.7437 without restraints) Performing minimization step: 2988. Total energy = 14660.7136 kcal/mol (14637.2094 without restraints) Performing minimization step: 2989. Total energy = 14653.1801 kcal/mol (14629.6772 without restraints) Performing minimization step: 2990. Total energy = 14645.6487 kcal/mol (14622.1472 without restraints) Performing minimization step: 2991. Total energy = 14638.1195 kcal/mol (14614.6193 without restraints) Performing minimization step: 2992. Total energy = 14630.5923 kcal/mol (14607.0934 without restraints) Performing minimization step: 2993. Total energy = 14623.0674 kcal/mol (14599.5698 without restraints) Performing minimization step: 2994. Total energy = 14615.5448 kcal/mol (14592.0486 without restraints) Performing minimization step: 2995. Total energy = 14608.0241 kcal/mol (14584.5292 without restraints) Performing minimization step: 2996. Total energy = 14600.5055 kcal/mol (14577.0120 without restraints) Performing minimization step: 2997. Total energy = 14592.9891 kcal/mol (14569.4969 without restraints) Performing minimization step: 2998. Total energy = 14585.4749 kcal/mol (14561.9840 without restraints) Performing minimization step: 2999. Total energy = 14577.9625 kcal/mol (14554.4730 without restraints) Performing minimization step: 3000. Total energy = 14570.4525 kcal/mol (14546.9644 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3001. Total energy = 14562.9445 kcal/mol (14539.4576 without restraints) Performing minimization step: 3002. Total energy = 14555.4388 kcal/mol (14531.9533 without restraints) Performing minimization step: 3003. Total energy = 14547.9350 kcal/mol (14524.4508 without restraints) Performing minimization step: 3004. Total energy = 14540.4336 kcal/mol (14516.9508 without restraints) Performing minimization step: 3005. Total energy = 14532.9342 kcal/mol (14509.4525 without restraints) Performing minimization step: 3006. Total energy = 14525.4368 kcal/mol (14501.9566 without restraints) Performing minimization step: 3007. Total energy = 14517.9422 kcal/mol (14494.4634 without restraints) Performing minimization step: 3008. Total energy = 14510.4492 kcal/mol (14486.9718 without restraints) Performing minimization step: 3009. Total energy = 14502.9587 kcal/mol (14479.4825 without restraints) Performing minimization step: 3010. Total energy = 14495.4700 kcal/mol (14471.9952 without restraints) Performing minimization step: 3011. Total energy = 14487.9833 kcal/mol (14464.5098 without restraints) Performing minimization step: 3012. Total energy = 14480.4989 kcal/mol (14457.0267 without restraints) Performing minimization step: 3013. Total energy = 14473.0166 kcal/mol (14449.5458 without restraints) Performing minimization step: 3014. Total energy = 14465.5365 kcal/mol (14442.0670 without restraints) Performing minimization step: 3015. Total energy = 14458.0584 kcal/mol (14434.5903 without restraints) Performing minimization step: 3016. Total energy = 14450.5825 kcal/mol (14427.1157 without restraints) Performing minimization step: 3017. Total energy = 14443.1088 kcal/mol (14419.6433 without restraints) Performing minimization step: 3018. Total energy = 14435.6373 kcal/mol (14412.1732 without restraints) Performing minimization step: 3019. Total energy = 14428.1680 kcal/mol (14404.7054 without restraints) Performing minimization step: 3020. Total energy = 14420.7008 kcal/mol (14397.2393 without restraints) Performing minimization step: 3021. Total energy = 14413.2357 kcal/mol (14389.7755 without restraints) Performing minimization step: 3022. Total energy = 14405.7728 kcal/mol (14382.3140 without restraints) Performing minimization step: 3023. Total energy = 14398.3121 kcal/mol (14374.8547 without restraints) Performing minimization step: 3024. Total energy = 14390.8532 kcal/mol (14367.3971 without restraints) Performing minimization step: 3025. Total energy = 14383.3965 kcal/mol (14359.9418 without restraints) Performing minimization step: 3026. Total energy = 14375.9420 kcal/mol (14352.4886 without restraints) Performing minimization step: 3027. Total energy = 14368.4895 kcal/mol (14345.0374 without restraints) Performing minimization step: 3028. Total energy = 14361.0391 kcal/mol (14337.5883 without restraints) Performing minimization step: 3029. Total energy = 14353.5911 kcal/mol (14330.1417 without restraints) Performing minimization step: 3030. Total energy = 14346.1450 kcal/mol (14322.6969 without restraints) Performing minimization step: 3031. Total energy = 14338.7010 kcal/mol (14315.2543 without restraints) Performing minimization step: 3032. Total energy = 14331.2593 kcal/mol (14307.8139 without restraints) Performing minimization step: 3033. Total energy = 14323.8198 kcal/mol (14300.3757 without restraints) Performing minimization step: 3034. Total energy = 14316.3822 kcal/mol (14292.9394 without restraints) Performing minimization step: 3035. Total energy = 14308.9467 kcal/mol (14285.5053 without restraints) Performing minimization step: 3036. Total energy = 14301.5134 kcal/mol (14278.0733 without restraints) Performing minimization step: 3037. Total energy = 14294.0821 kcal/mol (14270.6434 without restraints) Performing minimization step: 3038. Total energy = 14286.6532 kcal/mol (14263.2158 without restraints) Performing minimization step: 3039. Total energy = 14279.2263 kcal/mol (14255.7902 without restraints) Performing minimization step: 3040. Total energy = 14271.8017 kcal/mol (14248.3670 without restraints) Performing minimization step: 3041. Total energy = 14264.3790 kcal/mol (14240.9456 without restraints) Performing minimization step: 3042. Total energy = 14256.9583 kcal/mol (14233.5262 without restraints) Performing minimization step: 3043. Total energy = 14249.5398 kcal/mol (14226.1090 without restraints) Performing minimization step: 3044. Total energy = 14242.1234 kcal/mol (14218.6939 without restraints) Performing minimization step: 3045. Total energy = 14234.7091 kcal/mol (14211.2810 without restraints) Performing minimization step: 3046. Total energy = 14227.2965 kcal/mol (14203.8697 without restraints) Performing minimization step: 3047. Total energy = 14219.8864 kcal/mol (14196.4608 without restraints) Performing minimization step: 3048. Total energy = 14212.4784 kcal/mol (14189.0543 without restraints) Performing minimization step: 3049. Total energy = 14205.0729 kcal/mol (14181.6502 without restraints) Performing minimization step: 3050. Total energy = 14197.6691 kcal/mol (14174.2477 without restraints) Performing minimization step: 3051. Total energy = 14190.2676 kcal/mol (14166.8476 without restraints) Performing minimization step: 3052. Total energy = 14182.8683 kcal/mol (14159.4495 without restraints) Performing minimization step: 3053. Total energy = 14175.4710 kcal/mol (14152.0536 without restraints) Performing minimization step: 3054. Total energy = 14168.0759 kcal/mol (14144.6599 without restraints) Performing minimization step: 3055. Total energy = 14160.6830 kcal/mol (14137.2683 without restraints) Performing minimization step: 3056. Total energy = 14153.2922 kcal/mol (14129.8788 without restraints) Performing minimization step: 3057. Total energy = 14145.9035 kcal/mol (14122.4916 without restraints) Performing minimization step: 3058. Total energy = 14138.5171 kcal/mol (14115.1064 without restraints) Performing minimization step: 3059. Total energy = 14131.1325 kcal/mol (14107.7231 without restraints) Performing minimization step: 3060. Total energy = 14123.7500 kcal/mol (14100.3419 without restraints) Performing minimization step: 3061. Total energy = 14116.3698 kcal/mol (14092.9630 without restraints) Performing minimization step: 3062. Total energy = 14108.9919 kcal/mol (14085.5864 without restraints) Performing minimization step: 3063. Total energy = 14101.6159 kcal/mol (14078.2118 without restraints) Performing minimization step: 3064. Total energy = 14094.2425 kcal/mol (14070.8397 without restraints) Performing minimization step: 3065. Total energy = 14086.8708 kcal/mol (14063.4694 without restraints) Performing minimization step: 3066. Total energy = 14079.5013 kcal/mol (14056.1012 without restraints) Performing minimization step: 3067. Total energy = 14072.1342 kcal/mol (14048.7353 without restraints) Performing minimization step: 3068. Total energy = 14064.7688 kcal/mol (14041.3714 without restraints) Performing minimization step: 3069. Total energy = 14057.4057 kcal/mol (14034.0096 without restraints) Performing minimization step: 3070. Total energy = 14050.0444 kcal/mol (14026.6496 without restraints) Performing minimization step: 3071. Total energy = 14042.6855 kcal/mol (14019.2921 without restraints) Performing minimization step: 3072. Total energy = 14035.3285 kcal/mol (14011.9365 without restraints) Performing minimization step: 3073. Total energy = 14027.9741 kcal/mol (14004.5834 without restraints) Performing minimization step: 3074. Total energy = 14020.6216 kcal/mol (13997.2322 without restraints) Performing minimization step: 3075. Total energy = 14013.2713 kcal/mol (13989.8832 without restraints) Performing minimization step: 3076. Total energy = 14005.9230 kcal/mol (13982.5363 without restraints) Performing minimization step: 3077. Total energy = 13998.5767 kcal/mol (13975.1913 without restraints) Performing minimization step: 3078. Total energy = 13991.2330 kcal/mol (13967.8489 without restraints) Performing minimization step: 3079. Total energy = 13983.8913 kcal/mol (13960.5086 without restraints) Performing minimization step: 3080. Total energy = 13976.5517 kcal/mol (13953.1703 without restraints) Performing minimization step: 3081. Total energy = 13969.2141 kcal/mol (13945.8340 without restraints) Performing minimization step: 3082. Total energy = 13961.8786 kcal/mol (13938.4997 without restraints) Performing minimization step: 3083. Total energy = 13954.5453 kcal/mol (13931.1681 without restraints) Performing minimization step: 3084. Total energy = 13947.2143 kcal/mol (13923.8382 without restraints) Performing minimization step: 3085. Total energy = 13939.8855 kcal/mol (13916.5107 without restraints) Performing minimization step: 3086. Total energy = 13932.5588 kcal/mol (13909.1853 without restraints) Performing minimization step: 3087. Total energy = 13925.2340 kcal/mol (13901.8619 without restraints) Performing minimization step: 3088. Total energy = 13917.9114 kcal/mol (13894.5406 without restraints) Performing minimization step: 3089. Total energy = 13910.5904 kcal/mol (13887.2210 without restraints) Performing minimization step: 3090. Total energy = 13903.2721 kcal/mol (13879.9040 without restraints) Performing minimization step: 3091. Total energy = 13895.9560 kcal/mol (13872.5892 without restraints) Performing minimization step: 3092. Total energy = 13888.6419 kcal/mol (13865.2764 without restraints) Performing minimization step: 3093. Total energy = 13881.3299 kcal/mol (13857.9658 without restraints) Performing minimization step: 3094. Total energy = 13874.0203 kcal/mol (13850.6575 without restraints) Performing minimization step: 3095. Total energy = 13866.7127 kcal/mol (13843.3512 without restraints) Performing minimization step: 3096. Total energy = 13859.4072 kcal/mol (13836.0471 without restraints) Performing minimization step: 3097. Total energy = 13852.1038 kcal/mol (13828.7451 without restraints) Performing minimization step: 3098. Total energy = 13844.8026 kcal/mol (13821.4451 without restraints) Performing minimization step: 3099. Total energy = 13837.5035 kcal/mol (13814.1474 without restraints) Performing minimization step: 3100. Total energy = 13830.2069 kcal/mol (13806.8521 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3101. Total energy = 13822.9122 kcal/mol (13799.5587 without restraints) Performing minimization step: 3102. Total energy = 13815.6194 kcal/mol (13792.2672 without restraints) Performing minimization step: 3103. Total energy = 13808.3286 kcal/mol (13784.9778 without restraints) Performing minimization step: 3104. Total energy = 13801.0406 kcal/mol (13777.6911 without restraints) Performing minimization step: 3105. Total energy = 13793.7545 kcal/mol (13770.4064 without restraints) Performing minimization step: 3106. Total energy = 13786.4703 kcal/mol (13763.1235 without restraints) Performing minimization step: 3107. Total energy = 13779.1885 kcal/mol (13755.8431 without restraints) Performing minimization step: 3108. Total energy = 13771.9091 kcal/mol (13748.5649 without restraints) Performing minimization step: 3109. Total energy = 13764.6314 kcal/mol (13741.2886 without restraints) Performing minimization step: 3110. Total energy = 13757.3561 kcal/mol (13734.0147 without restraints) Performing minimization step: 3111. Total energy = 13750.0828 kcal/mol (13726.7427 without restraints) Performing minimization step: 3112. Total energy = 13742.8117 kcal/mol (13719.4729 without restraints) Performing minimization step: 3113. Total energy = 13735.5427 kcal/mol (13712.2053 without restraints) Performing minimization step: 3114. Total energy = 13728.2759 kcal/mol (13704.9397 without restraints) Performing minimization step: 3115. Total energy = 13721.0112 kcal/mol (13697.6764 without restraints) Performing minimization step: 3116. Total energy = 13713.7485 kcal/mol (13690.4150 without restraints) Performing minimization step: 3117. Total energy = 13706.4881 kcal/mol (13683.1559 without restraints) Performing minimization step: 3118. Total energy = 13699.2300 kcal/mol (13675.8992 without restraints) Performing minimization step: 3119. Total energy = 13691.9739 kcal/mol (13668.6445 without restraints) Performing minimization step: 3120. Total energy = 13684.7203 kcal/mol (13661.3921 without restraints) Performing minimization step: 3121. Total energy = 13677.4687 kcal/mol (13654.1419 without restraints) Performing minimization step: 3122. Total energy = 13670.2190 kcal/mol (13646.8935 without restraints) Performing minimization step: 3123. Total energy = 13662.9715 kcal/mol (13639.6474 without restraints) Performing minimization step: 3124. Total energy = 13655.7263 kcal/mol (13632.4035 without restraints) Performing minimization step: 3125. Total energy = 13648.4832 kcal/mol (13625.1617 without restraints) Performing minimization step: 3126. Total energy = 13641.2422 kcal/mol (13617.9220 without restraints) Performing minimization step: 3127. Total energy = 13634.0034 kcal/mol (13610.6845 without restraints) Performing minimization step: 3128. Total energy = 13626.7668 kcal/mol (13603.4493 without restraints) Performing minimization step: 3129. Total energy = 13619.5325 kcal/mol (13596.2164 without restraints) Performing minimization step: 3130. Total energy = 13612.3001 kcal/mol (13588.9851 without restraints) Performing minimization step: 3131. Total energy = 13605.0698 kcal/mol (13581.7563 without restraints) Performing minimization step: 3132. Total energy = 13597.8420 kcal/mol (13574.5298 without restraints) Performing minimization step: 3133. Total energy = 13590.6162 kcal/mol (13567.3053 without restraints) Performing minimization step: 3134. Total energy = 13583.3925 kcal/mol (13560.0830 without restraints) Performing minimization step: 3135. Total energy = 13576.1710 kcal/mol (13552.8629 without restraints) Performing minimization step: 3136. Total energy = 13568.9517 kcal/mol (13545.6449 without restraints) Performing minimization step: 3137. Total energy = 13561.7348 kcal/mol (13538.4292 without restraints) Performing minimization step: 3138. Total energy = 13554.5198 kcal/mol (13531.2156 without restraints) Performing minimization step: 3139. Total energy = 13547.3069 kcal/mol (13524.0040 without restraints) Performing minimization step: 3140. Total energy = 13540.0962 kcal/mol (13516.7947 without restraints) Performing minimization step: 3141. Total energy = 13532.8877 kcal/mol (13509.5875 without restraints) Performing minimization step: 3142. Total energy = 13525.6818 kcal/mol (13502.3830 without restraints) Performing minimization step: 3143. Total energy = 13518.4780 kcal/mol (13495.1806 without restraints) Performing minimization step: 3144. Total energy = 13511.2757 kcal/mol (13487.9795 without restraints) Performing minimization step: 3145. Total energy = 13504.0757 kcal/mol (13480.7809 without restraints) Performing minimization step: 3146. Total energy = 13496.8782 kcal/mol (13473.5847 without restraints) Performing minimization step: 3147. Total energy = 13489.6830 kcal/mol (13466.3909 without restraints) Performing minimization step: 3148. Total energy = 13482.4898 kcal/mol (13459.1990 without restraints) Performing minimization step: 3149. Total energy = 13475.2987 kcal/mol (13452.0092 without restraints) Performing minimization step: 3150. Total energy = 13468.1104 kcal/mol (13444.8223 without restraints) Performing minimization step: 3151. Total energy = 13460.9238 kcal/mol (13437.6370 without restraints) Performing minimization step: 3152. Total energy = 13453.7393 kcal/mol (13430.4538 without restraints) Performing minimization step: 3153. Total energy = 13446.5570 kcal/mol (13423.2728 without restraints) Performing minimization step: 3154. Total energy = 13439.3772 kcal/mol (13416.0944 without restraints) Performing minimization step: 3155. Total energy = 13432.1991 kcal/mol (13408.9176 without restraints) Performing minimization step: 3156. Total energy = 13425.0234 kcal/mol (13401.7432 without restraints) Performing minimization step: 3157. Total energy = 13417.8498 kcal/mol (13394.5710 without restraints) Performing minimization step: 3158. Total energy = 13410.6785 kcal/mol (13387.4010 without restraints) Performing minimization step: 3159. Total energy = 13403.5094 kcal/mol (13380.2333 without restraints) Performing minimization step: 3160. Total energy = 13396.3425 kcal/mol (13373.0676 without restraints) Performing minimization step: 3161. Total energy = 13389.1776 kcal/mol (13365.9040 without restraints) Performing minimization step: 3162. Total energy = 13382.0152 kcal/mol (13358.7430 without restraints) Performing minimization step: 3163. Total energy = 13374.8553 kcal/mol (13351.5845 without restraints) Performing minimization step: 3164. Total energy = 13367.6971 kcal/mol (13344.4277 without restraints) Performing minimization step: 3165. Total energy = 13360.5410 kcal/mol (13337.2729 without restraints) Performing minimization step: 3166. Total energy = 13353.3871 kcal/mol (13330.1202 without restraints) Performing minimization step: 3167. Total energy = 13346.2355 kcal/mol (13322.9701 without restraints) Performing minimization step: 3168. Total energy = 13339.0860 kcal/mol (13315.8218 without restraints) Performing minimization step: 3169. Total energy = 13331.9386 kcal/mol (13308.6758 without restraints) Performing minimization step: 3170. Total energy = 13324.7937 kcal/mol (13301.5322 without restraints) Performing minimization step: 3171. Total energy = 13317.6510 kcal/mol (13294.3909 without restraints) Performing minimization step: 3172. Total energy = 13310.5103 kcal/mol (13287.2514 without restraints) Performing minimization step: 3173. Total energy = 13303.3719 kcal/mol (13280.1144 without restraints) Performing minimization step: 3174. Total energy = 13296.2354 kcal/mol (13272.9791 without restraints) Performing minimization step: 3175. Total energy = 13289.1013 kcal/mol (13265.8465 without restraints) Performing minimization step: 3176. Total energy = 13281.9697 kcal/mol (13258.7162 without restraints) Performing minimization step: 3177. Total energy = 13274.8400 kcal/mol (13251.5878 without restraints) Performing minimization step: 3178. Total energy = 13267.7127 kcal/mol (13244.4619 without restraints) Performing minimization step: 3179. Total energy = 13260.5876 kcal/mol (13237.3382 without restraints) Performing minimization step: 3180. Total energy = 13253.4647 kcal/mol (13230.2167 without restraints) Performing minimization step: 3181. Total energy = 13246.3444 kcal/mol (13223.0976 without restraints) Performing minimization step: 3182. Total energy = 13239.2259 kcal/mol (13215.9805 without restraints) Performing minimization step: 3183. Total energy = 13232.1097 kcal/mol (13208.8656 without restraints) Performing minimization step: 3184. Total energy = 13224.9957 kcal/mol (13201.7529 without restraints) Performing minimization step: 3185. Total energy = 13217.8837 kcal/mol (13194.6423 without restraints) Performing minimization step: 3186. Total energy = 13210.7741 kcal/mol (13187.5340 without restraints) Performing minimization step: 3187. Total energy = 13203.6666 kcal/mol (13180.4278 without restraints) Performing minimization step: 3188. Total energy = 13196.5617 kcal/mol (13173.3243 without restraints) Performing minimization step: 3189. Total energy = 13189.4589 kcal/mol (13166.2228 without restraints) Performing minimization step: 3190. Total energy = 13182.3582 kcal/mol (13159.1235 without restraints) Performing minimization step: 3191. Total energy = 13175.2601 kcal/mol (13152.0266 without restraints) Performing minimization step: 3192. Total energy = 13168.1639 kcal/mol (13144.9318 without restraints) Performing minimization step: 3193. Total energy = 13161.0699 kcal/mol (13137.8392 without restraints) Performing minimization step: 3194. Total energy = 13153.9782 kcal/mol (13130.7488 without restraints) Performing minimization step: 3195. Total energy = 13146.8887 kcal/mol (13123.6606 without restraints) Performing minimization step: 3196. Total energy = 13139.8014 kcal/mol (13116.5747 without restraints) Performing minimization step: 3197. Total energy = 13132.7164 kcal/mol (13109.4910 without restraints) Performing minimization step: 3198. Total energy = 13125.6340 kcal/mol (13102.4100 without restraints) Performing minimization step: 3199. Total energy = 13118.5539 kcal/mol (13095.3312 without restraints) Performing minimization step: 3200. Total energy = 13111.4756 kcal/mol (13088.2542 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3201. Total energy = 13104.3995 kcal/mol (13081.1795 without restraints) Performing minimization step: 3202. Total energy = 13097.3256 kcal/mol (13074.1069 without restraints) Performing minimization step: 3203. Total energy = 13090.2540 kcal/mol (13067.0367 without restraints) Performing minimization step: 3204. Total energy = 13083.1845 kcal/mol (13059.9685 without restraints) Performing minimization step: 3205. Total energy = 13076.1175 kcal/mol (13052.9028 without restraints) Performing minimization step: 3206. Total energy = 13069.0526 kcal/mol (13045.8393 without restraints) Performing minimization step: 3207. Total energy = 13061.9898 kcal/mol (13038.7778 without restraints) Performing minimization step: 3208. Total energy = 13054.9295 kcal/mol (13031.7189 without restraints) Performing minimization step: 3209. Total energy = 13047.8715 kcal/mol (13024.6622 without restraints) Performing minimization step: 3210. Total energy = 13040.8155 kcal/mol (13017.6075 without restraints) Performing minimization step: 3211. Total energy = 13033.7619 kcal/mol (13010.5553 without restraints) Performing minimization step: 3212. Total energy = 13026.7108 kcal/mol (13003.5055 without restraints) Performing minimization step: 3213. Total energy = 13019.6617 kcal/mol (12996.4578 without restraints) Performing minimization step: 3214. Total energy = 13012.6153 kcal/mol (12989.4126 without restraints) Performing minimization step: 3215. Total energy = 13005.5707 kcal/mol (12982.3695 without restraints) Performing minimization step: 3216. Total energy = 12998.5285 kcal/mol (12975.3286 without restraints) Performing minimization step: 3217. Total energy = 12991.4885 kcal/mol (12968.2899 without restraints) Performing minimization step: 3218. Total energy = 12984.4505 kcal/mol (12961.2533 without restraints) Performing minimization step: 3219. Total energy = 12977.4152 kcal/mol (12954.2192 without restraints) Performing minimization step: 3220. Total energy = 12970.3820 kcal/mol (12947.1874 without restraints) Performing minimization step: 3221. Total energy = 12963.3510 kcal/mol (12940.1578 without restraints) Performing minimization step: 3222. Total energy = 12956.3225 kcal/mol (12933.1306 without restraints) Performing minimization step: 3223. Total energy = 12949.2961 kcal/mol (12926.1056 without restraints) Performing minimization step: 3224. Total energy = 12942.2720 kcal/mol (12919.0828 without restraints) Performing minimization step: 3225. Total energy = 12935.2501 kcal/mol (12912.0621 without restraints) Performing minimization step: 3226. Total energy = 12928.2304 kcal/mol (12905.0439 without restraints) Performing minimization step: 3227. Total energy = 12921.2131 kcal/mol (12898.0279 without restraints) Performing minimization step: 3228. Total energy = 12914.1981 kcal/mol (12891.0144 without restraints) Performing minimization step: 3229. Total energy = 12907.1855 kcal/mol (12884.0030 without restraints) Performing minimization step: 3230. Total energy = 12900.1750 kcal/mol (12876.9939 without restraints) Performing minimization step: 3231. Total energy = 12893.1669 kcal/mol (12869.9871 without restraints) Performing minimization step: 3232. Total energy = 12886.1610 kcal/mol (12862.9826 without restraints) Performing minimization step: 3233. Total energy = 12879.1576 kcal/mol (12855.9805 without restraints) Performing minimization step: 3234. Total energy = 12872.1567 kcal/mol (12848.9809 without restraints) Performing minimization step: 3235. Total energy = 12865.1576 kcal/mol (12841.9832 without restraints) Performing minimization step: 3236. Total energy = 12858.1609 kcal/mol (12834.9878 without restraints) Performing minimization step: 3237. Total energy = 12851.1665 kcal/mol (12827.9948 without restraints) Performing minimization step: 3238. Total energy = 12844.1746 kcal/mol (12821.0042 without restraints) Performing minimization step: 3239. Total energy = 12837.1849 kcal/mol (12814.0159 without restraints) Performing minimization step: 3240. Total energy = 12830.1976 kcal/mol (12807.0300 without restraints) Performing minimization step: 3241. Total energy = 12823.2124 kcal/mol (12800.0460 without restraints) Performing minimization step: 3242. Total energy = 12816.2295 kcal/mol (12793.0645 without restraints) Performing minimization step: 3243. Total energy = 12809.2491 kcal/mol (12786.0854 without restraints) Performing minimization step: 3244. Total energy = 12802.2708 kcal/mol (12779.1085 without restraints) Performing minimization step: 3245. Total energy = 12795.2948 kcal/mol (12772.1338 without restraints) Performing minimization step: 3246. Total energy = 12788.3212 kcal/mol (12765.1616 without restraints) Performing minimization step: 3247. Total energy = 12781.3498 kcal/mol (12758.1915 without restraints) Performing minimization step: 3248. Total energy = 12774.3806 kcal/mol (12751.2237 without restraints) Performing minimization step: 3249. Total energy = 12767.4141 kcal/mol (12744.2585 without restraints) Performing minimization step: 3250. Total energy = 12760.4497 kcal/mol (12737.2954 without restraints) Performing minimization step: 3251. Total energy = 12753.4875 kcal/mol (12730.3346 without restraints) Performing minimization step: 3252. Total energy = 12746.5277 kcal/mol (12723.3762 without restraints) Performing minimization step: 3253. Total energy = 12739.5706 kcal/mol (12716.4206 without restraints) Performing minimization step: 3254. Total energy = 12732.6157 kcal/mol (12709.4668 without restraints) Performing minimization step: 3255. Total energy = 12725.6628 kcal/mol (12702.5152 without restraints) Performing minimization step: 3256. Total energy = 12718.7120 kcal/mol (12695.5658 without restraints) Performing minimization step: 3257. Total energy = 12711.7639 kcal/mol (12688.6191 without restraints) Performing minimization step: 3258. Total energy = 12704.8183 kcal/mol (12681.6748 without restraints) Performing minimization step: 3259. Total energy = 12697.8747 kcal/mol (12674.7326 without restraints) Performing minimization step: 3260. Total energy = 12690.9335 kcal/mol (12667.7927 without restraints) Performing minimization step: 3261. Total energy = 12683.9945 kcal/mol (12660.8551 without restraints) Performing minimization step: 3262. Total energy = 12677.0582 kcal/mol (12653.9201 without restraints) Performing minimization step: 3263. Total energy = 12670.1239 kcal/mol (12646.9872 without restraints) Performing minimization step: 3264. Total energy = 12663.1920 kcal/mol (12640.0566 without restraints) Performing minimization step: 3265. Total energy = 12656.2624 kcal/mol (12633.1284 without restraints) Performing minimization step: 3266. Total energy = 12649.3352 kcal/mol (12626.2025 without restraints) Performing minimization step: 3267. Total energy = 12642.4102 kcal/mol (12619.2789 without restraints) Performing minimization step: 3268. Total energy = 12635.4879 kcal/mol (12612.3579 without restraints) Performing minimization step: 3269. Total energy = 12628.5673 kcal/mol (12605.4386 without restraints) Performing minimization step: 3270. Total energy = 12621.6496 kcal/mol (12598.5223 without restraints) Performing minimization step: 3271. Total energy = 12614.7341 kcal/mol (12591.6081 without restraints) Performing minimization step: 3272. Total energy = 12607.8214 kcal/mol (12584.6969 without restraints) Performing minimization step: 3273. Total energy = 12600.9107 kcal/mol (12577.7874 without restraints) Performing minimization step: 3274. Total energy = 12594.0022 kcal/mol (12570.8803 without restraints) Performing minimization step: 3275. Total energy = 12587.0958 kcal/mol (12563.9752 without restraints) Performing minimization step: 3276. Total energy = 12580.1921 kcal/mol (12557.0729 without restraints) Performing minimization step: 3277. Total energy = 12573.2907 kcal/mol (12550.1729 without restraints) Performing minimization step: 3278. Total energy = 12566.3917 kcal/mol (12543.2752 without restraints) Performing minimization step: 3279. Total energy = 12559.4951 kcal/mol (12536.3800 without restraints) Performing minimization step: 3280. Total energy = 12552.6008 kcal/mol (12529.4870 without restraints) Performing minimization step: 3281. Total energy = 12545.7089 kcal/mol (12522.5965 without restraints) Performing minimization step: 3282. Total energy = 12538.8193 kcal/mol (12515.7083 without restraints) Performing minimization step: 3283. Total energy = 12531.9321 kcal/mol (12508.8224 without restraints) Performing minimization step: 3284. Total energy = 12525.0474 kcal/mol (12501.9392 without restraints) Performing minimization step: 3285. Total energy = 12518.1651 kcal/mol (12495.0581 without restraints) Performing minimization step: 3286. Total energy = 12511.2850 kcal/mol (12488.1793 without restraints) Performing minimization step: 3287. Total energy = 12504.4069 kcal/mol (12481.3026 without restraints) Performing minimization step: 3288. Total energy = 12497.5316 kcal/mol (12474.4286 without restraints) Performing minimization step: 3289. Total energy = 12490.6584 kcal/mol (12467.5568 without restraints) Performing minimization step: 3290. Total energy = 12483.7881 kcal/mol (12460.6880 without restraints) Performing minimization step: 3291. Total energy = 12476.9202 kcal/mol (12453.8213 without restraints) Performing minimization step: 3292. Total energy = 12470.0544 kcal/mol (12446.9569 without restraints) Performing minimization step: 3293. Total energy = 12463.1905 kcal/mol (12440.0943 without restraints) Performing minimization step: 3294. Total energy = 12456.3294 kcal/mol (12433.2346 without restraints) Performing minimization step: 3295. Total energy = 12449.4709 kcal/mol (12426.3774 without restraints) Performing minimization step: 3296. Total energy = 12442.6148 kcal/mol (12419.5227 without restraints) Performing minimization step: 3297. Total energy = 12435.7610 kcal/mol (12412.6702 without restraints) Performing minimization step: 3298. Total energy = 12428.9095 kcal/mol (12405.8201 without restraints) Performing minimization step: 3299. Total energy = 12422.0604 kcal/mol (12398.9724 without restraints) Performing minimization step: 3300. Total energy = 12415.2138 kcal/mol (12392.1271 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3301. Total energy = 12408.3695 kcal/mol (12385.2842 without restraints) Performing minimization step: 3302. Total energy = 12401.5274 kcal/mol (12378.4434 without restraints) Performing minimization step: 3303. Total energy = 12394.6879 kcal/mol (12371.6053 without restraints) Performing minimization step: 3304. Total energy = 12387.8510 kcal/mol (12364.7698 without restraints) Performing minimization step: 3305. Total energy = 12381.0162 kcal/mol (12357.9363 without restraints) Performing minimization step: 3306. Total energy = 12374.1839 kcal/mol (12351.1054 without restraints) Performing minimization step: 3307. Total energy = 12367.3543 kcal/mol (12344.2771 without restraints) Performing minimization step: 3308. Total energy = 12360.5268 kcal/mol (12337.4510 without restraints) Performing minimization step: 3309. Total energy = 12353.7018 kcal/mol (12330.6274 without restraints) Performing minimization step: 3310. Total energy = 12346.8793 kcal/mol (12323.8062 without restraints) Performing minimization step: 3311. Total energy = 12340.0591 kcal/mol (12316.9874 without restraints) Performing minimization step: 3312. Total energy = 12333.2413 kcal/mol (12310.1710 without restraints) Performing minimization step: 3313. Total energy = 12326.4260 kcal/mol (12303.3570 without restraints) Performing minimization step: 3314. Total energy = 12319.6129 kcal/mol (12296.5453 without restraints) Performing minimization step: 3315. Total energy = 12312.8027 kcal/mol (12289.7364 without restraints) Performing minimization step: 3316. Total energy = 12305.9947 kcal/mol (12282.9297 without restraints) Performing minimization step: 3317. Total energy = 12299.1891 kcal/mol (12276.1255 without restraints) Performing minimization step: 3318. Total energy = 12292.3859 kcal/mol (12269.3237 without restraints) Performing minimization step: 3319. Total energy = 12285.5852 kcal/mol (12262.5243 without restraints) Performing minimization step: 3320. Total energy = 12278.7872 kcal/mol (12255.7277 without restraints) Performing minimization step: 3321. Total energy = 12271.9913 kcal/mol (12248.9332 without restraints) Performing minimization step: 3322. Total energy = 12265.1979 kcal/mol (12242.1411 without restraints) Performing minimization step: 3323. Total energy = 12258.4071 kcal/mol (12235.3517 without restraints) Performing minimization step: 3324. Total energy = 12251.6186 kcal/mol (12228.5645 without restraints) Performing minimization step: 3325. Total energy = 12244.8326 kcal/mol (12221.7800 without restraints) Performing minimization step: 3326. Total energy = 12238.0489 kcal/mol (12214.9976 without restraints) Performing minimization step: 3327. Total energy = 12231.2677 kcal/mol (12208.2178 without restraints) Performing minimization step: 3328. Total energy = 12224.4889 kcal/mol (12201.4404 without restraints) Performing minimization step: 3329. Total energy = 12217.7127 kcal/mol (12194.6655 without restraints) Performing minimization step: 3330. Total energy = 12210.9386 kcal/mol (12187.8928 without restraints) Performing minimization step: 3331. Total energy = 12204.1675 kcal/mol (12181.1232 without restraints) Performing minimization step: 3332. Total energy = 12197.3988 kcal/mol (12174.3556 without restraints) Performing minimization step: 3333. Total energy = 12190.6327 kcal/mol (12167.5910 without restraints) Performing minimization step: 3334. Total energy = 12183.8687 kcal/mol (12160.8283 without restraints) Performing minimization step: 3335. Total energy = 12177.1072 kcal/mol (12154.0682 without restraints) Performing minimization step: 3336. Total energy = 12170.3479 kcal/mol (12147.3102 without restraints) Performing minimization step: 3337. Total energy = 12163.5916 kcal/mol (12140.5556 without restraints) Performing minimization step: 3338. Total energy = 12156.8381 kcal/mol (12133.8032 without restraints) Performing minimization step: 3339. Total energy = 12150.0865 kcal/mol (12127.0529 without restraints) Performing minimization step: 3340. Total energy = 12143.3371 kcal/mol (12120.3049 without restraints) Performing minimization step: 3341. Total energy = 12136.5904 kcal/mol (12113.5596 without restraints) Performing minimization step: 3342. Total energy = 12129.8461 kcal/mol (12106.8168 without restraints) Performing minimization step: 3343. Total energy = 12123.1045 kcal/mol (12100.0764 without restraints) Performing minimization step: 3344. Total energy = 12116.3652 kcal/mol (12093.3385 without restraints) Performing minimization step: 3345. Total energy = 12109.6284 kcal/mol (12086.6031 without restraints) Performing minimization step: 3346. Total energy = 12102.8943 kcal/mol (12079.8703 without restraints) Performing minimization step: 3347. Total energy = 12096.1626 kcal/mol (12073.1400 without restraints) Performing minimization step: 3348. Total energy = 12089.4333 kcal/mol (12066.4120 without restraints) Performing minimization step: 3349. Total energy = 12082.7065 kcal/mol (12059.6866 without restraints) Performing minimization step: 3350. Total energy = 12075.9820 kcal/mol (12052.9635 without restraints) Performing minimization step: 3351. Total energy = 12069.2604 kcal/mol (12046.2433 without restraints) Performing minimization step: 3352. Total energy = 12062.5413 kcal/mol (12039.5256 without restraints) Performing minimization step: 3353. Total energy = 12055.8245 kcal/mol (12032.8102 without restraints) Performing minimization step: 3354. Total energy = 12049.1100 kcal/mol (12026.0970 without restraints) Performing minimization step: 3355. Total energy = 12042.3983 kcal/mol (12019.3866 without restraints) Performing minimization step: 3356. Total energy = 12035.6890 kcal/mol (12012.6787 without restraints) Performing minimization step: 3357. Total energy = 12028.9826 kcal/mol (12005.9737 without restraints) Performing minimization step: 3358. Total energy = 12022.2783 kcal/mol (11999.2708 without restraints) Performing minimization step: 3359. Total energy = 12015.5767 kcal/mol (11992.5706 without restraints) Performing minimization step: 3360. Total energy = 12008.8774 kcal/mol (11985.8727 without restraints) Performing minimization step: 3361. Total energy = 12002.1810 kcal/mol (11979.1776 without restraints) Performing minimization step: 3362. Total energy = 11995.4868 kcal/mol (11972.4848 without restraints) Performing minimization step: 3363. Total energy = 11988.7952 kcal/mol (11965.7947 without restraints) Performing minimization step: 3364. Total energy = 11982.1062 kcal/mol (11959.1069 without restraints) Performing minimization step: 3365. Total energy = 11975.4199 kcal/mol (11952.4220 without restraints) Performing minimization step: 3366. Total energy = 11968.7358 kcal/mol (11945.7393 without restraints) Performing minimization step: 3367. Total energy = 11962.0542 kcal/mol (11939.0591 without restraints) Performing minimization step: 3368. Total energy = 11955.3752 kcal/mol (11932.3814 without restraints) Performing minimization step: 3369. Total energy = 11948.6987 kcal/mol (11925.7063 without restraints) Performing minimization step: 3370. Total energy = 11942.0247 kcal/mol (11919.0337 without restraints) Performing minimization step: 3371. Total energy = 11935.3534 kcal/mol (11912.3638 without restraints) Performing minimization step: 3372. Total energy = 11928.6844 kcal/mol (11905.6961 without restraints) Performing minimization step: 3373. Total energy = 11922.0182 kcal/mol (11899.0313 without restraints) Performing minimization step: 3374. Total energy = 11915.3544 kcal/mol (11892.3689 without restraints) Performing minimization step: 3375. Total energy = 11908.6933 kcal/mol (11885.7091 without restraints) Performing minimization step: 3376. Total energy = 11902.0345 kcal/mol (11879.0517 without restraints) Performing minimization step: 3377. Total energy = 11895.3783 kcal/mol (11872.3969 without restraints) Performing minimization step: 3378. Total energy = 11888.7248 kcal/mol (11865.7450 without restraints) Performing minimization step: 3379. Total energy = 11882.0742 kcal/mol (11859.0956 without restraints) Performing minimization step: 3380. Total energy = 11875.4257 kcal/mol (11852.4485 without restraints) Performing minimization step: 3381. Total energy = 11868.7798 kcal/mol (11845.8039 without restraints) Performing minimization step: 3382. Total energy = 11862.1365 kcal/mol (11839.1621 without restraints) Performing minimization step: 3383. Total energy = 11855.4958 kcal/mol (11832.5227 without restraints) Performing minimization step: 3384. Total energy = 11848.8577 kcal/mol (11825.8860 without restraints) Performing minimization step: 3385. Total energy = 11842.2220 kcal/mol (11819.2517 without restraints) Performing minimization step: 3386. Total energy = 11835.5890 kcal/mol (11812.6201 without restraints) Performing minimization step: 3387. Total energy = 11828.9585 kcal/mol (11805.9909 without restraints) Performing minimization step: 3388. Total energy = 11822.3305 kcal/mol (11799.3643 without restraints) Performing minimization step: 3389. Total energy = 11815.7051 kcal/mol (11792.7403 without restraints) Performing minimization step: 3390. Total energy = 11809.0824 kcal/mol (11786.1190 without restraints) Performing minimization step: 3391. Total energy = 11802.4624 kcal/mol (11779.5004 without restraints) Performing minimization step: 3392. Total energy = 11795.8448 kcal/mol (11772.8841 without restraints) Performing minimization step: 3393. Total energy = 11789.2297 kcal/mol (11766.2706 without restraints) Performing minimization step: 3394. Total energy = 11782.6172 kcal/mol (11759.6594 without restraints) Performing minimization step: 3395. Total energy = 11776.0073 kcal/mol (11753.0508 without restraints) Performing minimization step: 3396. Total energy = 11769.4001 kcal/mol (11746.4450 without restraints) Performing minimization step: 3397. Total energy = 11762.7954 kcal/mol (11739.8417 without restraints) Performing minimization step: 3398. Total energy = 11756.1933 kcal/mol (11733.2410 without restraints) Performing minimization step: 3399. Total energy = 11749.5940 kcal/mol (11726.6431 without restraints) Performing minimization step: 3400. Total energy = 11742.9973 kcal/mol (11720.0478 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3401. Total energy = 11736.4030 kcal/mol (11713.4549 without restraints) Performing minimization step: 3402. Total energy = 11729.8115 kcal/mol (11706.8648 without restraints) Performing minimization step: 3403. Total energy = 11723.2224 kcal/mol (11700.2771 without restraints) Performing minimization step: 3404. Total energy = 11716.6360 kcal/mol (11693.6920 without restraints) Performing minimization step: 3405. Total energy = 11710.0518 kcal/mol (11687.1091 without restraints) Performing minimization step: 3406. Total energy = 11703.4705 kcal/mol (11680.5293 without restraints) Performing minimization step: 3407. Total energy = 11696.8917 kcal/mol (11673.9518 without restraints) Performing minimization step: 3408. Total energy = 11690.3157 kcal/mol (11667.3772 without restraints) Performing minimization step: 3409. Total energy = 11683.7424 kcal/mol (11660.8052 without restraints) Performing minimization step: 3410. Total energy = 11677.1715 kcal/mol (11654.2358 without restraints) Performing minimization step: 3411. Total energy = 11670.6035 kcal/mol (11647.6692 without restraints) Performing minimization step: 3412. Total energy = 11664.0378 kcal/mol (11641.1049 without restraints) Performing minimization step: 3413. Total energy = 11657.4748 kcal/mol (11634.5433 without restraints) Performing minimization step: 3414. Total energy = 11650.9146 kcal/mol (11627.9846 without restraints) Performing minimization step: 3415. Total energy = 11644.3571 kcal/mol (11621.4284 without restraints) Performing minimization step: 3416. Total energy = 11637.8021 kcal/mol (11614.8748 without restraints) Performing minimization step: 3417. Total energy = 11631.2497 kcal/mol (11608.3238 without restraints) Performing minimization step: 3418. Total energy = 11624.7000 kcal/mol (11601.7755 without restraints) Performing minimization step: 3419. Total energy = 11618.1527 kcal/mol (11595.2295 without restraints) Performing minimization step: 3420. Total energy = 11611.6083 kcal/mol (11588.6866 without restraints) Performing minimization step: 3421. Total energy = 11605.0664 kcal/mol (11582.1461 without restraints) Performing minimization step: 3422. Total energy = 11598.5274 kcal/mol (11575.6084 without restraints) Performing minimization step: 3423. Total energy = 11591.9911 kcal/mol (11569.0735 without restraints) Performing minimization step: 3424. Total energy = 11585.4576 kcal/mol (11562.5415 without restraints) Performing minimization step: 3425. Total energy = 11578.9265 kcal/mol (11556.0117 without restraints) Performing minimization step: 3426. Total energy = 11572.3980 kcal/mol (11549.4846 without restraints) Performing minimization step: 3427. Total energy = 11565.8721 kcal/mol (11542.9601 without restraints) Performing minimization step: 3428. Total energy = 11559.3489 kcal/mol (11536.4383 without restraints) Performing minimization step: 3429. Total energy = 11552.8285 kcal/mol (11529.9193 without restraints) Performing minimization step: 3430. Total energy = 11546.3109 kcal/mol (11523.4031 without restraints) Performing minimization step: 3431. Total energy = 11539.7957 kcal/mol (11516.8893 without restraints) Performing minimization step: 3432. Total energy = 11533.2832 kcal/mol (11510.3782 without restraints) Performing minimization step: 3433. Total energy = 11526.7734 kcal/mol (11503.8698 without restraints) Performing minimization step: 3434. Total energy = 11520.2662 kcal/mol (11497.3640 without restraints) Performing minimization step: 3435. Total energy = 11513.7618 kcal/mol (11490.8609 without restraints) Performing minimization step: 3436. Total energy = 11507.2601 kcal/mol (11484.3608 without restraints) Performing minimization step: 3437. Total energy = 11500.7611 kcal/mol (11477.8631 without restraints) Performing minimization step: 3438. Total energy = 11494.2647 kcal/mol (11471.3681 without restraints) Performing minimization step: 3439. Total energy = 11487.7710 kcal/mol (11464.8759 without restraints) Performing minimization step: 3440. Total energy = 11481.2803 kcal/mol (11458.3865 without restraints) Performing minimization step: 3441. Total energy = 11474.7921 kcal/mol (11451.8998 without restraints) Performing minimization step: 3442. Total energy = 11468.3065 kcal/mol (11445.4155 without restraints) Performing minimization step: 3443. Total energy = 11461.8237 kcal/mol (11438.9341 without restraints) Performing minimization step: 3444. Total energy = 11455.3432 kcal/mol (11432.4550 without restraints) Performing minimization step: 3445. Total energy = 11448.8656 kcal/mol (11425.9789 without restraints) Performing minimization step: 3446. Total energy = 11442.3907 kcal/mol (11419.5053 without restraints) Performing minimization step: 3447. Total energy = 11435.9186 kcal/mol (11413.0346 without restraints) Performing minimization step: 3448. Total energy = 11429.4491 kcal/mol (11406.5665 without restraints) Performing minimization step: 3449. Total energy = 11422.9824 kcal/mol (11400.1012 without restraints) Performing minimization step: 3450. Total energy = 11416.5186 kcal/mol (11393.6389 without restraints) Performing minimization step: 3451. Total energy = 11410.0574 kcal/mol (11387.1790 without restraints) Performing minimization step: 3452. Total energy = 11403.5986 kcal/mol (11380.7217 without restraints) Performing minimization step: 3453. Total energy = 11397.1426 kcal/mol (11374.2670 without restraints) Performing minimization step: 3454. Total energy = 11390.6895 kcal/mol (11367.8154 without restraints) Performing minimization step: 3455. Total energy = 11384.2393 kcal/mol (11361.3666 without restraints) Performing minimization step: 3456. Total energy = 11377.7918 kcal/mol (11354.9205 without restraints) Performing minimization step: 3457. Total energy = 11371.3468 kcal/mol (11348.4769 without restraints) Performing minimization step: 3458. Total energy = 11364.9046 kcal/mol (11342.0361 without restraints) Performing minimization step: 3459. Total energy = 11358.4654 kcal/mol (11335.5983 without restraints) Performing minimization step: 3460. Total energy = 11352.0286 kcal/mol (11329.1629 without restraints) Performing minimization step: 3461. Total energy = 11345.5946 kcal/mol (11322.7303 without restraints) Performing minimization step: 3462. Total energy = 11339.1633 kcal/mol (11316.3005 without restraints) Performing minimization step: 3463. Total energy = 11332.7349 kcal/mol (11309.8734 without restraints) Performing minimization step: 3464. Total energy = 11326.3094 kcal/mol (11303.4495 without restraints) Performing minimization step: 3465. Total energy = 11319.8866 kcal/mol (11297.0280 without restraints) Performing minimization step: 3466. Total energy = 11313.4663 kcal/mol (11290.6091 without restraints) Performing minimization step: 3467. Total energy = 11307.0488 kcal/mol (11284.1930 without restraints) Performing minimization step: 3468. Total energy = 11300.6342 kcal/mol (11277.7798 without restraints) Performing minimization step: 3469. Total energy = 11294.2221 kcal/mol (11271.3692 without restraints) Performing minimization step: 3470. Total energy = 11287.8129 kcal/mol (11264.9614 without restraints) Performing minimization step: 3471. Total energy = 11281.4065 kcal/mol (11258.5564 without restraints) Performing minimization step: 3472. Total energy = 11275.0033 kcal/mol (11252.1546 without restraints) Performing minimization step: 3473. Total energy = 11268.6023 kcal/mol (11245.7550 without restraints) Performing minimization step: 3474. Total energy = 11262.2041 kcal/mol (11239.3583 without restraints) Performing minimization step: 3475. Total energy = 11255.8088 kcal/mol (11232.9643 without restraints) Performing minimization step: 3476. Total energy = 11249.4164 kcal/mol (11226.5734 without restraints) Performing minimization step: 3477. Total energy = 11243.0267 kcal/mol (11220.1852 without restraints) Performing minimization step: 3478. Total energy = 11236.6400 kcal/mol (11213.7997 without restraints) Performing minimization step: 3479. Total energy = 11230.2556 kcal/mol (11207.4168 without restraints) Performing minimization step: 3480. Total energy = 11223.8742 kcal/mol (11201.0368 without restraints) Performing minimization step: 3481. Total energy = 11217.4955 kcal/mol (11194.6596 without restraints) Performing minimization step: 3482. Total energy = 11211.1195 kcal/mol (11188.2850 without restraints) Performing minimization step: 3483. Total energy = 11204.7464 kcal/mol (11181.9134 without restraints) Performing minimization step: 3484. Total energy = 11198.3761 kcal/mol (11175.5444 without restraints) Performing minimization step: 3485. Total energy = 11192.0083 kcal/mol (11169.1780 without restraints) Performing minimization step: 3486. Total energy = 11185.6438 kcal/mol (11162.8149 without restraints) Performing minimization step: 3487. Total energy = 11179.2818 kcal/mol (11156.4544 without restraints) Performing minimization step: 3488. Total energy = 11172.9227 kcal/mol (11150.0967 without restraints) Performing minimization step: 3489. Total energy = 11166.5663 kcal/mol (11143.7415 without restraints) Performing minimization step: 3490. Total energy = 11160.2128 kcal/mol (11137.3896 without restraints) Performing minimization step: 3491. Total energy = 11153.8621 kcal/mol (11131.0404 without restraints) Performing minimization step: 3492. Total energy = 11147.5142 kcal/mol (11124.6939 without restraints) Performing minimization step: 3493. Total energy = 11141.1694 kcal/mol (11118.3504 without restraints) Performing minimization step: 3494. Total energy = 11134.8271 kcal/mol (11112.0096 without restraints) Performing minimization step: 3495. Total energy = 11128.4876 kcal/mol (11105.6715 without restraints) Performing minimization step: 3496. Total energy = 11122.1509 kcal/mol (11099.3361 without restraints) Performing minimization step: 3497. Total energy = 11115.8171 kcal/mol (11093.0039 without restraints) Performing minimization step: 3498. Total energy = 11109.4863 kcal/mol (11086.6745 without restraints) Performing minimization step: 3499. Total energy = 11103.1582 kcal/mol (11080.3478 without restraints) Performing minimization step: 3500. Total energy = 11096.8326 kcal/mol (11074.0237 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3501. Total energy = 11090.5100 kcal/mol (11067.7026 without restraints) Performing minimization step: 3502. Total energy = 11084.1903 kcal/mol (11061.3842 without restraints) Performing minimization step: 3503. Total energy = 11077.8733 kcal/mol (11055.0686 without restraints) Performing minimization step: 3504. Total energy = 11071.5591 kcal/mol (11048.7557 without restraints) Performing minimization step: 3505. Total energy = 11065.2477 kcal/mol (11042.4459 without restraints) Performing minimization step: 3506. Total energy = 11058.9394 kcal/mol (11036.1390 without restraints) Performing minimization step: 3507. Total energy = 11052.6341 kcal/mol (11029.8352 without restraints) Performing minimization step: 3508. Total energy = 11046.3315 kcal/mol (11023.5340 without restraints) Performing minimization step: 3509. Total energy = 11040.0317 kcal/mol (11017.2357 without restraints) Performing minimization step: 3510. Total energy = 11033.7354 kcal/mol (11010.9408 without restraints) Performing minimization step: 3511. Total energy = 11027.4414 kcal/mol (11004.6481 without restraints) Performing minimization step: 3512. Total energy = 11021.1502 kcal/mol (10998.3584 without restraints) Performing minimization step: 3513. Total energy = 11014.8619 kcal/mol (10992.0716 without restraints) Performing minimization step: 3514. Total energy = 11008.5765 kcal/mol (10985.7876 without restraints) Performing minimization step: 3515. Total energy = 11002.2940 kcal/mol (10979.5065 without restraints) Performing minimization step: 3516. Total energy = 10996.0143 kcal/mol (10973.2282 without restraints) Performing minimization step: 3517. Total energy = 10989.7374 kcal/mol (10966.9528 without restraints) Performing minimization step: 3518. Total energy = 10983.4635 kcal/mol (10960.6803 without restraints) Performing minimization step: 3519. Total energy = 10977.1924 kcal/mol (10954.4107 without restraints) Performing minimization step: 3520. Total energy = 10970.9243 kcal/mol (10948.1440 without restraints) Performing minimization step: 3521. Total energy = 10964.6590 kcal/mol (10941.8801 without restraints) Performing minimization step: 3522. Total energy = 10958.3968 kcal/mol (10935.6194 without restraints) Performing minimization step: 3523. Total energy = 10952.1373 kcal/mol (10929.3613 without restraints) Performing minimization step: 3524. Total energy = 10945.8807 kcal/mol (10923.1061 without restraints) Performing minimization step: 3525. Total energy = 10939.6269 kcal/mol (10916.8538 without restraints) Performing minimization step: 3526. Total energy = 10933.3764 kcal/mol (10910.6048 without restraints) Performing minimization step: 3527. Total energy = 10927.1285 kcal/mol (10904.3583 without restraints) Performing minimization step: 3528. Total energy = 10920.8832 kcal/mol (10898.1144 without restraints) Performing minimization step: 3529. Total energy = 10914.6411 kcal/mol (10891.8738 without restraints) Performing minimization step: 3530. Total energy = 10908.4023 kcal/mol (10885.6364 without restraints) Performing minimization step: 3531. Total energy = 10902.1662 kcal/mol (10879.4019 without restraints) Performing minimization step: 3532. Total energy = 10895.9331 kcal/mol (10873.1701 without restraints) Performing minimization step: 3533. Total energy = 10889.7026 kcal/mol (10866.9410 without restraints) Performing minimization step: 3534. Total energy = 10883.4751 kcal/mol (10860.7150 without restraints) Performing minimization step: 3535. Total energy = 10877.2504 kcal/mol (10854.4917 without restraints) Performing minimization step: 3536. Total energy = 10871.0285 kcal/mol (10848.2712 without restraints) Performing minimization step: 3537. Total energy = 10864.8097 kcal/mol (10842.0539 without restraints) Performing minimization step: 3538. Total energy = 10858.5938 kcal/mol (10835.8395 without restraints) Performing minimization step: 3539. Total energy = 10852.3809 kcal/mol (10829.6280 without restraints) Performing minimization step: 3540. Total energy = 10846.1708 kcal/mol (10823.4194 without restraints) Performing minimization step: 3541. Total energy = 10839.9638 kcal/mol (10817.2138 without restraints) Performing minimization step: 3542. Total energy = 10833.7594 kcal/mol (10811.0108 without restraints) Performing minimization step: 3543. Total energy = 10827.5581 kcal/mol (10804.8110 without restraints) Performing minimization step: 3544. Total energy = 10821.3603 kcal/mol (10798.6146 without restraints) Performing minimization step: 3545. Total energy = 10815.1649 kcal/mol (10792.4207 without restraints) Performing minimization step: 3546. Total energy = 10808.9725 kcal/mol (10786.2297 without restraints) Performing minimization step: 3547. Total energy = 10802.7828 kcal/mol (10780.0415 without restraints) Performing minimization step: 3548. Total energy = 10796.5965 kcal/mol (10773.8566 without restraints) Performing minimization step: 3549. Total energy = 10790.4132 kcal/mol (10767.6748 without restraints) Performing minimization step: 3550. Total energy = 10784.2326 kcal/mol (10761.4957 without restraints) Performing minimization step: 3551. Total energy = 10778.0550 kcal/mol (10755.3194 without restraints) Performing minimization step: 3552. Total energy = 10771.8801 kcal/mol (10749.1460 without restraints) Performing minimization step: 3553. Total energy = 10765.7084 kcal/mol (10742.9758 without restraints) Performing minimization step: 3554. Total energy = 10759.5397 kcal/mol (10736.8086 without restraints) Performing minimization step: 3555. Total energy = 10753.3740 kcal/mol (10730.6443 without restraints) Performing minimization step: 3556. Total energy = 10747.2112 kcal/mol (10724.4829 without restraints) Performing minimization step: 3557. Total energy = 10741.0514 kcal/mol (10718.3248 without restraints) Performing minimization step: 3558. Total energy = 10734.8951 kcal/mol (10712.1697 without restraints) Performing minimization step: 3559. Total energy = 10728.7412 kcal/mol (10706.0173 without restraints) Performing minimization step: 3560. Total energy = 10722.5903 kcal/mol (10699.8679 without restraints) Performing minimization step: 3561. Total energy = 10716.4424 kcal/mol (10693.7214 without restraints) Performing minimization step: 3562. Total energy = 10710.2976 kcal/mol (10687.5782 without restraints) Performing minimization step: 3563. Total energy = 10704.1557 kcal/mol (10681.4377 without restraints) Performing minimization step: 3564. Total energy = 10698.0172 kcal/mol (10675.3008 without restraints) Performing minimization step: 3565. Total energy = 10691.8816 kcal/mol (10669.1664 without restraints) Performing minimization step: 3566. Total energy = 10685.7487 kcal/mol (10663.0351 without restraints) Performing minimization step: 3567. Total energy = 10679.6189 kcal/mol (10656.9066 without restraints) Performing minimization step: 3568. Total energy = 10673.4919 kcal/mol (10650.7812 without restraints) Performing minimization step: 3569. Total energy = 10667.3680 kcal/mol (10644.6587 without restraints) Performing minimization step: 3570. Total energy = 10661.2469 kcal/mol (10638.5390 without restraints) Performing minimization step: 3571. Total energy = 10655.1289 kcal/mol (10632.4225 without restraints) Performing minimization step: 3572. Total energy = 10649.0140 kcal/mol (10626.3091 without restraints) Performing minimization step: 3573. Total energy = 10642.9021 kcal/mol (10620.1986 without restraints) Performing minimization step: 3574. Total energy = 10636.7932 kcal/mol (10614.0913 without restraints) Performing minimization step: 3575. Total energy = 10630.6874 kcal/mol (10607.9870 without restraints) Performing minimization step: 3576. Total energy = 10624.5847 kcal/mol (10601.8856 without restraints) Performing minimization step: 3577. Total energy = 10618.4849 kcal/mol (10595.7873 without restraints) Performing minimization step: 3578. Total energy = 10612.3881 kcal/mol (10589.6920 without restraints) Performing minimization step: 3579. Total energy = 10606.2943 kcal/mol (10583.5997 without restraints) Performing minimization step: 3580. Total energy = 10600.2036 kcal/mol (10577.5104 without restraints) Performing minimization step: 3581. Total energy = 10594.1160 kcal/mol (10571.4243 without restraints) Performing minimization step: 3582. Total energy = 10588.0314 kcal/mol (10565.3412 without restraints) Performing minimization step: 3583. Total energy = 10581.9499 kcal/mol (10559.2612 without restraints) Performing minimization step: 3584. Total energy = 10575.8716 kcal/mol (10553.1843 without restraints) Performing minimization step: 3585. Total energy = 10569.7963 kcal/mol (10547.1104 without restraints) Performing minimization step: 3586. Total energy = 10563.7238 kcal/mol (10541.0394 without restraints) Performing minimization step: 3587. Total energy = 10557.6545 kcal/mol (10534.9716 without restraints) Performing minimization step: 3588. Total energy = 10551.5881 kcal/mol (10528.9067 without restraints) Performing minimization step: 3589. Total energy = 10545.5245 kcal/mol (10522.8446 without restraints) Performing minimization step: 3590. Total energy = 10539.4642 kcal/mol (10516.7858 without restraints) Performing minimization step: 3591. Total energy = 10533.4070 kcal/mol (10510.7300 without restraints) Performing minimization step: 3592. Total energy = 10527.3528 kcal/mol (10504.6773 without restraints) Performing minimization step: 3593. Total energy = 10521.3017 kcal/mol (10498.6277 without restraints) Performing minimization step: 3594. Total energy = 10515.2537 kcal/mol (10492.5811 without restraints) Performing minimization step: 3595. Total energy = 10509.2087 kcal/mol (10486.5376 without restraints) Performing minimization step: 3596. Total energy = 10503.1669 kcal/mol (10480.4972 without restraints) Performing minimization step: 3597. Total energy = 10497.1281 kcal/mol (10474.4599 without restraints) Performing minimization step: 3598. Total energy = 10491.0923 kcal/mol (10468.4256 without restraints) Performing minimization step: 3599. Total energy = 10485.0595 kcal/mol (10462.3943 without restraints) Performing minimization step: 3600. Total energy = 10479.0300 kcal/mol (10456.3663 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3601. Total energy = 10473.0035 kcal/mol (10450.3413 without restraints) Performing minimization step: 3602. Total energy = 10466.9801 kcal/mol (10444.3194 without restraints) Performing minimization step: 3603. Total energy = 10460.9598 kcal/mol (10438.3006 without restraints) Performing minimization step: 3604. Total energy = 10454.9429 kcal/mol (10432.2851 without restraints) Performing minimization step: 3605. Total energy = 10448.9287 kcal/mol (10426.2724 without restraints) Performing minimization step: 3606. Total energy = 10442.9177 kcal/mol (10420.2628 without restraints) Performing minimization step: 3607. Total energy = 10436.9095 kcal/mol (10414.2561 without restraints) Performing minimization step: 3608. Total energy = 10430.9045 kcal/mol (10408.2526 without restraints) Performing minimization step: 3609. Total energy = 10424.9027 kcal/mol (10402.2523 without restraints) Performing minimization step: 3610. Total energy = 10418.9042 kcal/mol (10396.2553 without restraints) Performing minimization step: 3611. Total energy = 10412.9089 kcal/mol (10390.2616 without restraints) Performing minimization step: 3612. Total energy = 10406.9168 kcal/mol (10384.2710 without restraints) Performing minimization step: 3613. Total energy = 10400.9271 kcal/mol (10378.2827 without restraints) Performing minimization step: 3614. Total energy = 10394.9410 kcal/mol (10372.2981 without restraints) Performing minimization step: 3615. Total energy = 10388.9582 kcal/mol (10366.3168 without restraints) Performing minimization step: 3616. Total energy = 10382.9787 kcal/mol (10360.3389 without restraints) Performing minimization step: 3617. Total energy = 10377.0021 kcal/mol (10354.3636 without restraints) Performing minimization step: 3618. Total energy = 10371.0285 kcal/mol (10348.3915 without restraints) Performing minimization step: 3619. Total energy = 10365.0583 kcal/mol (10342.4228 without restraints) Performing minimization step: 3620. Total energy = 10359.0909 kcal/mol (10336.4569 without restraints) Performing minimization step: 3621. Total energy = 10353.1268 kcal/mol (10330.4943 without restraints) Performing minimization step: 3622. Total energy = 10347.1660 kcal/mol (10324.5351 without restraints) Performing minimization step: 3623. Total energy = 10341.2082 kcal/mol (10318.5787 without restraints) Performing minimization step: 3624. Total energy = 10335.2534 kcal/mol (10312.6253 without restraints) Performing minimization step: 3625. Total energy = 10329.3017 kcal/mol (10306.6752 without restraints) Performing minimization step: 3626. Total energy = 10323.3532 kcal/mol (10300.7282 without restraints) Performing minimization step: 3627. Total energy = 10317.4079 kcal/mol (10294.7843 without restraints) Performing minimization step: 3628. Total energy = 10311.4652 kcal/mol (10288.8432 without restraints) Performing minimization step: 3629. Total energy = 10305.5262 kcal/mol (10282.9056 without restraints) Performing minimization step: 3630. Total energy = 10299.5905 kcal/mol (10276.9714 without restraints) Performing minimization step: 3631. Total energy = 10293.6578 kcal/mol (10271.0403 without restraints) Performing minimization step: 3632. Total energy = 10287.7283 kcal/mol (10265.1122 without restraints) Performing minimization step: 3633. Total energy = 10281.8018 kcal/mol (10259.1872 without restraints) Performing minimization step: 3634. Total energy = 10275.8784 kcal/mol (10253.2654 without restraints) Performing minimization step: 3635. Total energy = 10269.9583 kcal/mol (10247.3468 without restraints) Performing minimization step: 3636. Total energy = 10264.0415 kcal/mol (10241.4315 without restraints) Performing minimization step: 3637. Total energy = 10258.1278 kcal/mol (10235.5193 without restraints) Performing minimization step: 3638. Total energy = 10252.2173 kcal/mol (10229.6102 without restraints) Performing minimization step: 3639. Total energy = 10246.3099 kcal/mol (10223.7044 without restraints) Performing minimization step: 3640. Total energy = 10240.4058 kcal/mol (10217.8017 without restraints) Performing minimization step: 3641. Total energy = 10234.5048 kcal/mol (10211.9023 without restraints) Performing minimization step: 3642. Total energy = 10228.6066 kcal/mol (10206.0055 without restraints) Performing minimization step: 3643. Total energy = 10222.7120 kcal/mol (10200.1124 without restraints) Performing minimization step: 3644. Total energy = 10216.8206 kcal/mol (10194.2226 without restraints) Performing minimization step: 3645. Total energy = 10210.9323 kcal/mol (10188.3357 without restraints) Performing minimization step: 3646. Total energy = 10205.0473 kcal/mol (10182.4522 without restraints) Performing minimization step: 3647. Total energy = 10199.1655 kcal/mol (10176.5720 without restraints) Performing minimization step: 3648. Total energy = 10193.2869 kcal/mol (10170.6949 without restraints) Performing minimization step: 3649. Total energy = 10187.4115 kcal/mol (10164.8210 without restraints) Performing minimization step: 3650. Total energy = 10181.5397 kcal/mol (10158.9506 without restraints) Performing minimization step: 3651. Total energy = 10175.6708 kcal/mol (10153.0833 without restraints) Performing minimization step: 3652. Total energy = 10169.8054 kcal/mol (10147.2194 without restraints) Performing minimization step: 3653. Total energy = 10163.9433 kcal/mol (10141.3589 without restraints) Performing minimization step: 3654. Total energy = 10158.0841 kcal/mol (10135.5015 without restraints) Performing minimization step: 3655. Total energy = 10152.2283 kcal/mol (10129.6469 without restraints) Performing minimization step: 3656. Total energy = 10146.3754 kcal/mol (10123.7954 without restraints) Performing minimization step: 3657. Total energy = 10140.5258 kcal/mol (10117.9473 without restraints) Performing minimization step: 3658. Total energy = 10134.6797 kcal/mol (10112.1027 without restraints) Performing minimization step: 3659. Total energy = 10128.8366 kcal/mol (10106.2614 without restraints) Performing minimization step: 3660. Total energy = 10122.9970 kcal/mol (10100.4231 without restraints) Performing minimization step: 3661. Total energy = 10117.1608 kcal/mol (10094.5884 without restraints) Performing minimization step: 3662. Total energy = 10111.3272 kcal/mol (10088.7564 without restraints) Performing minimization step: 3663. Total energy = 10105.4971 kcal/mol (10082.9278 without restraints) Performing minimization step: 3664. Total energy = 10099.6700 kcal/mol (10077.1022 without restraints) Performing minimization step: 3665. Total energy = 10093.8464 kcal/mol (10071.2801 without restraints) Performing minimization step: 3666. Total energy = 10088.0260 kcal/mol (10065.4612 without restraints) Performing minimization step: 3667. Total energy = 10082.2089 kcal/mol (10059.6456 without restraints) Performing minimization step: 3668. Total energy = 10076.3950 kcal/mol (10053.8332 without restraints) Performing minimization step: 3669. Total energy = 10070.5844 kcal/mol (10048.0242 without restraints) Performing minimization step: 3670. Total energy = 10064.7770 kcal/mol (10042.2183 without restraints) Performing minimization step: 3671. Total energy = 10058.9732 kcal/mol (10036.4161 without restraints) Performing minimization step: 3672. Total energy = 10053.1722 kcal/mol (10030.6166 without restraints) Performing minimization step: 3673. Total energy = 10047.3747 kcal/mol (10024.8206 without restraints) Performing minimization step: 3674. Total energy = 10041.5808 kcal/mol (10019.0282 without restraints) Performing minimization step: 3675. Total energy = 10035.7899 kcal/mol (10013.2389 without restraints) Performing minimization step: 3676. Total energy = 10030.0022 kcal/mol (10007.4527 without restraints) Performing minimization step: 3677. Total energy = 10024.2178 kcal/mol (10001.6699 without restraints) Performing minimization step: 3678. Total energy = 10018.4371 kcal/mol (9995.8907 without restraints) Performing minimization step: 3679. Total energy = 10012.6593 kcal/mol (9990.1143 without restraints) Performing minimization step: 3680. Total energy = 10006.8847 kcal/mol (9984.3412 without restraints) Performing minimization step: 3681. Total energy = 10001.1134 kcal/mol (9978.5715 without restraints) Performing minimization step: 3682. Total energy = 9995.3455 kcal/mol (9972.8051 without restraints) Performing minimization step: 3683. Total energy = 9989.5807 kcal/mol (9967.0418 without restraints) Performing minimization step: 3684. Total energy = 9983.8193 kcal/mol (9961.2820 without restraints) Performing minimization step: 3685. Total energy = 9978.0612 kcal/mol (9955.5255 without restraints) Performing minimization step: 3686. Total energy = 9972.3065 kcal/mol (9949.7722 without restraints) Performing minimization step: 3687. Total energy = 9966.5550 kcal/mol (9944.0223 without restraints) Performing minimization step: 3688. Total energy = 9960.8072 kcal/mol (9938.2760 without restraints) Performing minimization step: 3689. Total energy = 9955.0623 kcal/mol (9932.5327 without restraints) Performing minimization step: 3690. Total energy = 9949.3208 kcal/mol (9926.7927 without restraints) Performing minimization step: 3691. Total energy = 9943.5828 kcal/mol (9921.0562 without restraints) Performing minimization step: 3692. Total energy = 9937.8481 kcal/mol (9915.3231 without restraints) Performing minimization step: 3693. Total energy = 9932.1166 kcal/mol (9909.5933 without restraints) Performing minimization step: 3694. Total energy = 9926.3883 kcal/mol (9903.8664 without restraints) Performing minimization step: 3695. Total energy = 9920.6634 kcal/mol (9898.1430 without restraints) Performing minimization step: 3696. Total energy = 9914.9418 kcal/mol (9892.4230 without restraints) Performing minimization step: 3697. Total energy = 9909.2241 kcal/mol (9886.7068 without restraints) Performing minimization step: 3698. Total energy = 9903.5092 kcal/mol (9880.9934 without restraints) Performing minimization step: 3699. Total energy = 9897.7976 kcal/mol (9875.2833 without restraints) Performing minimization step: 3700. Total energy = 9892.0893 kcal/mol (9869.5766 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3701. Total energy = 9886.3844 kcal/mol (9863.8732 without restraints) Performing minimization step: 3702. Total energy = 9880.6830 kcal/mol (9858.1732 without restraints) Performing minimization step: 3703. Total energy = 9874.9847 kcal/mol (9852.4766 without restraints) Performing minimization step: 3704. Total energy = 9869.2900 kcal/mol (9846.7835 without restraints) Performing minimization step: 3705. Total energy = 9863.5984 kcal/mol (9841.0934 without restraints) Performing minimization step: 3706. Total energy = 9857.9103 kcal/mol (9835.4069 without restraints) Performing minimization step: 3707. Total energy = 9852.2258 kcal/mol (9829.7239 without restraints) Performing minimization step: 3708. Total energy = 9846.5446 kcal/mol (9824.0442 without restraints) Performing minimization step: 3709. Total energy = 9840.8665 kcal/mol (9818.3677 without restraints) Performing minimization step: 3710. Total energy = 9835.1919 kcal/mol (9812.6946 without restraints) Performing minimization step: 3711. Total energy = 9829.5205 kcal/mol (9807.0249 without restraints) Performing minimization step: 3712. Total energy = 9823.8523 kcal/mol (9801.3581 without restraints) Performing minimization step: 3713. Total energy = 9818.1877 kcal/mol (9795.6951 without restraints) Performing minimization step: 3714. Total energy = 9812.5266 kcal/mol (9790.0356 without restraints) Performing minimization step: 3715. Total energy = 9806.8690 kcal/mol (9784.3796 without restraints) Performing minimization step: 3716. Total energy = 9801.2145 kcal/mol (9778.7265 without restraints) Performing minimization step: 3717. Total energy = 9795.5635 kcal/mol (9773.0771 without restraints) Performing minimization step: 3718. Total energy = 9789.9161 kcal/mol (9767.4313 without restraints) Performing minimization step: 3719. Total energy = 9784.2718 kcal/mol (9761.7886 without restraints) Performing minimization step: 3720. Total energy = 9778.6310 kcal/mol (9756.1493 without restraints) Performing minimization step: 3721. Total energy = 9772.9936 kcal/mol (9750.5134 without restraints) Performing minimization step: 3722. Total energy = 9767.3597 kcal/mol (9744.8811 without restraints) Performing minimization step: 3723. Total energy = 9761.7292 kcal/mol (9739.2522 without restraints) Performing minimization step: 3724. Total energy = 9756.1020 kcal/mol (9733.6265 without restraints) Performing minimization step: 3725. Total energy = 9750.4784 kcal/mol (9728.0045 without restraints) Performing minimization step: 3726. Total energy = 9744.8581 kcal/mol (9722.3858 without restraints) Performing minimization step: 3727. Total energy = 9739.2411 kcal/mol (9716.7704 without restraints) Performing minimization step: 3728. Total energy = 9733.6276 kcal/mol (9711.1584 without restraints) Performing minimization step: 3729. Total energy = 9728.0175 kcal/mol (9705.5498 without restraints) Performing minimization step: 3730. Total energy = 9722.4108 kcal/mol (9699.9447 without restraints) Performing minimization step: 3731. Total energy = 9716.8079 kcal/mol (9694.3434 without restraints) Performing minimization step: 3732. Total energy = 9711.2080 kcal/mol (9688.7450 without restraints) Performing minimization step: 3733. Total energy = 9705.6115 kcal/mol (9683.1501 without restraints) Performing minimization step: 3734. Total energy = 9700.0185 kcal/mol (9677.5587 without restraints) Performing minimization step: 3735. Total energy = 9694.4292 kcal/mol (9671.9709 without restraints) Performing minimization step: 3736. Total energy = 9688.8430 kcal/mol (9666.3863 without restraints) Performing minimization step: 3737. Total energy = 9683.2602 kcal/mol (9660.8051 without restraints) Performing minimization step: 3738. Total energy = 9677.6809 kcal/mol (9655.2274 without restraints) Performing minimization step: 3739. Total energy = 9672.1055 kcal/mol (9649.6537 without restraints) Performing minimization step: 3740. Total energy = 9666.5330 kcal/mol (9644.0828 without restraints) Performing minimization step: 3741. Total energy = 9660.9643 kcal/mol (9638.5155 without restraints) Performing minimization step: 3742. Total energy = 9655.3988 kcal/mol (9632.9516 without restraints) Performing minimization step: 3743. Total energy = 9649.8369 kcal/mol (9627.3912 without restraints) Performing minimization step: 3744. Total energy = 9644.2785 kcal/mol (9621.8344 without restraints) Performing minimization step: 3745. Total energy = 9638.7234 kcal/mol (9616.2808 without restraints) Performing minimization step: 3746. Total energy = 9633.1716 kcal/mol (9610.7305 without restraints) Performing minimization step: 3747. Total energy = 9627.6233 kcal/mol (9605.1839 without restraints) Performing minimization step: 3748. Total energy = 9622.0788 kcal/mol (9599.6410 without restraints) Performing minimization step: 3749. Total energy = 9616.5376 kcal/mol (9594.1013 without restraints) Performing minimization step: 3750. Total energy = 9611.0000 kcal/mol (9588.5654 without restraints) Performing minimization step: 3751. Total energy = 9605.4657 kcal/mol (9583.0327 without restraints) Performing minimization step: 3752. Total energy = 9599.9349 kcal/mol (9577.5034 without restraints) Performing minimization step: 3753. Total energy = 9594.4076 kcal/mol (9571.9776 without restraints) Performing minimization step: 3754. Total energy = 9588.8836 kcal/mol (9566.4553 without restraints) Performing minimization step: 3755. Total energy = 9583.3632 kcal/mol (9560.9365 without restraints) Performing minimization step: 3756. Total energy = 9577.8463 kcal/mol (9555.4212 without restraints) Performing minimization step: 3757. Total energy = 9572.3333 kcal/mol (9549.9098 without restraints) Performing minimization step: 3758. Total energy = 9566.8237 kcal/mol (9544.4017 without restraints) Performing minimization step: 3759. Total energy = 9561.3173 kcal/mol (9538.8969 without restraints) Performing minimization step: 3760. Total energy = 9555.8143 kcal/mol (9533.3955 without restraints) Performing minimization step: 3761. Total energy = 9550.3148 kcal/mol (9527.8975 without restraints) Performing minimization step: 3762. Total energy = 9544.8190 kcal/mol (9522.4034 without restraints) Performing minimization step: 3763. Total energy = 9539.3266 kcal/mol (9516.9126 without restraints) Performing minimization step: 3764. Total energy = 9533.8377 kcal/mol (9511.4252 without restraints) Performing minimization step: 3765. Total energy = 9528.3523 kcal/mol (9505.9415 without restraints) Performing minimization step: 3766. Total energy = 9522.8705 kcal/mol (9500.4612 without restraints) Performing minimization step: 3767. Total energy = 9517.3919 kcal/mol (9494.9842 without restraints) Performing minimization step: 3768. Total energy = 9511.9173 kcal/mol (9489.5112 without restraints) Performing minimization step: 3769. Total energy = 9506.4460 kcal/mol (9484.0415 without restraints) Performing minimization step: 3770. Total energy = 9500.9781 kcal/mol (9478.5752 without restraints) Performing minimization step: 3771. Total energy = 9495.5139 kcal/mol (9473.1126 without restraints) Performing minimization step: 3772. Total energy = 9490.0531 kcal/mol (9467.6534 without restraints) Performing minimization step: 3773. Total energy = 9484.5960 kcal/mol (9462.1980 without restraints) Performing minimization step: 3774. Total energy = 9479.1425 kcal/mol (9456.7460 without restraints) Performing minimization step: 3775. Total energy = 9473.6925 kcal/mol (9451.2976 without restraints) Performing minimization step: 3776. Total energy = 9468.2459 kcal/mol (9445.8526 without restraints) Performing minimization step: 3777. Total energy = 9462.8029 kcal/mol (9440.4113 without restraints) Performing minimization step: 3778. Total energy = 9457.3636 kcal/mol (9434.9734 without restraints) Performing minimization step: 3779. Total energy = 9451.9277 kcal/mol (9429.5392 without restraints) Performing minimization step: 3780. Total energy = 9446.4955 kcal/mol (9424.1088 without restraints) Performing minimization step: 3781. Total energy = 9441.0668 kcal/mol (9418.6815 without restraints) Performing minimization step: 3782. Total energy = 9435.6415 kcal/mol (9413.2578 without restraints) Performing minimization step: 3783. Total energy = 9430.2198 kcal/mol (9407.8377 without restraints) Performing minimization step: 3784. Total energy = 9424.8019 kcal/mol (9402.4214 without restraints) Performing minimization step: 3785. Total energy = 9419.3872 kcal/mol (9397.0083 without restraints) Performing minimization step: 3786. Total energy = 9413.9762 kcal/mol (9391.5989 without restraints) Performing minimization step: 3787. Total energy = 9408.5688 kcal/mol (9386.1931 without restraints) Performing minimization step: 3788. Total energy = 9403.1649 kcal/mol (9380.7908 without restraints) Performing minimization step: 3789. Total energy = 9397.7647 kcal/mol (9375.3922 without restraints) Performing minimization step: 3790. Total energy = 9392.3678 kcal/mol (9369.9970 without restraints) Performing minimization step: 3791. Total energy = 9386.9746 kcal/mol (9364.6054 without restraints) Performing minimization step: 3792. Total energy = 9381.5850 kcal/mol (9359.2174 without restraints) Performing minimization step: 3793. Total energy = 9376.1990 kcal/mol (9353.8330 without restraints) Performing minimization step: 3794. Total energy = 9370.8168 kcal/mol (9348.4524 without restraints) Performing minimization step: 3795. Total energy = 9365.4379 kcal/mol (9343.0752 without restraints) Performing minimization step: 3796. Total energy = 9360.0627 kcal/mol (9337.7015 without restraints) Performing minimization step: 3797. Total energy = 9354.6909 kcal/mol (9332.3314 without restraints) Performing minimization step: 3798. Total energy = 9349.3229 kcal/mol (9326.9650 without restraints) Performing minimization step: 3799. Total energy = 9343.9584 kcal/mol (9321.6021 without restraints) Performing minimization step: 3800. Total energy = 9338.5975 kcal/mol (9316.2429 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3801. Total energy = 9333.2402 kcal/mol (9310.8872 without restraints) Performing minimization step: 3802. Total energy = 9327.8870 kcal/mol (9305.5357 without restraints) Performing minimization step: 3803. Total energy = 9322.5370 kcal/mol (9300.1872 without restraints) Performing minimization step: 3804. Total energy = 9317.1907 kcal/mol (9294.8425 without restraints) Performing minimization step: 3805. Total energy = 9311.8478 kcal/mol (9289.5013 without restraints) Performing minimization step: 3806. Total energy = 9306.5089 kcal/mol (9284.1640 without restraints) Performing minimization step: 3807. Total energy = 9301.1733 kcal/mol (9278.8300 without restraints) Performing minimization step: 3808. Total energy = 9295.8413 kcal/mol (9273.4996 without restraints) Performing minimization step: 3809. Total energy = 9290.5128 kcal/mol (9268.1728 without restraints) Performing minimization step: 3810. Total energy = 9285.1882 kcal/mol (9262.8499 without restraints) Performing minimization step: 3811. Total energy = 9279.8672 kcal/mol (9257.5305 without restraints) Performing minimization step: 3812. Total energy = 9274.5498 kcal/mol (9252.2146 without restraints) Performing minimization step: 3813. Total energy = 9269.2360 kcal/mol (9246.9026 without restraints) Performing minimization step: 3814. Total energy = 9263.9261 kcal/mol (9241.5942 without restraints) Performing minimization step: 3815. Total energy = 9258.6195 kcal/mol (9236.2893 without restraints) Performing minimization step: 3816. Total energy = 9253.3167 kcal/mol (9230.9882 without restraints) Performing minimization step: 3817. Total energy = 9248.0175 kcal/mol (9225.6905 without restraints) Performing minimization step: 3818. Total energy = 9242.7220 kcal/mol (9220.3966 without restraints) Performing minimization step: 3819. Total energy = 9237.4300 kcal/mol (9215.1063 without restraints) Performing minimization step: 3820. Total energy = 9232.1417 kcal/mol (9209.8196 without restraints) Performing minimization step: 3821. Total energy = 9226.8570 kcal/mol (9204.5365 without restraints) Performing minimization step: 3822. Total energy = 9221.5758 kcal/mol (9199.2570 without restraints) Performing minimization step: 3823. Total energy = 9216.2985 kcal/mol (9193.9813 without restraints) Performing minimization step: 3824. Total energy = 9211.0248 kcal/mol (9188.7093 without restraints) Performing minimization step: 3825. Total energy = 9205.7548 kcal/mol (9183.4409 without restraints) Performing minimization step: 3826. Total energy = 9200.4884 kcal/mol (9178.1761 without restraints) Performing minimization step: 3827. Total energy = 9195.2258 kcal/mol (9172.9152 without restraints) Performing minimization step: 3828. Total energy = 9189.9670 kcal/mol (9167.6580 without restraints) Performing minimization step: 3829. Total energy = 9184.7122 kcal/mol (9162.4048 without restraints) Performing minimization step: 3830. Total energy = 9179.4606 kcal/mol (9157.1549 without restraints) Performing minimization step: 3831. Total energy = 9174.2126 kcal/mol (9151.9086 without restraints) Performing minimization step: 3832. Total energy = 9168.9682 kcal/mol (9146.6658 without restraints) Performing minimization step: 3833. Total energy = 9163.7279 kcal/mol (9141.4272 without restraints) Performing minimization step: 3834. Total energy = 9158.4910 kcal/mol (9136.1919 without restraints) Performing minimization step: 3835. Total energy = 9153.2577 kcal/mol (9130.9603 without restraints) Performing minimization step: 3836. Total energy = 9148.0285 kcal/mol (9125.7327 without restraints) Performing minimization step: 3837. Total energy = 9142.8026 kcal/mol (9120.5085 without restraints) Performing minimization step: 3838. Total energy = 9137.5804 kcal/mol (9115.2880 without restraints) Performing minimization step: 3839. Total energy = 9132.3620 kcal/mol (9110.0711 without restraints) Performing minimization step: 3840. Total energy = 9127.1472 kcal/mol (9104.8580 without restraints) Performing minimization step: 3841. Total energy = 9121.9360 kcal/mol (9099.6485 without restraints) Performing minimization step: 3842. Total energy = 9116.7286 kcal/mol (9094.4428 without restraints) Performing minimization step: 3843. Total energy = 9111.5250 kcal/mol (9089.2408 without restraints) Performing minimization step: 3844. Total energy = 9106.3250 kcal/mol (9084.0425 without restraints) Performing minimization step: 3845. Total energy = 9101.1288 kcal/mol (9078.8479 without restraints) Performing minimization step: 3846. Total energy = 9095.9364 kcal/mol (9073.6572 without restraints) Performing minimization step: 3847. Total energy = 9090.7476 kcal/mol (9068.4700 without restraints) Performing minimization step: 3848. Total energy = 9085.5623 kcal/mol (9063.2864 without restraints) Performing minimization step: 3849. Total energy = 9080.3809 kcal/mol (9058.1067 without restraints) Performing minimization step: 3850. Total energy = 9075.2035 kcal/mol (9052.9309 without restraints) Performing minimization step: 3851. Total energy = 9070.0300 kcal/mol (9047.7591 without restraints) Performing minimization step: 3852. Total energy = 9064.8599 kcal/mol (9042.5906 without restraints) Performing minimization step: 3853. Total energy = 9059.6934 kcal/mol (9037.4258 without restraints) Performing minimization step: 3854. Total energy = 9054.5306 kcal/mol (9032.2647 without restraints) Performing minimization step: 3855. Total energy = 9049.3717 kcal/mol (9027.1074 without restraints) Performing minimization step: 3856. Total energy = 9044.2167 kcal/mol (9021.9542 without restraints) Performing minimization step: 3857. Total energy = 9039.0652 kcal/mol (9016.8043 without restraints) Performing minimization step: 3858. Total energy = 9033.9175 kcal/mol (9011.6583 without restraints) Performing minimization step: 3859. Total energy = 9028.7736 kcal/mol (9006.5160 without restraints) Performing minimization step: 3860. Total energy = 9023.6333 kcal/mol (9001.3774 without restraints) Performing minimization step: 3861. Total energy = 9018.4970 kcal/mol (8996.2428 without restraints) Performing minimization step: 3862. Total energy = 9013.3640 kcal/mol (8991.1114 without restraints) Performing minimization step: 3863. Total energy = 9008.2350 kcal/mol (8985.9842 without restraints) Performing minimization step: 3864. Total energy = 9003.1096 kcal/mol (8980.8604 without restraints) Performing minimization step: 3865. Total energy = 8997.9881 kcal/mol (8975.7406 without restraints) Performing minimization step: 3866. Total energy = 8992.8702 kcal/mol (8970.6243 without restraints) Performing minimization step: 3867. Total energy = 8987.7568 kcal/mol (8965.5127 without restraints) Performing minimization step: 3868. Total energy = 8982.6466 kcal/mol (8960.4040 without restraints) Performing minimization step: 3869. Total energy = 8977.5401 kcal/mol (8955.2993 without restraints) Performing minimization step: 3870. Total energy = 8972.4378 kcal/mol (8950.1987 without restraints) Performing minimization step: 3871. Total energy = 8967.3389 kcal/mol (8945.1015 without restraints) Performing minimization step: 3872. Total energy = 8962.2440 kcal/mol (8940.0083 without restraints) Performing minimization step: 3873. Total energy = 8957.1525 kcal/mol (8934.9185 without restraints) Performing minimization step: 3874. Total energy = 8952.0650 kcal/mol (8929.8326 without restraints) Performing minimization step: 3875. Total energy = 8946.9816 kcal/mol (8924.7509 without restraints) Performing minimization step: 3876. Total energy = 8941.9016 kcal/mol (8919.6726 without restraints) Performing minimization step: 3877. Total energy = 8936.8255 kcal/mol (8914.5982 without restraints) Performing minimization step: 3878. Total energy = 8931.7538 kcal/mol (8909.5282 without restraints) Performing minimization step: 3879. Total energy = 8926.6853 kcal/mol (8904.4613 without restraints) Performing minimization step: 3880. Total energy = 8921.6205 kcal/mol (8899.3983 without restraints) Performing minimization step: 3881. Total energy = 8916.5596 kcal/mol (8894.3390 without restraints) Performing minimization step: 3882. Total energy = 8911.5024 kcal/mol (8889.2836 without restraints) Performing minimization step: 3883. Total energy = 8906.4491 kcal/mol (8884.2320 without restraints) Performing minimization step: 3884. Total energy = 8901.3996 kcal/mol (8879.1841 without restraints) Performing minimization step: 3885. Total energy = 8896.3540 kcal/mol (8874.1402 without restraints) Performing minimization step: 3886. Total energy = 8891.3122 kcal/mol (8869.1001 without restraints) Performing minimization step: 3887. Total energy = 8886.2738 kcal/mol (8864.0635 without restraints) Performing minimization step: 3888. Total energy = 8881.2396 kcal/mol (8859.0310 without restraints) Performing minimization step: 3889. Total energy = 8876.2093 kcal/mol (8854.0024 without restraints) Performing minimization step: 3890. Total energy = 8871.1827 kcal/mol (8848.9775 without restraints) Performing minimization step: 3891. Total energy = 8866.1600 kcal/mol (8843.9565 without restraints) Performing minimization step: 3892. Total energy = 8861.1411 kcal/mol (8838.9392 without restraints) Performing minimization step: 3893. Total energy = 8856.1259 kcal/mol (8833.9257 without restraints) Performing minimization step: 3894. Total energy = 8851.1146 kcal/mol (8828.9161 without restraints) Performing minimization step: 3895. Total energy = 8846.1068 kcal/mol (8823.9101 without restraints) Performing minimization step: 3896. Total energy = 8841.1036 kcal/mol (8818.9086 without restraints) Performing minimization step: 3897. Total energy = 8836.1039 kcal/mol (8813.9107 without restraints) Performing minimization step: 3898. Total energy = 8831.1080 kcal/mol (8808.9164 without restraints) Performing minimization step: 3899. Total energy = 8826.1158 kcal/mol (8803.9259 without restraints) Performing minimization step: 3900. Total energy = 8821.1275 kcal/mol (8798.9393 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 3901. Total energy = 8816.1431 kcal/mol (8793.9566 without restraints) Performing minimization step: 3902. Total energy = 8811.1625 kcal/mol (8788.9777 without restraints) Performing minimization step: 3903. Total energy = 8806.1857 kcal/mol (8784.0026 without restraints) Performing minimization step: 3904. Total energy = 8801.2129 kcal/mol (8779.0317 without restraints) Performing minimization step: 3905. Total energy = 8796.2437 kcal/mol (8774.0641 without restraints) Performing minimization step: 3906. Total energy = 8791.2783 kcal/mol (8769.1004 without restraints) Performing minimization step: 3907. Total energy = 8786.3172 kcal/mol (8764.1410 without restraints) Performing minimization step: 3908. Total energy = 8781.3597 kcal/mol (8759.1853 without restraints) Performing minimization step: 3909. Total energy = 8776.4061 kcal/mol (8754.2334 without restraints) Performing minimization step: 3910. Total energy = 8771.4564 kcal/mol (8749.2853 without restraints) Performing minimization step: 3911. Total energy = 8766.5105 kcal/mol (8744.3412 without restraints) Performing minimization step: 3912. Total energy = 8761.5686 kcal/mol (8739.4010 without restraints) Performing minimization step: 3913. Total energy = 8756.6306 kcal/mol (8734.4649 without restraints) Performing minimization step: 3914. Total energy = 8751.6963 kcal/mol (8729.5322 without restraints) Performing minimization step: 3915. Total energy = 8746.7660 kcal/mol (8724.6036 without restraints) Performing minimization step: 3916. Total energy = 8741.8395 kcal/mol (8719.6788 without restraints) Performing minimization step: 3917. Total energy = 8736.9173 kcal/mol (8714.7583 without restraints) Performing minimization step: 3918. Total energy = 8731.9987 kcal/mol (8709.8415 without restraints) Performing minimization step: 3919. Total energy = 8727.0838 kcal/mol (8704.9283 without restraints) Performing minimization step: 3920. Total energy = 8722.1729 kcal/mol (8700.0191 without restraints) Performing minimization step: 3921. Total energy = 8717.2659 kcal/mol (8695.1138 without restraints) Performing minimization step: 3922. Total energy = 8712.3628 kcal/mol (8690.2126 without restraints) Performing minimization step: 3923. Total energy = 8707.4637 kcal/mol (8685.3151 without restraints) Performing minimization step: 3924. Total energy = 8702.5684 kcal/mol (8680.4216 without restraints) Performing minimization step: 3925. Total energy = 8697.6770 kcal/mol (8675.5319 without restraints) Performing minimization step: 3926. Total energy = 8692.7899 kcal/mol (8670.6466 without restraints) Performing minimization step: 3927. Total energy = 8687.9063 kcal/mol (8665.7647 without restraints) Performing minimization step: 3928. Total energy = 8683.0266 kcal/mol (8660.8867 without restraints) Performing minimization step: 3929. Total energy = 8678.1511 kcal/mol (8656.0131 without restraints) Performing minimization step: 3930. Total energy = 8673.2795 kcal/mol (8651.1433 without restraints) Performing minimization step: 3931. Total energy = 8668.4117 kcal/mol (8646.2771 without restraints) Performing minimization step: 3932. Total energy = 8663.5474 kcal/mol (8641.4145 without restraints) Performing minimization step: 3933. Total energy = 8658.6872 kcal/mol (8636.5561 without restraints) Performing minimization step: 3934. Total energy = 8653.8310 kcal/mol (8631.7016 without restraints) Performing minimization step: 3935. Total energy = 8648.9787 kcal/mol (8626.8510 without restraints) Performing minimization step: 3936. Total energy = 8644.1303 kcal/mol (8622.0044 without restraints) Performing minimization step: 3937. Total energy = 8639.2858 kcal/mol (8617.1616 without restraints) Performing minimization step: 3938. Total energy = 8634.4452 kcal/mol (8612.3228 without restraints) Performing minimization step: 3939. Total energy = 8629.6088 kcal/mol (8607.4882 without restraints) Performing minimization step: 3940. Total energy = 8624.7763 kcal/mol (8602.6575 without restraints) Performing minimization step: 3941. Total energy = 8619.9476 kcal/mol (8597.8305 without restraints) Performing minimization step: 3942. Total energy = 8615.1229 kcal/mol (8593.0075 without restraints) Performing minimization step: 3943. Total energy = 8610.3023 kcal/mol (8588.1886 without restraints) Performing minimization step: 3944. Total energy = 8605.4850 kcal/mol (8583.3731 without restraints) Performing minimization step: 3945. Total energy = 8600.6722 kcal/mol (8578.5622 without restraints) Performing minimization step: 3946. Total energy = 8595.8634 kcal/mol (8573.7550 without restraints) Performing minimization step: 3947. Total energy = 8591.0586 kcal/mol (8568.9520 without restraints) Performing minimization step: 3948. Total energy = 8586.2578 kcal/mol (8564.1530 without restraints) Performing minimization step: 3949. Total energy = 8581.4609 kcal/mol (8559.3579 without restraints) Performing minimization step: 3950. Total energy = 8576.6678 kcal/mol (8554.5665 without restraints) Performing minimization step: 3951. Total energy = 8571.8787 kcal/mol (8549.7793 without restraints) Performing minimization step: 3952. Total energy = 8567.0936 kcal/mol (8544.9958 without restraints) Performing minimization step: 3953. Total energy = 8562.3123 kcal/mol (8540.2163 without restraints) Performing minimization step: 3954. Total energy = 8557.5347 kcal/mol (8535.4405 without restraints) Performing minimization step: 3955. Total energy = 8552.7614 kcal/mol (8530.6690 without restraints) Performing minimization step: 3956. Total energy = 8547.9922 kcal/mol (8525.9016 without restraints) Performing minimization step: 3957. Total energy = 8543.2267 kcal/mol (8521.1378 without restraints) Performing minimization step: 3958. Total energy = 8538.4656 kcal/mol (8516.3785 without restraints) Performing minimization step: 3959. Total energy = 8533.7082 kcal/mol (8511.6229 without restraints) Performing minimization step: 3960. Total energy = 8528.9547 kcal/mol (8506.8712 without restraints) Performing minimization step: 3961. Total energy = 8524.2053 kcal/mol (8502.1235 without restraints) Performing minimization step: 3962. Total energy = 8519.4598 kcal/mol (8497.3798 without restraints) Performing minimization step: 3963. Total energy = 8514.7185 kcal/mol (8492.6402 without restraints) Performing minimization step: 3964. Total energy = 8509.9810 kcal/mol (8487.9045 without restraints) Performing minimization step: 3965. Total energy = 8505.2477 kcal/mol (8483.1730 without restraints) Performing minimization step: 3966. Total energy = 8500.5184 kcal/mol (8478.4455 without restraints) Performing minimization step: 3967. Total energy = 8495.7928 kcal/mol (8473.7217 without restraints) Performing minimization step: 3968. Total energy = 8491.0714 kcal/mol (8469.0021 without restraints) Performing minimization step: 3969. Total energy = 8486.3540 kcal/mol (8464.2865 without restraints) Performing minimization step: 3970. Total energy = 8481.6405 kcal/mol (8459.5747 without restraints) Performing minimization step: 3971. Total energy = 8476.9311 kcal/mol (8454.8671 without restraints) Performing minimization step: 3972. Total energy = 8472.2256 kcal/mol (8450.1634 without restraints) Performing minimization step: 3973. Total energy = 8467.5240 kcal/mol (8445.4637 without restraints) Performing minimization step: 3974. Total energy = 8462.8265 kcal/mol (8440.7679 without restraints) Performing minimization step: 3975. Total energy = 8458.1329 kcal/mol (8436.0761 without restraints) Performing minimization step: 3976. Total energy = 8453.4436 kcal/mol (8431.3886 without restraints) Performing minimization step: 3977. Total energy = 8448.7583 kcal/mol (8426.7051 without restraints) Performing minimization step: 3978. Total energy = 8444.0768 kcal/mol (8422.0254 without restraints) Performing minimization step: 3979. Total energy = 8439.3993 kcal/mol (8417.3496 without restraints) Performing minimization step: 3980. Total energy = 8434.7261 kcal/mol (8412.6782 without restraints) Performing minimization step: 3981. Total energy = 8430.0567 kcal/mol (8408.0107 without restraints) Performing minimization step: 3982. Total energy = 8425.3913 kcal/mol (8403.3471 without restraints) Performing minimization step: 3983. Total energy = 8420.7299 kcal/mol (8398.6875 without restraints) Performing minimization step: 3984. Total energy = 8416.0730 kcal/mol (8394.0324 without restraints) Performing minimization step: 3985. Total energy = 8411.4197 kcal/mol (8389.3808 without restraints) Performing minimization step: 3986. Total energy = 8406.7704 kcal/mol (8384.7334 without restraints) Performing minimization step: 3987. Total energy = 8402.1252 kcal/mol (8380.0900 without restraints) Performing minimization step: 3988. Total energy = 8397.4840 kcal/mol (8375.4506 without restraints) Performing minimization step: 3989. Total energy = 8392.8467 kcal/mol (8370.8151 without restraints) Performing minimization step: 3990. Total energy = 8388.2136 kcal/mol (8366.1838 without restraints) Performing minimization step: 3991. Total energy = 8383.5846 kcal/mol (8361.5566 without restraints) Performing minimization step: 3992. Total energy = 8378.9597 kcal/mol (8356.9336 without restraints) Performing minimization step: 3993. Total energy = 8374.3387 kcal/mol (8352.3143 without restraints) Performing minimization step: 3994. Total energy = 8369.7217 kcal/mol (8347.6992 without restraints) Performing minimization step: 3995. Total energy = 8365.1088 kcal/mol (8343.0880 without restraints) Performing minimization step: 3996. Total energy = 8360.4997 kcal/mol (8338.4807 without restraints) Performing minimization step: 3997. Total energy = 8355.8951 kcal/mol (8333.8781 without restraints) Performing minimization step: 3998. Total energy = 8351.2945 kcal/mol (8329.2792 without restraints) Performing minimization step: 3999. Total energy = 8346.6978 kcal/mol (8324.6843 without restraints) Performing minimization step: 4000. Total energy = 8342.1051 kcal/mol (8320.0935 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4001. Total energy = 8337.5167 kcal/mol (8315.5069 without restraints) Performing minimization step: 4002. Total energy = 8332.9320 kcal/mol (8310.9240 without restraints) Performing minimization step: 4003. Total energy = 8328.3515 kcal/mol (8306.3455 without restraints) Performing minimization step: 4004. Total energy = 8323.7753 kcal/mol (8301.7709 without restraints) Performing minimization step: 4005. Total energy = 8319.2028 kcal/mol (8297.2003 without restraints) Performing minimization step: 4006. Total energy = 8314.6345 kcal/mol (8292.6338 without restraints) Performing minimization step: 4007. Total energy = 8310.0704 kcal/mol (8288.0715 without restraints) Performing minimization step: 4008. Total energy = 8305.5103 kcal/mol (8283.5132 without restraints) Performing minimization step: 4009. Total energy = 8300.9542 kcal/mol (8278.9591 without restraints) Performing minimization step: 4010. Total energy = 8296.4024 kcal/mol (8274.4092 without restraints) Performing minimization step: 4011. Total energy = 8291.8548 kcal/mol (8269.8634 without restraints) Performing minimization step: 4012. Total energy = 8287.3111 kcal/mol (8265.3214 without restraints) Performing minimization step: 4013. Total energy = 8282.7718 kcal/mol (8260.7841 without restraints) Performing minimization step: 4014. Total energy = 8278.2364 kcal/mol (8256.2505 without restraints) Performing minimization step: 4015. Total energy = 8273.7050 kcal/mol (8251.7209 without restraints) Performing minimization step: 4016. Total energy = 8269.1779 kcal/mol (8247.1956 without restraints) Performing minimization step: 4017. Total energy = 8264.6545 kcal/mol (8242.6739 without restraints) Performing minimization step: 4018. Total energy = 8260.1352 kcal/mol (8238.1566 without restraints) Performing minimization step: 4019. Total energy = 8255.6201 kcal/mol (8233.6433 without restraints) Performing minimization step: 4020. Total energy = 8251.1092 kcal/mol (8229.1343 without restraints) Performing minimization step: 4021. Total energy = 8246.6021 kcal/mol (8224.6289 without restraints) Performing minimization step: 4022. Total energy = 8242.0994 kcal/mol (8220.1282 without restraints) Performing minimization step: 4023. Total energy = 8237.6006 kcal/mol (8215.6311 without restraints) Performing minimization step: 4024. Total energy = 8233.1059 kcal/mol (8211.1383 without restraints) Performing minimization step: 4025. Total energy = 8228.6153 kcal/mol (8206.6496 without restraints) Performing minimization step: 4026. Total energy = 8224.1289 kcal/mol (8202.1651 without restraints) Performing minimization step: 4027. Total energy = 8219.6466 kcal/mol (8197.6846 without restraints) Performing minimization step: 4028. Total energy = 8215.1684 kcal/mol (8193.2083 without restraints) Performing minimization step: 4029. Total energy = 8210.6944 kcal/mol (8188.7361 without restraints) Performing minimization step: 4030. Total energy = 8206.2249 kcal/mol (8184.2686 without restraints) Performing minimization step: 4031. Total energy = 8201.7596 kcal/mol (8179.8051 without restraints) Performing minimization step: 4032. Total energy = 8197.2982 kcal/mol (8175.3455 without restraints) Performing minimization step: 4033. Total energy = 8192.8406 kcal/mol (8170.8898 without restraints) Performing minimization step: 4034. Total energy = 8188.3871 kcal/mol (8166.4380 without restraints) Performing minimization step: 4035. Total energy = 8183.9377 kcal/mol (8161.9906 without restraints) Performing minimization step: 4036. Total energy = 8179.4923 kcal/mol (8157.5470 without restraints) Performing minimization step: 4037. Total energy = 8175.0516 kcal/mol (8153.1082 without restraints) Performing minimization step: 4038. Total energy = 8170.6145 kcal/mol (8148.6729 without restraints) Performing minimization step: 4039. Total energy = 8166.1816 kcal/mol (8144.2420 without restraints) Performing minimization step: 4040. Total energy = 8161.7529 kcal/mol (8139.8152 without restraints) Performing minimization step: 4041. Total energy = 8157.3283 kcal/mol (8135.3925 without restraints) Performing minimization step: 4042. Total energy = 8152.9081 kcal/mol (8130.9741 without restraints) Performing minimization step: 4043. Total energy = 8148.4919 kcal/mol (8126.5597 without restraints) Performing minimization step: 4044. Total energy = 8144.0800 kcal/mol (8122.1497 without restraints) Performing minimization step: 4045. Total energy = 8139.6720 kcal/mol (8117.7436 without restraints) Performing minimization step: 4046. Total energy = 8135.2685 kcal/mol (8113.3420 without restraints) Performing minimization step: 4047. Total energy = 8130.8688 kcal/mol (8108.9442 without restraints) Performing minimization step: 4048. Total energy = 8126.4733 kcal/mol (8104.5505 without restraints) Performing minimization step: 4049. Total energy = 8122.0817 kcal/mol (8100.1608 without restraints) Performing minimization step: 4050. Total energy = 8117.6944 kcal/mol (8095.7755 without restraints) Performing minimization step: 4051. Total energy = 8113.3115 kcal/mol (8091.3944 without restraints) Performing minimization step: 4052. Total energy = 8108.9326 kcal/mol (8087.0174 without restraints) Performing minimization step: 4053. Total energy = 8104.5578 kcal/mol (8082.6445 without restraints) Performing minimization step: 4054. Total energy = 8100.1872 kcal/mol (8078.2757 without restraints) Performing minimization step: 4055. Total energy = 8095.8207 kcal/mol (8073.9112 without restraints) Performing minimization step: 4056. Total energy = 8091.4582 kcal/mol (8069.5506 without restraints) Performing minimization step: 4057. Total energy = 8087.1001 kcal/mol (8065.1942 without restraints) Performing minimization step: 4058. Total energy = 8082.7461 kcal/mol (8060.8422 without restraints) Performing minimization step: 4059. Total energy = 8078.3965 kcal/mol (8056.4945 without restraints) Performing minimization step: 4060. Total energy = 8074.0508 kcal/mol (8052.1508 without restraints) Performing minimization step: 4061. Total energy = 8069.7093 kcal/mol (8047.8112 without restraints) Performing minimization step: 4062. Total energy = 8065.3722 kcal/mol (8043.4760 without restraints) Performing minimization step: 4063. Total energy = 8061.0393 kcal/mol (8039.1450 without restraints) Performing minimization step: 4064. Total energy = 8056.7105 kcal/mol (8034.8180 without restraints) Performing minimization step: 4065. Total energy = 8052.3859 kcal/mol (8030.4953 without restraints) Performing minimization step: 4066. Total energy = 8048.0653 kcal/mol (8026.1766 without restraints) Performing minimization step: 4067. Total energy = 8043.7489 kcal/mol (8021.8621 without restraints) Performing minimization step: 4068. Total energy = 8039.4366 kcal/mol (8017.5518 without restraints) Performing minimization step: 4069. Total energy = 8035.1286 kcal/mol (8013.2457 without restraints) Performing minimization step: 4070. Total energy = 8030.8246 kcal/mol (8008.9436 without restraints) Performing minimization step: 4071. Total energy = 8026.5250 kcal/mol (8004.6458 without restraints) Performing minimization step: 4072. Total energy = 8022.2289 kcal/mol (8000.3516 without restraints) Performing minimization step: 4073. Total energy = 8017.9375 kcal/mol (7996.0622 without restraints) Performing minimization step: 4074. Total energy = 8013.6504 kcal/mol (7991.7770 without restraints) Performing minimization step: 4075. Total energy = 8009.3676 kcal/mol (7987.4962 without restraints) Performing minimization step: 4076. Total energy = 8005.0890 kcal/mol (7983.2195 without restraints) Performing minimization step: 4077. Total energy = 8000.8143 kcal/mol (7978.9467 without restraints) Performing minimization step: 4078. Total energy = 7996.5440 kcal/mol (7974.6783 without restraints) Performing minimization step: 4079. Total energy = 7992.2779 kcal/mol (7970.4142 without restraints) Performing minimization step: 4080. Total energy = 7988.0160 kcal/mol (7966.1541 without restraints) Performing minimization step: 4081. Total energy = 7983.7583 kcal/mol (7961.8984 without restraints) Performing minimization step: 4082. Total energy = 7979.5051 kcal/mol (7957.6472 without restraints) Performing minimization step: 4083. Total energy = 7975.2561 kcal/mol (7953.4001 without restraints) Performing minimization step: 4084. Total energy = 7971.0110 kcal/mol (7949.1568 without restraints) Performing minimization step: 4085. Total energy = 7966.7698 kcal/mol (7944.9176 without restraints) Performing minimization step: 4086. Total energy = 7962.5332 kcal/mol (7940.6829 without restraints) Performing minimization step: 4087. Total energy = 7958.3008 kcal/mol (7936.4524 without restraints) Performing minimization step: 4088. Total energy = 7954.0719 kcal/mol (7932.2254 without restraints) Performing minimization step: 4089. Total energy = 7949.8477 kcal/mol (7928.0033 without restraints) Performing minimization step: 4090. Total energy = 7945.6280 kcal/mol (7923.7855 without restraints) Performing minimization step: 4091. Total energy = 7941.4122 kcal/mol (7919.5716 without restraints) Performing minimization step: 4092. Total energy = 7937.2007 kcal/mol (7915.3621 without restraints) Performing minimization step: 4093. Total energy = 7932.9935 kcal/mol (7911.1568 without restraints) Performing minimization step: 4094. Total energy = 7928.7904 kcal/mol (7906.9557 without restraints) Performing minimization step: 4095. Total energy = 7924.5916 kcal/mol (7902.7588 without restraints) Performing minimization step: 4096. Total energy = 7920.3968 kcal/mol (7898.5660 without restraints) Performing minimization step: 4097. Total energy = 7916.2065 kcal/mol (7894.3777 without restraints) Performing minimization step: 4098. Total energy = 7912.0205 kcal/mol (7890.1935 without restraints) Performing minimization step: 4099. Total energy = 7907.8386 kcal/mol (7886.0136 without restraints) Performing minimization step: 4100. Total energy = 7903.6612 kcal/mol (7881.8381 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4101. Total energy = 7899.4877 kcal/mol (7877.6666 without restraints) Performing minimization step: 4102. Total energy = 7895.3185 kcal/mol (7873.4993 without restraints) Performing minimization step: 4103. Total energy = 7891.1535 kcal/mol (7869.3363 without restraints) Performing minimization step: 4104. Total energy = 7886.9928 kcal/mol (7865.1776 without restraints) Performing minimization step: 4105. Total energy = 7882.8364 kcal/mol (7861.0231 without restraints) Performing minimization step: 4106. Total energy = 7878.6843 kcal/mol (7856.8730 without restraints) Performing minimization step: 4107. Total energy = 7874.5363 kcal/mol (7852.7269 without restraints) Performing minimization step: 4108. Total energy = 7870.3926 kcal/mol (7848.5852 without restraints) Performing minimization step: 4109. Total energy = 7866.2531 kcal/mol (7844.4476 without restraints) Performing minimization step: 4110. Total energy = 7862.1177 kcal/mol (7840.3143 without restraints) Performing minimization step: 4111. Total energy = 7857.9866 kcal/mol (7836.1851 without restraints) Performing minimization step: 4112. Total energy = 7853.8598 kcal/mol (7832.0602 without restraints) Performing minimization step: 4113. Total energy = 7849.7371 kcal/mol (7827.9396 without restraints) Performing minimization step: 4114. Total energy = 7845.6192 kcal/mol (7823.8236 without restraints) Performing minimization step: 4115. Total energy = 7841.5051 kcal/mol (7819.7115 without restraints) Performing minimization step: 4116. Total energy = 7837.3953 kcal/mol (7815.6037 without restraints) Performing minimization step: 4117. Total energy = 7833.2898 kcal/mol (7811.5001 without restraints) Performing minimization step: 4118. Total energy = 7829.1885 kcal/mol (7807.4009 without restraints) Performing minimization step: 4119. Total energy = 7825.0915 kcal/mol (7803.3058 without restraints) Performing minimization step: 4120. Total energy = 7820.9988 kcal/mol (7799.2151 without restraints) Performing minimization step: 4121. Total energy = 7816.9102 kcal/mol (7795.1285 without restraints) Performing minimization step: 4122. Total energy = 7812.8259 kcal/mol (7791.0462 without restraints) Performing minimization step: 4123. Total energy = 7808.7458 kcal/mol (7786.9680 without restraints) Performing minimization step: 4124. Total energy = 7804.6700 kcal/mol (7782.8942 without restraints) Performing minimization step: 4125. Total energy = 7800.5987 kcal/mol (7778.8249 without restraints) Performing minimization step: 4126. Total energy = 7796.5316 kcal/mol (7774.7598 without restraints) Performing minimization step: 4127. Total energy = 7792.4685 kcal/mol (7770.6987 without restraints) Performing minimization step: 4128. Total energy = 7788.4097 kcal/mol (7766.6419 without restraints) Performing minimization step: 4129. Total energy = 7784.3552 kcal/mol (7762.5894 without restraints) Performing minimization step: 4130. Total energy = 7780.3051 kcal/mol (7758.5413 without restraints) Performing minimization step: 4131. Total energy = 7776.2591 kcal/mol (7754.4973 without restraints) Performing minimization step: 4132. Total energy = 7772.2176 kcal/mol (7750.4578 without restraints) Performing minimization step: 4133. Total energy = 7768.1801 kcal/mol (7746.4223 without restraints) Performing minimization step: 4134. Total energy = 7764.1471 kcal/mol (7742.3912 without restraints) Performing minimization step: 4135. Total energy = 7760.1184 kcal/mol (7738.3645 without restraints) Performing minimization step: 4136. Total energy = 7756.0938 kcal/mol (7734.3421 without restraints) Performing minimization step: 4137. Total energy = 7752.0735 kcal/mol (7730.3237 without restraints) Performing minimization step: 4138. Total energy = 7748.0574 kcal/mol (7726.3096 without restraints) Performing minimization step: 4139. Total energy = 7744.0455 kcal/mol (7722.2997 without restraints) Performing minimization step: 4140. Total energy = 7740.0381 kcal/mol (7718.2945 without restraints) Performing minimization step: 4141. Total energy = 7736.0349 kcal/mol (7714.2932 without restraints) Performing minimization step: 4142. Total energy = 7732.0359 kcal/mol (7710.2961 without restraints) Performing minimization step: 4143. Total energy = 7728.0412 kcal/mol (7706.3034 without restraints) Performing minimization step: 4144. Total energy = 7724.0509 kcal/mol (7702.3152 without restraints) Performing minimization step: 4145. Total energy = 7720.0647 kcal/mol (7698.3310 without restraints) Performing minimization step: 4146. Total energy = 7716.0828 kcal/mol (7694.3512 without restraints) Performing minimization step: 4147. Total energy = 7712.1050 kcal/mol (7690.3754 without restraints) Performing minimization step: 4148. Total energy = 7708.1317 kcal/mol (7686.4041 without restraints) Performing minimization step: 4149. Total energy = 7704.1629 kcal/mol (7682.4372 without restraints) Performing minimization step: 4150. Total energy = 7700.1981 kcal/mol (7678.4745 without restraints) Performing minimization step: 4151. Total energy = 7696.2376 kcal/mol (7674.5161 without restraints) Performing minimization step: 4152. Total energy = 7692.2814 kcal/mol (7670.5619 without restraints) Performing minimization step: 4153. Total energy = 7688.3303 kcal/mol (7666.6128 without restraints) Performing minimization step: 4154. Total energy = 7684.3824 kcal/mol (7662.6668 without restraints) Performing minimization step: 4155. Total energy = 7680.4389 kcal/mol (7658.7255 without restraints) Performing minimization step: 4156. Total energy = 7676.5000 kcal/mol (7654.7887 without restraints) Performing minimization step: 4157. Total energy = 7672.5654 kcal/mol (7650.8560 without restraints) Performing minimization step: 4158. Total energy = 7668.6348 kcal/mol (7646.9275 without restraints) Performing minimization step: 4159. Total energy = 7664.7087 kcal/mol (7643.0034 without restraints) Performing minimization step: 4160. Total energy = 7660.7869 kcal/mol (7639.0837 without restraints) Performing minimization step: 4161. Total energy = 7656.8692 kcal/mol (7635.1680 without restraints) Performing minimization step: 4162. Total energy = 7652.9559 kcal/mol (7631.2568 without restraints) Performing minimization step: 4163. Total energy = 7649.0467 kcal/mol (7627.3496 without restraints) Performing minimization step: 4164. Total energy = 7645.1420 kcal/mol (7623.4470 without restraints) Performing minimization step: 4165. Total energy = 7641.2412 kcal/mol (7619.5482 without restraints) Performing minimization step: 4166. Total energy = 7637.3451 kcal/mol (7615.6542 without restraints) Performing minimization step: 4167. Total energy = 7633.4533 kcal/mol (7611.7645 without restraints) Performing minimization step: 4168. Total energy = 7629.5660 kcal/mol (7607.8792 without restraints) Performing minimization step: 4169. Total energy = 7625.6833 kcal/mol (7603.9987 without restraints) Performing minimization step: 4170. Total energy = 7621.8045 kcal/mol (7600.1218 without restraints) Performing minimization step: 4171. Total energy = 7617.9303 kcal/mol (7596.2497 without restraints) Performing minimization step: 4172. Total energy = 7614.0600 kcal/mol (7592.3814 without restraints) Performing minimization step: 4173. Total energy = 7610.1940 kcal/mol (7588.5175 without restraints) Performing minimization step: 4174. Total energy = 7606.3322 kcal/mol (7584.6578 without restraints) Performing minimization step: 4175. Total energy = 7602.4750 kcal/mol (7580.8026 without restraints) Performing minimization step: 4176. Total energy = 7598.6220 kcal/mol (7576.9517 without restraints) Performing minimization step: 4177. Total energy = 7594.7732 kcal/mol (7573.1050 without restraints) Performing minimization step: 4178. Total energy = 7590.9293 kcal/mol (7569.2631 without restraints) Performing minimization step: 4179. Total energy = 7587.0889 kcal/mol (7565.4248 without restraints) Performing minimization step: 4180. Total energy = 7583.2531 kcal/mol (7561.5910 without restraints) Performing minimization step: 4181. Total energy = 7579.4216 kcal/mol (7557.7616 without restraints) Performing minimization step: 4182. Total energy = 7575.5944 kcal/mol (7553.9366 without restraints) Performing minimization step: 4183. Total energy = 7571.7716 kcal/mol (7550.1159 without restraints) Performing minimization step: 4184. Total energy = 7567.9533 kcal/mol (7546.2996 without restraints) Performing minimization step: 4185. Total energy = 7564.1392 kcal/mol (7542.4875 without restraints) Performing minimization step: 4186. Total energy = 7560.3293 kcal/mol (7538.6799 without restraints) Performing minimization step: 4187. Total energy = 7556.5236 kcal/mol (7534.8761 without restraints) Performing minimization step: 4188. Total energy = 7552.7225 kcal/mol (7531.0771 without restraints) Performing minimization step: 4189. Total energy = 7548.9259 kcal/mol (7527.2827 without restraints) Performing minimization step: 4190. Total energy = 7545.1332 kcal/mol (7523.4920 without restraints) Performing minimization step: 4191. Total energy = 7541.3448 kcal/mol (7519.7057 without restraints) Performing minimization step: 4192. Total energy = 7537.5611 kcal/mol (7515.9241 without restraints) Performing minimization step: 4193. Total energy = 7533.7813 kcal/mol (7512.1465 without restraints) Performing minimization step: 4194. Total energy = 7530.0061 kcal/mol (7508.3733 without restraints) Performing minimization step: 4195. Total energy = 7526.2350 kcal/mol (7504.6043 without restraints) Performing minimization step: 4196. Total energy = 7522.4690 kcal/mol (7500.8404 without restraints) Performing minimization step: 4197. Total energy = 7518.7065 kcal/mol (7497.0800 without restraints) Performing minimization step: 4198. Total energy = 7514.9485 kcal/mol (7493.3242 without restraints) Performing minimization step: 4199. Total energy = 7511.1949 kcal/mol (7489.5726 without restraints) Performing minimization step: 4200. Total energy = 7507.4452 kcal/mol (7485.8251 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4201. Total energy = 7503.7001 kcal/mol (7482.0820 without restraints) Performing minimization step: 4202. Total energy = 7499.9592 kcal/mol (7478.3432 without restraints) Performing minimization step: 4203. Total energy = 7496.2226 kcal/mol (7474.6088 without restraints) Performing minimization step: 4204. Total energy = 7492.4904 kcal/mol (7470.8787 without restraints) Performing minimization step: 4205. Total energy = 7488.7625 kcal/mol (7467.1529 without restraints) Performing minimization step: 4206. Total energy = 7485.0387 kcal/mol (7463.4312 without restraints) Performing minimization step: 4207. Total energy = 7481.3193 kcal/mol (7459.7139 without restraints) Performing minimization step: 4208. Total energy = 7477.6044 kcal/mol (7456.0011 without restraints) Performing minimization step: 4209. Total energy = 7473.8937 kcal/mol (7452.2926 without restraints) Performing minimization step: 4210. Total energy = 7470.1873 kcal/mol (7448.5882 without restraints) Performing minimization step: 4211. Total energy = 7466.4859 kcal/mol (7444.8890 without restraints) Performing minimization step: 4212. Total energy = 7462.7883 kcal/mol (7441.1937 without restraints) Performing minimization step: 4213. Total energy = 7459.0955 kcal/mol (7437.5029 without restraints) Performing minimization step: 4214. Total energy = 7455.4065 kcal/mol (7433.8160 without restraints) Performing minimization step: 4215. Total energy = 7451.7218 kcal/mol (7430.1335 without restraints) Performing minimization step: 4216. Total energy = 7448.0419 kcal/mol (7426.4557 without restraints) Performing minimization step: 4217. Total energy = 7444.3662 kcal/mol (7422.7821 without restraints) Performing minimization step: 4218. Total energy = 7440.6945 kcal/mol (7419.1126 without restraints) Performing minimization step: 4219. Total energy = 7437.0271 kcal/mol (7415.4474 without restraints) Performing minimization step: 4220. Total energy = 7433.3639 kcal/mol (7411.7863 without restraints) Performing minimization step: 4221. Total energy = 7429.7052 kcal/mol (7408.1296 without restraints) Performing minimization step: 4222. Total energy = 7426.0505 kcal/mol (7404.4772 without restraints) Performing minimization step: 4223. Total energy = 7422.4005 kcal/mol (7400.8293 without restraints) Performing minimization step: 4224. Total energy = 7418.7545 kcal/mol (7397.1855 without restraints) Performing minimization step: 4225. Total energy = 7415.1132 kcal/mol (7393.5463 without restraints) Performing minimization step: 4226. Total energy = 7411.4761 kcal/mol (7389.9114 without restraints) Performing minimization step: 4227. Total energy = 7407.8433 kcal/mol (7386.2808 without restraints) Performing minimization step: 4228. Total energy = 7404.2154 kcal/mol (7382.6550 without restraints) Performing minimization step: 4229. Total energy = 7400.5913 kcal/mol (7379.0330 without restraints) Performing minimization step: 4230. Total energy = 7396.9715 kcal/mol (7375.4154 without restraints) Performing minimization step: 4231. Total energy = 7393.3563 kcal/mol (7371.8024 without restraints) Performing minimization step: 4232. Total energy = 7389.7452 kcal/mol (7368.1935 without restraints) Performing minimization step: 4233. Total energy = 7386.1385 kcal/mol (7364.5889 without restraints) Performing minimization step: 4234. Total energy = 7382.5361 kcal/mol (7360.9886 without restraints) Performing minimization step: 4235. Total energy = 7378.9382 kcal/mol (7357.3930 without restraints) Performing minimization step: 4236. Total energy = 7375.3445 kcal/mol (7353.8014 without restraints) Performing minimization step: 4237. Total energy = 7371.7551 kcal/mol (7350.2144 without restraints) Performing minimization step: 4238. Total energy = 7368.1699 kcal/mol (7346.6312 without restraints) Performing minimization step: 4239. Total energy = 7364.5896 kcal/mol (7343.0529 without restraints) Performing minimization step: 4240. Total energy = 7361.0134 kcal/mol (7339.4789 without restraints) Performing minimization step: 4241. Total energy = 7357.4412 kcal/mol (7335.9090 without restraints) Performing minimization step: 4242. Total energy = 7353.8734 kcal/mol (7332.3434 without restraints) Performing minimization step: 4243. Total energy = 7350.3102 kcal/mol (7328.7824 without restraints) Performing minimization step: 4244. Total energy = 7346.7515 kcal/mol (7325.2260 without restraints) Performing minimization step: 4245. Total energy = 7343.1964 kcal/mol (7321.6730 without restraints) Performing minimization step: 4246. Total energy = 7339.6460 kcal/mol (7318.1248 without restraints) Performing minimization step: 4247. Total energy = 7336.0999 kcal/mol (7314.5808 without restraints) Performing minimization step: 4248. Total energy = 7332.5582 kcal/mol (7311.0413 without restraints) Performing minimization step: 4249. Total energy = 7329.0207 kcal/mol (7307.5061 without restraints) Performing minimization step: 4250. Total energy = 7325.4876 kcal/mol (7303.9751 without restraints) Performing minimization step: 4251. Total energy = 7321.9588 kcal/mol (7300.4485 without restraints) Performing minimization step: 4252. Total energy = 7318.4343 kcal/mol (7296.9263 without restraints) Performing minimization step: 4253. Total energy = 7314.9142 kcal/mol (7293.4084 without restraints) Performing minimization step: 4254. Total energy = 7311.3985 kcal/mol (7289.8949 without restraints) Performing minimization step: 4255. Total energy = 7307.8873 kcal/mol (7286.3859 without restraints) Performing minimization step: 4256. Total energy = 7304.3800 kcal/mol (7282.8807 without restraints) Performing minimization step: 4257. Total energy = 7300.8771 kcal/mol (7279.3801 without restraints) Performing minimization step: 4258. Total energy = 7297.3787 kcal/mol (7275.8839 without restraints) Performing minimization step: 4259. Total energy = 7293.8846 kcal/mol (7272.3920 without restraints) Performing minimization step: 4260. Total energy = 7290.3949 kcal/mol (7268.9045 without restraints) Performing minimization step: 4261. Total energy = 7286.9094 kcal/mol (7265.4212 without restraints) Performing minimization step: 4262. Total energy = 7283.4283 kcal/mol (7261.9424 without restraints) Performing minimization step: 4263. Total energy = 7279.9513 kcal/mol (7258.4676 without restraints) Performing minimization step: 4264. Total energy = 7276.4788 kcal/mol (7254.9973 without restraints) Performing minimization step: 4265. Total energy = 7273.0109 kcal/mol (7251.5315 without restraints) Performing minimization step: 4266. Total energy = 7269.5471 kcal/mol (7248.0701 without restraints) Performing minimization step: 4267. Total energy = 7266.0877 kcal/mol (7244.6129 without restraints) Performing minimization step: 4268. Total energy = 7262.6325 kcal/mol (7241.1599 without restraints) Performing minimization step: 4269. Total energy = 7259.1816 kcal/mol (7237.7112 without restraints) Performing minimization step: 4270. Total energy = 7255.7350 kcal/mol (7234.2669 without restraints) Performing minimization step: 4271. Total energy = 7252.2925 kcal/mol (7230.8267 without restraints) Performing minimization step: 4272. Total energy = 7248.8549 kcal/mol (7227.3913 without restraints) Performing minimization step: 4273. Total energy = 7245.4213 kcal/mol (7223.9599 without restraints) Performing minimization step: 4274. Total energy = 7241.9918 kcal/mol (7220.5327 without restraints) Performing minimization step: 4275. Total energy = 7238.5666 kcal/mol (7217.1098 without restraints) Performing minimization step: 4276. Total energy = 7235.1460 kcal/mol (7213.6914 without restraints) Performing minimization step: 4277. Total energy = 7231.7296 kcal/mol (7210.2771 without restraints) Performing minimization step: 4278. Total energy = 7228.3176 kcal/mol (7206.8674 without restraints) Performing minimization step: 4279. Total energy = 7224.9099 kcal/mol (7203.4620 without restraints) Performing minimization step: 4280. Total energy = 7221.5068 kcal/mol (7200.0612 without restraints) Performing minimization step: 4281. Total energy = 7218.1080 kcal/mol (7196.6645 without restraints) Performing minimization step: 4282. Total energy = 7214.7129 kcal/mol (7193.2718 without restraints) Performing minimization step: 4283. Total energy = 7211.3224 kcal/mol (7189.8835 without restraints) Performing minimization step: 4284. Total energy = 7207.9364 kcal/mol (7186.4997 without restraints) Performing minimization step: 4285. Total energy = 7204.5545 kcal/mol (7183.1202 without restraints) Performing minimization step: 4286. Total energy = 7201.1770 kcal/mol (7179.7450 without restraints) Performing minimization step: 4287. Total energy = 7197.8038 kcal/mol (7176.3740 without restraints) Performing minimization step: 4288. Total energy = 7194.4350 kcal/mol (7173.0075 without restraints) Performing minimization step: 4289. Total energy = 7191.0705 kcal/mol (7169.6452 without restraints) Performing minimization step: 4290. Total energy = 7187.7104 kcal/mol (7166.2875 without restraints) Performing minimization step: 4291. Total energy = 7184.3547 kcal/mol (7162.9341 without restraints) Performing minimization step: 4292. Total energy = 7181.0033 kcal/mol (7159.5849 without restraints) Performing minimization step: 4293. Total energy = 7177.6564 kcal/mol (7156.2403 without restraints) Performing minimization step: 4294. Total energy = 7174.3137 kcal/mol (7152.8999 without restraints) Performing minimization step: 4295. Total energy = 7170.9756 kcal/mol (7149.5640 without restraints) Performing minimization step: 4296. Total energy = 7167.6413 kcal/mol (7146.2321 without restraints) Performing minimization step: 4297. Total energy = 7164.3113 kcal/mol (7142.9044 without restraints) Performing minimization step: 4298. Total energy = 7160.9857 kcal/mol (7139.5811 without restraints) Performing minimization step: 4299. Total energy = 7157.6644 kcal/mol (7136.2620 without restraints) Performing minimization step: 4300. Total energy = 7154.3474 kcal/mol (7132.9473 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4301. Total energy = 7151.0349 kcal/mol (7129.6371 without restraints) Performing minimization step: 4302. Total energy = 7147.7266 kcal/mol (7126.3312 without restraints) Performing minimization step: 4303. Total energy = 7144.4226 kcal/mol (7123.0295 without restraints) Performing minimization step: 4304. Total energy = 7141.1229 kcal/mol (7119.7320 without restraints) Performing minimization step: 4305. Total energy = 7137.8274 kcal/mol (7116.4388 without restraints) Performing minimization step: 4306. Total energy = 7134.5362 kcal/mol (7113.1499 without restraints) Performing minimization step: 4307. Total energy = 7131.2489 kcal/mol (7109.8649 without restraints) Performing minimization step: 4308. Total energy = 7127.9663 kcal/mol (7106.5847 without restraints) Performing minimization step: 4309. Total energy = 7124.6882 kcal/mol (7103.3089 without restraints) Performing minimization step: 4310. Total energy = 7121.4142 kcal/mol (7100.0372 without restraints) Performing minimization step: 4311. Total energy = 7118.1443 kcal/mol (7096.7696 without restraints) Performing minimization step: 4312. Total energy = 7114.8789 kcal/mol (7093.5066 without restraints) Performing minimization step: 4313. Total energy = 7111.6179 kcal/mol (7090.2479 without restraints) Performing minimization step: 4314. Total energy = 7108.3611 kcal/mol (7086.9934 without restraints) Performing minimization step: 4315. Total energy = 7105.1086 kcal/mol (7083.7432 without restraints) Performing minimization step: 4316. Total energy = 7101.8604 kcal/mol (7080.4973 without restraints) Performing minimization step: 4317. Total energy = 7098.6167 kcal/mol (7077.2560 without restraints) Performing minimization step: 4318. Total energy = 7095.3775 kcal/mol (7074.0191 without restraints) Performing minimization step: 4319. Total energy = 7092.1420 kcal/mol (7070.7859 without restraints) Performing minimization step: 4320. Total energy = 7088.9109 kcal/mol (7067.5572 without restraints) Performing minimization step: 4321. Total energy = 7085.6842 kcal/mol (7064.3328 without restraints) Performing minimization step: 4322. Total energy = 7082.4617 kcal/mol (7061.1127 without restraints) Performing minimization step: 4323. Total energy = 7079.2443 kcal/mol (7057.8976 without restraints) Performing minimization step: 4324. Total energy = 7076.0304 kcal/mol (7054.6861 without restraints) Performing minimization step: 4325. Total energy = 7072.8209 kcal/mol (7051.4789 without restraints) Performing minimization step: 4326. Total energy = 7069.6156 kcal/mol (7048.2759 without restraints) Performing minimization step: 4327. Total energy = 7066.4146 kcal/mol (7045.0773 without restraints) Performing minimization step: 4328. Total energy = 7063.2179 kcal/mol (7041.8829 without restraints) Performing minimization step: 4329. Total energy = 7060.0252 kcal/mol (7038.6926 without restraints) Performing minimization step: 4330. Total energy = 7056.8368 kcal/mol (7035.5066 without restraints) Performing minimization step: 4331. Total energy = 7053.6533 kcal/mol (7032.3255 without restraints) Performing minimization step: 4332. Total energy = 7050.4737 kcal/mol (7029.1483 without restraints) Performing minimization step: 4333. Total energy = 7047.2984 kcal/mol (7025.9753 without restraints) Performing minimization step: 4334. Total energy = 7044.1274 kcal/mol (7022.8067 without restraints) Performing minimization step: 4335. Total energy = 7040.9610 kcal/mol (7019.6428 without restraints) Performing minimization step: 4336. Total energy = 7037.7990 kcal/mol (7016.4830 without restraints) Performing minimization step: 4337. Total energy = 7034.6410 kcal/mol (7013.3274 without restraints) Performing minimization step: 4338. Total energy = 7031.4873 kcal/mol (7010.1760 without restraints) Performing minimization step: 4339. Total energy = 7028.3377 kcal/mol (7007.0289 without restraints) Performing minimization step: 4340. Total energy = 7025.1926 kcal/mol (7003.8861 without restraints) Performing minimization step: 4341. Total energy = 7022.0514 kcal/mol (7000.7473 without restraints) Performing minimization step: 4342. Total energy = 7018.9149 kcal/mol (6997.6134 without restraints) Performing minimization step: 4343. Total energy = 7015.7825 kcal/mol (6994.4831 without restraints) Performing minimization step: 4344. Total energy = 7012.6541 kcal/mol (6991.3571 without restraints) Performing minimization step: 4345. Total energy = 7009.5300 kcal/mol (6988.2354 without restraints) Performing minimization step: 4346. Total energy = 7006.4101 kcal/mol (6985.1179 without restraints) Performing minimization step: 4347. Total energy = 7003.2947 kcal/mol (6982.0052 without restraints) Performing minimization step: 4348. Total energy = 7000.1837 kcal/mol (6978.8964 without restraints) Performing minimization step: 4349. Total energy = 6997.0773 kcal/mol (6975.7924 without restraints) Performing minimization step: 4350. Total energy = 6993.9744 kcal/mol (6972.6919 without restraints) Performing minimization step: 4351. Total energy = 6990.8761 kcal/mol (6969.5959 without restraints) Performing minimization step: 4352. Total energy = 6987.7817 kcal/mol (6966.5040 without restraints) Performing minimization step: 4353. Total energy = 6984.6917 kcal/mol (6963.4163 without restraints) Performing minimization step: 4354. Total energy = 6981.6061 kcal/mol (6960.3332 without restraints) Performing minimization step: 4355. Total energy = 6978.5246 kcal/mol (6957.2542 without restraints) Performing minimization step: 4356. Total energy = 6975.4473 kcal/mol (6954.1793 without restraints) Performing minimization step: 4357. Total energy = 6972.3745 kcal/mol (6951.1089 without restraints) Performing minimization step: 4358. Total energy = 6969.3057 kcal/mol (6948.0425 without restraints) Performing minimization step: 4359. Total energy = 6966.2411 kcal/mol (6944.9803 without restraints) Performing minimization step: 4360. Total energy = 6963.1809 kcal/mol (6941.9225 without restraints) Performing minimization step: 4361. Total energy = 6960.1247 kcal/mol (6938.8688 without restraints) Performing minimization step: 4362. Total energy = 6957.0730 kcal/mol (6935.8195 without restraints) Performing minimization step: 4363. Total energy = 6954.0253 kcal/mol (6932.7742 without restraints) Performing minimization step: 4364. Total energy = 6950.9818 kcal/mol (6929.7332 without restraints) Performing minimization step: 4365. Total energy = 6947.9428 kcal/mol (6926.6968 without restraints) Performing minimization step: 4366. Total energy = 6944.9081 kcal/mol (6923.6643 without restraints) Performing minimization step: 4367. Total energy = 6941.8771 kcal/mol (6920.6358 without restraints) Performing minimization step: 4368. Total energy = 6938.8509 kcal/mol (6917.6120 without restraints) Performing minimization step: 4369. Total energy = 6935.8288 kcal/mol (6914.5924 without restraints) Performing minimization step: 4370. Total energy = 6932.8110 kcal/mol (6911.5771 without restraints) Performing minimization step: 4371. Total energy = 6929.7974 kcal/mol (6908.5658 without restraints) Performing minimization step: 4372. Total energy = 6926.7879 kcal/mol (6905.5588 without restraints) Performing minimization step: 4373. Total energy = 6923.7825 kcal/mol (6902.5559 without restraints) Performing minimization step: 4374. Total energy = 6920.7817 kcal/mol (6899.5575 without restraints) Performing minimization step: 4375. Total energy = 6917.7848 kcal/mol (6896.5631 without restraints) Performing minimization step: 4376. Total energy = 6914.7920 kcal/mol (6893.5727 without restraints) Performing minimization step: 4377. Total energy = 6911.8042 kcal/mol (6890.5874 without restraints) Performing minimization step: 4378. Total energy = 6908.8200 kcal/mol (6887.6058 without restraints) Performing minimization step: 4379. Total energy = 6905.8403 kcal/mol (6884.6285 without restraints) Performing minimization step: 4380. Total energy = 6902.8643 kcal/mol (6881.6549 without restraints) Performing minimization step: 4381. Total energy = 6899.8924 kcal/mol (6878.6856 without restraints) Performing minimization step: 4382. Total energy = 6896.9246 kcal/mol (6875.7202 without restraints) Performing minimization step: 4383. Total energy = 6893.9612 kcal/mol (6872.7593 without restraints) Performing minimization step: 4384. Total energy = 6891.0023 kcal/mol (6869.8029 without restraints) Performing minimization step: 4385. Total energy = 6888.0473 kcal/mol (6866.8503 without restraints) Performing minimization step: 4386. Total energy = 6885.0965 kcal/mol (6863.9021 without restraints) Performing minimization step: 4387. Total energy = 6882.1499 kcal/mol (6860.9580 without restraints) Performing minimization step: 4388. Total energy = 6879.2076 kcal/mol (6858.0182 without restraints) Performing minimization step: 4389. Total energy = 6876.2693 kcal/mol (6855.0823 without restraints) Performing minimization step: 4390. Total energy = 6873.3356 kcal/mol (6852.1512 without restraints) Performing minimization step: 4391. Total energy = 6870.4057 kcal/mol (6849.2237 without restraints) Performing minimization step: 4392. Total energy = 6867.4799 kcal/mol (6846.3004 without restraints) Performing minimization step: 4393. Total energy = 6864.5584 kcal/mol (6843.3815 without restraints) Performing minimization step: 4394. Total energy = 6861.6412 kcal/mol (6840.4668 without restraints) Performing minimization step: 4395. Total energy = 6858.7280 kcal/mol (6837.5561 without restraints) Performing minimization step: 4396. Total energy = 6855.8187 kcal/mol (6834.6494 without restraints) Performing minimization step: 4397. Total energy = 6852.9140 kcal/mol (6831.7472 without restraints) Performing minimization step: 4398. Total energy = 6850.0130 kcal/mol (6828.8487 without restraints) Performing minimization step: 4399. Total energy = 6847.1167 kcal/mol (6825.9549 without restraints) Performing minimization step: 4400. Total energy = 6844.2243 kcal/mol (6823.0649 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4401. Total energy = 6841.3358 kcal/mol (6820.1790 without restraints) Performing minimization step: 4402. Total energy = 6838.4517 kcal/mol (6817.2974 without restraints) Performing minimization step: 4403. Total energy = 6835.5718 kcal/mol (6814.4200 without restraints) Performing minimization step: 4404. Total energy = 6832.6959 kcal/mol (6811.5467 without restraints) Performing minimization step: 4405. Total energy = 6829.8242 kcal/mol (6808.6775 without restraints) Performing minimization step: 4406. Total energy = 6826.9564 kcal/mol (6805.8122 without restraints) Performing minimization step: 4407. Total energy = 6824.0930 kcal/mol (6802.9512 without restraints) Performing minimization step: 4408. Total energy = 6821.2337 kcal/mol (6800.0947 without restraints) Performing minimization step: 4409. Total energy = 6818.3783 kcal/mol (6797.2418 without restraints) Performing minimization step: 4410. Total energy = 6815.5277 kcal/mol (6794.3938 without restraints) Performing minimization step: 4411. Total energy = 6812.6808 kcal/mol (6791.5493 without restraints) Performing minimization step: 4412. Total energy = 6809.8381 kcal/mol (6788.7091 without restraints) Performing minimization step: 4413. Total energy = 6806.9997 kcal/mol (6785.8734 without restraints) Performing minimization step: 4414. Total energy = 6804.1653 kcal/mol (6783.0414 without restraints) Performing minimization step: 4415. Total energy = 6801.3349 kcal/mol (6780.2136 without restraints) Performing minimization step: 4416. Total energy = 6798.5089 kcal/mol (6777.3903 without restraints) Performing minimization step: 4417. Total energy = 6795.6868 kcal/mol (6774.5707 without restraints) Performing minimization step: 4418. Total energy = 6792.8689 kcal/mol (6771.7553 without restraints) Performing minimization step: 4419. Total energy = 6790.0552 kcal/mol (6768.9445 without restraints) Performing minimization step: 4420. Total energy = 6787.2457 kcal/mol (6766.1373 without restraints) Performing minimization step: 4421. Total energy = 6784.4396 kcal/mol (6763.3335 without restraints) Performing minimization step: 4422. Total energy = 6781.6378 kcal/mol (6760.5344 without restraints) Performing minimization step: 4423. Total energy = 6778.8407 kcal/mol (6757.7400 without restraints) Performing minimization step: 4424. Total energy = 6776.0474 kcal/mol (6754.9493 without restraints) Performing minimization step: 4425. Total energy = 6773.2583 kcal/mol (6752.1630 without restraints) Performing minimization step: 4426. Total energy = 6770.4734 kcal/mol (6749.3804 without restraints) Performing minimization step: 4427. Total energy = 6767.6923 kcal/mol (6746.6019 without restraints) Performing minimization step: 4428. Total energy = 6764.9154 kcal/mol (6743.8277 without restraints) Performing minimization step: 4429. Total energy = 6762.1424 kcal/mol (6741.0573 without restraints) Performing minimization step: 4430. Total energy = 6759.3737 kcal/mol (6738.2912 without restraints) Performing minimization step: 4431. Total energy = 6756.6091 kcal/mol (6735.5291 without restraints) Performing minimization step: 4432. Total energy = 6753.8484 kcal/mol (6732.7710 without restraints) Performing minimization step: 4433. Total energy = 6751.0911 kcal/mol (6730.0164 without restraints) Performing minimization step: 4434. Total energy = 6748.3386 kcal/mol (6727.2665 without restraints) Performing minimization step: 4435. Total energy = 6745.5901 kcal/mol (6724.5205 without restraints) Performing minimization step: 4436. Total energy = 6742.8457 kcal/mol (6721.7788 without restraints) Performing minimization step: 4437. Total energy = 6740.1055 kcal/mol (6719.0412 without restraints) Performing minimization step: 4438. Total energy = 6737.3695 kcal/mol (6716.3078 without restraints) Performing minimization step: 4439. Total energy = 6734.6373 kcal/mol (6713.5783 without restraints) Performing minimization step: 4440. Total energy = 6731.9092 kcal/mol (6710.8527 without restraints) Performing minimization step: 4441. Total energy = 6729.1851 kcal/mol (6708.1312 without restraints) Performing minimization step: 4442. Total energy = 6726.4653 kcal/mol (6705.4140 without restraints) Performing minimization step: 4443. Total energy = 6723.7492 kcal/mol (6702.7007 without restraints) Performing minimization step: 4444. Total energy = 6721.0372 kcal/mol (6699.9913 without restraints) Performing minimization step: 4445. Total energy = 6718.3293 kcal/mol (6697.2860 without restraints) Performing minimization step: 4446. Total energy = 6715.6260 kcal/mol (6694.5855 without restraints) Performing minimization step: 4447. Total energy = 6712.9264 kcal/mol (6691.8884 without restraints) Performing minimization step: 4448. Total energy = 6710.2306 kcal/mol (6689.1953 without restraints) Performing minimization step: 4449. Total energy = 6707.5386 kcal/mol (6686.5059 without restraints) Performing minimization step: 4450. Total energy = 6704.8509 kcal/mol (6683.8208 without restraints) Performing minimization step: 4451. Total energy = 6702.1671 kcal/mol (6681.1397 without restraints) Performing minimization step: 4452. Total energy = 6699.4873 kcal/mol (6678.4624 without restraints) Performing minimization step: 4453. Total energy = 6696.8112 kcal/mol (6675.7891 without restraints) Performing minimization step: 4454. Total energy = 6694.1398 kcal/mol (6673.1205 without restraints) Performing minimization step: 4455. Total energy = 6691.4723 kcal/mol (6670.4556 without restraints) Performing minimization step: 4456. Total energy = 6688.8089 kcal/mol (6667.7949 without restraints) Performing minimization step: 4457. Total energy = 6686.1492 kcal/mol (6665.1379 without restraints) Performing minimization step: 4458. Total energy = 6683.4936 kcal/mol (6662.4849 without restraints) Performing minimization step: 4459. Total energy = 6680.8418 kcal/mol (6659.8357 without restraints) Performing minimization step: 4460. Total energy = 6678.1943 kcal/mol (6657.1909 without restraints) Performing minimization step: 4461. Total energy = 6675.5507 kcal/mol (6654.5500 without restraints) Performing minimization step: 4462. Total energy = 6672.9110 kcal/mol (6651.9129 without restraints) Performing minimization step: 4463. Total energy = 6670.2754 kcal/mol (6649.2800 without restraints) Performing minimization step: 4464. Total energy = 6667.6436 kcal/mol (6646.6510 without restraints) Performing minimization step: 4465. Total energy = 6665.0158 kcal/mol (6644.0258 without restraints) Performing minimization step: 4466. Total energy = 6662.3920 kcal/mol (6641.4047 without restraints) Performing minimization step: 4467. Total energy = 6659.7722 kcal/mol (6638.7877 without restraints) Performing minimization step: 4468. Total energy = 6657.1568 kcal/mol (6636.1749 without restraints) Performing minimization step: 4469. Total energy = 6654.5447 kcal/mol (6633.5655 without restraints) Performing minimization step: 4470. Total energy = 6651.9374 kcal/mol (6630.9609 without restraints) Performing minimization step: 4471. Total energy = 6649.3333 kcal/mol (6628.3595 without restraints) Performing minimization step: 4472. Total energy = 6646.7332 kcal/mol (6625.7621 without restraints) Performing minimization step: 4473. Total energy = 6644.1371 kcal/mol (6623.1687 without restraints) Performing minimization step: 4474. Total energy = 6641.5450 kcal/mol (6620.5793 without restraints) Performing minimization step: 4475. Total energy = 6638.9567 kcal/mol (6617.9938 without restraints) Performing minimization step: 4476. Total energy = 6636.3724 kcal/mol (6615.4122 without restraints) Performing minimization step: 4477. Total energy = 6633.7919 kcal/mol (6612.8344 without restraints) Performing minimization step: 4478. Total energy = 6631.2154 kcal/mol (6610.2606 without restraints) Performing minimization step: 4479. Total energy = 6628.6428 kcal/mol (6607.6908 without restraints) Performing minimization step: 4480. Total energy = 6626.0746 kcal/mol (6605.1253 without restraints) Performing minimization step: 4481. Total energy = 6623.5099 kcal/mol (6602.5633 without restraints) Performing minimization step: 4482. Total energy = 6620.9493 kcal/mol (6600.0054 without restraints) Performing minimization step: 4483. Total energy = 6618.3928 kcal/mol (6597.4517 without restraints) Performing minimization step: 4484. Total energy = 6615.8398 kcal/mol (6594.9014 without restraints) Performing minimization step: 4485. Total energy = 6613.2907 kcal/mol (6592.3551 without restraints) Performing minimization step: 4486. Total energy = 6610.7458 kcal/mol (6589.8130 without restraints) Performing minimization step: 4487. Total energy = 6608.2047 kcal/mol (6587.2746 without restraints) Performing minimization step: 4488. Total energy = 6605.6676 kcal/mol (6584.7403 without restraints) Performing minimization step: 4489. Total energy = 6603.1344 kcal/mol (6582.2099 without restraints) Performing minimization step: 4490. Total energy = 6600.6048 kcal/mol (6579.6830 without restraints) Performing minimization step: 4491. Total energy = 6598.0791 kcal/mol (6577.1601 without restraints) Performing minimization step: 4492. Total energy = 6595.5570 kcal/mol (6574.6407 without restraints) Performing minimization step: 4493. Total energy = 6593.0392 kcal/mol (6572.1257 without restraints) Performing minimization step: 4494. Total energy = 6590.5249 kcal/mol (6569.6141 without restraints) Performing minimization step: 4495. Total energy = 6588.0146 kcal/mol (6567.1066 without restraints) Performing minimization step: 4496. Total energy = 6585.5084 kcal/mol (6564.6032 without restraints) Performing minimization step: 4497. Total energy = 6583.0059 kcal/mol (6562.1035 without restraints) Performing minimization step: 4498. Total energy = 6580.5070 kcal/mol (6559.6073 without restraints) Performing minimization step: 4499. Total energy = 6578.0125 kcal/mol (6557.1157 without restraints) Performing minimization step: 4500. Total energy = 6575.5215 kcal/mol (6554.6275 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4501. Total energy = 6573.0346 kcal/mol (6552.1433 without restraints) Performing minimization step: 4502. Total energy = 6570.5512 kcal/mol (6549.6627 without restraints) Performing minimization step: 4503. Total energy = 6568.0718 kcal/mol (6547.1862 without restraints) Performing minimization step: 4504. Total energy = 6565.5964 kcal/mol (6544.7135 without restraints) Performing minimization step: 4505. Total energy = 6563.1247 kcal/mol (6542.2445 without restraints) Performing minimization step: 4506. Total energy = 6560.6570 kcal/mol (6539.7797 without restraints) Performing minimization step: 4507. Total energy = 6558.1928 kcal/mol (6537.3184 without restraints) Performing minimization step: 4508. Total energy = 6555.7327 kcal/mol (6534.8610 without restraints) Performing minimization step: 4509. Total energy = 6553.2765 kcal/mol (6532.4076 without restraints) Performing minimization step: 4510. Total energy = 6550.8235 kcal/mol (6529.9575 without restraints) Performing minimization step: 4511. Total energy = 6548.3747 kcal/mol (6527.5115 without restraints) Performing minimization step: 4512. Total energy = 6545.9291 kcal/mol (6525.0686 without restraints) Performing minimization step: 4513. Total energy = 6543.4876 kcal/mol (6522.6300 without restraints) Performing minimization step: 4514. Total energy = 6541.0500 kcal/mol (6520.1952 without restraints) Performing minimization step: 4515. Total energy = 6538.6161 kcal/mol (6517.7642 without restraints) Performing minimization step: 4516. Total energy = 6536.1860 kcal/mol (6515.3370 without restraints) Performing minimization step: 4517. Total energy = 6533.7593 kcal/mol (6512.9131 without restraints) Performing minimization step: 4518. Total energy = 6531.3370 kcal/mol (6510.4936 without restraints) Performing minimization step: 4519. Total energy = 6528.9181 kcal/mol (6508.0776 without restraints) Performing minimization step: 4520. Total energy = 6526.5036 kcal/mol (6505.6659 without restraints) Performing minimization step: 4521. Total energy = 6524.0924 kcal/mol (6503.2575 without restraints) Performing minimization step: 4522. Total energy = 6521.6849 kcal/mol (6500.8530 without restraints) Performing minimization step: 4523. Total energy = 6519.2814 kcal/mol (6498.4524 without restraints) Performing minimization step: 4524. Total energy = 6516.8817 kcal/mol (6496.0555 without restraints) Performing minimization step: 4525. Total energy = 6514.4862 kcal/mol (6493.6628 without restraints) Performing minimization step: 4526. Total energy = 6512.0935 kcal/mol (6491.2730 without restraints) Performing minimization step: 4527. Total energy = 6509.7052 kcal/mol (6488.8875 without restraints) Performing minimization step: 4528. Total energy = 6507.3202 kcal/mol (6486.5054 without restraints) Performing minimization step: 4529. Total energy = 6504.9390 kcal/mol (6484.1272 without restraints) Performing minimization step: 4530. Total energy = 6502.5618 kcal/mol (6481.7528 without restraints) Performing minimization step: 4531. Total energy = 6500.1881 kcal/mol (6479.3820 without restraints) Performing minimization step: 4532. Total energy = 6497.8183 kcal/mol (6477.0151 without restraints) Performing minimization step: 4533. Total energy = 6495.4522 kcal/mol (6474.6519 without restraints) Performing minimization step: 4534. Total energy = 6493.0896 kcal/mol (6472.2921 without restraints) Performing minimization step: 4535. Total energy = 6490.7306 kcal/mol (6469.9360 without restraints) Performing minimization step: 4536. Total energy = 6488.3750 kcal/mol (6467.5833 without restraints) Performing minimization step: 4537. Total energy = 6486.0229 kcal/mol (6465.2341 without restraints) Performing minimization step: 4538. Total energy = 6483.6752 kcal/mol (6462.8892 without restraints) Performing minimization step: 4539. Total energy = 6481.3308 kcal/mol (6460.5478 without restraints) Performing minimization step: 4540. Total energy = 6478.9902 kcal/mol (6458.2101 without restraints) Performing minimization step: 4541. Total energy = 6476.6534 kcal/mol (6455.8762 without restraints) Performing minimization step: 4542. Total energy = 6474.3202 kcal/mol (6453.5460 without restraints) Performing minimization step: 4543. Total energy = 6471.9907 kcal/mol (6451.2193 without restraints) Performing minimization step: 4544. Total energy = 6469.6646 kcal/mol (6448.8962 without restraints) Performing minimization step: 4545. Total energy = 6467.3424 kcal/mol (6446.5770 without restraints) Performing minimization step: 4546. Total energy = 6465.0240 kcal/mol (6444.2614 without restraints) Performing minimization step: 4547. Total energy = 6462.7090 kcal/mol (6441.9493 without restraints) Performing minimization step: 4548. Total energy = 6460.3974 kcal/mol (6439.6406 without restraints) Performing minimization step: 4549. Total energy = 6458.0896 kcal/mol (6437.3358 without restraints) Performing minimization step: 4550. Total energy = 6455.7856 kcal/mol (6435.0347 without restraints) Performing minimization step: 4551. Total energy = 6453.4851 kcal/mol (6432.7372 without restraints) Performing minimization step: 4552. Total energy = 6451.1881 kcal/mol (6430.4432 without restraints) Performing minimization step: 4553. Total energy = 6448.8949 kcal/mol (6428.1529 without restraints) Performing minimization step: 4554. Total energy = 6446.6049 kcal/mol (6425.8657 without restraints) Performing minimization step: 4555. Total energy = 6444.3187 kcal/mol (6423.5826 without restraints) Performing minimization step: 4556. Total energy = 6442.0363 kcal/mol (6421.3032 without restraints) Performing minimization step: 4557. Total energy = 6439.7573 kcal/mol (6419.0270 without restraints) Performing minimization step: 4558. Total energy = 6437.4817 kcal/mol (6416.7545 without restraints) Performing minimization step: 4559. Total energy = 6435.2107 kcal/mol (6414.4864 without restraints) Performing minimization step: 4560. Total energy = 6432.9425 kcal/mol (6412.2212 without restraints) Performing minimization step: 4561. Total energy = 6430.6780 kcal/mol (6409.9596 without restraints) Performing minimization step: 4562. Total energy = 6428.4171 kcal/mol (6407.7018 without restraints) Performing minimization step: 4563. Total energy = 6426.1600 kcal/mol (6405.4476 without restraints) Performing minimization step: 4564. Total energy = 6423.9061 kcal/mol (6403.1967 without restraints) Performing minimization step: 4565. Total energy = 6421.6562 kcal/mol (6400.9497 without restraints) Performing minimization step: 4566. Total energy = 6419.4095 kcal/mol (6398.7061 without restraints) Performing minimization step: 4567. Total energy = 6417.1666 kcal/mol (6396.4663 without restraints) Performing minimization step: 4568. Total energy = 6414.9273 kcal/mol (6394.2298 without restraints) Performing minimization step: 4569. Total energy = 6412.6913 kcal/mol (6391.9969 without restraints) Performing minimization step: 4570. Total energy = 6410.4587 kcal/mol (6389.7673 without restraints) Performing minimization step: 4571. Total energy = 6408.2302 kcal/mol (6387.5418 without restraints) Performing minimization step: 4572. Total energy = 6406.0044 kcal/mol (6385.3189 without restraints) Performing minimization step: 4573. Total energy = 6403.7823 kcal/mol (6383.0998 without restraints) Performing minimization step: 4574. Total energy = 6401.5641 kcal/mol (6380.8848 without restraints) Performing minimization step: 4575. Total energy = 6399.3493 kcal/mol (6378.6729 without restraints) Performing minimization step: 4576. Total energy = 6397.1378 kcal/mol (6376.4644 without restraints) Performing minimization step: 4577. Total energy = 6394.9297 kcal/mol (6374.2593 without restraints) Performing minimization step: 4578. Total energy = 6392.7249 kcal/mol (6372.0576 without restraints) Performing minimization step: 4579. Total energy = 6390.5238 kcal/mol (6369.8595 without restraints) Performing minimization step: 4580. Total energy = 6388.3264 kcal/mol (6367.6651 without restraints) Performing minimization step: 4581. Total energy = 6386.1327 kcal/mol (6365.4746 without restraints) Performing minimization step: 4582. Total energy = 6383.9420 kcal/mol (6363.2868 without restraints) Performing minimization step: 4583. Total energy = 6381.7549 kcal/mol (6361.1027 without restraints) Performing minimization step: 4584. Total energy = 6379.5712 kcal/mol (6358.9221 without restraints) Performing minimization step: 4585. Total energy = 6377.3909 kcal/mol (6356.7448 without restraints) Performing minimization step: 4586. Total energy = 6375.2140 kcal/mol (6354.5710 without restraints) Performing minimization step: 4587. Total energy = 6373.0407 kcal/mol (6352.4008 without restraints) Performing minimization step: 4588. Total energy = 6370.8710 kcal/mol (6350.2341 without restraints) Performing minimization step: 4589. Total energy = 6368.7045 kcal/mol (6348.0707 without restraints) Performing minimization step: 4590. Total energy = 6366.5418 kcal/mol (6345.9112 without restraints) Performing minimization step: 4591. Total energy = 6364.3824 kcal/mol (6343.7547 without restraints) Performing minimization step: 4592. Total energy = 6362.2262 kcal/mol (6341.6015 without restraints) Performing minimization step: 4593. Total energy = 6360.0733 kcal/mol (6339.4517 without restraints) Performing minimization step: 4594. Total energy = 6357.9239 kcal/mol (6337.3054 without restraints) Performing minimization step: 4595. Total energy = 6355.7778 kcal/mol (6335.1624 without restraints) Performing minimization step: 4596. Total energy = 6353.6352 kcal/mol (6333.0228 without restraints) Performing minimization step: 4597. Total energy = 6351.4960 kcal/mol (6330.8867 without restraints) Performing minimization step: 4598. Total energy = 6349.3600 kcal/mol (6328.7537 without restraints) Performing minimization step: 4599. Total energy = 6347.2277 kcal/mol (6326.6247 without restraints) Performing minimization step: 4600. Total energy = 6345.0991 kcal/mol (6324.4991 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4601. Total energy = 6342.9732 kcal/mol (6322.3763 without restraints) Performing minimization step: 4602. Total energy = 6340.8506 kcal/mol (6320.2568 without restraints) Performing minimization step: 4603. Total energy = 6338.7319 kcal/mol (6318.1413 without restraints) Performing minimization step: 4604. Total energy = 6336.6164 kcal/mol (6316.0288 without restraints) Performing minimization step: 4605. Total energy = 6334.5041 kcal/mol (6313.9196 without restraints) Performing minimization step: 4606. Total energy = 6332.3952 kcal/mol (6311.8140 without restraints) Performing minimization step: 4607. Total energy = 6330.2897 kcal/mol (6309.7115 without restraints) Performing minimization step: 4608. Total energy = 6328.1875 kcal/mol (6307.6124 without restraints) Performing minimization step: 4609. Total energy = 6326.0885 kcal/mol (6305.5166 without restraints) Performing minimization step: 4610. Total energy = 6323.9931 kcal/mol (6303.4243 without restraints) Performing minimization step: 4611. Total energy = 6321.9006 kcal/mol (6301.3349 without restraints) Performing minimization step: 4612. Total energy = 6319.8118 kcal/mol (6299.2493 without restraints) Performing minimization step: 4613. Total energy = 6317.7261 kcal/mol (6297.1667 without restraints) Performing minimization step: 4614. Total energy = 6315.6440 kcal/mol (6295.0877 without restraints) Performing minimization step: 4615. Total energy = 6313.5650 kcal/mol (6293.0119 without restraints) Performing minimization step: 4616. Total energy = 6311.4892 kcal/mol (6290.9393 without restraints) Performing minimization step: 4617. Total energy = 6309.4171 kcal/mol (6288.8702 without restraints) Performing minimization step: 4618. Total energy = 6307.3479 kcal/mol (6286.8042 without restraints) Performing minimization step: 4619. Total energy = 6305.2821 kcal/mol (6284.7416 without restraints) Performing minimization step: 4620. Total energy = 6303.2197 kcal/mol (6282.6826 without restraints) Performing minimization step: 4621. Total energy = 6301.1605 kcal/mol (6280.6263 without restraints) Performing minimization step: 4622. Total energy = 6299.1042 kcal/mol (6278.5731 without restraints) Performing minimization step: 4623. Total energy = 6297.0511 kcal/mol (6276.5232 without restraints) Performing minimization step: 4624. Total energy = 6295.0013 kcal/mol (6274.4767 without restraints) Performing minimization step: 4625. Total energy = 6292.9550 kcal/mol (6272.4335 without restraints) Performing minimization step: 4626. Total energy = 6290.9118 kcal/mol (6270.3935 without restraints) Performing minimization step: 4627. Total energy = 6288.8718 kcal/mol (6268.3567 without restraints) Performing minimization step: 4628. Total energy = 6286.8355 kcal/mol (6266.3236 without restraints) Performing minimization step: 4629. Total energy = 6284.8018 kcal/mol (6264.2930 without restraints) Performing minimization step: 4630. Total energy = 6282.7716 kcal/mol (6262.2661 without restraints) Performing minimization step: 4631. Total energy = 6280.7446 kcal/mol (6260.2422 without restraints) Performing minimization step: 4632. Total energy = 6278.7213 kcal/mol (6258.2224 without restraints) Performing minimization step: 4633. Total energy = 6276.7010 kcal/mol (6256.2050 without restraints) Performing minimization step: 4634. Total energy = 6274.6837 kcal/mol (6254.1909 without restraints) Performing minimization step: 4635. Total energy = 6272.6693 kcal/mol (6252.1798 without restraints) Performing minimization step: 4636. Total energy = 6270.6580 kcal/mol (6250.1717 without restraints) Performing minimization step: 4637. Total energy = 6268.6503 kcal/mol (6248.1672 without restraints) Performing minimization step: 4638. Total energy = 6266.6456 kcal/mol (6246.1657 without restraints) Performing minimization step: 4639. Total energy = 6264.6440 kcal/mol (6244.1675 without restraints) Performing minimization step: 4640. Total energy = 6262.6456 kcal/mol (6242.1722 without restraints) Performing minimization step: 4641. Total energy = 6260.6506 kcal/mol (6240.1804 without restraints) Performing minimization step: 4642. Total energy = 6258.6588 kcal/mol (6238.1918 without restraints) Performing minimization step: 4643. Total energy = 6256.6698 kcal/mol (6236.2060 without restraints) Performing minimization step: 4644. Total energy = 6254.6841 kcal/mol (6234.2237 without restraints) Performing minimization step: 4645. Total energy = 6252.7015 kcal/mol (6232.2443 without restraints) Performing minimization step: 4646. Total energy = 6250.7219 kcal/mol (6230.2679 without restraints) Performing minimization step: 4647. Total energy = 6248.7454 kcal/mol (6228.2948 without restraints) Performing minimization step: 4648. Total energy = 6246.7720 kcal/mol (6226.3245 without restraints) Performing minimization step: 4649. Total energy = 6244.8021 kcal/mol (6224.3579 without restraints) Performing minimization step: 4650. Total energy = 6242.8353 kcal/mol (6222.3943 without restraints) Performing minimization step: 4651. Total energy = 6240.8711 kcal/mol (6220.4334 without restraints) Performing minimization step: 4652. Total energy = 6238.9101 kcal/mol (6218.4756 without restraints) Performing minimization step: 4653. Total energy = 6236.9521 kcal/mol (6216.5210 without restraints) Performing minimization step: 4654. Total energy = 6234.9972 kcal/mol (6214.5693 without restraints) Performing minimization step: 4655. Total energy = 6233.0454 kcal/mol (6212.6207 without restraints) Performing minimization step: 4656. Total energy = 6231.0963 kcal/mol (6210.6749 without restraints) Performing minimization step: 4657. Total energy = 6229.1505 kcal/mol (6208.7325 without restraints) Performing minimization step: 4658. Total energy = 6227.2079 kcal/mol (6206.7931 without restraints) Performing minimization step: 4659. Total energy = 6225.2685 kcal/mol (6204.8571 without restraints) Performing minimization step: 4660. Total energy = 6223.3320 kcal/mol (6202.9238 without restraints) Performing minimization step: 4661. Total energy = 6221.3987 kcal/mol (6200.9938 without restraints) Performing minimization step: 4662. Total energy = 6219.4681 kcal/mol (6199.0666 without restraints) Performing minimization step: 4663. Total energy = 6217.5406 kcal/mol (6197.1423 without restraints) Performing minimization step: 4664. Total energy = 6215.6160 kcal/mol (6195.2211 without restraints) Performing minimization step: 4665. Total energy = 6213.6948 kcal/mol (6193.3032 without restraints) Performing minimization step: 4666. Total energy = 6211.7764 kcal/mol (6191.3881 without restraints) Performing minimization step: 4667. Total energy = 6209.8610 kcal/mol (6189.4760 without restraints) Performing minimization step: 4668. Total energy = 6207.9486 kcal/mol (6187.5669 without restraints) Performing minimization step: 4669. Total energy = 6206.0391 kcal/mol (6185.6608 without restraints) Performing minimization step: 4670. Total energy = 6204.1331 kcal/mol (6183.7581 without restraints) Performing minimization step: 4671. Total energy = 6202.2296 kcal/mol (6181.8579 without restraints) Performing minimization step: 4672. Total energy = 6200.3294 kcal/mol (6179.9611 without restraints) Performing minimization step: 4673. Total energy = 6198.4319 kcal/mol (6178.0669 without restraints) Performing minimization step: 4674. Total energy = 6196.5373 kcal/mol (6176.1757 without restraints) Performing minimization step: 4675. Total energy = 6194.6462 kcal/mol (6174.2879 without restraints) Performing minimization step: 4676. Total energy = 6192.7576 kcal/mol (6172.4026 without restraints) Performing minimization step: 4677. Total energy = 6190.8719 kcal/mol (6170.5202 without restraints) Performing minimization step: 4678. Total energy = 6188.9891 kcal/mol (6168.6409 without restraints) Performing minimization step: 4679. Total energy = 6187.1092 kcal/mol (6166.7642 without restraints) Performing minimization step: 4680. Total energy = 6185.2326 kcal/mol (6164.8910 without restraints) Performing minimization step: 4681. Total energy = 6183.3588 kcal/mol (6163.0206 without restraints) Performing minimization step: 4682. Total energy = 6181.4879 kcal/mol (6161.1531 without restraints) Performing minimization step: 4683. Total energy = 6179.6198 kcal/mol (6159.2883 without restraints) Performing minimization step: 4684. Total energy = 6177.7546 kcal/mol (6157.4265 without restraints) Performing minimization step: 4685. Total energy = 6175.8922 kcal/mol (6155.5675 without restraints) Performing minimization step: 4686. Total energy = 6174.0329 kcal/mol (6153.7116 without restraints) Performing minimization step: 4687. Total energy = 6172.1767 kcal/mol (6151.8588 without restraints) Performing minimization step: 4688. Total energy = 6170.3232 kcal/mol (6150.0087 without restraints) Performing minimization step: 4689. Total energy = 6168.4729 kcal/mol (6148.1617 without restraints) Performing minimization step: 4690. Total energy = 6166.6251 kcal/mol (6146.3176 without restraints) Performing minimization step: 4691. Total energy = 6164.7803 kcal/mol (6144.4761 without restraints) Performing minimization step: 4692. Total energy = 6162.9384 kcal/mol (6142.6376 without restraints) Performing minimization step: 4693. Total energy = 6161.0993 kcal/mol (6140.8018 without restraints) Performing minimization step: 4694. Total energy = 6159.2631 kcal/mol (6138.9690 without restraints) Performing minimization step: 4695. Total energy = 6157.4295 kcal/mol (6137.1390 without restraints) Performing minimization step: 4696. Total energy = 6155.5989 kcal/mol (6135.3117 without restraints) Performing minimization step: 4697. Total energy = 6153.7707 kcal/mol (6133.4868 without restraints) Performing minimization step: 4698. Total energy = 6151.9457 kcal/mol (6131.6653 without restraints) Performing minimization step: 4699. Total energy = 6150.1235 kcal/mol (6129.8465 without restraints) Performing minimization step: 4700. Total energy = 6148.3041 kcal/mol (6128.0306 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4701. Total energy = 6146.4876 kcal/mol (6126.2177 without restraints) Performing minimization step: 4702. Total energy = 6144.6740 kcal/mol (6124.4073 without restraints) Performing minimization step: 4703. Total energy = 6142.8629 kcal/mol (6122.5996 without restraints) Performing minimization step: 4704. Total energy = 6141.0547 kcal/mol (6120.7950 without restraints) Performing minimization step: 4705. Total energy = 6139.2495 kcal/mol (6118.9932 without restraints) Performing minimization step: 4706. Total energy = 6137.4467 kcal/mol (6117.1938 without restraints) Performing minimization step: 4707. Total energy = 6135.6467 kcal/mol (6115.3974 without restraints) Performing minimization step: 4708. Total energy = 6133.8494 kcal/mol (6113.6034 without restraints) Performing minimization step: 4709. Total energy = 6132.0547 kcal/mol (6111.8122 without restraints) Performing minimization step: 4710. Total energy = 6130.2631 kcal/mol (6110.0240 without restraints) Performing minimization step: 4711. Total energy = 6128.4742 kcal/mol (6108.2388 without restraints) Performing minimization step: 4712. Total energy = 6126.6884 kcal/mol (6106.4562 without restraints) Performing minimization step: 4713. Total energy = 6124.9056 kcal/mol (6104.6772 without restraints) Performing minimization step: 4714. Total energy = 6123.1258 kcal/mol (6102.9007 without restraints) Performing minimization step: 4715. Total energy = 6121.3479 kcal/mol (6101.1262 without restraints) Performing minimization step: 4716. Total energy = 6119.5722 kcal/mol (6099.3540 without restraints) Performing minimization step: 4717. Total energy = 6117.7997 kcal/mol (6097.5850 without restraints) Performing minimization step: 4718. Total energy = 6116.0297 kcal/mol (6095.8185 without restraints) Performing minimization step: 4719. Total energy = 6114.2632 kcal/mol (6094.0554 without restraints) Performing minimization step: 4720. Total energy = 6112.4984 kcal/mol (6092.2940 without restraints) Performing minimization step: 4721. Total energy = 6110.7368 kcal/mol (6090.5361 without restraints) Performing minimization step: 4722. Total energy = 6108.9781 kcal/mol (6088.7809 without restraints) Performing minimization step: 4723. Total energy = 6107.2216 kcal/mol (6087.0279 without restraints) Performing minimization step: 4724. Total energy = 6105.4678 kcal/mol (6085.2776 without restraints) Performing minimization step: 4725. Total energy = 6103.7168 kcal/mol (6083.5301 without restraints) Performing minimization step: 4726. Total energy = 6101.9686 kcal/mol (6081.7854 without restraints) Performing minimization step: 4727. Total energy = 6100.2228 kcal/mol (6080.0432 without restraints) Performing minimization step: 4728. Total energy = 6098.4800 kcal/mol (6078.3039 without restraints) Performing minimization step: 4729. Total energy = 6096.7397 kcal/mol (6076.5671 without restraints) Performing minimization step: 4730. Total energy = 6095.0020 kcal/mol (6074.8331 without restraints) Performing minimization step: 4731. Total energy = 6093.2678 kcal/mol (6073.1025 without restraints) Performing minimization step: 4732. Total energy = 6091.5350 kcal/mol (6071.3728 without restraints) Performing minimization step: 4733. Total energy = 6089.8048 kcal/mol (6069.6464 without restraints) Performing minimization step: 4734. Total energy = 6088.0777 kcal/mol (6067.9231 without restraints) Performing minimization step: 4735. Total energy = 6086.3535 kcal/mol (6066.2021 without restraints) Performing minimization step: 4736. Total energy = 6084.6313 kcal/mol (6064.4836 without restraints) Performing minimization step: 4737. Total energy = 6082.9122 kcal/mol (6062.7679 without restraints) Performing minimization step: 4738. Total energy = 6081.1952 kcal/mol (6061.0545 without restraints) Performing minimization step: 4739. Total energy = 6079.4808 kcal/mol (6059.3437 without restraints) Performing minimization step: 4740. Total energy = 6077.7691 kcal/mol (6057.6357 without restraints) Performing minimization step: 4741. Total energy = 6076.0600 kcal/mol (6055.9300 without restraints) Performing minimization step: 4742. Total energy = 6074.3536 kcal/mol (6054.2272 without restraints) Performing minimization step: 4743. Total energy = 6072.6502 kcal/mol (6052.5273 without restraints) Performing minimization step: 4744. Total energy = 6070.9488 kcal/mol (6050.8297 without restraints) Performing minimization step: 4745. Total energy = 6069.2502 kcal/mol (6049.1345 without restraints) Performing minimization step: 4746. Total energy = 6067.5539 kcal/mol (6047.4418 without restraints) Performing minimization step: 4747. Total energy = 6065.8602 kcal/mol (6045.7517 without restraints) Performing minimization step: 4748. Total energy = 6064.1694 kcal/mol (6044.0646 without restraints) Performing minimization step: 4749. Total energy = 6062.4808 kcal/mol (6042.3795 without restraints) Performing minimization step: 4750. Total energy = 6060.7945 kcal/mol (6040.6969 without restraints) Performing minimization step: 4751. Total energy = 6059.1112 kcal/mol (6039.0171 without restraints) Performing minimization step: 4752. Total energy = 6057.4300 kcal/mol (6037.3395 without restraints) Performing minimization step: 4753. Total energy = 6055.7512 kcal/mol (6035.6644 without restraints) Performing minimization step: 4754. Total energy = 6054.0750 kcal/mol (6033.9917 without restraints) Performing minimization step: 4755. Total energy = 6052.4013 kcal/mol (6032.3217 without restraints) Performing minimization step: 4756. Total energy = 6050.7303 kcal/mol (6030.6542 without restraints) Performing minimization step: 4757. Total energy = 6049.0616 kcal/mol (6028.9892 without restraints) Performing minimization step: 4758. Total energy = 6047.3954 kcal/mol (6027.3266 without restraints) Performing minimization step: 4759. Total energy = 6045.7316 kcal/mol (6025.6665 without restraints) Performing minimization step: 4760. Total energy = 6044.0703 kcal/mol (6024.0088 without restraints) Performing minimization step: 4761. Total energy = 6042.4115 kcal/mol (6022.3537 without restraints) Performing minimization step: 4762. Total energy = 6040.7552 kcal/mol (6020.7010 without restraints) Performing minimization step: 4763. Total energy = 6039.1013 kcal/mol (6019.0507 without restraints) Performing minimization step: 4764. Total energy = 6037.4498 kcal/mol (6017.4029 without restraints) Performing minimization step: 4765. Total energy = 6035.8007 kcal/mol (6015.7574 without restraints) Performing minimization step: 4766. Total energy = 6034.1543 kcal/mol (6014.1147 without restraints) Performing minimization step: 4767. Total energy = 6032.5108 kcal/mol (6012.4749 without restraints) Performing minimization step: 4768. Total energy = 6030.8692 kcal/mol (6010.8370 without restraints) Performing minimization step: 4769. Total energy = 6029.2300 kcal/mol (6009.2014 without restraints) Performing minimization step: 4770. Total energy = 6027.5931 kcal/mol (6007.5681 without restraints) Performing minimization step: 4771. Total energy = 6025.9587 kcal/mol (6005.9375 without restraints) Performing minimization step: 4772. Total energy = 6024.3267 kcal/mol (6004.3090 without restraints) Performing minimization step: 4773. Total energy = 6022.6981 kcal/mol (6002.6841 without restraints) Performing minimization step: 4774. Total energy = 6021.0712 kcal/mol (6001.0609 without restraints) Performing minimization step: 4775. Total energy = 6019.4465 kcal/mol (5999.4399 without restraints) Performing minimization step: 4776. Total energy = 6017.8241 kcal/mol (5997.8213 without restraints) Performing minimization step: 4777. Total energy = 6016.2042 kcal/mol (5996.2050 without restraints) Performing minimization step: 4778. Total energy = 6014.5864 kcal/mol (5994.5909 without restraints) Performing minimization step: 4779. Total energy = 6012.9711 kcal/mol (5992.9794 without restraints) Performing minimization step: 4780. Total energy = 6011.3582 kcal/mol (5991.3700 without restraints) Performing minimization step: 4781. Total energy = 6009.7479 kcal/mol (5989.7635 without restraints) Performing minimization step: 4782. Total energy = 6008.1397 kcal/mol (5988.1591 without restraints) Performing minimization step: 4783. Total energy = 6006.5338 kcal/mol (5986.5567 without restraints) Performing minimization step: 4784. Total energy = 6004.9301 kcal/mol (5984.9567 without restraints) Performing minimization step: 4785. Total energy = 6003.3289 kcal/mol (5983.3593 without restraints) Performing minimization step: 4786. Total energy = 6001.7300 kcal/mol (5981.7641 without restraints) Performing minimization step: 4787. Total energy = 6000.1333 kcal/mol (5980.1712 without restraints) Performing minimization step: 4788. Total energy = 5998.5390 kcal/mol (5978.5805 without restraints) Performing minimization step: 4789. Total energy = 5996.9469 kcal/mol (5976.9922 without restraints) Performing minimization step: 4790. Total energy = 5995.3569 kcal/mol (5975.4059 without restraints) Performing minimization step: 4791. Total energy = 5993.7698 kcal/mol (5973.8227 without restraints) Performing minimization step: 4792. Total energy = 5992.1851 kcal/mol (5972.2416 without restraints) Performing minimization step: 4793. Total energy = 5990.6028 kcal/mol (5970.6631 without restraints) Performing minimization step: 4794. Total energy = 5989.0224 kcal/mol (5969.0863 without restraints) Performing minimization step: 4795. Total energy = 5987.4441 kcal/mol (5967.5118 without restraints) Performing minimization step: 4796. Total energy = 5985.8683 kcal/mol (5965.9398 without restraints) Performing minimization step: 4797. Total energy = 5984.2948 kcal/mol (5964.3702 without restraints) Performing minimization step: 4798. Total energy = 5982.7237 kcal/mol (5962.8027 without restraints) Performing minimization step: 4799. Total energy = 5981.1548 kcal/mol (5961.2375 without restraints) Performing minimization step: 4800. Total energy = 5979.5883 kcal/mol (5959.6748 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4801. Total energy = 5978.0241 kcal/mol (5958.1143 without restraints) Performing minimization step: 4802. Total energy = 5976.4616 kcal/mol (5956.5556 without restraints) Performing minimization step: 4803. Total energy = 5974.9016 kcal/mol (5954.9994 without restraints) Performing minimization step: 4804. Total energy = 5973.3438 kcal/mol (5953.4454 without restraints) Performing minimization step: 4805. Total energy = 5971.7880 kcal/mol (5951.8934 without restraints) Performing minimization step: 4806. Total energy = 5970.2350 kcal/mol (5950.3441 without restraints) Performing minimization step: 4807. Total energy = 5968.6844 kcal/mol (5948.7973 without restraints) Performing minimization step: 4808. Total energy = 5967.1355 kcal/mol (5947.2523 without restraints) Performing minimization step: 4809. Total energy = 5965.5892 kcal/mol (5945.7097 without restraints) Performing minimization step: 4810. Total energy = 5964.0449 kcal/mol (5944.1694 without restraints) Performing minimization step: 4811. Total energy = 5962.5027 kcal/mol (5942.6309 without restraints) Performing minimization step: 4812. Total energy = 5960.9624 kcal/mol (5941.0943 without restraints) Performing minimization step: 4813. Total energy = 5959.4244 kcal/mol (5939.5602 without restraints) Performing minimization step: 4814. Total energy = 5957.8891 kcal/mol (5938.0288 without restraints) Performing minimization step: 4815. Total energy = 5956.3557 kcal/mol (5936.4990 without restraints) Performing minimization step: 4816. Total energy = 5954.8245 kcal/mol (5934.9719 without restraints) Performing minimization step: 4817. Total energy = 5953.2953 kcal/mol (5933.4463 without restraints) Performing minimization step: 4818. Total energy = 5951.7682 kcal/mol (5931.9229 without restraints) Performing minimization step: 4819. Total energy = 5950.2431 kcal/mol (5930.4019 without restraints) Performing minimization step: 4820. Total energy = 5948.7207 kcal/mol (5928.8831 without restraints) Performing minimization step: 4821. Total energy = 5947.2004 kcal/mol (5927.3668 without restraints) Performing minimization step: 4822. Total energy = 5945.6821 kcal/mol (5925.8522 without restraints) Performing minimization step: 4823. Total energy = 5944.1660 kcal/mol (5924.3399 without restraints) Performing minimization step: 4824. Total energy = 5942.6517 kcal/mol (5922.8295 without restraints) Performing minimization step: 4825. Total energy = 5941.1398 kcal/mol (5921.3214 without restraints) Performing minimization step: 4826. Total energy = 5939.6299 kcal/mol (5919.8154 without restraints) Performing minimization step: 4827. Total energy = 5938.1219 kcal/mol (5918.3113 without restraints) Performing minimization step: 4828. Total energy = 5936.6161 kcal/mol (5916.8093 without restraints) Performing minimization step: 4829. Total energy = 5935.1124 kcal/mol (5915.3094 without restraints) Performing minimization step: 4830. Total energy = 5933.6103 kcal/mol (5913.8112 without restraints) Performing minimization step: 4831. Total energy = 5932.1109 kcal/mol (5912.3159 without restraints) Performing minimization step: 4832. Total energy = 5930.6140 kcal/mol (5910.8226 without restraints) Performing minimization step: 4833. Total energy = 5929.1186 kcal/mol (5909.3311 without restraints) Performing minimization step: 4834. Total energy = 5927.6256 kcal/mol (5907.8420 without restraints) Performing minimization step: 4835. Total energy = 5926.1351 kcal/mol (5906.3553 without restraints) Performing minimization step: 4836. Total energy = 5924.6459 kcal/mol (5904.8699 without restraints) Performing minimization step: 4837. Total energy = 5923.1589 kcal/mol (5903.3869 without restraints) Performing minimization step: 4838. Total energy = 5921.6743 kcal/mol (5901.9062 without restraints) Performing minimization step: 4839. Total energy = 5920.1916 kcal/mol (5900.4273 without restraints) Performing minimization step: 4840. Total energy = 5918.7106 kcal/mol (5898.9502 without restraints) Performing minimization step: 4841. Total energy = 5917.2319 kcal/mol (5897.4755 without restraints) Performing minimization step: 4842. Total energy = 5915.7550 kcal/mol (5896.0025 without restraints) Performing minimization step: 4843. Total energy = 5914.2807 kcal/mol (5894.5320 without restraints) Performing minimization step: 4844. Total energy = 5912.8077 kcal/mol (5893.0629 without restraints) Performing minimization step: 4845. Total energy = 5911.3369 kcal/mol (5891.5960 without restraints) Performing minimization step: 4846. Total energy = 5909.8685 kcal/mol (5890.1315 without restraints) Performing minimization step: 4847. Total energy = 5908.4020 kcal/mol (5888.6689 without restraints) Performing minimization step: 4848. Total energy = 5906.9375 kcal/mol (5887.2084 without restraints) Performing minimization step: 4849. Total energy = 5905.4751 kcal/mol (5885.7498 without restraints) Performing minimization step: 4850. Total energy = 5904.0145 kcal/mol (5884.2931 without restraints) Performing minimization step: 4851. Total energy = 5902.5556 kcal/mol (5882.8382 without restraints) Performing minimization step: 4852. Total energy = 5901.0989 kcal/mol (5881.3854 without restraints) Performing minimization step: 4853. Total energy = 5899.6447 kcal/mol (5879.9351 without restraints) Performing minimization step: 4854. Total energy = 5898.1924 kcal/mol (5878.4867 without restraints) Performing minimization step: 4855. Total energy = 5896.7415 kcal/mol (5877.0399 without restraints) Performing minimization step: 4856. Total energy = 5895.2931 kcal/mol (5875.5953 without restraints) Performing minimization step: 4857. Total energy = 5893.8462 kcal/mol (5874.1523 without restraints) Performing minimization step: 4858. Total energy = 5892.4015 kcal/mol (5872.7116 without restraints) Performing minimization step: 4859. Total energy = 5890.9588 kcal/mol (5871.2728 without restraints) Performing minimization step: 4860. Total energy = 5889.5182 kcal/mol (5869.8361 without restraints) Performing minimization step: 4861. Total energy = 5888.0794 kcal/mol (5868.4013 without restraints) Performing minimization step: 4862. Total energy = 5886.6426 kcal/mol (5866.9687 without restraints) Performing minimization step: 4863. Total energy = 5885.2078 kcal/mol (5865.5376 without restraints) Performing minimization step: 4864. Total energy = 5883.7750 kcal/mol (5864.1087 without restraints) Performing minimization step: 4865. Total energy = 5882.3442 kcal/mol (5862.6819 without restraints) Performing minimization step: 4866. Total energy = 5880.9152 kcal/mol (5861.2568 without restraints) Performing minimization step: 4867. Total energy = 5879.4881 kcal/mol (5859.8337 without restraints) Performing minimization step: 4868. Total energy = 5878.0625 kcal/mol (5858.4121 without restraints) Performing minimization step: 4869. Total energy = 5876.6393 kcal/mol (5856.9928 without restraints) Performing minimization step: 4870. Total energy = 5875.2178 kcal/mol (5855.5754 without restraints) Performing minimization step: 4871. Total energy = 5873.7982 kcal/mol (5854.1597 without restraints) Performing minimization step: 4872. Total energy = 5872.3806 kcal/mol (5852.7461 without restraints) Performing minimization step: 4873. Total energy = 5870.9649 kcal/mol (5851.3343 without restraints) Performing minimization step: 4874. Total energy = 5869.5515 kcal/mol (5849.9249 without restraints) Performing minimization step: 4875. Total energy = 5868.1396 kcal/mol (5848.5170 without restraints) Performing minimization step: 4876. Total energy = 5866.7297 kcal/mol (5847.1111 without restraints) Performing minimization step: 4877. Total energy = 5865.3214 kcal/mol (5845.7068 without restraints) Performing minimization step: 4878. Total energy = 5863.9150 kcal/mol (5844.3044 without restraints) Performing minimization step: 4879. Total energy = 5862.5106 kcal/mol (5842.9040 without restraints) Performing minimization step: 4880. Total energy = 5861.1080 kcal/mol (5841.5054 without restraints) Performing minimization step: 4881. Total energy = 5859.7073 kcal/mol (5840.1086 without restraints) Performing minimization step: 4882. Total energy = 5858.3086 kcal/mol (5838.7141 without restraints) Performing minimization step: 4883. Total energy = 5856.9116 kcal/mol (5837.3211 without restraints) Performing minimization step: 4884. Total energy = 5855.5165 kcal/mol (5835.9299 without restraints) Performing minimization step: 4885. Total energy = 5854.1241 kcal/mol (5834.5416 without restraints) Performing minimization step: 4886. Total energy = 5852.7329 kcal/mol (5833.1543 without restraints) Performing minimization step: 4887. Total energy = 5851.3433 kcal/mol (5831.7690 without restraints) Performing minimization step: 4888. Total energy = 5849.9556 kcal/mol (5830.3851 without restraints) Performing minimization step: 4889. Total energy = 5848.5698 kcal/mol (5829.0033 without restraints) Performing minimization step: 4890. Total energy = 5847.1855 kcal/mol (5827.6230 without restraints) Performing minimization step: 4891. Total energy = 5845.8033 kcal/mol (5826.2449 without restraints) Performing minimization step: 4892. Total energy = 5844.4227 kcal/mol (5824.8683 without restraints) Performing minimization step: 4893. Total energy = 5843.0441 kcal/mol (5823.4937 without restraints) Performing minimization step: 4894. Total energy = 5841.6672 kcal/mol (5822.1210 without restraints) Performing minimization step: 4895. Total energy = 5840.2925 kcal/mol (5820.7501 without restraints) Performing minimization step: 4896. Total energy = 5838.9193 kcal/mol (5819.3810 without restraints) Performing minimization step: 4897. Total energy = 5837.5476 kcal/mol (5818.0132 without restraints) Performing minimization step: 4898. Total energy = 5836.1778 kcal/mol (5816.6476 without restraints) Performing minimization step: 4899. Total energy = 5834.8100 kcal/mol (5815.2839 without restraints) Performing minimization step: 4900. Total energy = 5833.4438 kcal/mol (5813.9217 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. Performing minimization step: 4901. Total energy = 5832.0797 kcal/mol (5812.5619 without restraints) Performing minimization step: 4902. Total energy = 5830.7174 kcal/mol (5811.2033 without restraints) Performing minimization step: 4903. Total energy = 5829.3570 kcal/mol (5809.8470 without restraints) Performing minimization step: 4904. Total energy = 5827.9982 kcal/mol (5808.4923 without restraints) Performing minimization step: 4905. Total energy = 5826.6407 kcal/mol (5807.1389 without restraints) Performing minimization step: 4906. Total energy = 5825.2855 kcal/mol (5805.7877 without restraints) Performing minimization step: 4907. Total energy = 5823.9323 kcal/mol (5804.4386 without restraints) Performing minimization step: 4908. Total energy = 5822.5802 kcal/mol (5803.0905 without restraints) Performing minimization step: 4909. Total energy = 5821.2304 kcal/mol (5801.7447 without restraints) Performing minimization step: 4910. Total energy = 5819.8816 kcal/mol (5800.4001 without restraints) Performing minimization step: 4911. Total energy = 5818.5347 kcal/mol (5799.0573 without restraints) Performing minimization step: 4912. Total energy = 5817.1898 kcal/mol (5797.7166 without restraints) Performing minimization step: 4913. Total energy = 5815.8462 kcal/mol (5796.3769 without restraints) Performing minimization step: 4914. Total energy = 5814.5045 kcal/mol (5795.0394 without restraints) Performing minimization step: 4915. Total energy = 5813.1644 kcal/mol (5793.7033 without restraints) Performing minimization step: 4916. Total energy = 5811.8262 kcal/mol (5792.3693 without restraints) Performing minimization step: 4917. Total energy = 5810.4898 kcal/mol (5791.0370 without restraints) Performing minimization step: 4918. Total energy = 5809.1548 kcal/mol (5789.7060 without restraints) Performing minimization step: 4919. Total energy = 5807.8216 kcal/mol (5788.3768 without restraints) Performing minimization step: 4920. Total energy = 5806.4908 kcal/mol (5787.0502 without restraints) Performing minimization step: 4921. Total energy = 5805.1615 kcal/mol (5785.7249 without restraints) Performing minimization step: 4922. Total energy = 5803.8330 kcal/mol (5784.4005 without restraints) Performing minimization step: 4923. Total energy = 5802.5065 kcal/mol (5783.0782 without restraints) Performing minimization step: 4924. Total energy = 5801.1823 kcal/mol (5781.7582 without restraints) Performing minimization step: 4925. Total energy = 5799.8595 kcal/mol (5780.4395 without restraints) Performing minimization step: 4926. Total energy = 5798.5382 kcal/mol (5779.1222 without restraints) Performing minimization step: 4927. Total energy = 5797.2186 kcal/mol (5777.8067 without restraints) Performing minimization step: 4928. Total energy = 5795.9005 kcal/mol (5776.4927 without restraints) Performing minimization step: 4929. Total energy = 5794.5843 kcal/mol (5775.1806 without restraints) Performing minimization step: 4930. Total energy = 5793.2697 kcal/mol (5773.8702 without restraints) Performing minimization step: 4931. Total energy = 5791.9568 kcal/mol (5772.5612 without restraints) Performing minimization step: 4932. Total energy = 5790.6455 kcal/mol (5771.2541 without restraints) Performing minimization step: 4933. Total energy = 5789.3355 kcal/mol (5769.9483 without restraints) Performing minimization step: 4934. Total energy = 5788.0277 kcal/mol (5768.6446 without restraints) Performing minimization step: 4935. Total energy = 5786.7212 kcal/mol (5767.3423 without restraints) Performing minimization step: 4936. Total energy = 5785.4163 kcal/mol (5766.0416 without restraints) Performing minimization step: 4937. Total energy = 5784.1135 kcal/mol (5764.7429 without restraints) Performing minimization step: 4938. Total energy = 5782.8118 kcal/mol (5763.4453 without restraints) Performing minimization step: 4939. Total energy = 5781.5124 kcal/mol (5762.1501 without restraints) Performing minimization step: 4940. Total energy = 5780.2146 kcal/mol (5760.8563 without restraints) Performing minimization step: 4941. Total energy = 5778.9181 kcal/mol (5759.5640 without restraints) Performing minimization step: 4942. Total energy = 5777.6235 kcal/mol (5758.2736 without restraints) Performing minimization step: 4943. Total energy = 5776.3302 kcal/mol (5756.9844 without restraints) Performing minimization step: 4944. Total energy = 5775.0384 kcal/mol (5755.6967 without restraints) Performing minimization step: 4945. Total energy = 5773.7484 kcal/mol (5754.4108 without restraints) Performing minimization step: 4946. Total energy = 5772.4599 kcal/mol (5753.1267 without restraints) Performing minimization step: 4947. Total energy = 5771.1736 kcal/mol (5751.8444 without restraints) Performing minimization step: 4948. Total energy = 5769.8880 kcal/mol (5750.5630 without restraints) Performing minimization step: 4949. Total energy = 5768.6050 kcal/mol (5749.2840 without restraints) Performing minimization step: 4950. Total energy = 5767.3226 kcal/mol (5748.0058 without restraints) Performing minimization step: 4951. Total energy = 5766.0419 kcal/mol (5746.7293 without restraints) Performing minimization step: 4952. Total energy = 5764.7634 kcal/mol (5745.4549 without restraints) Performing minimization step: 4953. Total energy = 5763.4856 kcal/mol (5744.1813 without restraints) Performing minimization step: 4954. Total energy = 5762.2098 kcal/mol (5742.9097 without restraints) Performing minimization step: 4955. Total energy = 5760.9355 kcal/mol (5741.6396 without restraints) Performing minimization step: 4956. Total energy = 5759.6628 kcal/mol (5740.3710 without restraints) Performing minimization step: 4957. Total energy = 5758.3916 kcal/mol (5739.1039 without restraints) Performing minimization step: 4958. Total energy = 5757.1218 kcal/mol (5737.8384 without restraints) Performing minimization step: 4959. Total energy = 5755.8538 kcal/mol (5736.5747 without restraints) Performing minimization step: 4960. Total energy = 5754.5874 kcal/mol (5735.3123 without restraints) Performing minimization step: 4961. Total energy = 5753.3222 kcal/mol (5734.0513 without restraints) Performing minimization step: 4962. Total energy = 5752.0590 kcal/mol (5732.7923 without restraints) Performing minimization step: 4963. Total energy = 5750.7975 kcal/mol (5731.5352 without restraints) Performing minimization step: 4964. Total energy = 5749.5374 kcal/mol (5730.2791 without restraints) Performing minimization step: 4965. Total energy = 5748.2786 kcal/mol (5729.0245 without restraints) Performing minimization step: 4966. Total energy = 5747.0212 kcal/mol (5727.7712 without restraints) Performing minimization step: 4967. Total energy = 5745.7654 kcal/mol (5726.5196 without restraints) Performing minimization step: 4968. Total energy = 5744.5110 kcal/mol (5725.2694 without restraints) Performing minimization step: 4969. Total energy = 5743.2577 kcal/mol (5724.0204 without restraints) Performing minimization step: 4970. Total energy = 5742.0068 kcal/mol (5722.7736 without restraints) Performing minimization step: 4971. Total energy = 5740.7575 kcal/mol (5721.5285 without restraints) Performing minimization step: 4972. Total energy = 5739.5091 kcal/mol (5720.2843 without restraints) Performing minimization step: 4973. Total energy = 5738.2623 kcal/mol (5719.0418 without restraints) Performing minimization step: 4974. Total energy = 5737.0174 kcal/mol (5717.8010 without restraints) Performing minimization step: 4975. Total energy = 5735.7739 kcal/mol (5716.5617 without restraints) Performing minimization step: 4976. Total energy = 5734.5317 kcal/mol (5715.3237 without restraints) Performing minimization step: 4977. Total energy = 5733.2908 kcal/mol (5714.0870 without restraints) Performing minimization step: 4978. Total energy = 5732.0519 kcal/mol (5712.8522 without restraints) Performing minimization step: 4979. Total energy = 5730.8141 kcal/mol (5711.6187 without restraints) Performing minimization step: 4980. Total energy = 5729.5778 kcal/mol (5710.3867 without restraints) Performing minimization step: 4981. Total energy = 5728.3438 kcal/mol (5709.1569 without restraints) Performing minimization step: 4982. Total energy = 5727.1108 kcal/mol (5707.9282 without restraints) Performing minimization step: 4983. Total energy = 5725.8788 kcal/mol (5706.7003 without restraints) Performing minimization step: 4984. Total energy = 5724.6486 kcal/mol (5705.4743 without restraints) Performing minimization step: 4985. Total energy = 5723.4200 kcal/mol (5704.2500 without restraints) Performing minimization step: 4986. Total energy = 5722.1929 kcal/mol (5703.0270 without restraints) Performing minimization step: 4987. Total energy = 5720.9666 kcal/mol (5701.8050 without restraints) Performing minimization step: 4988. Total energy = 5719.7421 kcal/mol (5700.5847 without restraints) Performing minimization step: 4989. Total energy = 5718.5188 kcal/mol (5699.3656 without restraints) Performing minimization step: 4990. Total energy = 5717.2973 kcal/mol (5698.1483 without restraints) Performing minimization step: 4991. Total energy = 5716.0768 kcal/mol (5696.9320 without restraints) Performing minimization step: 4992. Total energy = 5714.8575 kcal/mol (5695.7169 without restraints) Performing minimization step: 4993. Total energy = 5713.6398 kcal/mol (5694.5035 without restraints) Performing minimization step: 4994. Total energy = 5712.4239 kcal/mol (5693.2918 without restraints) Performing minimization step: 4995. Total energy = 5711.2103 kcal/mol (5692.0825 without restraints) Performing minimization step: 4996. Total energy = 5709.9974 kcal/mol (5690.8738 without restraints) Performing minimization step: 4997. Total energy = 5708.7856 kcal/mol (5689.6663 without restraints) Performing minimization step: 4998. Total energy = 5707.5757 kcal/mol (5688.4605 without restraints) Performing minimization step: 4999. Total energy = 5706.3672 kcal/mol (5687.2564 without restraints) Performing minimization step: 5000. Total energy = 5705.1601 kcal/mol (5686.0534 without restraints) Writing PDB file: /home/ubuntu/rna-tools/rna_tools/tools/webserver-engine/media/jobs/49c82d14/tmp/mir222m5ref_refx/mir222m5ref_refx.pdb ...Done. /home/ubuntu/rna-tools//opt/qrnas/ Save to mir222m5ref_refx.pdb DONE!